Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis

Active Site Loop Dynamics of a Class IIa Fructose 1,6-Bisphosphate Aldolase from Mycobacterium tuberculosis

(2013) Scott D. Pegan et al.   BIOCHEMISTRY

A Noncompetitive Inhibitor for Mycobacterium tuberculosis’s Class IIa Fructose 1,6-Bisphosphate Aldolase

(2013) Glenn C. Capodagli et al.   BIOCHEMISTRY

13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis

(2013) Dany J.V. Beste et al.   CHEMISTRY & BIOLOGY

A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

(2013) J.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis

(2013) H. Eoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose Phosphorylation Is Required for Mycobacterium tuberculosis Persistence in Mice

(2013) Joeli Marrero et al.   PLoS Pathogens

Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations

(2012) Jennifer E. Griffin et al.   CHEMISTRY & BIOLOGY

Development of metal-chelating inhibitors for the Class II fructose 1,6-bisphosphate (FBP) aldolase

(2012) Geneviève Labbé et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Virulence of Mycobacterium tuberculosis Depends on Lipoamide Dehydrogenase, a Member of Three Multienzyme Complexes

(2011) Aditya Venugopal et al.   Cell Host & Microbe

Glycolytic and Non-glycolytic Functions ofMycobacterium tuberculosisFructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli

(2011) Maria de la Paz Santangelo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of antibiotic targets has widely varying effects on growth

(2011) J.-R. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fumarate Reductase Activity Maintains an Energized Membrane in Anaerobic Mycobacterium tuberculosis

(2011) Shinya Watanabe et al.   PLoS Pathogens

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

13C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation

(2011) Dany J. V. Beste et al.   PLoS Pathogens

Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates

(2010) Luiz Pedro S. de Carvalho et al.   CHEMISTRY & BIOLOGY

Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism

(2010) Mi-Jeong Kim et al.   EMBO Molecular Medicine

Rational Design, Synthesis, and Evaluation of New Selective Inhibitors of Microbial Class II (Zinc Dependent) Fructose Bis-phosphate Aldolases

(2010) Racha Daher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway

(2010) Rainer Kalscheuer et al.   Nature Chemical Biology

Simultaneous Analysis of Multiple Mycobacterium tuberculosis Knockdown Mutants In Vitro and In Vivo

(2010) Antje Blumenthal et al.   PLoS One

Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

(2010) J. Marrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis

(2010) R. Kalscheuer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Selective Inhibitors of Class II Microbial Fructose Bis-phosphate Aldolases

(2010) Racha Daher et al.   ACS Medicinal Chemistry Letters

Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model

(2009) P. L. Lin et al.   INFECTION AND IMMUNITY

Structural Basis for Catalysis of a Tetrameric Class IIa Fructose 1,6-Bisphosphate Aldolase from Mycobacterium tuberculosis

(2009) Scott D. Pegan et al.   JOURNAL OF MOLECULAR BIOLOGY

A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis

(2008) Omar H Vandal et al.   NATURE MEDICINE

Carbon catabolite repression in bacteria: many ways to make the most out of nutrients

(2008) Boris Görke et al.   NATURE REVIEWS MICROBIOLOGY

Mycobacterial persistence requires the utilization of host cholesterol

(2008) A. K. Pandey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens