Hydrogel scaffolds as in vitro models to study fibroblast activation in wound healing and disease

A Unified Model for De Novo Design of Elastin-like Polypeptides with Tunable Inverse Transition Temperatures

(2013) Jonathan R. McDaniel et al.   BIOMACROMOLECULES

Designing degradable hydrogels for orthogonal control of cell microenvironments

(2013) Prathamesh M. Kharkar et al.   CHEMICAL SOCIETY REVIEWS

From tissue mechanics to transcription factors

(2013) Paul A. Janmey et al.   DIFFERENTIATION

Three-dimensional fibroblast morphology on compliant substrates of controlled negative curvature

(2013) Yi-hsuan Lee et al.   Integrative Biology

Regulation of Matrix Assembly through Rigidity-dependent Fibronectin Conformational Changes

(2013) Cara L. Carraher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-1 Induces Proinflammatory Leukocyte Infiltration and Regulates Fibroblast Phenotype in the Infarcted Myocardium

(2013) A. Saxena et al.   JOURNAL OF IMMUNOLOGY

Hyaluronic Acid Click Hydrogels Emulate the Extracellular Matrix

(2013) Shawn C. Owen et al.   LANGMUIR

Mechanical Properties and Degradation of Chain and Step-Polymerized Photodegradable Hydrogels

(2013) Mark W. Tibbitt et al.   MACROMOLECULES

In situ cell manipulation through enzymatic hydrogel photopatterning

(2013) Katarzyna A. Mosiewicz et al.   NATURE MATERIALS

Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway

(2013) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implantable Three-Dimensional Salivary Spheroid Assemblies Demonstrate Fluid and Protein Secretory Responses to Neurotransmitters

(2013) Swati Pradhan-Bhatt et al.   TISSUE ENGINEERING PART A

FGF-1 and proteolytically mediated cleavage site presentation influence three-dimensional fibroblast invasion in biomimetic PEGDA hydrogels

(2012) Sonja Sokic et al.   Acta Biomaterialia

Small peptide functionalized thiol–ene hydrogels as culture substrates for understanding valvular interstitial cell activation and de novo tissue deposition

(2012) Sarah T. Gould et al.   Acta Biomaterialia

Effect of substrate stiffness on pulmonary fibroblast activation by TGF-β

(2012) H.N. Chia et al.   Acta Biomaterialia

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System forIn VitroInvestigation

(2012) Adam J. Booth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Matrix Stiffness–Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction

(2012) Xiangwei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Matrices of Physiologic Stiffness Potently Inactivate Idiopathic Pulmonary Fibrosis Fibroblasts

(2012) Aleksandar Marinković et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Laminin peptide YIGSR induces collagen synthesis in Hs27 human dermal fibroblasts

(2012) Jong Hyuk Yoon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tuning the Properties of Elastin Mimetic Hybrid Copolymers via a Modular Polymerization Method

(2012) Sarah E. Grieshaber et al.   BIOMACROMOLECULES

Cell Therapy for Skin Wound Using Fibroblast Encapsulated Poly(ethylene glycol)-poly(l-alanine) Thermogel

(2012) Eun Jung Yun et al.   BIOMACROMOLECULES

Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation

(2012) Kristin Moreth et al.   CELL CYCLE

Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells

(2012) Florian Rehfeldt et al.   Integrative Biology

The mechanical memory of lung myofibroblasts

(2012) Jenna L. Balestrini et al.   Integrative Biology

Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering

(2012) Ofra Ziv-Polat et al.   International Journal of Nanomedicine

Differential effects of substrate modulus on human vascular endothelial, smooth muscle, and fibroblastic cells

(2012) Karyn G. Robinson et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Biglycan

(2012) Madalina V. Nastase et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Stiffness-controlled three-dimensional extracellular matrices for high-resolution imaging of cell behavior

(2012) Robert S Fischer et al.   Nature Protocols

Redirecting Valvular Myofibroblasts into Dormant Fibroblasts through Light-mediated Reduction in Substrate Modulus

(2012) Huan Wang et al.   PLoS One

Hyaluronic acid-based hydrogels: from a natural polysaccharide to complex networks

(2012) Xian Xu et al.   Soft Matter

Tailored Integrin–Extracellular Matrix Interactions to Direct Human Mesenchymal Stem Cell Differentiation

(2012) Jessica Ellen Frith et al.   STEM CELLS AND DEVELOPMENT

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

(2012) Murat Guvendiren et al.   Nature Communications

Flexural characterization of cell encapsulated PEGDA hydrogels with applications for tissue engineered heart valves

(2011) Christopher A. Durst et al.   Acta Biomaterialia

Hyaluronic Acid Hydrogels for Biomedical Applications

(2011) Jason A. Burdick et al.   ADVANCED MATERIALS

Three-Dimensional Spatial Patterning of Proteins in Hydrogels

(2011) Ryan G. Wylie et al.   BIOMACROMOLECULES

Synergistic regulation of cell function by matrix rigidity and adhesive pattern

(2011) Shinuo Weng et al.   BIOMATERIALS

Construction and Activity of a Synthetic Basement Membrane with Active Laminin Peptides and Polysaccharides

