Galectin-9 and IL-21 Mediate Cross-regulation between Th17 and Treg Cells during Acute Hepatitis C

Hepatitis C Virus-Specific Th17 Cells Are Suppressed by Virus-Induced TGF- 

(2014) A. G. Rowan et al.   JOURNAL OF IMMUNOLOGY

TIM-3 Does Not Act as a Receptor for Galectin-9

(2013) Judith Leitner et al.   PLoS Pathogens

IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis

(2012) K. Attridge et al.   BLOOD

Expression of CD39 on FoxP3+ T regulatory cells correlates with progression of HBV infection

(2012) Yan Tang et al.   BMC IMMUNOLOGY

Broadly directed virus-specific CD4+T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence

(2012) Julian Schulze zur Wiesch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Th17 Cells Express High Levels of Enzymatically Active Dipeptidylpeptidase IV (CD26)

(2012) B. Bengsch et al.   JOURNAL OF IMMUNOLOGY

Differential Antigen Specificity of Hepatitis C Virus–Specific Interleukin 17– and Interferon γ–Producing CD8+ T Cells During Chronic Infection

(2012) Stefanie Grafmueller et al.   JOURNAL OF INFECTIOUS DISEASES

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion

(2012) Manu Rangachari et al.   NATURE MEDICINE

Responsiveness of HIV-specific CD4 T cells to PD-1 blockade

(2011) F. Porichis et al.   BLOOD

Interleukin (IL)-17/IL-22-Producing T cells Enriched Within the Liver of Patients with Chronic Hepatitis C Viral (HCV) Infection

(2011) Richard G. Foster et al.   DIGESTIVE DISEASES AND SCIENCES

Inhibitory Molecules That Regulate Expansion and Restoration of HCV-Specific CD4+ T Cells in Patients With Chronic Infection

(2011) Bijan Raziorrouh et al.   GASTROENTEROLOGY

Notch Signaling Regulates Mouse and Human Th17 Differentiation

(2011) S. Keerthivasan et al.   JOURNAL OF IMMUNOLOGY

Th17 expansion in MS patients is counterbalanced by an expanded CD39+ regulatory T cell population during remission but not during relapse

(2011) Evelyn Peelen et al.   JOURNAL OF NEUROIMMUNOLOGY

A siege of hepatitis: Immune boost for viral hepatitis

(2011) Benoît Callendret et al.   NATURE MEDICINE

Protective HIV-specific CD8+ T cells evade Treg cell suppression

(2011) Shokrollah Elahi et al.   NATURE MEDICINE

Temporal Association Between Increased Virus-Specific Th17 Response and Spontaneous Recovery From Recurrent Hepatitis C in a Liver Transplant Recipient

(2011) Anil B. Seetharam et al.   TRANSPLANTATION

Dual Function of the NK Cell Receptor 2B4 (CD244) in the Regulation of HCV-Specific CD8+ T Cells

(2011) Verena Schlaphoff et al.   PLoS Pathogens

CD39/Adenosine Pathway Is Involved in AIDS Progression

(2011) Maria Nikolova et al.   PLoS Pathogens

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

Interleukin-21 and cellular activation concurrently induce potent cytotoxic function and promote antiviral activity in human CD8 T cells

(2010) Anita Parmigiani et al.   HUMAN IMMUNOLOGY

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

(2010) Rachel H. McMahan et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatitis C virus infection: A “liaison a trois” amongst the virus, the host, and chronic low-level inflammation for human survival

(2010) Vincenzo Barnaba   JOURNAL OF HEPATOLOGY

HIV-Specific IL-21 Producing CD4+ T Cells Are Induced in Acute and Chronic Progressive HIV Infection and Are Associated with Relative Viral Control

(2010) F. Y. Yue et al.   JOURNAL OF IMMUNOLOGY

HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function

(2010) M. F. Chevalier et al.   JOURNAL OF VIROLOGY

Comprehensive Analysis of Frequency and Phenotype of T Regulatory Cells in HIV Infection: CD39 Expression of FoxP3+ T Regulatory Cells Correlates with Progressive Disease

(2010) J. Schulze zur Wiesch et al.   JOURNAL OF VIROLOGY

A Crucial Role for Kupffer Cell-Derived Galectin-9 in Regulation of T Cell Immunity in Hepatitis C Infection

(2010) John A. Mengshol et al.   PLoS One

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

(2010) E. Billerbeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation

(2010) Bertram Bengsch et al.   PLoS Pathogens

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Interleukin-17-producing CD4+ T cells increase with severity of liver damage in patients with chronic hepatitis B

(2009) Ji-Yuan Zhang et al.   HEPATOLOGY

Generation and Accumulation of Immunosuppressive Adenosine by Human CD4+CD25highFOXP3+Regulatory T Cells

(2009) Magis Mandapathil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Implication of Th17 and Th1 Cells in Patients with Chronic Active Hepatitis B

(2009) Jian Ge et al.   JOURNAL OF CLINICAL IMMUNOLOGY

PD-1 tempers Tregs in chronic HCV infection

(2009) Henry Radziewicz et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence

(2009) Barbara Rehermann   JOURNAL OF CLINICAL INVESTIGATION

Dynamics and Consequences of IL-21 Production in HIV-Infected Individuals: A Longitudinal and Cross-Sectional Study

(2009) Alexandre Iannello et al.   JOURNAL OF IMMUNOLOGY

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

(2009) J. M. Fletcher et al.   JOURNAL OF IMMUNOLOGY

Induction of granulysin in CD8+ T cells by IL-21 and IL-15 is suppressed by human immunodeficiency virus-1

(2009) A. E. Hogg et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

(2009) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection

(2009) J. S. Yi et al.   SCIENCE

IL-21 Is Required to Control Chronic Viral Infection

(2009) H. Elsaesser et al.   SCIENCE

IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

(2009) A. Frohlich et al.   SCIENCE

Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

(2009) David Favre et al.   PLoS Pathogens

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

(2009) Nobuhiro Nakamoto et al.   PLoS Pathogens

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

(2008) Nobuhiro Nakamoto et al.   GASTROENTEROLOGY

Rare Birds in North America: Acute Hepatitis C Cohorts

(2008) Andrea L. Cox et al.   GASTROENTEROLOGY

CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation

(2008) John W. Northfield et al.   HEPATOLOGY

Human interleukin 17–producing cells originate from a CD161+CD4+T cell precursor

(2008) Lorenzo Cosmi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impaired Hepatitis C Virus (HCV)-Specific Effector CD8+ T Cells Undergo Massive Apoptosis in the Peripheral Blood during Acute HCV Infection and in the Liver during the Chronic Phase of Infection

(2008) H. Radziewicz et al.   JOURNAL OF VIROLOGY

Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8+ Memory T Cells

(2008) G. Badr et al.   JOURNAL OF VIROLOGY

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

(2007) Rosanne Spolski et al.   Annual Review of Immunology