SIRT1 Regulation Modulates Stroke Outcome

SIRT1 silencing confers neuroprotection through IGF-1 pathway activation

(2013) Luigi Sansone et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sirt1 Mediates Hyperbaric Oxygen Preconditioning-Induced Ischemic Tolerance in Rat Brain

(2013) Wenjun Yan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Temporal Regulation of Apoptotic and Anti-apoptotic Molecules After Middle Cerebral Artery Occlusion Followed by Reperfusion

(2013) Bharath Chelluboina et al.   MOLECULAR NEUROBIOLOGY

Epigenetics and the Environment: In Search of the “Toleroasome” Vital to Execution of Ischemic Preconditioning

(2013) David Brand et al.   Translational Stroke Research

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

(2012) Pei Wang et al.   Autophagy

Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence

(2012) Hongwei Yao et al.   BIOCHEMICAL PHARMACOLOGY

Sirtuins and Pyridine Nucleotides

(2012) Maha Abdellatif   CIRCULATION RESEARCH

Aberrant Cytoplasm Localization and Protein Stability of SIRT1 is Regulated by PI3K/IGF-1R Signaling in Human Cancer Cells

(2012) Vanessa Byles et al.   International Journal of Biological Sciences

SIRT1 Protects against  -Synuclein Aggregation by Activating Molecular Chaperones

(2012) G. Donmez et al.   JOURNAL OF NEUROSCIENCE

Effects of vascular endothelial growth factor in ischemic stroke

(2012) Yihui Ma et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity

(2012) Jae-Kyo Jeong et al.   NEUROBIOLOGY OF AGING

Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window

(2012) Annamaria Lanzillotta et al.   NEUROBIOLOGY OF DISEASE

Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions

(2012) Alexander Laemmle et al.   PLoS One

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

(2012) Hongying Yang et al.   PLoS One

Resveratrol Inhibits LPS-Induced MAPKs Activation via Activation of the Phosphatidylinositol 3-Kinase Pathway in Murine RAW 264.7 Macrophage Cells

(2012) Yi Zong et al.   PLoS One

The neurobiology of sirtuins and their role in neurodegeneration

(2012) Gizem Donmez   TRENDS IN PHARMACOLOGICAL SCIENCES

Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway

(2011) Pei Wang et al.   ANNALS OF NEUROLOGY

Sirtuin 1 in immune regulation and autoimmunity

(2011) Sinyi Kong et al.   IMMUNOLOGY AND CELL BIOLOGY

Sirtuins: Molecular Traffic Lights in the Crossroad of Oxidative Stress, Chromatin Remodeling, and Transcription

(2011) Ramkumar Rajendran et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Pathways for Ischemic Cytoprotection: Role of Sirtuins in Caloric Restriction, Resveratrol, and Ischemic Preconditioning

(2011) Kahlilia C Morris et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling

(2011) Wenjing Guo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

(2011) Mali Jiang et al.   NATURE MEDICINE

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

(2011) Hyunkyung Jeong et al.   NATURE MEDICINE

Ageing and neurodegenerative diseases

(2010) Chia-Wei Hung et al.   AGEING RESEARCH REVIEWS

Preventing NAD+ Depletion Protects Neurons against Excitotoxicity

(2010) Dong Liu et al.   Annals of the New York Academy of Sciences

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

(2010) Feng-Ming Wang et al.   BIOCHEMICAL JOURNAL

SIRT1 and p53, effect on cancer, senescence and beyond

(2010) Jingjie Yi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2010) Gizem Donmez et al.   CELL

SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells

(2010) Geunyeong Park et al.   FEBS LETTERS

A single-nucleotide variation in a p53-binding site affects nutrient-sensitive human SIRT1 expression

(2010) Asma Naqvi et al.   HUMAN MOLECULAR GENETICS

Mammalian circadian clock and metabolism - the epigenetic link

(2010) M. M. Bellet et al.   JOURNAL OF CELL SCIENCE

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

(2010) Hiyaa Singhee Ghosh et al.   PLoS One

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

(2010) Shin-ichiro Imai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury

(2010) A Lanzillotta et al.   Cell Death & Disease

Age and energy intake interact to modify cell stress pathways and stroke outcome

(2009) Thiruma V. Arumugam et al.   ANNALS OF NEUROLOGY

Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection

(2009) Kenichi Kakefuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia Inducible Factor 1 as a Therapeutic Target in Ischemic Stroke

(2009) Honglian Shi   CURRENT MEDICINAL CHEMISTRY

Cellular Regulation of SIRT1

(2009) Jo Milner   CURRENT PHARMACEUTICAL DESIGN

Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation

(2009) Zoya Marinova et al.   JOURNAL OF NEUROCHEMISTRY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised Neurons

(2009) Dong Liu et al.   NEUROMOLECULAR MEDICINE

Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway

(2009) D. Della-Morte et al.   NEUROSCIENCE

Multiple roles of HDAC inhibition in neurodegenerative conditions

(2009) De-Maw Chuang et al.   TRENDS IN NEUROSCIENCES

Nitric oxide mediates NMDA-induced persistent inhibition of protein synthesis through dephosphorylation of eukaryotic initiation factor 4E-binding protein 1 and eukaryotic initiation factor 4G proteolysis

(2008) Valérie Petegnief et al.   BIOCHEMICAL JOURNAL

SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons

(2008) Ying Li et al.   Cell Metabolism

The neuroprotection of prodromal transient ischaemic attack on cerebral infarction

(2008) Y. Fu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Necdin Regulates p53 Acetylation via Sirtuin1 to Modulate DNA Damage Response in Cortical Neurons

(2008) K. Hasegawa et al.   JOURNAL OF NEUROSCIENCE

Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability

(2008) G. Ramadori et al.   JOURNAL OF NEUROSCIENCE

Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications

(2008) Xiang-Jiao Yang et al.   MOLECULAR CELL

Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity

(2008) Jason A. Pfister et al.   PLoS One

Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation

(2008) S. Hisahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA