Article
Cell Biology
P. Brancaccio, S. Anzilotti, O. Cuomo, A. Vinciguerra, M. Campanile, A. Herchuelz, S. Amoroso, L. Annunziato, G. Pignataro
Summary: Researchers are studying endogenous neuroprotective strategies to identify alternative interventions for neonatal hypoxic-ischemic encephalopathy. They found that hypoxic preconditioning can promote neurogenesis and provide neuroprotection by regulating ionic homeostasis.
CELL DEATH DISCOVERY
(2022)
Article
Immunology
Hongtao Liu, Ye Shen
Summary: The exosomes extracted from splenic ischemic preconditioning models have a protective effect on renal ischemia-reperfusion injury, reducing inflammation and apoptosis. Additionally, they can modulate the levels of cytokines in the exosomes.
Article
Cell Biology
Shridhar Sanghvi, Kalina Szteyn, Devasena Ponnalagu, Divya Sridharan, Alexender Lam, Inderjot Hansra, Ankur Chaudhury, Uddalak Majumdar, Andrew R. Kohut, Shubha Gururaja Rao, Mahmood Khan, Vidu Garg, Harpreet Singh
Summary: This study reveals the presence of BKCa channels in the plasma membrane and mitochondria of neonatal murine and rodent cardiomyocytes, and demonstrates their protective effect on the heart. Inhibition of plasma membrane BKCa channels can protect the neonatal heart from ischemia-reperfusion injury.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Evelin Csepanyi, Alexandra Gyongyosi, Istvan Lekli, Arpad Tosaki, Istvan Bak
Summary: This study suggests that beta-carotene may become pro-oxidant under severe oxidative conditions, potentially enhanced by the presence of iron. The use of an iron-chelator can reverse the pro-oxidant effects of beta-carotene and reduce cardiac injury caused by ischemia/reperfusion.
Article
Multidisciplinary Sciences
Marie V. Hjortbak, Nichlas R. Jespersen, Rebekka V. Jensen, Thomas R. Lassen, Johanne Hjort, Jonas A. Povlsen, Nicolaj B. Stottrup, Jakob Hansen, Derek J. Hausenloy, Hans Erik Botker
Summary: The study showed that mild hypothermia combined with IPC has an additive effect on reducing ischemia-reperfusion injury, while the combination of mild hypothermia and RIC did not provide additional cardioprotection. Mild hypothermia appeared to have an anti-ischemic effect during the ischemic period, while IPC and RIC targeted reperfusion injury.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Mohamad Nusier, Mohammad Alqudah, Vijayan Elimban, Naranjan S. Dhalla
Summary: The study found that ischemic preconditioning can reduce the injury induced by ischemia/reperfusion in both normal and hypertrophied hearts. In hypertrophied hearts, reduced activation of p38-MAPK may lead to a diminished cardioprotective effect of ischemic preconditioning.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Physiology
Thijs R. J. Landman, Laween Uthman, Inge A. H. Hofmans, Yvonne Schoon, Frank-Erik de Leeuw, Dick H. J. Thijssen
Summary: This study compared the effects of handgrip exercise and remote ischemic preconditioning on inflammatory biomarkers in patients with cerebral small vessel disease. The results showed that both single and repeated handgrip exercise and remote ischemic preconditioning immediately reduced inflammatory markers in cSVD patients.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Joerg W. Wegener, Ahmed Wagdi, Eva Wagner, Doerthe M. Katschinski, Gerd Hasenfuss, Tobias Bruegmann, Stephan E. Lehnart
Summary: Missense mutations in cardiac Ryanodine receptor type 2 (RyR2) cause catecholaminergic arrhythmias. In RyR2-R2474S cardiomyocytes, catecholaminergic stimulation and contractile activity pathologically amplify mitochondrial oxidation, leading to excessive E-GSH oxidization of the mitochondrial matrix. This effect can be significantly attenuated by treatment with the RyR2 channel blocker dantrolene.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuan Cheng, Mengzuo Wu, Min Liu, Birong Zhou, Xianhe Lin, Bangning Wang
Summary: Through administration of CCK-8 to rats and observing its preconditioning effects on ischemic hearts, it was found that CCK-8 may exert cardioprotective effects by modulating HIF-1α, PI3K, Akt, and GSK-3β signaling pathways.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Clinical Neurology
Natascia Guida, Luigi Mascolo, Angelo Serani, Ornella Cuomo, Serenella Anzilotti, Paola Brancaccio, Giuseppe Pignataro, Pasquale Molinaro, Lucio Annunziato, Luigi Formisano
Summary: The study revealed that the GATA3/KMT2A complex epigenetically activates NCX3 gene transcription during ischemic preconditioning, playing a crucial role in neuroprotection.
