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Multidisciplinary Sciences
Sophia Schonherr-Hellec, Eirini Chatzopoulou, Jean-Philippe Barnier, Yoann Atlas, Sebastien Dupichaud, Thomas Guilbert, Yves Dupraz, Julie Meyer, Catherine Chaussain, Carolin Gurin, Xavie Nassif, Stephane Germain, Laurent Muller, Mathieu Coureuil
Summary: This article describes the implantation of engineered human microvasculature in mice, which allows the study of human pathogens. Using Neisseria meningitidis as an example, the authors demonstrate the strength and opportunities associated with this approach.
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Multidisciplinary Sciences
Jean-Philippe Barnier, Julie Meyer, Subramania Kolappan, Haniaa Bouzinba-Segard, Gael Gesbert, Anne Jamet, Eric Frapy, Sophia Schonherr-Hellec, Elena Capel, Zoe Virion, Marion Dupuis, Emmanuelle Bille, Philippe Morand, Taliah Schmitt, Sandrine Bourdoulous, Xavier Nassif, Lisa Craig, Mathieu Coureuil
Summary: Neisseria meningitidis utilizes type IV pili to adhere to and colonize host endothelial cells, with PilE and PilV playing critical roles. Mutants lacking PilV showed significant adhesion defects, indicating its importance in adhesion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Critical Care Medicine
Damien Contou, Gaetan Beduneau, Charlotte Rabault, Romain Sonneville, Antoine Marchalot, Remi Coudroy, Damien Roux, Martin Cour, Julien Massol, Sebastien Preau, Nicolas de Prost
Summary: This study aimed to assess the sensitivity of skin biopsy in adult patients with meningococcal purpura fulminans. The results showed that skin biopsy combined with conventional culture and meningococcal PCR had a global sensitivity of 88%, and should be considered even after the initiation of antimicrobial treatment.
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Biochemistry & Molecular Biology
Meagan Belcher Dufrisne, Nicole Swope, Marissa Kieber, Jeong-Yeh Yang, Ji Han, Jason Li, Kelley W. Moremen, James H. Prestegard, Linda Columbus
Summary: Carcinoembryonic cellular adhesion molecules (CEACAMs) play diverse roles in cell signaling, proliferation, and survival. Understanding the physiological oligomeric state of CEACAMs and its contribution to protein function is crucial for cellular research.
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Medicine, General & Internal
Michael C. Kim, Jaimin Patel
Summary: Purpura fulminans is a rare and potentially fatal complication associated with severe bacterial infections like Neisseria meningitidis, leading to tissue necrosis and death. Early recognition, treatment, and multidisciplinary collaboration are crucial for optimal management of PF patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
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Cell Biology
James West, Anandharajan Rathinasabapathy, Xinping Chen, Sheila Shay, Shanti Gladson, Megha Talati
Summary: Overexpression of Msx1 in pulmonary arterial hypertension patients is associated with transformed lymphocytes, and in a mouse model leads to reduced pulmonary vessel numbers, with effects varying depending on cell type.
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Genetics & Heredity
Ruben Iruegas, Katharina Pfefferle, Stephan Goettig, Beate Averhoff, Ingo Ebersberger
Summary: Increased resolution of comparative genomics analysis reveals differences in T4aP components among Acinetobacter strains, indicating variations in their interactions with the host.
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Pathology
Yasuaki Kido, Tomofumi Ando, Takahito Iga, Masatsugu Ema, Yoshiaki Kubota, Ikue Tai-Nagara
Summary: The study reveals that the effects of vascular endothelial growth factor (VEGF) blockers on tumor vessels are not solely caused by blocking VEGF signaling, but also by actions on nonendothelial cells. Furthermore, deletion of endothelial VEGF receptor 2 leads to regression of healthy capillaries and adverse effects such as intestinal perforation.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Clinical Neurology
Yang Wu, Jia Ke, Song Ye, Li-Li Shan, Shuai Xu, Shu-Fen Guo, Meng-Ting Li, Tian-Ci Qiao, Zheng-Yu Peng, Yi-Lin Wang, Ming-Yuan Liu, He Wang, Jian-Feng Feng, Yan Han
Summary: Chronic cerebral hypoperfusion is a significant factor in neurodegenerative diseases. A study using a BCAS mouse model found impaired cognitive function and white matter damage in the brain. Analysis of vascular changes revealed a reduction in large vessels and an increase in small vessels. The most severe damage was observed in the corpus callosum. These findings provide evidence for the vascular pathology caused by chronic hypoperfusion.
TRANSLATIONAL STROKE RESEARCH
(2023)
Review
Genetics & Heredity
Ann-Kathrin Mix, Griseldis Goob, Erik Sontowski, Christof R. Hauck
Summary: Pathogenic bacteria have evolved highly selective adhesins to engage specific surface determinants of host cells, triggering localized communication and potentially leading to changes in cell morphology and physiology. These bacteria also utilize adhesins to diffuse nitric oxide into host tissues, offering an unconventional approach to prevent infectious diseases by interfering with microscale communication on the host side.
GENES AND IMMUNITY
(2021)
Article
Cardiac & Cardiovascular Systems
Changqing Sun, Wuyang Zheng, Ling Liang, Zuheng Liu, Wenchao Sun, Rong Tang
Summary: The study suggests that combination therapy of ezetimibe and rosuvastatin can significantly reduce inflammation markers and improve vascular endothelial function in patients with ACS undergoing PCI, leading to a lower incidence of adverse events.
