Article
Multidisciplinary Sciences
Yuan Rui, David R. Wilson, Stephany Y. Tzeng, Hannah M. Yamagata, Deepti Sudhakar, Marranne Conge, Cynthia A. Berlinicke, Donald J. Zack, Anthony Tuesca, Jordan J. Green
Summary: Nanoparticle-based mRNA therapeutics show great promise, but cellular internalization and endosomal escape pose challenges for cytosolic delivery. Researchers developed a dual nanoparticle uptake and endosomal disruption assay, which can detect cellular internalization and endosomal disruption. The study found that this assay has higher predictive capacity for mRNA delivery compared to conventional polymer and nanoparticle characteristics.
Review
Pharmacology & Pharmacy
Franziska Freitag, Ernst Wagner
Summary: Optimizing synthetic nanocarriers is a challenging process that involves strategies similar to chemical evolution. Libraries of nanocarriers are generated through combinatorial chemistry or variation and combination of known functional elements, with screening in appropriate test systems providing delivery candidates and a refined understanding of cellular delivery mechanisms. Rational design and computational algorithms are also used to further optimize candidates into nanocarriers with improved safety and efficacy.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Multidisciplinary Sciences
Krishnapriya Syama, Zygmunt J. Jakubek, Sam Chen, Josh Zaifman, Yuen Yi C. Tam, Shan Zou
Summary: This study evaluated the toxicity of six lipid-based formulations on cells and found that anionic, cationic, and neutral lipid formulations were non-toxic. These findings suggest that these lipid-based formulations have potential as drug carriers.
SCIENTIFIC REPORTS
(2022)
Article
Polymer Science
Mara K. Kuenen, Alexa M. Cuomo, Vincent P. Gray, Rachel A. Letteri
Summary: By modifying the charge, poly(beta-amino ester)s can be transformed into degradable anionic polymers, which can be utilized to create fully degradable polyelectrolyte complexes and delivery vehicles for cationic therapeutics.
Article
Engineering, Biomedical
Jin Qiu, Qianqian Fan, Sainan Xu, Dongmei Wang, Juntong Chen, Sainan Wang, Tianhui Hu, Xinran Ma, Yiyun Cheng, Lingyan Xu
Summary: This study discovered a highly efficient fluoropolypeptide for the delivery of siRNA-based therapeutics into adipocytes and adipose tissues, showing potential for gene therapy of obesity and metabolic disorders.
Article
Materials Science, Multidisciplinary
Wen Song, Qingyuan Ye, Zhe Li, Yajie Hou, Lina Niu, Zhiwei Ma, Chuanxu Yang
Summary: This study reveals the significant impact of transfection medium on chitosan-mediated siRNA delivery, with even disturbed physical parameters of nanoparticles still achieving high knockdown efficiency.
MATERIALS & DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Paul Klemm, Jana Solomun, Marko Rodewald, Maren T. Kuchenbrod, Veit G. Hansch, Friederike Richter, Juergen Popp, Christian Hertweck, Stephanie Hoeppener, Colin Bonduelle, Sebastien Lecommandoux, Anja Traeger, Stephanie Schubert
Summary: This study investigates the potential of amphiphilic and potentially biodegradable polypeptides for gene delivery. By studying the influence of different proportions of aliphatic and cationic side chains on the physicochemical properties of the polypeptides, the researchers were able to identify the best performer for transfection efficiency. Detailed studies of the transfection mechanism revealed the strong interaction of the identified polypeptide with cell membranes, promoting efficient cell uptake and release. The study demonstrates the great potential of polypeptides for gene delivery.
Article
Materials Science, Multidisciplinary
Huamin Zhu, Dongsheng Chen, Yunfei Yao, Xiangyang Xu, Xianghui Fu
Summary: Detonation nanodiamond (ND) clusters with different sizes were successfully prepared by high-energy ball milling, and ND60 showed the best dispersion stability and highest loading capacity for siRNA. ND60 also demonstrated effective siRNA delivery and transfection into human cells.
DIAMOND AND RELATED MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Friederike Richter, Katharina Leer, Liam Martin, Prosper Mapfumo, Jana Solomun, Maren T. Kuchenbrod, Stephanie Hoeppener, Johannes C. Brendel, Anja Traeger
Summary: Cationic polymers have been extensively studied for non-viral gene delivery, but their charged nature can lead to increased cytotoxicity and limited in vivo application. By utilizing hydrophilic or anionic shielding polymers, the toxicity of cationic polymers can be reduced, improving gene transfection efficiency. The study demonstrated the potential of using layering micelles with shielding polymers for gene delivery applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Pengkai Wu, Shuai Yin, Tianqing Liu, Dan Ding, Kaikai Wang
Summary: By incorporating different functional ligands and linked reductive disulfides into low-molecular-weight PEI 1.8k, this study constructed reductive-responsive PEI-X-SS-X-PEI copolymers to enhance siRNA transfection efficiency. The strategy, named building-block crosslinking, showed a simple and smart way to synthesize new materials and improve gene delivery systems.
SCIENCE CHINA-MATERIALS
(2021)
Article
Medicine, Research & Experimental
Yingshan Qiu, Maria Clarke, Leon T. L. Wan, Jason C. K. Lo, A. James Mason, Jenny K. W. Lam
Summary: Covalent attachment of monodisperse poly(ethylene glycol) (PEG) to KL4 peptide improves its solubility and enhances uptake into lung epithelial cells, leading to robust gene silencing effects. Among PEGylated KL4 peptides, PEG(12)KL4 was found to be optimal for siRNA delivery with low risk of inflammatory response and toxicity.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Analytical
Juliang Yang, Jing-Jing Hu, Jiaming Wei, Jun Dai, Hao Fang, Fan Xia, Xiaoding Lou
Summary: This study designed an enzyme-responsive modular peptide probe to improve the mitochondrial delivery efficiency and optimize image-guided therapeutic outcomes by regulating the intracellular delivery pathways. The system also shows potential for delivering siRNA and doxorubicin for precise cancer image-guided therapy.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Juliang Yang, Jing-Jing Hu, Jiaming Wei, Jun Dai, Hao Fang, Fan Xia, Xiaoding Lou
Summary: In this study, an enzyme-responsive modular peptide probe was designed to improve the delivery efficiency of therapeutic cargos to the mitochondria. By changing the endocytic pathway, the probe directly reached the mitochondrial sites without passing through the lysosomes, optimizing the image-guided therapeutic efficiency. This system also showed potential for delivering siRNA and doxorubicin for precise cancer image-guided therapy, facilitating the development of personalized therapy.
ANALYTICAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Franziska Mitrach, Maximilian Schmid, Magali Toussaint, Sladjana Dukic-Stefanovic, Winnie Deuther-Conrad, Heike Franke, Alexander Ewe, Achim Aigner, Christian Woelk, Peter Brust, Michael C. Hacker, Michaela Schulz-Siegmund
Summary: Convection-enhanced delivery (CED) is introduced as a concept in cancer treatment to generate high concentrations of anticancer drugs locally and overcome limited diffusion, particularly in the brain. This study investigates calcium phosphate nanoparticles (CaP-NPs) as carriers for CED application of siRNA. By introducing a new terpolymer (o14PEGMA(1:1:2.5) NH3) for stabilization of CaP-NPs, successful stabilization of NPs with desired properties is achieved. The terpolymer shows high affinity to CaP and efficient binding of siRNA to NPs, resulting in effective siRNA silencing in brain cancer cells.
Review
Materials Science, Multidisciplinary
Pei Huang, Hongzhang Deng, Yongfeng Zhou, Xiaoyuan Chen
Summary: This review summarizes the development of polymeric nanocarriers for mRNA delivery and discusses approaches to enhance mRNA transfection efficiency. The authors propose conclusions and perspectives on the clinical translation of mRNA therapy, believing that the introduction of mRNA will lead to promising techniques for disease prevention and treatment in the future.
Article
Chemistry, Multidisciplinary
Lauriane Chuzeville, Frank Boury, David Duday, Resmi Anand, Enzo Moretto, Jean-Sebastien Thomann
Summary: This article presents a new method for synthesizing ACC NPs in ethanol and explores methods for stabilizing these nanoparticles in aqueous media. By optimizing the process, the mass concentration of ACC NPs can be increased and the amount of ethanol required can be reduced, thereby reducing the ecological impact of the process. In addition, using a natural egg-sourced phospholipid as a stabilizer improves process efficiency.