(2011) Yuji Yamada et al.   CHEMISTRY-A EUROPEAN JOURNAL

Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44

(2011) Yuejuan Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cell Migration at the Interface of a Dual Chemical-Mechanical Gradient

(2010) N. A. Hale et al.   ACS Applied Materials & Interfaces

Bioactive hydrogels based on Designer Collagens

(2010) E. Cosgriff-Hernandez et al.   Acta Biomaterialia

Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels

(2010) Jennifer E. Saik et al.   Acta Biomaterialia

Mechanical Properties of Cellularly Responsive Hydrogels and Their Experimental Determination

(2010) April M. Kloxin et al.   ADVANCED MATERIALS

Diminished Prostaglandin E2Contributes to the Apoptosis Paradox in Idiopathic Pulmonary Fibrosis

(2010) Toby M. Maher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Role of Surfactant Protein A in Bleomycin-induced Acute Lung Injury

(2010) Hisatsugu Goto et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The use of low molecular weight heparin–pluronic nanogels to impede liver fibrosis by inhibition the TGF-β/Smad signaling pathway

(2010) Ju-Hee Lee et al.   BIOMATERIALS

Cell encapsulation using biopolymer gels for regenerative medicine

(2010) Nicola C. Hunt et al.   BIOTECHNOLOGY LETTERS

Fibroblasts in three dimensional matrices: cell migration and matrix remodeling

(2010) Sangmyung Rhee   EXPERIMENTAL AND MOLECULAR MEDICINE

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer

(2010) Benito Casu et al.   MATRIX BIOLOGY

Serum Amyloid P Therapeutically Attenuates Murine Bleomycin-Induced Pulmonary Fibrosis via Its Effects on Macrophages

(2010) Lynne A. Murray et al.   PLoS One

Significant Type I and Type III Collagen Production from Human Periodontal Ligament Fibroblasts in 3D Peptide Scaffolds without Extra Growth Factors

(2010) Yoshiyuki Kumada et al.   PLoS One

Microtopographical Cues in 3D Attenuate Fibrotic Phenotype and Extracellular Matrix Deposition: Implications for Tissue Regeneration

(2010) Perla Ayala et al.   TISSUE ENGINEERING PART A

Hydrogels in Regenerative Medicine

(2009) Brandon V. Slaughter et al.   ADVANCED MATERIALS

Characterization of valvular interstitial cell function in three dimensional matrix metalloproteinase degradable PEG hydrogels

(2009) Julie A. Benton et al.   BIOMATERIALS

Primary human dermal fibroblast interactions with open weave three-dimensional scaffolds prepared from synthetic human elastin

(2009) Jelena Rnjak et al.   BIOMATERIALS

Coating of biomaterial scaffolds with the collagen-mimetic peptide GFOGER for bone defect repair

(2009) Abigail M. Wojtowicz et al.   BIOMATERIALS

A collagen-mimetic triple helical supramolecule that evokes integrin-dependent cell responses

(2009) Chisato M. Yamazaki et al.   BIOMATERIALS

In situ elasticity modulation with dynamic substrates to direct cell phenotype

(2009) April M. Kloxin et al.   BIOMATERIALS

Hydrogels as extracellular matrix mimics for 3D cell culture

(2009) Mark W. Tibbitt et al.   BIOTECHNOLOGY AND BIOENGINEERING

Hyaluronan concentration within a 3D collagen matrix modulates matrix viscoelasticity, but not fibroblast response

(2009) S.T. Kreger et al.   MATRIX BIOLOGY

Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments

(2009) Cole A. DeForest et al.   NATURE MATERIALS

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

(2009) April M. Kloxin et al.   SCIENCE

A photo-modulatable material for probing cellular responses to substrate rigidity

(2009) Margo T. Frey et al.   Soft Matter

Fibrin sealant combined with fibroblasts and platelet-derived growth factor enhance wound healing in excisional wounds

(2009) Jon E. Mogford et al.   WOUND REPAIR AND REGENERATION

Differential effects of exogenous and endogenous hyaluronan on contraction and strength of collagen gels

(2008) D.D. Allison et al.   Acta Biomaterialia

Production of heparin-containing hydrogels for modulating cell responses

(2008) Ting Nie et al.   Acta Biomaterialia

Cell–collagen interactions: the use of peptide Toolkits to investigate collagen–receptor interactions

(2008) Richard W. Farndale et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Three-dimensional Chemical Patterning of Transparent Hydrogels

(2008) Jordan H. Wosnick et al.   CHEMISTRY OF MATERIALS

Fibroblast growth factor represses Smad-mediated myofibroblast activation in aortic valvular interstitial cells

(2008) Melinda C. Cushing et al.   FASEB JOURNAL

Effect of Linker and Spacer on the Design of a Fibronectin-Mimetic Peptide Evaluated via Cell Studies and AFM Adhesion Forces

(2008) Jennifer A. Craig et al.   LANGMUIR

Fibrin: A Versatile Scaffold for Tissue Engineering Applications

(2008) Tamer A.E. Ahmed et al.   TISSUE ENGINEERING PART B-REVIEWS

An Essential Role for Fibronectin Extra Type III Domain A in Pulmonary Fibrosis

(2007) Andrés F. Muro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE