Pathways for Ischemic Cytoprotection: Role of Sirtuins in Caloric Restriction, Resveratrol, and Ischemic Preconditioning

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair

(2016) Ronald A. McCord et al.   Aging-US

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

(2012) Kristi Muldoon Jacobs et al.   International Journal of Biological Sciences

JNK2-dependent regulation of SIRT1 protein stability

(2011) Jack Ford et al.   CELL CYCLE

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

(2010) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Dietary manipulation and caloric restriction in the development of mouse models relevant to neurological diseases

(2010) Joern E. Schroeder et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Sirtuin1-p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat

(2010) Erik Vahtola et al.   Cardiovascular Diabetology

Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients

(2010) Lingyun Zhu et al.   CELL RESEARCH

Early Apoptotic Vascular Signaling is Determined by Sirt1 Through Nuclear Shuttling, Forkhead Trafficking, Bad, and Mitochondrial Caspase Activation

(2010) Jinling Hou et al.   CURRENT NEUROVASCULAR RESEARCH

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria

(2010) Katia Aquilano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of Akt/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hypoxic pre-conditioning in adult rats

(2010) Lixuan Zhan et al.   JOURNAL OF NEUROCHEMISTRY

Resveratrol Reverses Endothelial Nitric-Oxide Synthase Uncoupling in Apolipoprotein E Knockout Mice

(2010) N. Xia et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Functional dissection of SIRT6: Identification of domains that regulate histone deacetylase activity and chromatin localization

(2010) Ruth I. Tennen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1α Expression in experimental stroke

(2010) Hai-rong Zhu et al.   NEUROPHARMACOLOGY

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

Ischemic Preconditioning Mediates Cyclooxygenase-2 Expression Via Nuclear Factor-Kappa B Activation in Mixed Cortical Neuronal Cultures

(2010) Eun Joo Kim et al.   Translational Stroke Research

Calorie restriction alters mitochondrial protein acetylation

(2009) Bjoern Schwer et al.   AGING CELL

SIRT6 protects against pathological damage caused by diet-induced obesity

(2009) Yariv Kanfi et al.   AGING CELL

PPAR-α activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway

(2009) Aliaksandr A. Bulhak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection

(2009) Kenichi Kakefuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2

(2009) Barbara Zschoernig et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Succinate Dehydrogenase Activity by SIRT3 in Mammalian Mitochondria

(2009) Huseyin Cimen et al.   BIOCHEMISTRY

Spatial and Temporal Dynamics of Mitochondrial Membrane Permeability Waves during Apoptosis

(2009) Patrick D. Bhola et al.   BIOPHYSICAL JOURNAL

Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway

(2009) Narasimman Gurusamy et al.   CARDIOVASCULAR RESEARCH

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity

(2009) Dirk Beher et al.   Chemical Biology & Drug Design

Autophagy in Ischemic Heart Disease

(2009) Åsa B. Gustafsson et al.   CIRCULATION RESEARCH

Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes

(2009) Shweta Rane et al.   CIRCULATION RESEARCH

Cellular Mechanisms of Cardioprotection by Calorie Restriction: State of the Science and Future Perspectives

(2009) Emanuele Marzetti et al.   CLINICS IN GERIATRIC MEDICINE

PGC-1α and PGC-1β Regulate Mitochondrial Density in Neurons

(2009) Przemyslaw Wareski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis

(2009) A. Grob et al.   JOURNAL OF CELL SCIENCE

Neuroprotective Role of Mitochondrial Uncoupling Protein 2 in Cerebral Stroke

(2009) Suresh L Mehta et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation

(2009) Sebastian Greiss et al.   MOLECULES AND CELLS

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Neuroprotective effects of resveratrol on ischemic injury mediated by modulating the release of neurotransmitter and neuromodulator in rats

(2009) Chao Li et al.   NEUROCHEMISTRY INTERNATIONAL

Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised Neurons

(2009) Dong Liu et al.   NEUROMOLECULAR MEDICINE

Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway

(2009) D. Della-Morte et al.   NEUROSCIENCE

Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System

(2009) Işin Çakir et al.   PLoS One

Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins

(2009) Ivy K. M. Law et al.   PROTEOMICS

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Metabolic reprogramming, caloric restriction and aging

(2009) Rozalyn M. Anderson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1

(2008) Ken Shinmura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1–FoxO1 pathway

(2008) Chun-Juan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diet and Aging

(2008) Matthew D.W. Piper et al.   Cell Metabolism

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

Resveratrol and Ischemic Preconditioning in the Brain

(2008) Ami Raval et al.   CURRENT MEDICINAL CHEMISTRY

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

RETRACTED: Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol

(2008) Subhendu Mukherjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Foxo3a Inhibits Cardiomyocyte Hypertrophy through Transactivating Catalase

(2008) Wei-Qi Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caloric Restriction Stimulates Revascularization in Response to Ischemia via Adiponectin-mediated Activation of Endothelial Nitric-oxide Synthase

(2008) Megumi Kondo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GABA Synapses Mediate Neuroprotection after Ischemic and εPKC Preconditioning in Rat Hippocampal Slice Cultures

(2008) R. Anthony DeFazio et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Preconditioning Mediated by Sublethal Oxygen—Glucose Deprivation-Induced Cyclooxygenase-2 Expression via the Signal Transducers and Activators of Transcription 3 Phosphorylation

(2008) Eun J Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway

(2008) Rajesh G. Katare et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

Ischemic Preconditioning Targets the Respiration of Synaptic Mitochondria via Protein Kinase C 

(2008) K. R. Dave et al.   JOURNAL OF NEUROSCIENCE

Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors

(2008) WenPeng Dong et al.   JOURNAL OF VASCULAR SURGERY

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

(2008) N. R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

Resveratrol inhibits MMP-9 expression by up-regulating PPAR α expression in an oxygen glucose deprivation-exposed neuron model

(2008) Gang Cheng et al.   NEUROSCIENCE LETTERS

Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes

(2008) Srujana Rayalam et al.   PHYTOTHERAPY RESEARCH

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

(2008) Gino Boily et al.   PLoS One

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular NAD Replenishment Confers Marked Neuroprotection Against Ischemic Cell Death

(2008) Suping Wang et al.   STROKE

Food restriction attenuates ischemia-induced spatial learning and memory deficits despite extensive CA1 ischemic injury

(2007) Marie-Claude Roberge et al.   BEHAVIOURAL BRAIN RESEARCH

Localization of mouse mitochondrial SIRT proteins: Shift of SIRT3 to nucleus by co-expression with SIRT5

(2007) Yasuhiko Nakamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS