Biomaterials in RNAi therapeutics: quo vadis?

Nanosized Multifunctional Polyplexes for Receptor-Mediated SiRNA Delivery

(2012) Christian Dohmen et al.   ACS Nano

Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression

(2012) Dongbo Yu et al.   CELL

Single-Stranded siRNAs Activate RNAi in Animals

(2012) Walt F. Lima et al.   CELL

Structure–activity relationships of siRNA carriers based on sequence-defined oligo (ethane amino) amides

(2012) Thomas Fröhlich et al.   JOURNAL OF CONTROLLED RELEASE

TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues—a comparative study of oligonucleotide length, design and chemistry

(2012) Sue Murray et al.   NUCLEIC ACIDS RESEARCH

Profiling of T helper cell-derived small RNAs reveals unique antisense transcripts and differential association of miRNAs with argonaute proteins 1 and 2

(2012) Sumanth Polikepahad et al.   NUCLEIC ACIDS RESEARCH

Distinct AGO1 and AGO2 associated miRNA profiles in human cells and blood plasma

(2012) Andrey Turchinovich et al.   RNA Biology

Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing

(2012) Christian Dohmen et al.   Molecular Therapy-Nucleic Acids

Antisense 2′-Deoxy, 2′-Fluoroarabino Nucleic Acid (2′F-ANA) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids

(2012) Naira Souleimanian et al.   Molecular Therapy-Nucleic Acids

The Business of RNAi Therapeutics in 2012

(2012) Dirk Haussecker   Molecular Therapy-Nucleic Acids

Polymers for siRNA Delivery: Inspired by Viruses to be Targeted, Dynamic, and Precise

(2011) Ernst Wagner   ACCOUNTS OF CHEMICAL RESEARCH

Solid-Phase Synthesis of Sequence-Defined T-, i-, and U-Shape Polymers for pDNA and siRNA Delivery

(2011) David Schaffert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Current progress of siRNA/shRNA therapeutics in clinical trials

(2011) John C. Burnett et al.   Biotechnology Journal

MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma

(2011) A. F. Ibrahim et al.   CANCER RESEARCH

Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses

(2011) Kanjiro Miyata et al.   CHEMICAL SOCIETY REVIEWS

To Be Targeted: Is the Magic Bullet Concept a Viable Option for Synthetic Nucleic Acid Therapeutics?

(2011) Manfred Ogris et al.   HUMAN GENE THERAPY

Pyridylthiourea-grafted polyethylenimine offers an effective assistance to siRNA-mediated gene silencing in vitro and in vivo

(2011) Gaelle Creusat et al.   JOURNAL OF CONTROLLED RELEASE

Therapeutic plasmid DNA versus siRNA delivery: Common and different tasks for synthetic carriers

(2011) Claudia Scholz et al.   JOURNAL OF CONTROLLED RELEASE

Silencing of microRNA families by seed-targeting tiny LNAs

(2011) Susanna Obad et al.   NATURE GENETICS

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

(2011) Samir EL Andaloussi et al.   NUCLEIC ACIDS RESEARCH

Novel Fmoc-Polyamino Acids for Solid-Phase Synthesis of Defined Polyamidoamines

(2011) David Schaffert et al.   ORGANIC LETTERS

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

Exploring Chemical Modifications for siRNA Therapeutics: A Structural and Functional Outlook

(2009) Siddharth Shukla et al.   ChemMedChem

Stability and cellular uptake of polymerized siRNA (poly-siRNA)/polyethylenimine (PEI) complexes for efficient gene silencing

(2009) Seung-Young Lee et al.   JOURNAL OF CONTROLLED RELEASE

Cationic siRNAs Provide Carrier-Free Gene Silencing in Animal Cells

(2009) Marc Nothisen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA−Polymer Conjugate

(2009) Martin Meyer et al.   MOLECULAR PHARMACEUTICS

Peptide- and polymer-based delivery of therapeutic RNA

(2009) Thomas Fröhlich et al.   Soft Matter

Simple Modifications of Branched PEI Lead to Highly Efficient siRNA Carriers with Low Toxicity

(2008) Arkadi Zintchenko et al.   BIOCONJUGATE CHEMISTRY

Structure of the guide-strand-containing argonaute silencing complex

(2008) Yanli Wang et al.   NATURE

Chemical Modification of siRNAs for In Vivo Use

(2008) Mark A. Behlke   OLIGONUCLEOTIDES