IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis

Release from Regulatory T Cell-Mediated Suppression during the Onset of Tissue-Specific Autoimmunity Is Associated with Elevated IL-21

(2014) L. E. Clough et al.   JOURNAL OF IMMUNOLOGY

A Role for IL-27 in Limiting T Regulatory Cell Populations

(2011) E. D. Tait Wojno et al.   JOURNAL OF IMMUNOLOGY

IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice

(2010) J. C. Markley et al.   BLOOD

Novel Gamma-Chain Cytokines as Candidate Immune Modulators in Immune Therapies for Cancer

(2010) Natasha M. Fewkes et al.   CANCER JOURNAL

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Mechanisms of IL-2-Dependent Maintenance of Functional Regulatory T Cells

(2010) L. Barron et al.   JOURNAL OF IMMUNOLOGY

Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response

(2010) Ofer Feinerman et al.   Molecular Systems Biology

Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments

(2010) D. Busse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T cells overturned: the effectors fight back

(2009) Lucy S. K. Walker   IMMUNOLOGY

The Initial Phase of an Immune Response Functions to Activate Regulatory T Cells

(2009) W. E. O'Gorman et al.   JOURNAL OF IMMUNOLOGY

IL-21 Mediates Suppressive Effects via Its Induction of IL-10

(2009) R. Spolski et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

(2009) C. Pot et al.   JOURNAL OF IMMUNOLOGY

Exogenous IFN-γ ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells

(2008) Gang Feng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells

(2008) Thomas Y. Wuest et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE