Fixed ratio (2:1) prolonged-release oxycodone/naloxone combination improves bowel function in patients with moderate-to-severe pain and opioid-induced constipation refractory to at least two classes of laxatives

The Bowel Function Index for Evaluating Constipation in Pain Patients: Definition of a Reference Range for a Non-Constipated Population of Pain Patients

(2013) MA Ueberall et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Prevalence and impact of constipation and bowel dysfunction induced by strong opioids: a cross-sectional survey of 520 patients with cancer pain: DYONISOS study

(2013) L. Abramowitz et al.   JOURNAL OF MEDICAL ECONOMICS

Management of cancer pain: ESMO Clinical Practice Guidelines

(2012) C. I. Ripamonti et al.   ANNALS OF ONCOLOGY

Opioid-Induced Bowel Dysfunction

(2012) Christina Brock et al.   DRUGS

Combined oral prolonged-release oxycodone and naloxone in chronic pain management

(2012) Sebastiano Mercadante et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Prolonged-release oxycodone/naloxone in the treatment of neuropathic pain – results from a large observational study

(2012) Kai Hermanns et al.   EXPERT OPINION ON PHARMACOTHERAPY

Low absolute bioavailability of oral naloxone in healthy subjects

(2012) Kevin Smith et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC

(2012) Augusto Caraceni et al.   LANCET ONCOLOGY

Pain Management in Patients with Cancer: Focus on Opioid Analgesics

(2011) Wojciech Leppert   Current Pain and Headache Reports

Naloxone as part of a prolonged release oxycodone/naloxone combination reduces oxycodone-induced slowing of gastrointestinal transit in healthy volunteers

(2011) Kevin Smith et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Diagnosis and treatment of chronic constipation - a European perspective

(2011) J. Tack et al.   NEUROGASTROENTEROLOGY AND MOTILITY

A randomized, double-blind, active-controlled, double-dummy, parallel-group study to determine the safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate/severe, chronic cancer pain

(2011) Sam H Ahmedzai et al.   PALLIATIVE MEDICINE

Gastrointestinal side effects in chronic opioid users: results from a population-based survey

(2010) S. F. COOK et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Innovative pain therapy with a fixed combination of prolonged-release oxycodone/naloxone: a large observational study under conditions of daily practice

(2010) U. Schutter et al.   CURRENT MEDICAL RESEARCH AND OPINION

Laxative Abuse

(2010) James L. Roerig et al.   DRUGS

Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain

(2010) A. Sandner-Kiesling et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

The Direct and Indirect Costs of Opioid-Induced Constipation

(2010) Frida Hjalte et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Combined prolonged-release oxycodone and naloxone improves bowel function in patients receiving opioids for moderate-to-severe non-malignant chronic pain: a randomised controlled trial

(2009) O Löwenstein et al.   EXPERT OPINION ON PHARMACOTHERAPY

Clinical Guidelines for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain

(2009) Roger Chou et al.   JOURNAL OF PAIN

Opioid receptors in the gastrointestinal tract

(2009) Peter Holzer   REGULATORY PEPTIDES

Validation of the Bowel Function Index to detect clinically meaningful changes in opioid-induced constipation

(2009) A. M. Rentz et al.   JOURNAL OF MEDICAL ECONOMICS

Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain

(2008) K. Simpson et al.   CURRENT MEDICAL RESEARCH AND OPINION

A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation

(2008) Winfried Meissner et al.   EUROPEAN JOURNAL OF PAIN

The Prevalence, Severity, and Impact of Opioid-Induced Bowel Dysfunction: Results of a US and European Patient Survey (PROBE 1)

(2008) Timothy J. Bell et al.   PAIN MEDICINE

Opioid-Induced Bowel Dysfunction

(2007) Jay Thomas   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT