Human Poisoning from Marine Toxins: Unknowns for Optimal Consumer Protection

Identification of 21,22-Dehydroazaspiracids in Mussels (Mytilus edulis) and in Vitro Toxicity of Azaspiracid-26

(2018) Jane Kilcoyne et al.   JOURNAL OF NATURAL PRODUCTS

Tetrodotoxin, a Candidate Drug for Nav1.1-Induced Mechanical Pain?

(2018) César Mattei   Marine Drugs

Toxic equivalency factors (TEFs) after acute oral exposure of azaspiracid 1, −2 and −3 in mice

(2018) M. Pelin et al.   TOXICOLOGY LETTERS

Immune effects of the neurotoxins ciguatoxins and brevetoxins

(2018) Ophelie Pierre et al.   TOXICON

Six domoic acid related compounds from the red alga, Chondria armata, and domoic acid biosynthesis by the diatom, Pseudo-nitzschia multiseries

(2018) Yukari Maeno et al.   Scientific Reports

Incidence and clinical characteristics of ciguatera fish poisoning in Guadeloupe (French West Indies) between 2013 and 2016: a retrospective cases-series

(2018) Denis Boucaud-Maitre et al.   Scientific Reports

Dose-Response Modelling of Paralytic Shellfish Poisoning (PSP) in Humans

(2018) Nathalie Arnich et al.   Toxins

Repeated Dietary Exposure to Low Levels of Domoic Acid and Problems with Everyday Memory: Research to Public Health Outreach

(2018) Lynn Grattan et al.   Toxins

Tectus niloticus (Tegulidae, Gastropod) as a Novel Vector of Ciguatera Poisoning: Clinical Characterization and Follow-Up of a Mass Poisoning Event in Nuku Hiva Island (French Polynesia)

(2018) Clémence Gatti et al.   Toxins

Acute and chronic dietary exposure to domoic acid in recreational harvesters: A survey of shellfish consumption behavior

(2017) Bridget E. Ferriss et al.   ENVIRONMENT INTERNATIONAL

Prevalence and characteristics of inhalational and dermal palytoxin exposures reported to the National Poison Data System in the U.S.

(2017) Lauren T. Murphy et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Characterization of the dinophysistoxin-2 acute oral toxicity in mice to define the Toxicity Equivalency Factor

(2017) Paula Abal et al.   FOOD AND CHEMICAL TOXICOLOGY

Identification of Azadinium species and a new azaspiracid from Azadinium poporum in Puget Sound, Washington State, USA

(2017) Joo-Hwan Kim et al.   HARMFUL ALGAE

Amphidoma languida (Amphidomatacea, Dinophyceae) with a novel azaspiracid toxin profile identified as the cause of molluscan contamination at the Atlantic coast of southern Spain

(2017) Urban Tillmann et al.   HARMFUL ALGAE

Guanidinium Toxins and Their Interactions with Voltage-Gated Sodium Ion Channels

(2017) Lorena Durán-Riveroll et al.   Marine Drugs

An Updated Review of Ciguatera Fish Poisoning: Clinical, Epidemiological, Environmental, and Public Health Management

(2017) Melissa Friedman et al.   Marine Drugs

How the marine biotoxins affect human health

(2017) Silvia Morabito et al.   NATURAL PRODUCT RESEARCH

Sublethal doses of dinophysistoxin-1 and okadaic acid stimulate secretion of inflammatory factors on innate immune cells: Negative health consequences

(2017) Miguel del Campo et al.   TOXICON

Derivation of toxicity equivalency factors for marine biotoxins associated with Bivalve Molluscs

(2017) Luis M. Botana et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)

(2017) Paula Abal et al.   Toxins

Acute Toxicities of the Saxitoxin Congeners Gonyautoxin 5, Gonyautoxin 6, Decarbamoyl Gonyautoxin 2&3, Decarbamoyl Neosaxitoxin, C-1&2 and C-3&4 to Mice by Various Routes of Administration

(2017) Andrew Selwood et al.   Toxins

Toxicity equivalence factors for regulated and non-regulated marine toxins

(2017) Maria Carmen Louzao et al.   Current Opinion in Food Science

Ciguatoxicity of Gambierdiscus and Fukuyoa species from the Caribbean and Gulf of Mexico

