Review
Cell Biology
Ya-Juan Liu, Cheng Wang
Summary: Extracellular vesicles (EVs) are small, membrane-bound structures released from cells that play a crucial role in intercellular communication. They have attracted significant clinical interest due to their potential in drug delivery, disease diagnosis, and therapeutic interventions. This review aims to summarize the current knowledge on EV targeting, binding, and uptake, as well as the factors influencing these interactions, such as EV properties, the cellular environment, and recipient cells. Despite the current limitations in our understanding, the field of EV-related intercellular communication is expanding, and further advancements are expected.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Pharmacology & Pharmacy
Marieke T. Roefs, Wolf Heusermann, Maike A. D. Brans, Christian Snijders Blok, Zhiyong Lei, Pieter Vader, Joost P. G. Sluijter
Summary: This study investigated the fate of cardiac progenitor cell-derived extracellular vesicles (CPC-EVs) in vivo and found that after intramyocardial injection, CPC-EVs did not immediately flush out of the heart but migrated in the myocardial tissue, while after intravenous injection, most CPC-EVs accumulated in the liver. The study also demonstrated that decorating EVs with targeting peptides enhanced EV delivery to cardiac endothelial cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Nicolas Cheuk Hang Lau, Judy Wai Ping Yam
Summary: Exosomes play a crucial role in intercellular communication and their biogenesis and function are important for understanding complex biological systems and developing novel therapies. This article outlines the steps in exosome biogenesis and absorption, as well as the major pathways and regulatory mechanisms. It also highlights the various mechanisms observed in cancer and suggests directions for improving study design in exosome biology. Further research is needed to elucidate the relationship between exosome biogenesis and function, which will aid the development of translational applications.
Review
Biology
Mona Sheta, Eman A. Taha, Yanyin Lu, Takanori Eguchi
Summary: Extracellular vesicles (EVs) are cell-derived membrane-surrounded vesicles that carry bioactive molecules and deliver them to recipient cells. They can be classified into classical EVs (exosomes, microvesicles, and apoptotic bodies) and additional types (autophagic EVs, matrix vesicles, and stressed EVs). EVs are involved in the communication between cancer cells and tumor-associated cells (TAC), leading to the establishment of immunosuppressive and chemoresistant microenvironments. Cancer EVs play important roles in immunosuppression, immune evasion, and cellular transformation, and can change hot tumors into cold ones.
Article
Chemistry, Multidisciplinary
O. G. Davies, S. Williams, K. Goldie
Summary: Extracellular vesicles (EVs) are lipid enveloped nanoparticles that function in the intercellular transfer of biological material, playing a role in regenerative processes such as tissue repair. EVs derived from mesenchymal stem cells (MSC-EVs) have shown potent effects on extracellular matrix turnover, cell recruitment, proliferation, and angiogenesis. Clinical trials have assessed the safety of MSC-EVs for wound healing and cosmetic applications. However, challenges related to standardization, potency, and regulation must be addressed to ensure safe and effective clinical adoption of regenerative EV therapeutics.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Jae Hyung Park
Summary: This article discusses the significance of exosomes as intercellular messengers and their applications in disease diagnosis and treatment. The author aims to address delivery challenges of exosomes using expertise in the field of nanomedicine to develop improved therapies. The article summarizes recent preclinical efforts in the author's research group to regulate the fate of exosomes in vivo, along with future development ambitions.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biochemistry & Molecular Biology
Hyosuk Kim, Eun Hye Kim, Gijung Kwak, Sung-Gil Chi, Sun Hwa Kim, Yoosoo Yang
Summary: Exosomes are nanovesicles secreted by cells that can mediate intercellular communication and serve as promising drug delivery vehicles due to their stability, biocompatibility, and targeting abilities. They can carry therapeutic signaling molecules from specific cell types, impacting cancer treatment significantly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Carlos Salomon, Saumya Das, Uta Erdbrugger, Raghu Kalluri, Sai Kiang Lim, Jerrold M. Olefsky, Gregory E. Rice, Susmita Sahoo, W. Andy Tao, Pieter Vader, Qun Wang, Alissa M. Weaver
Summary: The hormone-like role of extracellular vesicles (EVs) in cell-to-cell communication has gained significant interest in the past decade. EVs, as a heterogeneous population of membrane-bound vesicles, carry endocrine signals and play a role in various biological activities. They can also serve as indicators of diseases. This article aims to highlight the importance of EV research and its potential role in the field of endocrinology.
Review
Oncology
Chuanshi He, Ling Li, Linlin Wang, Wanrong Meng, Yaying Hao, Guiquan Zhu
Summary: The article reviews the role of exosome-mediated interactions between cells under radiotherapy conditions, highlighting the importance of exosomes in the tumor microenvironment and the rebuilding of regulatory processes under radiation stimulation.
CANCER BIOLOGY & MEDICINE
(2021)
Review
Medicine, Research & Experimental
Jian Li, Ye Zhang, Pei-Yu Dong, Guo-Ming Yang, Sangiliyandi Gurunathan
Summary: All forms of life produce extracellular vesicles called exosomes, which are enclosed in lipid bilayer membranes, and function in cell-to-cell communication as well as in various physiological and pathological processes. Exosomes deliver bioactive components including proteins, nucleic acids, and lipids to target cells. They have unique properties that make them ideal drug delivery vehicles, and can mediate cellular communication through the transfer of various bioactive molecules.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Yuki Takahashi, Yoshinobu Takakura
Summary: Extracellular vesicles (EVs) are cell-derived membrane vesicles composed of a lipid bilayer that contain biological molecules. They function as intercellular communication tools and have potential as therapeutic targets for various diseases. However, an EV-based drug delivery system utilizing their therapeutic properties has not yet been reported.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Immunology
Geovanny Genaro Reivan Ortiz, Neelam Hazoor Zaidi, Ravinder S. Saini, Andres Alexis Ramirez Coronel, Tahani Alsandook, Methaq Hadi Lafta, Jose Luis Arias-Gonzales, Ali H. Amin, Renato R. Maaliw III
Summary: Autoimmune diseases are chronic inflammatory conditions caused by the loss of immunological tolerance. Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) have immunomodulatory functions and show therapeutic potential for autoimmune diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Hee Byung Koh, Hyo Jeong Kim, Shin-Wook Kang, Tae-Hyun Yoo
Summary: Exosome-based drug delivery is a promising field that could revolutionize therapeutic interventions. These small extracellular vesicles have unique properties and can transport bioactive molecules. Despite challenges such as limited isolation methods and low cargo loading efficiency, exosomes have the potential to improve personalized medicine and precision therapy.
Review
Endocrinology & Metabolism
Zhiqi Liao, Chang Liu, Lan Wang, Cong Sui, Hanwang Zhang
Summary: Reproductive disorders such as intrauterine adhesion, premature ovarian insufficiency, and polycystic ovary syndrome pose significant threats to female reproduction, but mesenchymal stem cells derived-extracellular vesicles have shown potentials in treating these diseases through various mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Peng Qiu, Jing Zhou, Jin Zhang, Youjing Dong, Yang Liu
Summary: Sepsis is a life-threatening syndrome caused by the body's maladjusted response to infection, with evidence suggesting a core role of the immune system. Exosomes, derived from plasma membrane invagination, have the potential to alter immune cell responses and functions in sepsis, offering novel therapeutic opportunities.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Min-Hee Kang, Muniyandi Jeyaraj, Jin-Hoi Kim
Summary: Several studies have demonstrated the molecular mechanisms involved in the biogenesis and release of exosomes. PtNPs were shown to enhance exosome secretion in A549 cells by inducing oxidative stress and the ceramide pathway. Pre-treatment with NAC could inhibit the PtNPs-induced exosome biogenesis and release.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Min-Kyeung Choi, Minh Thong Le, Hye-Sun Cho, Juyoung Lee, Hyoim Jeon, Se-Yeoun Cha, Manheum Na, Taehoon Chun, Jin-Hoi Kim, Hyuk Song, Chankyu Park
Summary: The study on PG1 transgenic mice showed positive effects in resisting Staphylococcus aureus infection, with reduced lung injury, improved bacteria clearance, and lower inflammation. However, some individuals developed eye problems, indicating the importance of AMP expression regulation and localization to prevent adverse effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Correction
Cell Biology
Sangiliyandi Gurunathan, Min-Hee Kang, Muniyandi Jeyaraj, Muhammad Qasim, Jin-Hoi Kim
Review
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Min-Hee Kang, Muhammad Qasim, Khalid Khan, Jin-Hoi Kim
Summary: Extracellular vesicles (EVs) are a diverse group of membrane-bound vesicles that function as messengers between cells. Much remains unknown about their biogenesis, cargo sorting, and potential therapeutic applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Sangiliyandi Gurunathan, Muhammad Qasim, Min-Hee Kang, Jin-Hoi Kim
Summary: Cancer is the second leading cause of death worldwide, and melatonin has been shown to have oncostatic and anticancer properties by directly affecting carcinogenesis and indirectly disrupting the circadian cycle.
ONCOTARGETS AND THERAPY
(2021)
Article
Immunology
Hansam Cho, Yuyeon Jang, Ki-Hoon Park, Hanul Choi, Aleksandra Nowakowska, Hee-Jung Lee, Minjee Kim, Min-Hee Kang, Jin-Hoi Kim, Ha Youn Shin, Yu-Kyoung Oh, Young Bong Kim
Summary: A recombinant baculoviral vector-based DNA vaccine system against MERS-CoV and SARS-CoV2 was reported, showing high efficacy in preventing viral infections in animal models.
Article
Agriculture, Dairy & Animal Science
S. Youk, M. T. Le, M. Kang, B. Ahn, M. Choi, K. Kim, T. H. Kim, J. H. Kim, C. S. Ho, C. Park
Summary: A high-resolution typing method was developed for swine leukocyte antigen 3 (SLA-3), identifying 21 alleles with four novel ones, although the allelic diversity of SLA-3 was lower compared to SLA-1 and -2. More SLA-3 alleles were observed in Landrace and Yorkshire breeds, with SLA-3*04:01 being the most widely distributed allele across all breeds. This method aids in analyzing major SLA genes from field samples, enhancing understanding of immune responses and genetic makeup.
Article
Chemistry, Inorganic & Nuclear
Xu-Kai Chen, Xiao-Min Chen, Yu-Rong Xi, Wen-Chao Sun, Yong-Tao Wang, Yu-Song Wu, Min-Hui Kang, Gui-Mei Tang
Summary: The research focused on achieving luminescent properties through the control of substituents in organic compounds, with a rich presence of hydrogen bonds and C-H···π interactions. The stacking and collision effects have a significant impact on the fluorescent performance of the materials.
JOURNAL OF SOLID STATE CHEMISTRY
(2022)
Review
Agriculture, Dairy & Animal Science
Sangiliyandi Gurunathan, Min-Hee Kang, Hyuk Song, Nam Hyung Kim, Jin-Hoi Kim
Summary: Extracellular vesicles (EVs) are nanosized membrane-enclosed compartments that act as messengers in cell-to-cell communication. They influence the phenotype and function of recipient cells by transferring functional proteins and genetic information. Various types of EVs are present in biological fluids, carrying cargoes such as lipids, proteins, and nucleic acids. EVs associated with the reproductive system play a significant role in regulating physiological events such as gamete maturation, fertilization, and embryo and fetal development.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sangiliyandi Gurunathan, Ah Reum Lee, Jin Hoi Kim
Summary: SARS-CoV-2 has caused a pandemic of COVID-19, and some patients have acquired secondary infections such as black fungus disease. Prompt diagnosis and treatment are necessary to prevent high mortality and morbidity rates. Uncontrolled diabetes and immunosuppression are major risk factors, and the use of steroids can increase the risk of black fungus infection. Novel and effective antimicrobial agents are needed to combat this infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hyeonji Lee, Seong-Yeob You, Dong Wook Han, Hyeonwoo La, Chanhyeok Park, Seonho Yoo, Kiye Kang, Min-Hee Kang, Youngsok Choi, Kwonho Hong
Summary: The study reveals that R-loop dynamics are associated with the regulation of zygotic genome activation (ZGA) in mice, especially in the minor ZGA stage. R-loop formation and level changes may modulate gene transcription and DNA replication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Jin Hoi Kim
Summary: Graphene oxide (GO) stimulates exosome biogenesis and release in human ovarian cancer cells (SKOV3), indicating its potential as a tool for targeting the exosome pathway.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Obstetrics & Gynecology
Min-Hee Kang, Yu Jin Kim, Jae Ho Lee
Summary: This review summarizes the specific role of mitochondria in reproduction in oocytes and embryos. It provides an overview of the general characteristics of mitochondria in cells and their unique characteristics in female reproduction. Mitochondrial dysfunction is associated with various reproductive problems, and understanding the underlying mechanism is important for reproductive medicine.
CLINICAL AND EXPERIMENTAL REPRODUCTIVE MEDICINE-CERM
(2023)