JOURNAL OF INTERVENTIONAL CARDIOLOGY
(2021)
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Microbiology
Agneta Richter-Dahlfors, Keira Melican
MICROBIOLOGY SPECTRUM
(2019)
Editorial Material
Biochemistry & Molecular Biology
Guillaume Dumenil
TRENDS IN MICROBIOLOGY
(2019)
Article
Cell Biology
Anette Schulz, Long Jiang, Lisanne de Vor, Marcus Ehrstrom, Fredrik Wermeling, Liv Eidsmo, Keira Melican
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Immunology
John Sedin, Antoine Giraud, Svava E. e Steinr, David Ahl, A. Erik G. Persson, Keira Melican, Agneta Richter-Dahlfors, Mia Phillipson
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Microbiology
Alberto J. Martin-Rodriguez, Mikael Rhen, Keira Melican, Agneta Richter-Dahlfors
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Chemistry, Analytical
Martial Rey, Jonathan Dhenin, Youxin Kong, Lucienne Nouchikian, Isaac Filella, Magalie Duchateau, Mathieu Dupre, Riccardo Pellarin, Guillaume Dumenil, Julia Chamot-Rooke
Summary: The study developed an advanced in vivo cross-linking mass spectrometry platform for investigating cellular interactome of living bacterial cells. The approach successfully captured and characterized highly dynamic multiprotein complexes in all bacterial compartments, demonstrating the potential and precision of the proteome-wide approach.
ANALYTICAL CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Jill Ziesmer, Poojabahen Tajpara, Nele-Johanna Hempel, Marcus Ehrstrom, Keira Melican, Liv Eidsmo, Georgios A. Sotiriou
Summary: A microneedle array with a water-insoluble support layer has been developed for controlled delivery of vancomycin into the skin, showing promising results in reducing local drug concentration issues and systemic exposure risks.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Multidisciplinary Sciences
Valeria Manriquez, Pierre Nivoit, Tomas Urbina, Hebert Echenique-Rivera, Keira Melican, Marie-Paule Fernandez-Gerlinger, Patricia Flamant, Taliah Schmitt, Patrick Bruneval, Dorian Obino, Guillaume Dumenil
Summary: Neisseria meningitidis colonizes blood vessels and hinders the effective action of neutrophils, leading to immune escape and infection progression.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Remy Robinot, Mathieu Hubert, Guilherme Dias de Melo, Francoise Lazarini, Timothee Bruel, Nikaia Smith, Sylvain Levallois, Florence Larrous, Julien Fernandes, Stacy Gellenoncourt, Stephane Rigaud, Olivier Gorgette, Catherine Thouvenot, Celine Trebeau, Adeline Mallet, Guillaume Dumenil, Samy Gobaa, Raphael Etournay, Pierre-Marie Lledo, Marc Lecuit, Herve Bourhy, Darragh Duffy, Vincent Michel, Olivier Schwartz, Lisa A. Chakrabarti
Summary: Understanding how SARS-CoV-2 spreads within the respiratory tract is crucial in determining the severity of COVID-19. This study shows that SARS-CoV-2 infection leads to rapid loss of airway motile cilia, affecting cilia clearance function, with reduced expression of the ciliogenesis regulator Foxj1 preceding cilia loss. Further analysis in Syrian hamsters confirms the loss of motile cilia in vivo.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Svava E. Steiner, Ferdinand X. Choong, Haris Antypas, Carlos E. Morado-Urbina, Anette Schulz, Alex Bersellini Farinotti, Duygu B. Bas, Camilla I. Svensson, Agneta Richter-Dahlfors, Keira Melican
Summary: The study demonstrates the important role of neuro-immune communication in modulating inflammation during the initial stages of a bacterial infection. Nerve signaling triggers IFN-γ response in the spleen within 4 hours of infection, leading to systemic modulation of inflammation. This highlights the potential of nerves in monitoring and modulating the immune response during the early hours of infection.
Article
Biochemical Research Methods
Dmitry Ershov, Minh-Son Phan, Joanna W. Pylvanainen, Stephane U. Rigaud, Laure Le Blanc, Arthur Charles-Orszag, James R. W. Conway, Romain F. Laine, Nathan H. Roy, Daria Bonazzi, Guillaume Dumenil, Guillaume Jacquemet, Jean-Yves Tinevez
Summary: TrackMate is an automated tracking software that is used for analyzing bioimages. The new version, TrackMate 7, addresses modern research challenges by integrating advanced segmentation algorithms into tracking pipelines. This new version demonstrates its effectiveness across a wide range of bio-imaging experiments, combining machine and deep learning-based image segmentation with accurate object tracking for improved 2D and 3D tracking in biological research.
Article
Microbiology
Ferdinand X. Choong, Smilla Huzell, Ming Rosenberg, Johannes A. Eckert, Madhu Nagaraj, Tianqi Zhang, Keira Melican, Daniel E. Otzen, Agneta Richter-Dahlfors
Summary: Biofilms allow bacteria to colonize various environments, and optotracing is a new method for monitoring biofilm growth in real-time, aiding in understanding the formation and development of bacterial biofilms.
Article
Biology
Daria Bonazzi, Valentina Lo Schiavo, Silke Machata, Ilyas Djafer-Cherif, Pierre Nivoit, Valeria Manriquez, Hirokazu Tanimoto, Julien Husson, Nelly Henry, Hugues Chate, Raphael Voituriez, Guillaume Dumenil
COMPTES RENDUS BIOLOGIES
(2020)
Article
Microbiology
Dorian Obino, Guillaume Dumenil
MICROBIOLOGY SPECTRUM
(2019)