Chronic opioid induced constipation in patients with nonmalignant pain: challenges and opportunities

Definitions and Outcome Measures of Clinical Trials Regarding Opioid-induced Constipation

(2015) Jan Gaertner et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

848a Lubiprostone Significantly Improves Treatment Response in Non-Methadone Opioid-Induced Bowel Dysfunction Patients with Chronic, Non-Cancer Pain: Results from a Phase 3, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

(2015) M. Mazen Jamal et al.   GASTROENTEROLOGY

Site and mechanism of morphine tolerance in the gastrointestinal tract

(2015) H. I. Akbarali et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Emerging treatments in neurogastroenterology: a multidisciplinary working group consensus statement on opioid-induced constipation

(2015) M. Camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Randomised clinical trial: the long-term safety and tolerability of naloxegol in patients with pain and opioid-induced constipation

(2014) L. Webster et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Differentiation between human ClC-2 and CFTR Cl− channels with pharmacological agents

(2014) John Cuppoletti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Naloxegol

(2014) James Leonard et al.   ANNALS OF PHARMACOTHERAPY

Fixed ratio (2:1) prolonged-release oxycodone/naloxone combination improves bowel function in patients with moderate-to-severe pain and opioid-induced constipation refractory to at least two classes of laxatives

(2014) Gineke Koopmans et al.   CURRENT MEDICAL RESEARCH AND OPINION

Oxycodone/Naloxone Prolonged-Release: A Review of Its Use in the Management of Chronic Pain While Counteracting Opioid-Induced Constipation

(2014) Celeste B. Burness et al.   DRUGS

Circular muscle contraction in the mice rectum plays a key role in morphine-induced constipation

(2014) H. Ono et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Naloxegol for Opioid-Induced Constipation in Patients with Noncancer Pain

(2014) William D. Chey et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Randomized Study of Lubiprostone for Opioid-Induced Constipation in Patients with Chronic Noncancer Pain

(2014) Byron Cryer et al.   PAIN MEDICINE

Opioid-Induced Mitogen-Activated Protein Kinase Signaling in Rat Enteric Neurons following Chronic Morphine Treatment

(2014) Celine Duraffourd et al.   PLoS One

A phase 2, double-blind, randomized, placebo-controlled, dose-escalation study to evaluate the efficacy, safety, and tolerability of naloxegol in patients with opioid-induced constipation

(2013) Lynn Webster et al.   PAIN

Methadone but not Morphine Inhibits Lubiprostone-Stimulated Cl− Currents in T84 Intestinal Cells and Recombinant Human ClC-2, but not CFTR Cl− Currents

(2012) John Cuppoletti et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

A Randomized, Placebo-Controlled Phase 3 Trial (Study SB-767905/012) of Alvimopan for Opioid-Induced Bowel Dysfunction in Patients With Non-Cancer Pain

(2011) Jan-Peter Jansen et al.   JOURNAL OF PAIN

Subcutaneous Methylnaltrexone for Treatment of Opioid-Induced Constipation in Patients With Chronic, Nonmalignant Pain: A Randomized Controlled Study

(2011) Edward Michna et al.   JOURNAL OF PAIN

Effect of subcutaneous methylnaltrexone on patient-reported constipation symptoms

(2011) Shrividya S. Iyer et al.   VALUE IN HEALTH

Validation of a Bowel Function Diary for Assessing Opioid-Induced Constipation

(2010) Michael Camilleri et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Efficacy and Safety of Prucalopride in Patients with Chronic Noncancer Pain Suffering from Opioid-Induced Constipation

(2010) Cornelius E. J. Sloots et al.   DIGESTIVE DISEASES AND SCIENCES

Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain

(2010) A. Sandner-Kiesling et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

The Direct and Indirect Costs of Opioid-Induced Constipation

(2010) Frida Hjalte et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

(2010) Alexander P. Bryant et al.   LIFE SCIENCES

5-HT4 receptor agonists: similar but not the same

(2010) J. H. De Maeyer et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Opioid-induced bowel disorders and narcotic bowel syndrome in patients with chronic non-cancer pain

(2010) a. k. tuteja et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Combined prolonged-release oxycodone and naloxone improves bowel function in patients receiving opioids for moderate-to-severe non-malignant chronic pain: a randomised controlled trial

(2009) O Löwenstein et al.   EXPERT OPINION ON PHARMACOTHERAPY

Clinical Guidelines for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain

(2009) Roger Chou et al.   JOURNAL OF PAIN

Validation of the Bowel Function Index to detect clinically meaningful changes in opioid-induced constipation

(2009) A. M. Rentz et al.   JOURNAL OF MEDICAL ECONOMICS

Analgesic Efficacy and Safety of Oxycodone in Combination With Naloxone as Prolonged Release Tablets in Patients With Moderate to Severe Chronic Pain

(2008) Dana Vondrackova et al.   JOURNAL OF PAIN

Morphine Tolerance in the Mouse Ileum and Colon

(2008) G. R. Ross et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Prevalence, Severity, and Impact of Opioid-Induced Bowel Dysfunction: Results of a US and European Patient Survey (PROBE 1)

(2008) Timothy J. Bell et al.   PAIN MEDICINE