Article
Cell Biology
Maria Dobre, Vlad Herlea, Catalina Vladut, Mihai Ciocirlan, Vasile Daniel Balaban, Gabriel Constantinescu, Mircea Diculescu, Elena Milanesi
Summary: The study identified a panel of downregulated miRNAs in PDAC tissue, which could serve as potential therapeutic targets for the development of new miRNA-based therapies for PDAC.
Article
Agriculture, Dairy & Animal Science
Soo-Hyeon Kim, Byung-Joon Seung, Seung-Hee Cho, Ha-Young Lim, Min-Kyung Bae, Jung-Hyang Sur
Summary: The frequency of PIK3CA H1047R mutation in canine mammary tumors is 14.3%, leading to dysregulation of downstream molecules Akt2, p-Akt, and PTEN, with the exception of a higher level of PTEN in mutated tumors. No significant correlation was found between PIK3CA H1047R mutation and expression of downstream molecules, suggesting the dysregulation of components in the PI3K/Akt/PTEN pathway is a feature in canine mammary tumors distinct from the mutation.
Review
Oncology
Yubo Xiang, Yingxin Yang, Jia Liu, Xu Yang
Summary: Osteosarcoma is a primary malignant bone tumor that mainly affects children and adolescents, and it is often associated with overactivation of the PI3K/AKT pathway. MicroRNAs (miRNAs) are small RNA molecules that play a role in gene regulation, and they are involved in the PI3K/AKT pathway and the development of osteosarcoma. MiRNAs can influence various cellular functions by targeting the PI3K/AKT pathway and regulating the expression of osteosarcoma-related genes. Additionally, miRNAs associated with the PI3K/AKT pathway have potential as biomarkers for osteosarcoma diagnosis, treatment, and prognosis assessment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shiori Go, Chihiro Sato, Masaya Hane, Shinji Go, Ken Kitajima
Summary: The transition of Sia species from Neu5Ac to Neu5Gc in C2C12 myoblast cells promotes cell adhesiveness and differentiation, potentially involving the expression of the CMAH gene.
GLYCOCONJUGATE JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Maheshkumar Kannan, Sridharan Jayamohan, Rajesh Kannan Moorthy, Siva Chander Chabattula, Mathan Ganeshan, Antony Joseph Velanganni Arockiam
Summary: Hepatocellular carcinoma (HCC) is the third leading malignancy worldwide, causing high mortality in adults and children. This study explored the expression and function of the miR-221/AEG-1 axis in HCC. The silencing of the miR-221/AEG-1 axis induced apoptosis and G2/M phase arrest, inhibited cellular proliferation and angiogenesis in HCC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
RongXin Xiao, Hong Wang, Biao Yang
Summary: The study showed that overexpression of miR-98-5p can inhibit the growth and spread of cervical cancer cells, and promote cell apoptosis, making it a potential target for future research in treating cervical cancer.
Article
Biochemistry & Molecular Biology
Rongwen Ou, Chengjie Lin, Youting Chen
Summary: This study found that CST2 is overexpressed in pancreatic cancer and its knockdown can inhibit the proliferation, migration, and invasion of pancreatic cancer cells while increasing apoptosis. RUNX1 was identified as a transcription factor that positively regulates the expression of CST2. In addition, CST2 knockdown also suppressed the activation of the PI3K/AKT signaling pathway in pancreatic cells.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Environmental Sciences
Fa-Li Zhang, Hao-Hai Ma, Pei-Yu Dong, Zheng-Ning Yuan, Shu-Er Zhang, Ai-Hong Zhao, Huan-Qi Liu, Massimo De Felici, Wei Shen, Xi-Feng Zhang
Summary: The study found that Aflatoxins B1 (AFB1) leads to damage in porcine Sertoli cells and mice testis, resulting in decreased expression of GJA1, ZO1, and OCCLUDIN, and inhibition of porcine Sertoli cell proliferation. Transcriptomic analysis revealed changes in noncoding RNA expression profiles that affect the cell cycle-related Ras/PI3K/Akt signaling pathway in response to AFB1 exposure in both mice and pigs. AFB1 also caused abnormal cell cycle in the testis, with decreased expressions of CCNA1, CCNB1, and CDK1, and an increased G2/M phase. Furthermore, metabolome analysis confirmed alterations in the PI3K/Akt signaling pathway.
