Article
Biology
Yunyun Sun, Zi-Bing Jin, Shifei Wei, Hongyan Jia, Kai Cao, Jianping Hu, Caixia Lin, Wenzai An, Jiyuan Guo, He Li, Jing Fu, Shi-Ming Li, Ningli Wang
Summary: Myopia has become a major public health issue with increasing prevalence. Genetic factors might be protecting people from myopia, and certain risk genes for primary angle closure glaucoma (PACG) could act as a protective factor for myopia.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Psychiatry
Vlasios Brakoulias, Phuong Hien Duc Nguyen, Dongni Lin, Nguyen Dang Khoa Pham
Summary: This study analyzed responses from providers of TMS for patients with OCD internationally. The most common target area for TMS was the supplementary motor area and bilateral stimulation was common, although techniques varied between centers. Additionally, exposure tasks were not commonly used during TMS. The study concluded that more research is needed to clarify the best mode of TMS delivery for OCD.
PSYCHIATRY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Jiayong Wang, Zujun Sun, Yibao Yang, Junlu Wu, Wenqiang Quan, Xingcai Chen, Peihua Ni, Dong Li
Summary: This study found associations between certain clinical laboratory parameters and genetic polymorphisms such as ACE I/D, β-Fg-455 A/G, and PAI-1 4G/5G, which are closely related to the risk of IS. The D allele of ACE I/D may be associated with elevated levels of total cholesterol and LDL-C. Elevated levels of blood glucose, triglycerides, and LDL-C are risk factors for IS.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Minghan Jia, Ning Liao, Bo Chen, Guochun Zhang, Yulei Wang, Xuerui Li, Li Cao, Hsiaopei Mok, Chongyang Ren, Kai Li, Cheukfai Li, Lingzhu Wen, Jiali Lin, Guangnan Wei, Charles M. Balch
Summary: PIK3CA alterations are prevalent in Chinese breast cancer patients with different molecular features compared to Caucasians. These findings provide valuable insights for the application of PIK3CA inhibitors in Chinese patients.
Article
Immunology
Xin Tian, Baoyi Liu, Lijie Chen, Yongyi Xie, Jingyao Liang, Yan Yang, Lei Shao, Jing Zhang, Jianqin Wang, Xibao Zhang, Zhouwei Wu, Yumei Liu
Summary: This study identified marked Th17 activation in Chinese patients with atopic dermatitis (AD), as well as alterations in the expression of IL17A, IL4R, AQP5, and CFTR in AD patients with allergic rhinitis (AR) that were associated with AR severity. These findings partially explained the phenotypic differences among AD subtypes and provided potential references for endotype-targeted therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Ruimei Liu, Wei Tang, Weiping Wang, Feikang Xu, Weixing Fan, Yi Zhang, Chen Zhang
Summary: The study did not find a significant association between the NLRP3 gene and susceptibility to schizophrenia, but suggested a potential involvement in cognitive impairment, particularly attention deficits, in the disorder.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Chentao Yang, Yang Zhou, Yanni Song, Dongya Wu, Yan Zeng, Lei Nie, Panhong Liu, Shilong Zhang, Guangji Chen, Jinjin Xu, Hongling Zhou, Long Zhou, Xiaobo Qian, Chenlu Liu, Shangjin Tan, Chengran Zhou, Wei Dai, Mengyang Xu, Yanwei Qi, Xiaobo Wang, Lidong Guo, Guangyi Fan, Aijun Wang, Yuan Deng, Yong Zhang, Jiazheng Jin, Yunqiu He, Chunxue Guo, Guoji Guo, Qing Zhou, Xun Xu, Huanming Yang, Jian Wang, Shuhua Xu, Yafei Mao, Xin Jin, Jue Ruan, Guojie Zhang
Summary: Since the release of the complete human genome, efforts in human genomic study have shifted towards closing gaps in ethnic diversity. In this study, a fully phased diploid human genome from a Han Chinese male individual (CN1) was presented, achieving the telomere-to-telomere (T2T) level. Comparisons with the CHM13 haploid T2T genome revealed significant variations in the centromere and numerous novel structural variations outside the centromere. CN1 outperformed CHM13 as a reference genome for the East Asian population, impacting rare SNP calling and uncovering East Asian specific introgression sequences.
Article
Immunology
Shuyuan Liu, Nannan Liu, Hui Wang, Xinwen Zhang, Yufeng Yao, Shuqiong Zhang, Li Shi
Summary: The study found an association between CCR5 promoter polymorphisms and pulmonary TB and TB progression in the Chinese Han population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Maolan Wu, Xiangrong Zheng, Juan Huang, Xiaolei Hu
Summary: Polymorphisms of the IL33-IL1RL1-IL1RAP complex are associated with childhood asthma susceptibility, eosinophilic airway inflammation, and response to ICS treatment in Chinese Han children in Hunan. Certain genetic variants are linked to asthma risk, airway inflammation severity, and responsiveness to ICS treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Rebecca Herzog, Till M. Berger, Martje G. Pauly, Honghu Xue, Elmar Rueckert, Alexander Muenchau, Tobias Baeumer, Anne Weissbach
Summary: Transcranial current stimulation techniques can induce cortical plasticity. The cerebellum, an important relay in the motor system, is a promising target for plasticity induction. This study compared the effects of different tCS methods on cerebellar plasticity and found that 50 Hz tACS was the most effective in changing corticospinal excitability.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Oncology
Yuxin Wang
Summary: The study revealed that LRRC3B gene polymorphisms were associated with the risk of breast cancer, suggesting that LRRC3B variants might be helpful in predicting breast cancer progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Lianhua Sun, Zhengyu Lin, Xiaowen Wang, Jiali Shen, Yue Li, Yuyu Huang, Jun Yang
Summary: Hearing loss is a common congenital disease, with genetic defects being the main cause of non-syndromic hearing loss. This study identified several gene mutations associated with Chinese Han deafness families, providing further insights into the pathogenic causes of hearing loss patients negative for GJB2, SLC26A4, and mitochondrial 12S rRNA.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Yunchao Wang, Changhe Shi, Yusheng Li, Wenkai Yu, Sen Wei, Yu Fan, Chengyuan Mao, Zhihua Yang, Lulu Yu, Zichen Zhao, Shanshan Li, Yuan Gao, Yuming Xu
Summary: This study aimed to explore the genetic characteristics of CSVD in the Chinese Han population. Through target region sequencing, five novel variants associated with CSVD were identified in 182 CSVD patients, and these variants were not present in the healthy controls.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Ji-Lan Han, Yao-Xian Yue, Xiang Gao, Yan-Chen Xie, Hong-Jun Hao, Hong-Yan Li, Xiao-Long Yu, Jie Li, Rui-Sheng Duan, Hai-Feng Li
Summary: In a case-control study, the association between VDR gene polymorphism and susceptibility/severity of MG patients was investigated. There were no significant differences in allele and genotype frequencies between MG patients and healthy controls, as well as between different MG subgroups. However, significant differences were found in the frequencies of alleles and genotypes in rs731236 between adult non-thymoma AChRAb negative MG subgroup and the control group, as well as the adult non-thymoma AChRAb positive MG group in the comprehensive classification analysis. Further confirmation is needed to establish the possible association in the Chinese Han population.
FRONTIERS IN NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
He Jiang, Fei-Fei Yuan, Hai-Ning Wang, Wei Liu, Xiao-Ping Ye, Shao-Ying Yang, Hui-Jun Xie, Sha-Sha Yu, Yu-Ru Ma, Le-Le Zhang, Shuang-Xia Zhao, Huai-Dong Song
Summary: Mutations in the CD40 gene have been widely reported as risk factors for Graves' disease. The SNP rs1883832, located near CD40, has been confirmed to predispose individuals to GD regardless of ethnicity. This study found that rs1883832 influences CD40 gene expression and serum TRAb levels, contributing to the development of GD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
K. M. Riashad Foysal, Stuart N. Baker
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Neurosciences
Isabel S. Glover, Stuart N. Baker
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Swagata Sarkar, Supriyo Choudhury, Nazrul Islam, Mohammad Shah Jahirul Hoque Chowdhury, Md Tauhidul Islam Chowdhury, Mark R. Baker, Stuart N. Baker, Hrishikesh Kumar
FRONTIERS IN HUMAN NEUROSCIENCE
(2020)
Article
Neurosciences
Bonne Habekost, Maria Germann, Stuart N. Baker
Summary: Repeated paired stimulation of two peripheral nerves can produce lasting changes in motor cortical excitability, with asynchronous stimulation enhancing task performance and neural responses while synchronous stimulation impairs them. The changes in neural activity after paired stimulation can alter the efficiency of encoding stimulus type, indicating the potential of noninvasive stimuli to affect central motor circuits in human subjects.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Karen M. Fisher, Boubker Zaaimi, Steve A. Edgley, Stuart N. Baker
Summary: The study examined the corticoreticular connections in macaque monkeys and found a high degree of convergence. Reticulospinal neurons can integrate information from both sides of the motor cortex, adapting to bilateral motor context.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Maria Germann, Stuart N. Baker
Summary: Pairing clicks and muscle stimulation for long periods induces plasticity in subcortical systems such as the reticulospinal tract (RST). Changes were similar for either of the two paired stimulus rates tested, but absent after unpaired (control) stimulation.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Steve A. Edgley, Elizabeth R. Williams, Stuart N. Baker
Summary: Renshaw cells mediate recurrent inhibition between motoneurons in the spinal cord. The study found that recurrent inhibitory connections are strongest between motoneurons innervating shoulder muscles and elbow extensors, almost absent in intrinsic hand muscles. The connectivity often spans joints, reflecting the flexible usage of the primate upper limb.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Thomas Guiho, Stuart N. Baker, Andrew Jackson
Summary: The study found that ventral epidural SCS elicits movements more easily than dorsal sites, which require higher current intensities and are attenuated throughout the training process. Dorsal epidural SCS and transcutaneous SCS were effective at facilitating supraspinal-evoked responses, especially at intermediate stimulation frequencies.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Veterinary Sciences
Henri Georges Michel Justin Bertrand, Joseph Adam Middleton, Stuart Nicolas Baker, Isabel Glover, Paul Andrew Flecknell
Summary: This study investigated the effect of alphaxalone on SEPs in a rhesus macaque, revealing that alphaxalone increased latency time and decreased amplitude of SEPs but maintained waveform structure. This suggests that alphaxalone could be a suitable general anaesthetic option in neuroscience research, veterinary, or human medicine.
LABORATORY ANIMALS
(2021)
Article
Geriatrics & Gerontology
Stuart Maitland, Stuart N. Baker
Summary: The study found that younger adults had a negative correlation between grip strength and connectivity of corticospinal and reticulospinal pathways, while older adults had a positive correlation. Older individuals who maintain or strengthen their reticulospinal tract are stronger than their peers.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
J. Ibanez, A. Del Vecchio, J. C. Rothwell, S. N. Baker, D. Farina
Summary: This study investigates the transmission speeds of cortical beta rhythms to arm and leg muscles during mild contractions in humans. Two improvements for estimating corticomuscular beta transmission delays are proposed, leading to the discovery that descending corticomuscular beta transmission is only slightly slower than expected from the fastest corticospinal pathways. Simulation results suggest two possible scenarios to explain fast corticomuscular transmission, with implications for our understanding of corticomuscular interactions.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Karen M. Fisher, Stuart N. Baker
Summary: Homonymous facilitation of the H reflex in the flexor carpi radialis can be produced by segmental spinal mechanisms and a supranormal period of nerve excitability, rather than propriospinal circuits specifically.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2021)
Article
Clinical Neurology
Simin Rahman, Ummatul Siddique, Supriyo Choudhury, Nazrul Islam, Akash Roy, Purba Basu, Sidharth Shankar Anand, Mohammad Ariful Islam, Mohammad Selim Shahi, Abu Nayeem, Md Tauhidul Islam Chowdhury, Mohammad Shah Jahirul Hoque Chowdhury, John-Paul Taylor, Mark R. Baker, Stuart N. Baker, Hrishikesh Kumar
Summary: The study suggests that the subcortical networks encompassing dopaminergic pathways in the basal ganglia play a more important role than cortical networks in movement stopping. ocSSRT can be used to differentiate between AD and PD patients, and combining with other indices or biomarkers may increase early diagnostic accuracy.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2022)
Article
Neurosciences
Banashree Mondal, Supriyo Choudhury, Rebecca Banerjee, Akash Roy, Koustav Chatterjee, Purba Basu, Ravi Singh, Saptak Halder, Shantanu Shubham, Stuart N. Baker, Mark R. Baker, Hrishikesh Kumar
Summary: Non-invasive vagus nerve stimulation has shown significant efficacy in improving gait and motor function in patients with Parkinson's disease, with improvements in key gait parameters such as walking speed, stance time, and step length. Additionally, levels of inflammatory markers TNF-alpha and glutathione decreased, while BDNF levels increased significantly in serum after treatment with nVNS.
NPJ PARKINSONS DISEASE
(2021)
Letter
Clinical Neurology
Akash Roy, Supriyo Choudhury, Purba Basu, Mark R. Baker, Stuart N. Baker, Hrishikesh Kumar