Article
Zoology
Brooke A. Travis, William N. Batts, Maya L. Groner, Paul K. Hershberger, Steven C. Fradkin, Carla M. Conway, Linda Park, Maureen K. Purcell
Summary: The study found that nuclear inclusion X (NIX) infection in Pacific razor clams is associated with mass mortality in Washington coastal beaches. A detection method was developed and its specificity was confirmed. The research indicated significant differences in infection rates between razor clams from two different locations.
JOURNAL OF INVERTEBRATE PATHOLOGY
(2021)
Article
Fisheries
Charlotte A. Berry-Powell, Zachary Forster, Dan Ayres, Clayton Parson, James P. Losee
Summary: Since 1898, the Pacific razor clam has been a valuable resource, contributing to coastal communities' economic revenue in the Pacific Northwest. Washington State adopted the Pumped Area Method in 1996 to accurately assess razor clam populations, utilizing a water pump and random sampling to estimate the total population. This method, combined with biweekly sampling of toxic algae, supports sustainable harvest and generates significant economic income for Washington State.
JOURNAL OF SHELLFISH RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marco Cavallone, Patrik Goncalves Jorge, Raphael Moeckli, Claude Bailat, Alessandro Flacco, Yolanda Prezado, Rachel Delorme
Summary: Ultra-high dose-rate irradiations have gained interest in radiotherapy. In order to apply it to clinical treatments, practical tools and methods need to be developed. Recent research has found that instruments with small sensitive volumes have higher efficiency at high dose rates.
Article
Marine & Freshwater Biology
Seon-Sik Lee, Hyung-Jin Ahn, In-Uk Hwang, Eun Kim, Kyung-Nam Han
Summary: This study investigates the effect of chlorine on surf clams of varying sizes, finding that the maximum time to reach 100% mortality at a chlorine concentration of 0.5 mg L-1 was 568.0 hours for small clams and 824.0 hours for large clams. Physiological responses decreased significantly at sublethal chlorine concentrations, indicating weakened feeding regimens in M. quadrangularis.
OCEAN SCIENCE JOURNAL
(2021)
Article
Engineering, Biomedical
Alexandra Bourgouin, Adrian Knyziak, Marco Marinelli, Rafael Kranzer, Andreas Schueller, Ralf-Peter Kapsch
Summary: This investigation focuses on the characterization and optimization of ultra-high pulse dose rate (UHPDR) electron beam at the PTB facility in Germany. Through experimental and simulation studies, two suitable setups for delivering reference UHPDR electron beams have been identified, and the reliability of the Monte Carlo model and the potential of the diamond detector prototype have been demonstrated.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Physics, Multidisciplinary
Minqiang Liu, Xianguo Xu, Chao Zeng, Cen Xiong
Summary: This study investigated the influence of dose rate on the TID effect of an anti-fuse FPGA device through experiments and theoretical analysis, showing that low dose rate irradiation can attenuate the damage effect of the FPGA.
FRONTIERS IN PHYSICS
(2022)
Article
Chemistry, Analytical
Jae Hyeon Park, Hyeon Seong Kim, Seong Ho Jang, Dong Jin Hyun, Sang In Park, JuYoung Yoon, Hyunseop Lim, Mi Jung Kim
Summary: The study investigated the cardiorespiratory responses to 10 weeks of exoskeleton-assisted walking training in patients with spinal cord injury (SCI). The findings showed that the exercise intensity remained moderate according to METs, while the average %HRR significantly decreased after training. Additionally, walking efficiency progressively improved after the 10-week training period.
Article
Cardiac & Cardiovascular Systems
Yang Li, Bowen Zhu, Nana Song, Yiqin Shi, Yi Fang, Xiaoqiang Ding
Summary: This study explored the association between alcohol consumption and chronic kidney disease (CKD) in a Chinese population. The results showed that moderate drinkers had a lower likelihood of CKD, while the risk significantly increased when alcohol consumption exceeded a certain threshold. Drinking patterns also influenced disease prevalence.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Fisheries
Zamir Benitez-Polo, Nataly Gomez-Gomez, Luz A. Velasco
Summary: This study evaluated the energetic physiology performance of the estuarine clam Polymesoda arctata under laboratory conditions to understand its adaptation to food concentration and water quality changes. It was found that the clam showed the best physiological performance at intermediate conditions of food concentration, salinity, and temperature, while having the highest growth potential at low ammonia concentration and high dissolved oxygen saturation.
AQUACULTURE RESEARCH
(2023)
Article
Medicine, General & Internal
Parvin Mirmiran, Marjan Ramezan, Hossein Farhadnejad, Golaleh Asghari, Zhaleh Tahmasebinejad, Fereidoun Azizi
Summary: This study aimed to investigate the association between dietary diabetes risk reduction score (DDRRS) and chronic kidney disease (CKD) in an Iranian adult population. The findings suggest that adherence to a dietary pattern with a higher score of DDRRS may be associated with a lower risk of CKD incident.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Biology
Nurul Absar, Jainal Abedin, Md Mashiur Rahman, Moazzem Hossain Miah, Naziba Siddique, Masud Kamal, Mantazul Islam Chowdhury, Abdelmoneim Adam Mohamed Sulieman, Mohammad Rashed Iqbal Faruque, Mayeen Uddin Khandaker, David Andrew Bradley, Abdullah Alsubaie
Summary: Using HPGe gamma-ray spectrometry, this study analyzed the concentrations of radionuclides in soil and tea leaves from a large tea plantation in Bangladesh. The transfer factors from soil to tea leaves were found to be relatively low for Ra-226, Th-232, and K-40. The popular tea brands in the market showed similar radionuclide concentrations to the fresh tea leaves, indicating a low radiological risk from tea consumption.
Review
Nutrition & Dietetics
Ryohei Yamamoto, Qinyan Li, Naoko Otsuki, Maki Shinzawa, Makoto Yamaguchi, Minako Wakasugi, Yasuyuki Nagasawa, Yoshitaka Isaka
Summary: This systematic review examined the association between alcohol consumption and chronic kidney disease. The results showed a J-shaped association between alcohol consumption and the incidence of proteinuria. Mild drinkers had a lower risk of proteinuria and low eGFR, while heavy drinkers had a higher risk of proteinuria but a lower risk of low eGFR.
Article
Oncology
Thorir Einarsson Long, Olafur Skuli Indridason, Runolfur Palsson, Somundur Rognvaldsson, Thorvardur Jon Love, Sigrun Thorsteinsdottir, Ingigerdur Solveig Sverrisdottir, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni Agnar Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdottir, Isleifur Olafsson, Asdis Rosa Thordardottir, Elias Eythorsson, Asbjorn Jonsson, Gauti Gislason, Andri Olafsson, Hlif Steingrimsdottir, Malin Hultcrantz, Brian G. M. Durie, Stephen Harding, Ola Landgren, Sigurdur Yngvi Kristinsson
Summary: This study aimed to establish a reference interval for serum free light chain (FLC) in patients with chronic kidney disease (CKD). Using a large prospective population-based cohort, new reference intervals for FLC values based on estimated glomerular filtration rate (eGFR) were proposed. The current reference intervals were found to be inaccurate in CKD patients, suggesting the need for implementation of the new eGFR-based reference intervals.
BLOOD CANCER JOURNAL
(2022)
Review
Nutrition & Dietetics
H. C. Yuan, Q. T. Yu, H. Bai, H. Z. Xu, P. Gu, L. Y. Chen
Summary: This meta-analysis of prospective cohort studies found an inverse association between alcohol consumption and the risk of chronic kidney disease, especially in males. Light, moderate, and heavy alcohol intake may have a protective effect against CKD.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Veterinary Sciences
Kate KuKanich, Christopher George, James K. Roush, Sherry Sharp, Giosi Farace, Murthy Yerramilli, Sarah Peterson, Gregory F. Grauer
Summary: There was no decline in renal excretory function observed when meloxicam was administered to cats with CKD, but gastrointestinal adverse effects were observed. Cats receiving meloxicam had significantly higher proteinuria at 6 months compared to those receiving placebo. Therefore, caution should be exercised when using meloxicam in cats with CKD, with urine protein levels monitored for potential negative outcomes.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Matthew D. Campbell, David J. Marcinek
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2016)
Article
Cell Biology
Michael P. Siegel, Shane E. Kruse, Justin M. Percival, Jorming Goh, Collin C. White, Heather C. Hopkins, Terrance J. Kavanagh, Hazel H. Szeto, Peter S. Rabinovitch, David J. Marcinek
Editorial Material
Cell Biology
David J. Marcinek, Michael P. Siegel
Article
Biochemistry & Molecular Biology
Justin M. Percival, Michael P. Siegel, Gary Knowels, David J. Marcinek
HUMAN MOLECULAR GENETICS
(2013)
Article
Endocrinology & Metabolism
Kevin E. Conley, Catherine E. Amara, Sudip Bajpeyi, Sheila R. Costford, Kori Murray, Sharon A. Jubrias, Lori Arakaki, David J. Marcinek, Steven R. Smith
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2013)
Article
Cell Biology
Michael P. Siegel, Tim Wilbur, Mark Mathis, Eric G. Shankland, Atlas Trieu, Mary-Ellen Harper, David J. Marcinek
MECHANISMS OF AGEING AND DEVELOPMENT
(2012)
Article
Biochemistry & Molecular Biology
Ethan L. Ostrom, Ana P. Valencia, David J. Marcinek, Tinna Traustadottir
Summary: High intensity exercise significantly impacts Nrf2-ARE binding and Keap1 protein expression in mouse skeletal muscle, while low intensity exercise does not show significant effects on these factors. This suggests that the intensity of exercise plays a role in activating redox signaling pathways in skeletal muscle.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Baback Roshanravan, Sophia Z. Liu, Amir S. Ali, Eric G. Shankland, Chessa Goss, John K. Amory, H. Thomas Robertson, David J. Marcinek, Kevin E. Conley
Summary: The study showed that ELAM can rapidly and reversibly increase mitochondrial capacity after a single dose, but did not significantly affect muscle fatigue resistance.
Article
Physiology
Sophia Z. Liu, Ana P. Valencia, Matt P. VanDoren, Eric G. Shankland, Baback Roshanravan, Kevin E. Conley, David J. Marcinek
Summary: The study found that combining the natural antioxidant and anti-inflammatory dietary supplement astaxanthin (AX) with endurance training can improve specific muscle endurance and fat oxidation in elderly individuals, with a more significant effect observed in males.
PHYSIOLOGICAL REPORTS
(2021)
Article
Nutrition & Dietetics
Laurie K. K. Mischley, Eric Shankland, Sophia Z. Z. Liu, Saakshi Bhayana, Devon J. J. Fox, David J. J. Marcinek
Summary: The goal of this study was to identify bioenergetic and functional markers in the muscles of individuals with Parkinson's disease (PD). Mitochondrial ATP production and NAD levels were significantly lower in the leg muscles of PD patients compared to controls. The study suggests that skeletal muscle mitochondrial function may be a important tool for understanding PD and its clinical applications.
Article
Food Science & Technology
Alicia M. Hendrix, Kathi A. Lefebvre, Emily K. Bowers, Rudolph Stuppard, Thomas Burbacher, David J. Marcinek
Summary: The excitatory neurotoxin domoic acid (DA) consistently contaminates food webs in coastal regions, causing Amnesic Shellfish Poisoning. Age and sex can affect individual susceptibility to DA, with advanced age and female sex showing increased symptoms. This study found that aged mice and females demonstrated more severe neurotoxic symptoms and higher tissue DA concentrations after acute exposure to DA. These findings contribute to developing evidence-based public health protections against DA-producing algal blooms.
Article
Geriatrics & Gerontology
Matthew D. Campbell, Ashton T. Samuelson, Ying Ann Chiao, Mariya T. Sweetwyne, Warren C. Ladiges, Peter S. Rabinovitch, David J. Marcinek
Summary: The pathology of aging affects multiple organ systems. Previous studies have shown that long-term treatment with elamipretide can improve mitochondrial function in aged mice, resulting in various functional improvements. However, elamipretide is not orally bioavailable, limiting its administration routes. This study investigated whether intermittent injections of elamipretide could achieve similar functional improvements as continuous infusion. The results showed that intermittent treatment preserved exercise tolerance and left ventricular mass, but did not have the same effects on kidney function as continuous treatment.
Article
Neurosciences
Matthew D. Campbell, Danijel Djukovic, Daniel Raftery, David J. Marcinek
Summary: Mitochondrial metabolic response may be impaired with age, contributing to reduced exercise tolerance and skeletal muscle decline. This study found that aged mice showed decreased mitochondrial substrate utilization following muscle contraction, but treatment with elamipretide improved metabolic function and enhanced substrate utilization in aged muscle.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Cell Biology
Anna A. Bakhtina, Gavin A. Pharaoh, Matthew D. Campbell, Andrew Keller, Rudolph S. Stuppard, David J. Marcinek, James E. Bruce
Summary: This study applied quantitative chemical cross-linking technologies to investigate changes in the mitochondrial interactome of skeletal muscle in aging female mice. The authors identified age-related changes in protein cross-links related to electron transport system complexes, glutamate dehydrogenase activity, and fatty acid beta-oxidation and tricarboxylic acid cycle enzymes. These changes were correlated with complex I respiration differences, and each observed cross-link can serve as a probe for future studies on protein conformation and interactions.