(2017) R. Wayne Litaker et al.   PLoS One

In vivo cardiomyocyte response to YTX- and AZA-1-induced damage: autophagy versus apoptosis

(2016) Sara F. Ferreiro et al.   ARCHIVES OF TOXICOLOGY

Risk to human health associated with the environmental occurrence of cyanobacterial neurotoxic alkaloids anatoxins and saxitoxins

(2016) Emanuela Testai et al.   CRITICAL REVIEWS IN TOXICOLOGY

Ovatoxin-a, A Palytoxin Analogue Isolated from Ostreopsis cf. ovata Fukuyo: Cytotoxic Activity and ELISA Detection

(2016) Marco Pelin et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Low dose extended exposure to saxitoxin and its potential neurodevelopmental effects: A review

(2016) Katie O’Neill et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

In vitro bioaccessibility of the marine biotoxin okadaic acid in shellfish

(2016) Ana C. Braga et al.   FOOD AND CHEMICAL TOXICOLOGY

Azadinium poporum from the Argentine Continental Shelf, Southwestern Atlantic, produces azaspiracid-2 and azaspiracid-2 phosphate

(2016) Urban Tillmann et al.   HARMFUL ALGAE

Harmful algal blooms and public health

(2016) Lynn M. Grattan et al.   HARMFUL ALGAE

The association between razor clam consumption and memory in the CoASTAL cohort

(2016) Lynn M. Grattan et al.   HARMFUL ALGAE

Behavioral alterations induced by repeated saxitoxin exposure in drinking water

(2016) Felipe Diehl et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Structure–Activity Relationship Studies Using Natural and Synthetic Okadaic Acid/Dinophysistoxin Toxins

(2016) Michael Twiner et al.   Marine Drugs

Palytoxin-Containing Aquarium Soft Corals as an Emerging Sanitary Problem

(2016) Marco Pelin et al.   Marine Drugs

Subacute Cardiovascular Toxicity of the Marine Phycotoxin Azaspiracid-1 in Rats

(2016) Sara F. Ferreiro et al.   TOXICOLOGICAL SCIENCES

Investigation of the genotoxic potential of the marine biotoxins azaspiracid 1–3

(2016) Barbara Doerr et al.   TOXICON

Chelonitoxism in Andaman and Nicobar Island: A report on mass poisoning including a death of an adult

(2016) S.S. Singh et al.   TOXICON

Chemical, molecular, and eco-toxicological investigation of Ostreopsis sp. from Cyprus Island: structural insights into four new ovatoxins by LC-HRMS/MS

(2015) Luciana Tartaglione et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Effects of ocean warming on growth and distribution of dinoflagellates associated with ciguatera fish poisoning in the Caribbean

(2015) Steven R. Kibler et al.   ECOLOGICAL MODELLING

Determination of Palytoxins in Soft Coral and Seawater from a Home Aquarium. Comparison between Palythoa- and Ostreopsis-Related Inhalatory Poisonings

(2015) Luciana Tartaglione et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Detection of the pufferfish toxin tetrodotoxin in European bivalves, England, 2013 to 2014

(2015) A Turner et al.   Eurosurveillance

Characterization of ovatoxin-h, a new ovatoxin analog, and evaluation of chromatographic columns for ovatoxin analysis and purification

(2015) Charline Brissard et al.   JOURNAL OF CHROMATOGRAPHY A

Potential Threats Posed by New or Emerging Marine Biotoxins in UK Waters and Examination of Detection Methodology Used in Their Control: Brevetoxins

(2015) Andrew Turner et al.   Marine Drugs

Tetrodotoxin, an Extremely Potent Marine Neurotoxin: Distribution, Toxicity, Origin and Therapeutical Uses

(2015) Jorge Lago et al.   Marine Drugs

Ciguatera Fish Poisoning in East Asia and Southeast Asia

(2015) Thomas Chan   Marine Drugs

Hunt for Palytoxins in a Wide Variety of Marine Organisms Harvested in 2010 on the French Mediterranean Coast

(2015) Ronel Biré et al.   Marine Drugs

Dose-response and histopathological study, with special attention to the hypophysis, of the differential effects of domoic acid on rats and mice

(2015) Andrés Crespo Vieira et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Diarrhetic effect of okadaic acid could be related with its neuronal action: Changes in neuropeptide Y

(2015) M. Carmen Louzao et al.   TOXICOLOGY LETTERS

Two-year study of lipophilic marine toxin profile in mussels of the North-central Adriatic Sea: First report of azaspiracids in Mediterranean seafood

(2015) Simone Bacchiocchi et al.   TOXICON

Dangerous reef aquaristics: Palytoxin of a brown encrusting anemone causes toxic corneal reactions

(2015) Yasmin Ruiz et al.   TOXICON

Molecular Detection of a Potentially Toxic Diatom Species

(2015) Bidhan Dhar et al.   International Journal of Environmental Research and Public Health

Suspected Palytoxin Inhalation Exposures Associated with Zoanthid Corals in Aquarium Shops and Homes — Alaska, 2012–2014

(2015) Ali K. Hamade et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Hyperkalemia, Hyperphosphatemia, Acute Kidney Injury, and Fatal Dysrhythmias After Consumption of Palytoxin-Contaminated Goldspot Herring

(2014) Ming-Ling Wu et al.   ANNALS OF EMERGENCY MEDICINE

Respiratory impairment in four patients associated with exposure to palytoxin containing coral

(2014) Andre Wieringa et al.   CLINICAL TOXICOLOGY

First Finding of Ostreopsis cf. ovata Toxins in Marine Aerosols

(2014) Patrizia Ciminiello et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Oxidative stress in rats induced by consumption of saxitoxin contaminated drink water

(2014) Patrícia Baptista Ramos et al.   HARMFUL ALGAE

Chronic Toxicity Study of Neosaxitoxin in Rats

(2014) Ramiro Zepeda et al.   Marine Drugs

Domoic Acid Epileptic Disease

(2014) John Ramsdell et al.   Marine Drugs

Lipophilic toxins in cultivated mussels (Mytilus galloprovincialis) from Baja California, Mexico

(2014) Ernesto García-Mendoza et al.   TOXICON

Experimental Basis for the High Oral Toxicity of Dinophysistoxin 1: A Comparative Study of DSP

(2014) Diego Fernández et al.   Toxins

Mussel-Associated Azaspiracid Intoxication in the United States

(2013) Karl C. Klontz   ANNALS OF INTERNAL MEDICINE

Occurrence of palytoxins in marine organisms from different trophic levels of the French Mediterranean coast harvested in 2009

(2013) R. Biré et al.   HARMFUL ALGAE

Tumor promoters: from chemicals to inflammatory proteins

(2013) Hirota Fujiki et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Okadaic Acid Toxin at Sublethal Dose Produced Cell Proliferation in Gastric and Colon Epithelial Cell Lines

(2013) Miguel del Campo et al.   Marine Drugs

Okadaic Acid: More than a Diarrheic Toxin

(2013) Vanessa Valdiglesias et al.   Marine Drugs

Diarrhetic Shellfish Toxins and Other Lipophilic Toxins of Human Health Concern in Washington State

(2013) Vera Trainer et al.   Marine Drugs

Genetic Diversity and Distribution of the Ciguatera-Causing Dinoflagellate Gambierdiscus spp. (Dinophyceae) in Coastal Areas of Japan

(2013) Tomohiro Nishimura et al.   PLoS One

Bioavailability and intravenous toxicokinetic parameters for Pacific ciguatoxin P-CTX-1 in rats

(2013) Aurélie Ledreux et al.   TOXICON

Toxicity of palytoxin after repeated oral exposure in mice and in vitro effects on cardiomyocytes

(2013) Giorgia Del Favero et al.   TOXICON

Acute toxicities of saxitoxin, neosaxitoxin, decarbamoyl saxitoxin and gonyautoxins 1&4 and 2&3 to mice by various routes of administration

(2013) Rex Munday et al.   TOXICON

Oral Toxicity of Okadaic Acid in Mice: Study of Lethality, Organ Damage, Distribution and Effects on Detoxifying Gene Expression

(2013) Andres Vieira et al.   Toxins

Is Protein Phosphatase Inhibition Responsible for the Toxic Effects of Okadaic Acid in Animals?