ENVIRONMENTAL POLLUTION
(2023)
Review
Biochemistry & Molecular Biology
Silviu Constantin Badoiu, Maria Greabu, Daniela Miricescu, Iulia-Ioana Stanescu-Spinu, Radu Ilinca, Daniela Gabriela Balan, Andra-Elena Balcangiu-Stroescu, Doina-Andrada Mihai, Ileana Adela Vacaroiu, Constantin Stefani, Viorel Jinga
Summary: Renal cell carcinoma (RCC) is the most frequent type of renal cancer, accounting for 85-95% of cases. The dysregulation of the PI3K/AKT/mTOR signaling pathway is commonly observed in renal cancer and plays a significant role in tumor growth and survival. Metabolic reprogramming is an important characteristic of cancer cells, allowing them to adapt to nutrient and oxygen-deprived environments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fatemeh Yarmohammadi, Zainab Ebrahimian, Gholamreza Karimi
Summary: This manuscript reviews the regulation of the PI3K/Akt/p53 and the Sirt1/Nrf2 pathways by miRNAs in DOX-induced cardiotoxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Medicine, General & Internal
Min Wei, Hongjuan Jin, ShuLi Yang, Zhuo Li, Xinlei Wang, LiXiang Li, Yan Jia, ManHua Cui
Summary: The research demonstrated that miRNA-101 is down-regulated in ovarian cancer cells and its over-expression can suppress the growth of ovarian cancer cells by inducing apoptosis and cell cycle arrest, potentially through regulating molecules like PTEN, PI3K, and AKT.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Hana Lee, Won-Tae Jeong, Yoon-Sup So, Heung-Bin Lim, Junsoo Lee
Summary: Taxifolin and sorghum ethanol extract can alleviate hepatic insulin resistance induced by free fatty acids by regulating the expression of miR-195. This suggests that they may be potential anti-diabetic agents.
Article
Medicine, Research & Experimental
Zeyu Shi, Sally K. Y. To, Shuaishuai Zhang, Shan Deng, Margarita Artemenko, Minda Zhang, Juan Tang, Jin-Zhang Zeng, Alice S. T. Wong
Summary: Nur77 functions as a novel regulator of microRNA biogenesis in promoting CRC progression under hypoxia, potentially through inhibition of p63-dependent transcription. Knockdown of Nur77 or overexpression of let-7i-5p can inhibit CRC metastasis.
Article
Biochemistry & Molecular Biology
Agnese Graziosi, Giulia Sita, Camilla Corrieri, Sabrina Angelini, Roberta d'Emmanuele di Villa Bianca, Emma Mitidieri, Raffaella Sorrentino, Patrizia Hrelia, Fabiana Morroni
Summary: Endocrine-disrupting chemicals (EDCs) are a group of chemicals that may have adverse effects on human beings and wildlife. Research suggests that exposure to certain pesticides at low doses can influence gene expression and contribute to human diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Lin Shi, Weiliang Zhu, Yuanyuan Huang, Lin Zhuo, Siyun Wang, Shaobing Chen, Bei Zhang, Bin Ke
Summary: This study found that exosomes released by cancer-associated fibroblasts (CAFs) can promote the progression and chemoresistance of non-small-cell lung cancer (NSCLC). Mechanistically, the exosomes transmit miR-20a to tumor cells, enhancing chemoresistance and proliferation by targeting PTEN.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Toxicology
Hyun-Jung Park, Won-Young Lee, Mingtian Zhang, Kwon-Ho Hong, Chankyu Park, Jin-Hoi Kim, Hyuk Song
TOXICOLOGICAL SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Sangiliyandi Gurunathan, Muniyandi Jeyaraj, Hyeonwoo La, Hyunjin Yoo, Youngsok Choi, Jeong Tae Do, Chankyu Park, Jin-Hoi Kim, Kwonho Hong
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Min-Hee Kang, Muniyandi Jeyaraj, Jin-Hoi Kim
Summary: Several studies have demonstrated the molecular mechanisms involved in the biogenesis and release of exosomes. PtNPs were shown to enhance exosome secretion in A549 cells by inducing oxidative stress and the ceramide pathway. Pre-treatment with NAC could inhibit the PtNPs-induced exosome biogenesis and release.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Min-Kyeung Choi, Minh Thong Le, Hye-Sun Cho, Juyoung Lee, Hyoim Jeon, Se-Yeoun Cha, Manheum Na, Taehoon Chun, Jin-Hoi Kim, Hyuk Song, Chankyu Park
Summary: The study on PG1 transgenic mice showed positive effects in resisting Staphylococcus aureus infection, with reduced lung injury, improved bacteria clearance, and lower inflammation. However, some individuals developed eye problems, indicating the importance of AMP expression regulation and localization to prevent adverse effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Min-Hee Kang, Jin-Hoi Kim
