Involvement of PDGF in Fibrosis and Scleroderma: Recent Insights from Animal Models and Potential Therapeutic Opportunities

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis

(2012) A.-K. Meinecke et al.   BLOOD

Follicular Dendritic Cells Emerge from Ubiquitous Perivascular Precursors

(2012) Nike Julia Krautler et al.   CELL

In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding

(2012) Yun-Hee Lee et al.   Cell Metabolism

Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury

(2012) Sophie Dulauroy et al.   NATURE MEDICINE

B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin

(2012) Dimitrios Daoussis et al.   ARTHRITIS RESEARCH & THERAPY

Imatinib mesylate (Gleevec) in the treatment of diffuse cutaneous systemic sclerosis: results of a 1-year, phase IIa, single-arm, open-label clinical trial

(2011) R. F. Spiera et al.   ANNALS OF THE RHEUMATIC DISEASES

A one-year, phase I/IIa, open-label pilot trial of imatinib mesylate in the treatment of systemic sclerosis-associated active interstitial lung disease

(2011) Dinesh Khanna et al.   ARTHRITIS AND RHEUMATISM

Imatinib in active diffuse cutaneous systemic sclerosis: Results of a six-month, randomized, double-blind, placebo-controlled, proof-of-concept pilot study at a single center

(2011) Janet Pope et al.   ARTHRITIS AND RHEUMATISM

Sunitinib inhibits the phosphorylation of platelet-derived growth factor receptor β in the skin of mice with scleroderma-like features and prevents the development of the disease

(2011) Niloufar Kavian et al.   ARTHRITIS AND RHEUMATISM

Epicardial-Derived Cell Epithelial-to-Mesenchymal Transition and Fate Specification Require PDGF Receptor Signaling

(2011) Christopher L. Smith et al.   CIRCULATION RESEARCH

PDGFRβ Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development

(2011) Lorin E. Olson et al.   DEVELOPMENTAL CELL

Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities

(2011) Swati Bhattacharyya et al.   Nature Reviews Rheumatology

Decreased lymphatic vessel counts in patients with systemic sclerosis: Association with fingertip ulcers

(2010) Alfiya Akhmetshina et al.   ARTHRITIS AND RHEUMATISM

Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

(2010) Akiyoshi Uezumi et al.   NATURE CELL BIOLOGY

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

(2010) Aaron W. B. Joe et al.   NATURE CELL BIOLOGY

Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor α in a subset of normal and systemic sclerosis patient sera

(2009) Nick Loizos et al.   ARTHRITIS AND RHEUMATISM

Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis

(2009) Jean-François Classen et al.   ARTHRITIS AND RHEUMATISM

Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis

(2009) Alfiya Akhmetshina et al.   ARTHRITIS AND RHEUMATISM

Increased PDGFRα Activation Disrupts Connective Tissue Development and Drives Systemic Fibrosis

(2009) Lorin E. Olson et al.   DEVELOPMENTAL CELL

Cardiac mast cells cause atrial fibrillation through PDGF-A–mediated fibrosis in pressure-overloaded mouse hearts

(2009) Chien-hui Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of platelet-derived growth factors in physiology and medicine

(2008) J. Andrae et al.   GENES & DEVELOPMENT

White Fat Progenitor Cells Reside in the Adipose Vasculature

(2008) W. Tang et al.   SCIENCE

CXCL10 ( ) and CCL2 ( ) chemokines in systemic sclerosis a longitudinal study

(2007) A. Antonelli et al.   RHEUMATOLOGY