Article
Physiology
Philippe Diolez, Isabelle Bourdel-Marchasson, Guillaume Calmettes, Philippe Pasdois, Dominique Detaille, Richard Rouland, Gilles Gouspillou
FRONTIERS IN PHYSIOLOGY
(2015)
Review
Cardiac & Cardiovascular Systems
Rafael Jaimes, Richard D. Walton, Philippe Pasdois, Olivier Bernus, Igor R. Efimov, Matthew W. Kay
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2016)
Review
Cardiac & Cardiovascular Systems
Tatyana N. Andrienko, Philippe Pasdois, Goncalo C. Pereira, Matthew J. Ovens, Andrew P. Halestrap
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2017)
Article
Immunology
Yong-Gang He, Isabel Y. Pappworth, Andreas Rossbach, Joshua Paulin, Tarirai Mavimba, Christine Hayes, Liudmila Kulik, V. Michael Holers, Andrew M. Knight, Kevin J. Marchbank
Article
Cell Biology
Gilles Gouspillou, Isabelle Bourdel-Marchasson, Richard Rouland, Guillaume Calmettes, Marc Biran, Veronique Deschodt-Arsac, Sylvain Miraux, Eric Thiaudiere, Philippe Pasdois, Dominique Detaille, Jean-Michel Franconi, Marion Babot, Veronique Trezeguet, Laurent Arsac, Philippe Diolez
Review
Pharmacology & Pharmacy
Andrew P. Halestrap, Goncalo C. Pereira, Philippe Pasdois
BRITISH JOURNAL OF PHARMACOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Philippe Pasdois, Joanne E. Parker, Elinor J. Griffiths, Andrew P. Halestrap
CIRCULATION RESEARCH
(2013)
Article
Cardiac & Cardiovascular Systems
Richard D. Walton, Ali Pashaei, Marine E. Martinez, Marion Constantin, Josselin Duchateau, Laura Bear, Caroline Cros, Caroline Pascarel-Auclerc, Yunbo Guo, David Benoist, Virginie Dubes, Ndeye Rokhaya Faye, Sebastien Chaigne, Sebastien Dupuis, Dominique Detaille, Line Pourtau, Philippe Pasdois, Fabien Brette, Julien Rogier, Louis Labrousse, Meleze Hocini, Edward J. Vigmond, Michel Haissaguerre, Olivier Bernus
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2018)
Article
Multidisciplinary Sciences
Ben Littlejohns, Philippe Pasdois, Simon Duggan, Andrew R. Bond, Kate Heesom, Christopher L. Jackson, Gianni D. Angelini, Andrew P. Halestrap, M. -Saadeh Suleiman
Article
Chemistry, Applied
Jerome Cleach, Philippe Pasdois, Philippe Marchetti, Denis Watier, Guillaume Duflos, Emmanuelle Goffier, Anne-Sophie Lacoste, Christian Slomianny, Thierry Grard, Philippe Lencel
Article
Multidisciplinary Sciences
Dominique Detaille, Philippe Pasdois, Audrey Semont, Pierre Dos Santos, Philippe Diolez
Article
Multidisciplinary Sciences
Mario Rienzo, Julien Imbault, Younes El Boustani, Antoine Beurton, Carolina Carlos Sampedrano, Philippe Pasdois, Mathieu Pernot, Olivier Bernus, Michel Haissaguerre, Thierry Couffinhal, Alexandre Ouattara
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Nestor Pallares-Lupon, Jason D. Bayer, Bastien Guillot, Guido Caluori, Girish S. Ramlugun, Kanchan Kulkarni, Virginie Loyer, Stephane Bloquet, Dounia El Hamrani, Jerome Naulin, Marion Constantin, Pierre Dos Santos, Olivier Bernus, Pierre Jais, Philippe Pasdois, Richard D. Walton
Summary: Structural remodeling is a common result of chronic pathological stresses on the heart. Understanding the properties of diseased tissue is critical for determining their interactions with arrhythmic behavior. Microscale tissue remodeling is emerging as an important source of lethal arrhythmia, especially in young adults.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)