Article
Biochemistry & Molecular Biology
Xiangmei Hua, Conrad Dean Blosch, Hannah Dorsey, Maria K. Ficaro, Nicole L. Wallace, Richard P. Hsung, Jun Dai
Summary: The study found that the expression of epidermal RORα is highly expressed in normal skin and positively regulates the expression of differentiation markers and skin barrier-related genes in keratinocytes. However, in inflammatory skin diseases including atopic dermatitis (AD), the expression of RORα is downregulated. By using a mouse model with epidermis-specific Rora deficiency, it was found that the deficiency intensified AD-like symptoms and impaired the skin barrier function. These results demonstrate the importance of epidermal RORα in suppressing AD development by maintaining normal keratinocyte differentiation and skin barrier function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Leszek Blicharz, Lidia Rudnicka, Joanna Czuwara, Anna Waskiel-Burnat, Mohamad Goldust, Malgorzata Olszewska, Zbigniew Samochocki
Summary: Atopic dermatitis is a common inflammatory skin disease caused by epidermal barrier defects leading to immune dysregulation. Recent research has shown that skin microbiota and bacterial biofilms have a negative impact on skin barrier function, contributing to the onset and exacerbation of atopic dermatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Trinidad Montero-Vilchez, Carlos Cuenca-Barrales, Juan-Angel Rodriguez-Pozo, Pablo Diaz-Calvillo, Jesus Tercedor-Sanchez, Antonio Martinez-Lopez, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: This study investigated the changes in skin barrier function with age in patients with atopic dermatitis (AD). The results showed that as age increased, AD patients had higher transepidermal water loss (TEWL), lower stratum corneum hydration (SCH), and reduced elasticity compared to healthy individuals. There was a negative correlation between age and elasticity, which was stronger in AD patients than in controls. Linear regression analyses revealed that age and disease severity had a significant impact on elasticity in AD patients. These findings suggest that age plays a role in impairing skin barrier function in AD patients, particularly in terms of elasticity.
Review
Biochemistry & Molecular Biology
Tubanur Cetinarslan, Lisa Kuemper, Regina Foelster-Holst
Summary: Atopic dermatitis is a common and chronic inflammatory skin disease with various clinical presentations. The etiopathogenesis of AD involves structural and immunological epidermal barrier defect, imbalance of the skin microbiome, genetic background, and environmental factors. Therapeutic options targeting these pathways, such as topical steroids and biological therapies, have gained importance in the treatment of AD.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biology
Regina Foelster-Holst, Rahel Reimer, Claudia Neumann, Erhardt Proksch, Elke Rodriguez, Stephan Weidinger, Mohamad Goldust, Eckhard Hanisch, Stephan Daehnhardt-Pfeiffer, Sandra Freitag-Wolf
Summary: Atopic dermatitis and prurigo nodularis are two chronic skin diseases characterized by impaired skin barrier and disturbed water balance. Basic barrier repair is crucial for the treatment of both conditions.
Review
Cell Biology
Masanori Fujii
Summary: Ceramide abnormalities in atopic dermatitis (AD) are believed to be part of the disease's pathogenesis, with the involvement of Th2 and Th1 cytokines. Emollients rich in ceramides have been approved as adjunctive barrier repair agents for AD.
Article
Biochemistry & Molecular Biology
Chunying Xiao, Zhongbin Sun, Jixin Gao, Yaxing Bai, Chen Zhang, Bingyu Pang, Hongjiang Qiao, Meng Fu, Erle Dang, Gang Wang
Summary: This study demonstrated the critical role of skin barrier protein FLG in the pathogenesis of atopic dermatitis, with CPT-induced dermatitis being more severe in Flg(-/-) mice compared to wild-type mice. Additionally, emollients MPS and ceramide partially restored epidermal function and alleviated skin inflammation in the Flg(-/-) mouse model of AD induced by CPT.
Article
Dermatology
Jinjing Jia, Xiumei Mo, Fenggen Yan, Junfeng Liu, Siqi Ye, Yu Zhang, Ying Lin, Hongyi Li, Dacan Chen
Summary: The study found varying levels of Th1/Th2/Th17/Treg imbalance in patients with atopic dermatitis. YAP was downregulated in Treg cells and upregulated in Th17 cells, while it was downregulated in the AD epidermis. Changes in YAP expression may lead to T cell imbalance and hinder epidermal healing in AD.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Dermatology
Hye-Jin Ahn, Min Kyung Shin
Summary: This study objectively measured transepidermal water loss (TEWL) and skin tone improvements after dupilumab treatment in nonlesional areas through bioengineering devices. The results showed significant improvement in TEWL and skin tone parameters in all anatomical regions.
DERMATOLOGIC THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Wanlu Ouyang, Charlene E. Goh, Wei Bo Ng, Fook Tim Chew, Eric Peng Huat Yap, Chin-ying Stephen Hsu
Summary: Atopic dermatitis and tooth developmental abnormalities often occur together in some patients. It is suggested that there may be a common underlying mechanism involving gene mutations and protein interactions. This review explores the key gene mutations and signaling pathways associated with both diseases and identifies a possible association between the Wnt/beta-catenin signaling pathway and desmosomal proteins. Further research is needed to understand the mechanisms driving their co-occurrence and development of these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Maria Rasmussen Rinnov, Anne-Sofie Halling, Trine Gerner, Nina Haarup Ravn, Mette Hjorslev Knudgaard, Simon Trautner, Susan M. Goorden, Karen J. M. Ghauharali-van der Vlugt, Femke S. Stet, Lone Skov, Simon Francis Thomsen, Alexander Egeberg, Aske L. L. Rosted, Troels Petersen, Ivone Jakasa, Christoph Riethmuller, Sanja Kezic, Jacob P. Thyssen
Summary: This study found that levels and chain length of certain lipids were altered in infants who later developed AD, and that TARC/CCL17 levels were higher in these infants.
Review
Biochemistry & Molecular Biology
Manuela Machado, Sara Silva, Eduardo M. Costa
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disorder that is caused by various factors and leads to skin barrier dysfunction. It results in highly pruritic skin lesions, dry skin, and comorbidities including skin infections. The use of antimicrobial peptides (AMPs) has emerged as a promising alternative solution for managing AD by modulating the skin microbiome, fighting infections, and balancing immune response. However, there are limitations in the production and use of AMPs. This study aims to compile available information and provide a better understanding of the true potential of AMPs in addressing AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Pamelika Das, Pappula Mounika, Manoj Limbraj Yellurkar, Vani Sai Prasanna, Sulogna Sarkar, Ravichandiran Velayutham, Somasundaram Arumugam
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by rashes, itching, and pruritus. The pathogenesis of AD is closely related to immunological factors, including the role of the epidermal barrier and abnormal cytokine expressions. Disrupted epidermal barriers and the abnormal release of pro-inflammatory mediators from keratinocytes, as well as the role of immune cells, contribute to the pathophysiology of AD. Specific biomarkers for diagnosis are lacking, highlighting the need for further research in this area.
Article
Allergy
Evgeny Berdyshev, Elena Goleva, Irina Bronova, Anna-Sofia Bronoff, Bryce C. Hoffman, Marco A. Ramirez-Gama, Shannon L. Garcia, Debra Crumrine, Peter M. Elias, Christine B. Cho, Donald Y. M. Leung
Summary: The nonlesional skin of children with atopic dermatitis and peanut allergy is associated with decreased skin cis-UCA and PCA content, as well as alterations in the ratio of certain ceramide products. The presence of peanut allergy in children with atopic dermatitis appears to have a distinct impact on skin barrier abnormalities.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Cell Biology
Catharina Sagita Moniaga, Mitsutoshi Tominaga, Kenji Takamori
Summary: Skin and gut microbiota play important roles in the pathogenesis of atopic dermatitis (AD). The diversity of microbiota is altered in AD, and this alteration is correlated with disease severity, especially in the lesional skin. Recent evidence suggests that microbiota might affect itch in AD through gut-skin-brain interactions. Microbial metabolites, proinflammatory cytokines, and impaired immune response contribute to histamine-independent itch, disruption of the epidermal barrier, and central sensitization of itch mechanisms. Probiotics have shown positive effects in alleviating itch in AD, indicating potential novel strategies for managing itchy skin in AD patients.
Article
Allergy
Louise Cunningham, Clarisse Ganier, Felicity Ferguson, Ian R. White, Fiona M. Watt, John McFadden, Magnus D. Lynch
Summary: The study showed that the risk of a clinically relevant positive patch test can be predicted using clinical and demographic parameters. The gradient boosting method outperforms logistic regression in certain predictions, indicating the relevance of complex nonlinear interactions in risk prediction.
CONTACT DERMATITIS
(2022)
Article
Dermatology
Clarisse Ganier, Nasrat Harun, Imogen Peplow, Xinyi Du-Harpur, Callum Arthurs, Fiona M. Watt, Magnus D. Lynch
Summary: The study found that ACE2 is expressed in keratinocytes and skin vasculature, indicating a potential cutaneous entry point for SARS-CoV-2. The expression of ACE2 in vascular endothelial cells may support virally mediated mechanisms in the chilblain-like acral eruption seen in COVID-19 patients.
ADVANCES IN SKIN & WOUND CARE
(2022)
Article
Dermatology
Lisette Van Hove, Esther Hoste
Summary: This article discusses the importance of fibroblasts in the tumor microenvironment and their role in cancer. It focuses on the phenotypic plasticity and molecular pathways of cancer-associated fibroblasts (CAFs) identified through transcriptomic studies. The research shows that different tumor types and stages have distinct fibroblast activation profiles. A better understanding of the origin and function of skin CAFs will guide the development of novel therapeutic approaches.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Sophia Maschalidi, Parul Mehrotra, Burcu N. Keceli, Hannah K. L. De Cleene, Kim Lecomte, Renee Van der Cruyssen, Pauline Janssen, Jonathan Pinney, Geert van Loo, Dirk Elewaut, Ann Massie, Esther Hoste, Kodi S. Ravichandran
Summary: SLC7A11 acts as a negative regulator of efferocytosis, inhibiting its function can accelerate wound healing; it has important implications for wound management in diabetes.
Article
Dermatology
Elke Weisshaar, Philipp Bentz, Christian Apfelbacher, Eva Haufe, Luise Heinrich, Annice Heratizadeh, Susanne Abraham, Inken Harder, Andreas Kleinheinz, Andreas Wollenberg, Knut Schaekel, Franca Wiemers, Julia Ertner, Matthias Augustin, Julia Wildberger, Ralph von Kiedrowski, Margitta Worm, Alexander Zink, Isaak Effendy, Andrea Asmussen, Mario Pawlak, Michael Sticherling, Melanie Hilgers, Christiane Handrick, Sven Quist, Beate Schwarz, Magnus Bell, Petra Staubach-Renz, Sung-Hei Hong-Weldemann, Bernhard Homey, Jens-Joachim Bruecher, Stephan Weidinger, Thomas Werfel, Jochen Schmitt
Summary: TREATgermany is a disease registry that investigates the severity, symptoms, treatment, and quality of life in patients with moderate to severe atopic dermatitis. The results show that 97.2% of patients experienced itch, and the severity of itch is correlated with the patient's self-reported disease severity.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Dermatology
Osamu Ansai, Toshinari Miyauchi, Ryota Hayashi, Tatsuya Katsumi, Tomoki Nishiguchi, Akito Hasegawa, Satoru Shinkuma, Ken Natsuga, Toshifumi Nomura, Yutaka Shimomura, Riichiro Abe
Summary: Serum IL-18 levels are elevated in patients with epidermolytic ichthyosis and correlate with disease severity. Mutant keratin promotes NLRP3 inflammasome activation and IL-18 release in keratinocytes. IL-18 may serve as a severity marker and targeting it could be a potential therapeutic option for epidermolytic ichthyosis.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Letter
Dermatology
Shingo Takei, Ryota Hayashi, Tatsuya Katsumi, Osamu Ansai, Akari Sakai, Ken Natsuga, Riichiro Abe
JOURNAL OF DERMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Maarten A. Mees, Fleur Boone, Thomas Bouwen, Frederik Vanaerschot, Charlotte Titeca, Hanna-Kaisa Vikkula, Leen Catrysse, Anja Vananroye, Erin Koos, Stelios Alexandris, Sabine Rosenfeldt, Samuel Eyley, Joachim Koetz, Geert van Loo, Wim Thielemans, Esther Hoste
Summary: High-mobility group box 1 (HMGB1) released during wounding delays skin regeneration. We discovered that dissolving glycyrrhizin in water forms a hydrogel with remarkable rheological properties. Glycyrrhizin-based hydrogels accelerate the closure of cutaneous wounds in normoglycemic and diabetic mice by influencing keratinocyte migration.
Review
Genetics & Heredity
Hideyuki Kosumi, Ken Natsuga, Teruki Yanagi, Hideyuki Ujiie
Summary: Generalized verrucosis (GV) is a group of immunodeficiency disorders accompanied by widespread human papillomavirus infection. Two cases of GV due to congenital interleukin-7 deficiency were successfully treated with systemic retinoids. A review of the literature suggests that systemic retinoids are a safe and effective option for managing recalcitrant wart lesions in cases of GV.
Letter
Dermatology
Meng-Ling Li, Yi-Kai Hong, Yu-Chen Lin, Ken Natsuga, Hideyuki Ujiie, Kentaro Izumi, Hiroaki Iwata, Chao-Kai Hsu
Summary: This article presents a case study of a patient with bullous pemphigoid (BP) who showed significant improvement in skin lesions and reduced levels of autoantibodies after treatment with dupilumab. RNA sequencing analysis revealed that dupilumab reduced the expression of genes related to interleukin signalling, myeloid leucocyte activation, and T-cell activation, suggesting its effectiveness in reducing disease activity in BP patients.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Cell Biology
Joanne E. Anstee, Karen T. Feehan, James W. Opzoomer, Isaac Dean, Henrike P. Muller, Meriem Bahri, Tik Shing Cheung, Kifayathullah Liakath-Ali, Ziyan Liu, Desmond Choy, Jonathan Caron, Dominika Sosnowska, Richard Beatson, Tamara Muliaditan, Zhengwen An, Cheryl E. Gillett, Guocheng Lan, Xiangang Zou, Fiona M. Watt, Tony Ng, Joy M. Burchell, Shahram Kordasti, David R. Withers, Toby Lawrence, James N. Arnold
Summary: This study describes a population of LYVE-1-expressing TAMs that form complex multi-cellular nest structures and are distributed around blood vessels in breast cancer tumors. The researchers found that LYVE-1+ TAMs develop in response to IL-6, and their nest formation is guided by a CCR5-dependent signaling axis. Blocking the development of LYVE-1+ TAMs or their nest structures enhances the recruitment of CD8+ T cells to the tumor and improves response to chemotherapy.
DEVELOPMENTAL CELL
(2023)
Editorial Material
Biochemistry & Molecular Biology
Fiona M. Watt
Article
Dermatology
Kosei Nakamura, Shota Takashima, Takuma Nohara, Mika Watanabe, Ken Natsuga, Hideyuki Ujiie
Summary: Epidermolysis bullosa (EB) is a genetic blistering disorder affecting the skin and mucous membranes, leading to poor nutrition. A nutritionally balanced, melt-in-the-mouth chocolate called andew is introduced for EB patients. Andew chocolate is nutritionally superior and melts easily, suitable for EB patients prone to oral erosions. It provides better taste and texture compared to other dietary supplements, promoting enjoyable eating and potentially impacting patients' mental health.
JOURNAL OF DERMATOLOGY
(2023)
Article
Oncology
Priyanka G. Bhosale, Robert A. Kennedy, Fiona M. Watt
Summary: Oral squamous cell carcinomas (OSCCs) are genetically diverse and have different microenvironments. Despite the presence of lymphocytes, the activation of CASP8 and CASP3 is low in tumors, while apoptosis is high in lymphocytes. Higher FasL expression in CASP8 mutated tumors may predict disease progression.
JOURNAL OF PATHOLOGY
(2023)
Article
Cell & Tissue Engineering
Victor Augusti Negri, Blaise Louis, Sebastiaan Zijl, Clarisse Ganier, Christina Philippeos, Shahnawaz Ali, Gary Reynolds, Muzlifah Haniffa, Fiona M. Watt
Summary: This study validates previous experimental data and proposes new testable hypotheses by analyzing single-cell RNA sequencing resources from healthy human skin.
