Stiffness-controlled three-dimensional extracellular matrices for high-resolution imaging of cell behavior

Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells

(2012) Florian Rehfeldt et al.   Integrative Biology

Mechanosensitive mechanisms in transcriptional regulation

(2012) Akiko Mammoto et al.   JOURNAL OF CELL SCIENCE

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

Independent regulation of tumor cell migration by matrix stiffness and confinement

(2012) A. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of axonal outgrowth and pathfinding by integrin-ecm interactions

(2011) Jonathan P. Myers et al.   Developmental Neurobiology

Imaging adhesion and signaling dynamics in Xenopus laevis growth cones

(2011) Miguel Santiago-Medina et al.   Developmental Neurobiology

Distinct ECM mechanosensing pathways regulate microtubule dynamics to control endothelial cell branching morphogenesis

(2011) Kenneth A. Myers et al.   JOURNAL OF CELL BIOLOGY

Focal Adhesion Kinase Promotes Integrin Adhesion Dynamics Necessary for Chemotropic Turning of Nerve Growth Cones

(2011) J. P. Myers et al.   JOURNAL OF NEUROSCIENCE

Cell-matrix adhesions in 3D

(2011) Jill S. Harunaga et al.   MATRIX BIOLOGY

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Cell Motility and Mechanics in Three-Dimensional Collagen Matrices

(2010) Frederick Grinnell et al.   Annual Review of Cell and Developmental Biology

Developments in three-dimensional cell culture technology aimed at improving the accuracy ofin vitroanalyses

(2010) Daniel J. Maltman et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices

(2010) Miguel Miron-Mendoza et al.   BIOMATERIALS

Cancer Cell Stiffness: Integrated Roles of Three-Dimensional Matrix Stiffness and Transforming Potential

(2010) Erin L. Baker et al.   BIOPHYSICAL JOURNAL

New relationships between breast microcalcifications and cancer

(2010) R Baker et al.   BRITISH JOURNAL OF CANCER

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner

(2010) Quint le Duc et al.   JOURNAL OF CELL BIOLOGY

How deeply cells feel: methods for thin gels

(2010) Amnon Buxboim et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

A distinctive role for focal adhesion proteins in three-dimensional cell motility

(2010) Stephanie I. Fraley et al.   NATURE CELL BIOLOGY

Reducing background fluorescence reveals adhesions in 3D matrices

(2010) Kristopher E. Kubow et al.   NATURE CELL BIOLOGY

Stem cells feel the difference

(2010) Amnon Buxboim et al.   NATURE METHODS

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

(2010) Robert W. Tilghman et al.   PLoS One

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors

(2010) Edna Cukierman et al.   SEMINARS IN CANCER BIOLOGY

Effect of Dynamic Stiffness of the Substrates on Neurite Outgrowth by Using a DNA-Crosslinked Hydrogel

(2010) Frank Xue Jiang et al.   TISSUE ENGINEERING PART A

Direct Comparisons of the Morphology, Migration, Cell Adhesions, and Actin Cytoskeleton of Fibroblasts in Four Different Three-Dimensional Extracellular Matrices

(2010) Kirsi M. Hakkinen et al.   TISSUE ENGINEERING PART A

HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment

(2009) Britta Weigelt et al.   BREAST CANCER RESEARCH AND TREATMENT

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Local Cortical Tension by Myosin II Guides 3D Endothelial Cell Branching

(2009) Robert S. Fischer et al.   CURRENT BIOLOGY

Translating tissue engineering technology platforms into cancer research

(2009) Dietmar W. Hutmacher et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A mechanosensitive transcriptional mechanism that controls angiogenesis

(2009) Akiko Mammoto et al.   NATURE

Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way

(2009) Peter Carmeliet et al.   Nature Reviews Clinical Oncology

Random versus directionally persistent cell migration

(2009) Ryan J. Petrie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Three-dimensional context regulation of metastasis

(2008) Janine T. Erler et al.   CLINICAL & EXPERIMENTAL METASTASIS

Rho signaling and mechanical control of vascular development

(2008) Akiko Mammoto et al.   CURRENT OPINION IN HEMATOLOGY

Collagen in its fibrillar state is protected from glycation

(2008) David A. Slatter et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro

(2008) K. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA