Sunitinib inhibits the phosphorylation of platelet-derived growth factor receptor β in the skin of mice with scleroderma-like features and prevents the development of the disease

Imatinib Sensitivity in BCR-ABL1-Positive Chronic Myeloid Leukemia Cells Is Regulated by the Remaining Normal ABL1 Allele

(2011) A. Virgili et al.   CANCER RESEARCH

Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial

(2010) M. Matucci-Cerinic et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting ADAM-17/notch signaling abrogates the development of systemic sclerosis in a murine model

(2010) Niloufar Kavian et al.   ARTHRITIS AND RHEUMATISM

Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: Leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma

(2010) S. Tariq Mahmood et al.   INTERNATIONAL JOURNAL OF CANCER

New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

(2010) Yan Wang et al.   JOURNAL OF HEPATOLOGY

Limited Systemic Sclerosis Patients with Pulmonary Arterial Hypertension Show Biomarkers of Inflammation and Vascular Injury

(2010) Sarah A. Pendergrass et al.   PLoS One

Molecular framework for response to imatinib mesylate in systemic sclerosis

(2009) Lorinda Chung et al.   ARTHRITIS AND RHEUMATISM

Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis

(2009) Alfiya Akhmetshina et al.   ARTHRITIS AND RHEUMATISM

Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors

(2009) R Kumar et al.   BRITISH JOURNAL OF CANCER

Serum levels of soluble vascular endothelial growth factor receptor-2 in patients with systemic sclerosis

(2009) M. Jinnin et al.   BRITISH JOURNAL OF DERMATOLOGY

Vascular Endothelial Growth Factor Is a Key Mediator in the Development of T Cell Priming and Its Polarization to Type 1 and Type 17 T Helper Cells in the Airways

(2009) Y.-S. Kim et al.   JOURNAL OF IMMUNOLOGY

Selective Oxidation of DNA Topoisomerase 1 Induces Systemic Sclerosis in the Mouse

(2009) A. Servettaz et al.   JOURNAL OF IMMUNOLOGY

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-term outcome of systemic sclerosis-associated pulmonary arterial hypertension treated with bosentan as first-line monotherapy followed or not by the addition of prostanoids or sildenafil

(2009) D. Launay et al.   RHEUMATOLOGY

The Effect of Imatinib (Glivec®) on Scleroderma and Normal Dermal Fibroblasts: A Preclinical Study

(2008) A. Soria et al.   DERMATOLOGY

Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis

(2008) Alfiya Akhmetshina et al.   FASEB JOURNAL

Role of platelet-derived growth factors in physiology and medicine

(2008) J. Andrae et al.   GENES & DEVELOPMENT

Role of PDGF in fibrotic diseases and systemic sclerosis

(2008) M. Trojanowska   RHEUMATOLOGY

A novel therapeutic approach to the treatment of scleroderma-associated pulmonary complications: safety and efficacy of combination therapy with imatinib and cyclophosphamide

(2008) I. Sabnani et al.   RHEUMATOLOGY

Mechanisms of vascular damage in SSc--implications for vascular treatment strategies

(2008) S. Guiducci et al.   RHEUMATOLOGY