Review
Biochemistry & Molecular Biology
Chi-Jing Choong, Hideki Mochizuki, Cesar Borlongan
Summary: Mitochondrial dysregulation is strongly associated with the pathogenesis of Parkinson's disease (PD), with mutated genes affecting mitochondrial features. Disruption of mitochondrial quality control and abnormal secretion of mitochondrial contents play a role in PD, and circulating mitochondrial DNAs can elicit inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Joachim Brumberg, Anastasia Kuzkina, Constantin Lapa, Sona Mammadova, Andreas Buck, Jens Volkmann, Claudia Sommer, Ioannis U. Isaias, Kathrin Doppler
Summary: Pathological aggregates of alpha-synuclein can be detected in peripheral dermal nerve fibers of patients with idiopathic Parkinson's disease and multiple system atrophy, indicating overlapping pathophysiological mechanisms between the two diseases and suggesting that alpha-synuclein may contribute to cardiac sympathetic neurons impairment in patients with synucleinopathies.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Immunology
Valentina Leta, K. Ray Chaudhuri, Oliver Milner, Guy Chung-Faye, Vinod Metta, Carmine M. Pariante, Alessandra Borsini
Summary: The gut-brain axis plays a potential role in Parkinson's disease (PD), and probiotics have shown beneficial effects on energy metabolism, inflammation, neurodegeneration, and motor/non-motor function in both preclinical and clinical studies. However, further robust research is needed to confirm these outcomes and bridge the gap between preclinical and clinical findings.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Dong-Woo Ryu, Sang-Won Yoo, Yoon-Sang Oh, Kwang-Soo Lee, Seunggyun Ha, Joong- Seok Kim
Summary: According to this study, Parkinson's disease patients can be categorized into brain-predominant PD and PD with body involvement phenotypes based on the onset of cardiac sympathetic denervation (CSD). The study found that PD patients with body involvement had more severe initial symptoms and experienced faster progression of motor deterioration, indicating potentially more severe involvement of the central and peripheral nervous systems.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Pathology
Amir Tahavvori, Morad Kohandel Gargari, Yalda Yazdani, Alireza Soleimani Mamalo, Elmira Aboutalebi Vand Beilankouhi, Mohammad Valilo
Summary: The etiology of Parkinson's disease is multifactorial, involving both genetic and environmental factors. Exposure to pesticides and the production of reactive oxygen species are the primary environmental risk factors. Oxidative stress triggers a series of reactions that affect cell function and may lead to the development of Parkinson's disease.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Medicine, Research & Experimental
Sen Jiang, Hua Gao, Yuxuan Yong, Huaxiong Zhang, Peishan Li, Yanxia Li, Qin Luo, Xinling Yang
Summary: The study observed the effect of pramipexole on the behavior and central nervous system inflammatory cytokines of Parkinson's Disease (PD) model rats. It was found that pramipexole improved the behavior of PD model rats and down-regulated the expression and concentrations of IL-6 and TNF-alpha in their CNS.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Neurosciences
Lei Chang, Wen-Wen Dong, Bei Luo, Chang Qiu, Yue Lu, Xing-Jian Lin, Wen-Bin Zhang
Summary: This study found that Parkinson's disease patients have a persistent inflammatory profile, possibly due to the recruitment of activated monocytes, macrophages, and T lymphocytes to the central nervous system. Deep brain stimulation has been shown to have a significant therapeutic effect on Parkinson's disease, which may be achieved by improving the inflammatory environment of the central nervous system.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Cardiac & Cardiovascular Systems
Tarek Alsaied, Adriana H. Tremoulet, Jane C. Burns, Arwa Saidi, Audrey Dionne, Sean M. Lang, Jane W. Newburger, Sarah de Ferranti, Kevin G. Friedman
Summary: Multisystem inflammatory syndrome in children, triggered by SARS-CoV-2 infection, is a severe inflammatory disease with common symptoms of persistent fever and cardiac manifestations. Treatment mainly aims at reversing the inflammatory response with immunomodulatory medications.
Review
Medicine, General & Internal
Hong-Xing Li, Cui Zhang, Kai Zhang, Yi-Zhe Liu, Xiao-Xiao Peng, Qiang Zong
Summary: A meta-analysis was conducted to investigate the relationship between inflammatory bowel disease (IBD) and Parkinson's Disease (PD) risk. The results showed that patients with IBD have a moderately increased risk of PD, especially those aged 60 years or older.
FRONTIERS IN MEDICINE
(2023)
Review
Clinical Neurology
Albert Frank Magnusen, Shelby Loraine Hatton, Reena Rani, Manoj Kumar Pandey
Summary: Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, resulting in motor and non-motor symptoms. Genetic mutations and abnormal activation of microglial cells are believed to be key factors in neuroinflammation and neurodegeneration in PD. However, the exact disease mechanisms and innovative biomarkers for PD linked to specific genetic defects remain largely unknown.
FRONTIERS IN NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Xueping Chen, Weihua Feng, Ruwei Ou, Jiao Liu, Jing Yang, Jiajia Fu, Bei Cao, Yongping Chen, Qianqian Wei, Huifang Shang
Summary: Evidence suggests enhanced immune activation in the peripheral system in Parkinson's disease, with dynamic alterations in CD4+ T cell percentage and IgG level indicating an active role for peripheral immunity in disease progression, especially in female patients.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Anamaria Jurcau, Felicia Liana Andronie-Cioara, Delia Carmen Nistor-Cseppento, Nicoleta Pascalau, Marius Rus, Elisabeta Vasca, Maria Carolina Jurcau
Summary: Parkinson's disease is a neurodegenerative disease with unclear pathophysiology, but inflammation plays a significant role in its initiation and progression. Current therapies only provide symptomatic relief and do not interfere with the disease progression. Promising results have been seen in therapies targeting neuroinflammatory cascades.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Francesca R. Buccellato, Marianna D'Anca, Maria Serpente, Andrea Arighi, Daniela Galimberti
Summary: Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative disorders characterized by the accumulation of toxic proteins. Recent studies have explored the role of the glymphatic system in the pathogenesis of these diseases. This review aims to present the current knowledge linking the glymphatic system to the development of AD and PD, as well as the influence of lifestyle factors such as sleep deprivation and exercise on glymphatic system function. The potential of neuroimaging approaches to detect glymphatic system changes is also discussed.
Review
Cell Biology
Baptiste Texier, Morgane Prime, Djamaa Atamena, Pascale Belenguer, Marion Szelechowski
Summary: Mortalin is a chaperone protein that plays crucial roles in neuronal homeostasis and activity by controlling protein folding and regulating calcium fluxes. Its expression and stability are strongly modified in neurodegenerative diseases, particularly in response to altered oxidative conditions. This protein has been extensively studied for its contribution to the pathophysiology of Parkinson's disease and its potential therapeutic and prognostic implications.
NEURAL REGENERATION RESEARCH
(2023)
Article
Environmental Sciences
Zehao Chen, Jialu Zhu, Hanyu Zhou, Yangyang Jia, Honglian Ruan, Qinqin Diao, Meizhen Li, Liting Zheng, Shuwei Yao, Yaozheng Guo, Yun Zhou, Yiguo Jiang
Summary: Exposure to high concentrations of copper is associated with pulmonary inflammation and chronic respiratory disease (CRD). This study found that epigenetic modulation of noncoding RNAs may be involved in copper mediated pulmonary inflammation and CRD, and specific circRNAs may play a role in regulating CRD-associated inflammation.
Letter
Genetics & Heredity
Yin Xia Chao, Ebonne Yulin Ng, Jia Nee Foo, Jianjun Liu, Yi Zhao, Eng-King Tan
Article
Multidisciplinary Sciences
Yin Xia Chao, Ebonne Yulin Ng, Louis Tan, Kumar M. Prakash, Wing-Lok Au, Yi Zhao, Eng-King Tan
SCIENTIFIC REPORTS
(2015)
Article
Clinical Neurology
Yin Xia Chao, Ebonne Yu Lin Ng, Huihua Li, Kandiah Nagaendran, Yuen Yih, Mei Sian Chong, Kumar M. Prakash, Louis Tan, Wing Lok Au, Yi Zhao, Zhi Dong Zhou, Murni Tio, Ratnagopal Pavanni, Eng King Tan
PARKINSONS DISEASE
(2015)
Article
Clinical Neurology
Ming-Ching Wen, Samuel Y. E. Ng, Hannah S. E. Heng, Yin Xia Chao, Ling Ling Chan, Eng King Tan, Louis C. S. Tan
PARKINSONISM & RELATED DISORDERS
(2016)
Letter
Clinical Neurology
Yin Xia Chao, Ebonne Yu Lin Ng, Murni Tio, Prakash Kumar, Louis Tan, Wing Lok Au, Yuen Yih, Eng King Tan
PARKINSONISM & RELATED DISORDERS
(2016)
Letter
Clinical Neurology
Yin Xia Chao, Zhidong Zhou, Eng-King Tan
Article
Cell Biology
Yinxia Chao, Nivashini Kaliaperumal, Anne-Sophie Chretien, Suisheng Tang, Bernett Lee, Michael Poidinger, Anna-Marie Fairhurst, John E. Connolly
JOURNAL OF LEUKOCYTE BIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
P. Storm, S. Aits, M. K. Puthia, A. Urbano, T. Northen, S. Powers, B. Bowen, Y. Chao, W. Reindl, D. Y. Lee, N. L. Sullivan, J. Zhang, M. Trulsson, H. Yang, J. D. Watson, C. Svanborg
Article
Multidisciplinary Sciences
Ann-Kristin Mossberg, Maja Puchades, Oyvind Halskau, Anne Baumann, Ingela Lanekoff, Yinxia Chao, Aurora Martinez, Catharina Svanborg, Roger Karlsson
Article
Multidisciplinary Sciences
Maria Trulsson, Hao Yu, Lennart Gisselsson, Yinxia Chao, Alexander Urbano, Sonja Aits, Ann-Kristin Mossberg, Catharina Svanborg
Article
Multidisciplinary Sciences
Petter Storm, Thomas Kjaer Klausen, Maria Trulsson, James C. S. Ho, Marion Dosnon, Tomas Westergren, Yinxia Chao, Anna Rydstroem, Henry Yang, Stine Falsig Pedersen, Catharina Svanborg
Review
Clinical Neurology
Eng-King Tan, Yin-Xia Chao, Andrew West, Ling-Ling Chan, Werner Poewe, Joseph Jankovic
NATURE REVIEWS NEUROLOGY
(2020)
Letter
Clinical Neurology
Yin Xia Chao, Bernett Lee, Ebonne Yulin Ng, Michelle Mulan Lian, Elaine Guo Yan Chew, Moses Tandiono, Zheng Li, Chiea Chuen Khor, Prakash Kumar, Louis C. S. Tan, Jia Nee Foo, Eng-King Tan
Review
Clinical Neurology
Yin Xia Chao, Lai Mun Chew, Xiao Deng, Eng-King Tan
NEURODEGENERATIVE DISEASE MANAGEMENT
(2015)