Summary: Exosomes are nanoscale membrane vesicles secreted by cells, which play important roles in intercellular communication and disease diagnosis. Research on exosomes has great potential in biomedical fields, but the underlying biological mechanisms require further exploration.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Correction
Cell Biology
Sangiliyandi Gurunathan, Min-Hee Kang, Muniyandi Jeyaraj, Muhammad Qasim, Jin-Hoi Kim
Article
Biochemistry & Molecular Biology
Hye-sun Cho, Munjeong Choi, Yunjung Lee, Hyoim Jeon, Byeongyong Ahn, Nagasundarapandian Soundrarajan, Kwonho Hong, Jin-Hoi Kim, Chankyu Park
Summary: The study found that using broad-spectrum antimicrobial peptide PMAP-36 can effectively isolate high-quality RNA from various bacteria, providing an efficient method for nucleic acid isolation. Additionally, the use of PMAP-36 also successfully isolates high-quality genomic DNA from challenging bacterial strains, offering a new option for microbiome research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Min-Hee Kang, Muhammad Qasim, Khalid Khan, Jin-Hoi Kim
Summary: Extracellular vesicles (EVs) are a diverse group of membrane-bound vesicles that function as messengers between cells. Much remains unknown about their biogenesis, cargo sorting, and potential therapeutic applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Min-Hee Kang, Muniyandi Jeyaraj, Jin-Hoi Kim
Summary: This study demonstrates for the first time that PdNPs stimulate exosome biogenesis and release in THP-1 cells, simultaneously increasing levels of cytokines and chemokines by modulating various physiological processes. These findings offer a rational approach to enhancing exosome production for various therapeutic applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Sangiliyandi Gurunathan, Muhammad Qasim, Min-Hee Kang, Jin-Hoi Kim
Summary: Cancer is the second leading cause of death worldwide, and melatonin has been shown to have oncostatic and anticancer properties by directly affecting carcinogenesis and indirectly disrupting the circadian cycle.
ONCOTARGETS AND THERAPY
(2021)
Article
Immunology
Hansam Cho, Yuyeon Jang, Ki-Hoon Park, Hanul Choi, Aleksandra Nowakowska, Hee-Jung Lee, Minjee Kim, Min-Hee Kang, Jin-Hoi Kim, Ha Youn Shin, Yu-Kyoung Oh, Young Bong Kim
Summary: A recombinant baculoviral vector-based DNA vaccine system against MERS-CoV and SARS-CoV2 was reported, showing high efficacy in preventing viral infections in animal models.
Article
Agriculture, Dairy & Animal Science
S. Youk, M. T. Le, M. Kang, B. Ahn, M. Choi, K. Kim, T. H. Kim, J. H. Kim, C. S. Ho, C. Park
Summary: A high-resolution typing method was developed for swine leukocyte antigen 3 (SLA-3), identifying 21 alleles with four novel ones, although the allelic diversity of SLA-3 was lower compared to SLA-1 and -2. More SLA-3 alleles were observed in Landrace and Yorkshire breeds, with SLA-3*04:01 being the most widely distributed allele across all breeds. This method aids in analyzing major SLA genes from field samples, enhancing understanding of immune responses and genetic makeup.
Review
Agriculture, Dairy & Animal Science
Sangiliyandi Gurunathan, Min-Hee Kang, Hyuk Song, Nam Hyung Kim, Jin-Hoi Kim
Summary: Extracellular vesicles (EVs) are nanosized membrane-enclosed compartments that act as messengers in cell-to-cell communication. They influence the phenotype and function of recipient cells by transferring functional proteins and genetic information. Various types of EVs are present in biological fluids, carrying cargoes such as lipids, proteins, and nucleic acids. EVs associated with the reproductive system play a significant role in regulating physiological events such as gamete maturation, fertilization, and embryo and fetal development.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sangiliyandi Gurunathan, Ah Reum Lee, Jin Hoi Kim
Summary: SARS-CoV-2 has caused a pandemic of COVID-19, and some patients have acquired secondary infections such as black fungus disease. Prompt diagnosis and treatment are necessary to prevent high mortality and morbidity rates. Uncontrolled diabetes and immunosuppression are major risk factors, and the use of steroids can increase the risk of black fungus infection. Novel and effective antimicrobial agents are needed to combat this infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Jin Hoi Kim
Summary: Graphene oxide (GO) stimulates exosome biogenesis and release in human ovarian cancer cells (SKOV3), indicating its potential as a tool for targeting the exosome pathway.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