(2013) Rex Munday   Toxins

Elimination Kinetics of Domoic Acid from the Brain and Cerebrospinal Fluid of the Pregnant Rat

(2012) Jennifer Maucher Fuquay et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Exposure to domoic acid through shellfish consumption in Belgium

(2012) M. Andjelkovic et al.   ENVIRONMENT INTERNATIONAL

Use-dependent block of the voltage-gated Na+channel by tetrodotoxin and saxitoxin: Effect of pore mutations that change ionic selectivity

(2012) Chien-Jung Huang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Ovatoxin-a and Palytoxin Accumulation in Seafood in Relation to Ostreopsis cf. ovata Blooms on the French Mediterranean Coast

(2012) Zouher Amzil et al.   Marine Drugs

Aquarism: An Innocent Leisure Activity?

(2012) M. Bernasconi et al.   RESPIRATION

Study of possible combined toxic effects of azaspiracid-1 and okadaic acid in mice via the oral route

(2012) Tore Aune et al.   TOXICON

Azaspiracid accumulation, detoxification and biotransformation in blue mussels (Mytilus edulis) experimentally fed Azadinium spinosum

(2012) Thierry Jauffrais et al.   TOXICON

S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells

(2011) Kristen Park Hopson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Florida red tide toxins (brevetoxins) and longitudinal respiratory effects in asthmatics

(2011) Judy A. Bean et al.   HARMFUL ALGAE

Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep

(2011) Julia Zaias et al.   INHALATION TOXICOLOGY

Isolation and Structure Elucidation of Ovatoxin-a, the Major Toxin Produced by Ostreopsis ovata

(2011) Patrizia Ciminiello et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palytoxin Found in Palythoa sp. Zoanthids (Anthozoa, Hexacorallia) Sold in the Home Aquarium Trade

(2011) Jonathan R. Deeds et al.   PLoS One

Toxicokinetics of the ciguatoxin P-CTX-1 in rats after intraperitoneal or oral administration

(2011) Marie-Yasmine Dechraoui Bottein et al.   TOXICOLOGY

Acute oral toxicity in mice of a new palytoxin analog: 42-Hydroxy-palytoxin

(2011) A. Tubaro et al.   TOXICON

Ciguatera Fish Poisoning in the Pacific Islands (1998 to 2008)

(2011) Mark P. Skinner et al.   PLoS Neglected Tropical Diseases

First Toxin Profile of Ciguateric Fish in Madeira Arquipelago (Europe)

(2010) Paz Otero et al.   ANALYTICAL CHEMISTRY

Aquarium Coral Keratoconjunctivitis

(2010) Majid Moshirfar   ARCHIVES OF OPHTHALMOLOGY

Health impact of unicellular algae of theOstreopsisgenus blooms in the Mediterranean Sea: experience of the French Mediterranean coast surveillance network from 2006 to 2009

(2010) Lucia Tichadou et al.   CLINICAL TOXICOLOGY

Shellfish toxicity: human health implications of marine algal toxins

(2010) K. J. JAMES et al.   EPIDEMIOLOGY AND INFECTION

Review of Florida red tide and human health effects

(2010) Lora E. Fleming et al.   HARMFUL ALGAE

Everyday memory: Self-perception and structural brain correlates in a healthy elderly population

(2010) ASTRID BJØRNEBEKK et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Neurotoxic Alkaloids: Saxitoxin and Its Analogs

(2010) Maria Wiese et al.   Marine Drugs

Assessment of okadaic acid effects on cytotoxicity, DNA damage and DNA repair in human cells

(2010) Vanessa Valdiglesias et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Development and validation of a high-throughput double solid phase extraction–liquid chromatography–tandem mass spectrometry method for the determination of tetrodotoxin in human urine and plasma

(2010) Bonnie Mei-Wah Fong et al.   TALANTA

Sub-lethal dosing of azaspiracid-1 in female NMRI mice

(2010) John A.B. Aasen et al.   TOXICON

Ciguatera fish poisoning on the West Africa Coast: An emerging risk in the Canary Islands (Spain)

(2010) Luis D. Boada et al.   TOXICON

Ciguatera fish poisoning and sea surface temperatures in the Caribbean Sea and the West Indies

(2010) Patricia A. Tester et al.   TOXICON

Palytoxin toxicology: Animal studies

(2010) Rex Munday   TOXICON

The problem of toxicity equivalent factors in developing alternative methods to animal bioassays for marine-toxin detection

(2010) Luis M. Botana et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Ostreocin-D Impact on Globular Actin of Intact Cells

(2009) Isabel R. Ares et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Palytoxin Poisoning After Dermal Contact with Zoanthid Coral