Article
Chemistry, Physical
Chuanyu Yan, Enzo Moretto, Oussema Kachouri, Jean-Luc Biagi, Jean-Sebastien Thomann, Francois Kayser, Reiner Dieden
Summary: This study demonstrates the use of solid-state nuclear magnetic resonance spectroscopy for studying dehydration and deuterium exchange at the liquid-solid interface. The results provide evidence of complete removal of physically adsorbed water molecules on the silica surface in the presence of DMSO, and satisfactory deuteration of silanol groups in the presence of a DMSO-D2O mixture. Additionally, the study develops a liquid-state NMR-based technique for quantifying moisture and hydroxyls on solids.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Polymer Science
Mariapaola Staropoli, Dominik Gerstner, Benoit Duez, Michael Sztucki, Guido Vehres, Aurel Radulescu, Stephan Westermann, Wim Pyckhout-Hintzen, Jean-Sebestien Thomann
Summary: This study investigates the structural and dynamic characteristics of a silica filler network in an industrial elastomeric composite using time-resolved Ultra Small-Angle-X-ray Scattering (USAXS) technique. The in-situ observation under periodic uniaxial deformation reveals a correlation between the filler network evolution and the dynamic-mechanical stress-strain response of the composite. By analyzing the sector-averaged scattering intensities, the researchers identify the jamming/de-jamming transition between clusters during the deformation process.
Article
Polymer Science
Enzo Moretto, Chuanyu Yan, Reiner Dieden, Pascal Steiner, Benoit Duez, Damien Lenoble, Jean-Sebastien Thomann
Summary: This study investigates the impact of silica particle pre-treatments with strong amine or hydride bases on the silanization reaction for the fabrication of silica-rubber nanocomposites. The results show that pre-treatments have a significant effect on the silanization reaction and mechanical properties of the nanocomposites.
Article
Oncology
Charlotte Nazon, Marina Pierrevelcin, Thibault Willaume, Benoit Lhermitte, Noelle Weingertner, Antonio Di Marco, Laurent Bund, Florence Vincent, Guillaume Bierry, Anne Gomez-Brouchet, Francoise Redini, Nathalie Gaspar, Monique Dontenwill, Natacha Entz-Werle
Summary: This study correlates radiological and immunohistochemical data with the outcome in pediatric osteosarcomas (OTS) and identifies imaging and immunohistochemical markers associated with a worse overall survival. These findings suggest a potential dual signature association that can be used in future protocols to predict the outcome of OTS.
Article
Chemistry, Multidisciplinary
Enzo Moretto, Joao P. C. Fernandes, Mariapaola Staropoli, Vincent Roge, Pascal Steiner, Benoit Duez, Damien Lenoble, Jean-Sebastien Thomann
Summary: The study investigated the effects of different silane chemistries on the mechanical properties of silica-rubber based nanocomposites. The use of shorter chain silanes resulted in improved wet grip indicators while maintaining rolling resistance indicators.
Article
Chemistry, Physical
Ahilan Manisekaran, Patrick Grysan, Benoit Duez, Daniel F. Schmidt, Damien Lenoble, Jean-Sebastien Thomann
Summary: This study investigated the method and influencing factors of synthesizing Kraft lignin nanoparticles (KLNPs) using solvent shifting, and analyzed their physical properties.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Oncology
Conor McCartin, Candice Dussouillez, Chloe Bernhard, Eric Mathieu, Juliette Blumberger, Monique Dontenwill, Christel Herold-Mende, Ahmed Idbaih, Philippe Lavalle, Stephane Bellemin-Laponnaz, Antoine Kichler, Sylvie Fournel
Summary: The resistance and recurrence of tumors pose major challenges for cancer patient survival. Research has identified a subset of stem-cell-like cells in tumors that contribute to this problem. Developing new chemotherapeutic compounds to target these cells is of great interest for more effective cancer treatments.
Article
Pharmacology & Pharmacy
Elisabete Cruz Da Silva, Sophie Foppolo, Benoit Lhermitte, Marina Ingremeau, Helene Justiniano, Lorraine Klein, Marie-Pierre Chenard, Romain Vauchelles, Basma Abdallah, Maxime Lehmann, Nelly Etienne-Selloum, Monique Dontenwill, Laurence Choulier
Summary: In this study, nucleic-acid aptamers were used for fluorescence imaging to detect EGFR and integrin alpha 5 beta 1 in human glioblastoma tissues. The aptafluorescence assays proved to be able to easily reveal inter-tumoral and intra-tumoral heterogeneity. The strengths and limitations of nucleic-acid aptamers for biomarker detection in histology were also discussed.
Article
Engineering, Biomedical
Conor McCartin, Juliette Blumberger, Candice Dussouillez, Patricia Fernandez de Larrinoa, Monique Dontenwill, Christel Herold-Mende, Philippe Lavalle, Beatrice Heurtault, Stephane Bellemin-Laponnaz, Sylvie Fournel, Antoine Kichler
Summary: Cationic polymers like polyethylenimine (PEI) have been widely used as gene delivery agents and drug delivery agents. Recent studies have shown that certain polycations have higher toxicity towards cancer stem cells (CSCs) than differentiated tumor cells. Since CSCs play a critical role in cancer drug resistance, tumor recurrence, and poor clinical prognosis, it is important to investigate compounds that can target and eliminate these cells.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Chloe Bernhard, Damien Reita, Sophie Martin, Natacha Entz-Werle, Monique Dontenwill
Summary: Tumor metabolism is a potential target for cancer therapies, particularly for the treatment of glioblastoma, a resistant brain tumor. Glioma stem cells play a critical role in therapy resistance, making their elimination crucial for patients' long-term survival. Recent advancements have revealed the heterogeneous nature of glioblastoma metabolism and the specific metabolic traits of cancer stem cells, providing insights for therapeutic approaches targeting these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Lucas Geyer, Thibaut Wolf, Marie-Pierre Chenard, Helene Cebula, Roland Schott, Georges Noel, Eric Guerin, Erwan Pencreach, Damien Reita, Natacha Entz-Werle, Benoit Lhermitte
Summary: The 2021 WHO classification of central nervous system tumors is a histomolecular classification system that incorporates molecular data to improve patient prognoses and treatments. CDKN2A homozygous deletion is associated with poor prognosis in various types of gliomas, and its detection requires complex techniques. This study investigates the clinical significance of p16 immunohistochemical expression in gliomas and its correlation with CDKN2A homozygous deletion.
Article
Cell Biology
Aude Jehl, Ombline Conrad, Mickael Burgy, Sophie Foppolo, Romain Vauchelles, Carole Ronzani, Nelly Etienne-Selloum, Marie-Pierre Chenard, Aurelien Danic, Thomas Dourlhes, Claire Thibault, Philippe Schultz, Monique Dontenwill, Sophie Martin
Summary: This study found that the inactivation of Epiregulin (EREG) can increase the sensitivity of head and neck squamous cell carcinoma cells to cetuximab (CTX), and is associated with cellular metabolic disorder, iron accumulation, and lipid peroxidation. Therefore, the loss of EREG may serve as a predictive biomarker in clinical settings for patients who may undergo ferroptosis in response to CTX, and who may benefit the most from the combination therapy of ferroptosis inducers and CTX.
Article
Chemistry, Physical
Nadja Groysbeck, Victor Hanss, Mariel Donzeau, Jean-Marc Strub, Sarah Cianferani, Daniele Spehner, Mounib Bahri, Ovidiu Ersen, Mikhael Eltsov, Patrick Schultz, Guy Zuber
Summary: Advances in cryo-electron microscopy have allowed for near-native imaging of protein assemblies within mammalian cells. Gold nanoparticles have been synthesized and functionalized to bind to specific intracellular targets and be detected in vitreous sections. Cryo-EM of vitreous cell sections demonstrates the presence of these biofunctionalized gold nanoparticles in the nucleus, making them powerful labeling tools for cellular cryo-EM.
Article
Biochemistry & Molecular Biology
Ombline Conrad, Mickael Burgy, Sophie Foppolo, Aude Jehl, Alicia Thiery, Sebastien Guihard, Romain Vauchelles, Alain C. C. Jung, Jana Mourtada, Christine Macabre, Sonia Ledrappier, Marie-Pierre Chenard, Mihaela-Alina Onea, Aurelien Danic, Thomas Dourlhes, Claire Thibault, Philippe Schultz, Monique Dontenwill, Sophie Martin
Summary: The expression levels of the 3p passenger strands of miR-30a and miR-30e are correlated with the behavior and prognosis of head and neck squamous cell carcinoma. Low expression of miR-30a and miR-30e is associated with adverse prognosis and can potentially be used as biomarkers for diagnosis and treatment of head and neck squamous cell carcinoma. Additionally, miR-30a and miR-30e expression can affect tumor cell behavior and the tumor microenvironment, potentially improving treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)