Estimating the protein burden limit of yeast cells by measuring the expression limits of glycolytic proteins

Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress

(2017) Shady Saad et al.   NATURE CELL BIOLOGY

Functional Analysis of Kinases and Transcription Factors in Saccharomyces cerevisiae Using an Integrated Overexpression Library

(2017) Ji-Young Youn et al.   G3-Genes Genomes Genetics

A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression

(2016) Benedetta Bolognesi et al.   Cell Reports

The Cost of Protein Production

(2016) Moshe Kafri et al.   Cell Reports

Cellular growth defects triggered by an overload of protein localization processes

(2016) Reiko Kintaka et al.   Scientific Reports

Codon Optimality Is a Major Determinant of mRNA Stability

(2015) Vladimir Presnyak et al.   CELL

Yeast Interspecies Comparative Proteomics Reveals Divergence in Expression Profiles and Provides Insights into Proteome Resource Allocation and Evolutionary Roles of Gene Duplication

(2015) Keiji Kito et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative nature of overexpression experiments

(2015) Hisao Moriya   MOLECULAR BIOLOGY OF THE CELL

Determinants of the rate of protein sequence evolution

(2015) Jianzhi Zhang et al.   NATURE REVIEWS GENETICS

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

Rate-Limiting Steps in Yeast Protein Translation

(2013) Premal Shah et al.   CELL

A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes

(2013) Kieran Smallbone et al.   FEBS LETTERS

Temporal system-level organization of the switch from glycolytic to gluconeogenic operation in yeast

(2013) G. G. Zampar et al.   Molecular Systems Biology

Yeast Tdh3 (Glyceraldehyde 3-Phosphate Dehydrogenase) Is a Sir2-Interacting Factor That Regulates Transcriptional Silencing and rDNA Recombination

(2013) Alison E. Ringel et al.   PLoS Genetics

Gene Overexpression: Uses, Mechanisms, and Interpretation

(2012) G. Prelich   GENETICS

Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method

(2012) K. Makanae et al.   GENOME RESEARCH

Widely targeted metabolic profiling analysis of yeast central metabolites

(2012) Hiroko Kato et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Robustness analysis of cellular systems using the genetic tug-of-war method

(2012) Hisao Moriya et al.   Molecular BioSystems

Targeted protein depletion in Saccharomyces cerevisiae by activation of a bidirectional degron

(2011) Marc Jungbluth et al.   BMC Systems Biology

An Evolutionarily Conserved Mechanism for Controlling the Efficiency of Protein Translation

(2010) Tamir Tuller et al.   CELL

Proteins Deleterious on Overexpression Are Associated with High Intrinsic Disorder, Specific Interaction Domains, and Low Abundance

(2010) Liang Ma et al.   JOURNAL OF PROTEOME RESEARCH

Cost of Unneeded Proteins in E. coli Is Reduced after Several Generations in Exponential Growth

(2010) Irit Shachrai et al.   MOLECULAR CELL

Fragilities Caused by Dosage Imbalance in Regulation of the Budding Yeast Cell Cycle

(2010) Kazunari Kaizu et al.   PLoS Genetics

Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity

(2009) Tanya Vavouri et al.   CELL

The Systems Biology Graphical Notation

(2009) Nicolas Le Novère et al.   NATURE BIOTECHNOLOGY

The evolutionary consequences of erroneous protein synthesis

(2009) D. Allan Drummond et al.   NATURE REVIEWS GENETICS

The Cost of Expression of Escherichia coli lac Operon Proteins Is in the Process, Not in the Products

(2008) D. M. Stoebel et al.   GENETICS