(2009) Sean Patrick Nordt et al.   JOURNAL OF EMERGENCY MEDICINE

Palytoxin toxicity after acute oral administration in mice

(2009) S. Sosa et al.   TOXICOLOGY LETTERS

Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin

(2009) Reiko Ueoka et al.   TOXICON

The occurrence of domoic acid linked to a toxic diatom bloom in a new potential vector: The tunicate Pyura chilensis (piure)

(2009) Américo López-Rivera et al.   TOXICON

Toxicological studies on palytoxin and ostreocin-D administered to mice by three different routes

(2009) Emiko Ito et al.   TOXICON

First identification of azaspiracid and spirolides in Mesodesma donacium and Mulinia edulis from Northern Chile

(2009) Gonzalo Álvarez et al.   TOXICON

First evidence of azaspiracids (AZAs): A family of lipophilic polyether marine toxins in scallops (Argopecten purpuratus) and mussels (Mytilus chilensis) collected in two regions of Chile

(2009) A. López-Rivera et al.   TOXICON

Prevalence, symptoms and chronicity of ciguatera in New Caledonia: Results from an adult population survey conducted in Noumea during 2005

(2009) Francine Baumann et al.   TOXICON

Ciguatera: A public health perspective

(2009) Robert W. Dickey et al.   TOXICON

Human risk associated with palytoxin exposure

(2009) Jonathan R. Deeds et al.   TOXICON

Paralytic shellfish poisoning: Seafood safety and human health perspectives

(2009) Stacey M. Etheridge   TOXICON

Human fatality associated with Pacific ciguatoxin contaminated fish

(2009) Brett Hamilton et al.   TOXICON

First Toxicity Report of Tetrodotoxin and 5,6,11-TrideoxyTTX in the Trumpet Shell Charonia lampas lampas in Europe

(2008) Paula Rodriguez et al.   ANALYTICAL CHEMISTRY

In Vitro and in Vivo Evaluation of Paralytic Shellfish Poisoning Toxin Potency and the Influence of the pH of Extraction

(2008) Carmen Vale et al.   ANALYTICAL CHEMISTRY

Harmful algal toxins of the Florida red tide (Karenia brevis): natural chemical stressors in South Florida coastal ecosystems

(2008) R. H. Pierce et al.   ECOTOXICOLOGY

Formation of Azaspiracids-3, -4, -6, and -9 via Decarboxylation of Carboxyazaspiracid Metabolites from Shellfish

(2008) Pearse McCarron et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Detection of Diarrheic Shellfish Poisoning and Azaspiracids Toxins in Moroccan Mussels: Comparison of LC-MS Method with the Commercial Immunoassay Kit

(2008) Adra Elgarch et al.   Marine Drugs

Neurotoxic Shellfish Poisoning

(2008) Sharon Watkins et al.   Marine Drugs

Domoic Acid Toxicologic Pathology: A Review

(2008) Olga Pulido   Marine Drugs

Ciguatera Fish Poisoning: Treatment, Prevention and Management

(2008) Melissa Friedman et al.   Marine Drugs

Non-Traditional Vectors for Paralytic Shellfish Poisoning

(2008) Jonathan Deeds et al.   Marine Drugs

First report on azaspiracid and yessotoxin groups detection in French shellfish

(2008) Zouher Amzil et al.   TOXICON

Evidence of in vitro glucuronidation and enzymatic transformation of paralytic shellfish toxins by healthy human liver microsomes fraction

(2008) Carlos García et al.   TOXICON

A cytolytic assay for the measurement of palytoxin based on a cultured monolayer cell line

(2007) Mirella Bellocci et al.   ANALYTICAL BIOCHEMISTRY

Shellfish consumption: A major risk factor for colorectal cancer

(2007) Emilia Manerio et al.   MEDICAL HYPOTHESES

Novel symptomatology and changing epidemiology of domoic acid toxicosis in California sea lions (Zalophus californianus): an increasing risk to marine mammal health

(2007) T Goldstein et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: Relationship to blood ciguatoxin concentrations

(2007) Marie-Yasmine Bottein Dechraoui et al.   TOXICOLOGY

First episode of shellfish contamination by palytoxin-like compounds from Ostreopsis species (Aegean Sea, Greece)

(2007) Katerina Aligizaki et al.   TOXICON