标题
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing
作者
关键词
-
出版物
PLoS Pathogens
Volume 14, Issue 9, Pages e1007315
出版商
Public Library of Science (PLoS)
发表日期
2018-09-26
DOI
10.1371/journal.ppat.1007315
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei
- (2018) Pieter C. Steketee et al. PLoS Neglected Tropical Diseases
- Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
- (2018) Ning Zhang et al. PLoS Pathogens
- Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate
- (2017) Yong-Kang Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
- A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
- (2017) Ebere Sonoiki et al. Nature Communications
- Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase
- (2016) Andrés Palencia et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Untargeted Metabolomics To Ascertain Antibiotic Modes of Action
- (2016) Isabel M. Vincent et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal protein expression
- (2016) Enoch B. Antwi et al. BMC GENOMICS
- The animal trypanosomiases and their chemotherapy: a review
- (2016) FEDERICA GIORDANI et al. PARASITOLOGY
- The polyadenylation complex ofTrypanosoma brucei:Characterization of the functional poly(A) polymerase
- (2016) Henrik Koch et al. RNA Biology
- OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins
- (2015) Edward Harder et al. Journal of Chemical Theory and Computation
- The spliceosomal PRP19 complex of trypanosomes
- (2015) Daniela L. Ambrósio et al. MOLECULAR MICROBIOLOGY
- The Pfam protein families database: towards a more sustainable future
- (2015) Robert D. Finn et al. NUCLEIC ACIDS RESEARCH
- Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome
- (2015) Deuan C. Jones et al. PLoS Neglected Tropical Diseases
- The unique chemistry of benzoxaboroles: Current and emerging applications in biotechnology and therapeutic treatments
- (2014) C. Tony Liu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma brucei
- (2014) Bryan C Jensen et al. BMC GENOMICS
- Tavaborole for the treatment of onychomycosis
- (2014) Boni E Elewski et al. EXPERT OPINION ON PHARMACOTHERAPY
- Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels
- (2014) Abeer Fadda et al. MOLECULAR MICROBIOLOGY
- Metabolomics Guides Rational Development of a Simplified Cell Culture Medium for Drug Screening against Trypanosoma brucei
- (2013) Darren J. Creek et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria
- (2013) Vincent Hernandez et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Mapping the economic benefits to livestock keepers from intervening against bovine trypanosomosis in Eastern Africa
- (2013) A.P.M. Shaw et al. PREVENTIVE VETERINARY MEDICINE
- RNA in development: how ribonucleoprotein granules regulate the life cycles of pathogenic protozoa
- (2013) Susanne Kramer Wiley Interdisciplinary Reviews-RNA
- Trypanosoma evansiand Surra: A Review and Perspectives on Origin, History, Distribution, Taxonomy, Morphology, Hosts, and Pathogenic Effects
- (2013) Marc Desquesnes et al. Biomed Research International
- Time-dependent, reversible, oxaborole inhibition of Escherichia coli leucyl-tRNA synthetase measured with a continuous fluorescence assay
- (2012) Adam B. Shapiro et al. ANALYTICAL BIOCHEMISTRY
- IDEOM: an Excel interface for analysis of LC–MS-based metabolomics data
- (2012) Darren J. Creek et al. BIOINFORMATICS
- Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center
- (2012) Yvonne R. Freund et al. FEBS LETTERS
- Inhibition of mRNA maturation in trypanosomes causes the formation of novel foci at the nuclear periphery containing cytoplasmic regulators of mRNA fate
- (2012) Susanne Kramer et al. JOURNAL OF CELL SCIENCE
- Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAs
- (2012) Valentin Färber et al. NUCLEIC ACIDS RESEARCH
- Estimating and Mapping the Population at Risk of Sleeping Sickness
- (2012) Pere P. Simarro et al. PLoS Neglected Tropical Diseases
- Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles
- (2011) Yong-Kang Zhang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Trans-splicing in trypanosomes: machinery and its impact on the parasite transcriptome
- (2011) Shulamit Michaeli Future Microbiology
- Efficacy Study of Novel Diamidine Compounds in a Trypanosoma evansi Goat Model
- (2011) Kirsten Gillingwater et al. PLoS One
- Ring Structure and Aromatic Substituent Effects on the pKa of the Benzoxaborole Pharmacophore
- (2011) John W. Tomsho et al. ACS Medicinal Chemistry Letters
- SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis
- (2011) Robert T. Jacobs et al. PLoS Neglected Tropical Diseases
- Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis
- (2010) B. Nare et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Analysis of Spliceosomal Proteins in Trypanosomatids Reveals Novel Functions in mRNA Processing
- (2010) Itai Dov Tkacz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Processing of a phosphoglycerate kinase reporter mRNA in Trypanosoma brucei is not coupled to transcription by RNA polymerase II
- (2010) Mhairi Stewart et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
- Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents
- (2010) Dazhong Ding et al. ACS Medicinal Chemistry Letters
- Development of an Alamar Blue™ Viability Assay in 384-Well Format for High Throughput Whole Cell Screening of Trypanosoma brucei brucei Bloodstream Form Strain 427
- (2009) Melissa L. Sykes et al. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- Discovery and structure–activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis
- (2009) Tsutomu Akama et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Models for Trypanosoma evansi (surra), its control and economic impact on small-hold livestock owners in the Philippines
- (2009) R.J. Dobson et al. INTERNATIONAL JOURNAL FOR PARASITOLOGY
- Functional characterization and protein–protein interactions of trypanosome splicing factors U2AF35, U2AF65 and SF1
- (2009) Martin P. Vazquez et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
- Transcriptionally active TFIIH of the early-diverged eukaryote Trypanosoma brucei harbors two novel core subunits but not a cyclin-activating kinase complex
- (2009) Ju Huck Lee et al. NUCLEIC ACIDS RESEARCH
- Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2 phosphorylation at Thr169
- (2008) S. Kramer et al. JOURNAL OF CELL SCIENCE
- Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei
- (2008) Sam Alsford et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
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