Article
Gastroenterology & Hepatology
Dulari Jayawardena, Shubha Priyamvada, Takahiro Kageyama, Zachary White, Anoop Kumar, Theodor F. Griggs, Apurba Majumder, Ramsha Akram, Arivarasu N. Anbazhagan, Teruyuki Sano, Pradeep K. Dudeja
Summary: The down-regulation of chloride transporter SLC26A3 in colonocytes is associated with the pathogenesis of ulcerative colitis (UC) by triggering a type 2 immune response through IL-33 release, which is a result of altered epithelial-immune cell crosstalk.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Javier Sanchez-Solares, Luis Sanchez, Carmela Pablo-Torres, Celso Diaz-Fernandez, Poul Sorensen, Domingo Barber, Cristina Gomez-Casado
Summary: The study found that CD patients have significantly decreased expression of epithelial junction proteins in their oral mucosa, suggesting compromised barrier integrity. The increase in FoxP3+ cells in CD patients indicates recruitment of Tregs to the damaged mucosa. Amphiregulin mRNA levels in PBMCs and epithelial damage in the oral mucosa correlated with Treg infiltration, suggesting a potential repair phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Li-Hua Mo, Xiang-Qian Luo, Gui Yang, Jiang-Qi Liu, Li-Teng Yang, Zhi-Qiang Liu, Shuai Wang, Da-Bo Liu, Zhi-Gang Liu, Ping-Chang Yang
Summary: This study demonstrates the crucial role of CD83 in Treg differentiation in the airway mucosa and the ability of CD83/OVA-carrying exosomes to inhibit airway allergy. These findings provide a new potential approach for the treatment of airway allergic disorders.
Article
Oncology
Francesca Sozio, Tiziana Schioppa, Mattia Laffranchi, Valentina Salvi, Nicola Tamassia, Francisco M. Bianchetto-Aguilera, Laura Tiberio, Raffaella Bonecchi, Daniela Bosisio, Marc Parmentier, Barbara Bottazzi, Roberto Leone, Eleonora Russo, Giovanni Bernardini, Stefano Garofalo, Cristina Limatola, Angela Gismondi, Giuseppe Sciume, Alberto Mantovani, Annalisa Del Prete, Silvano Sozzani
Summary: Patterns of receptors play a crucial role in regulating the homing of leukocytes. A study reveals that the CCRL2/chemerin/CMKLR1 axis acts as a selective pathway for the homing of NK cells to the lung. Inactivation of CCRL2 or its ligand chemerin promotes lung tumor growth by affecting the recruitment of NK cells, while other receptors identified in lung-infiltrating NK cells are dispensable for this process.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Dominic Paquin-Proulx, Kerri G. Lal, Yuwadee Phuang-Ngern, Matthew Creegan, Andrey Tokarev, Suchada Suhkumvittaya, Aljawharah Alrubayyi, Eugene Kroon, Suteeraporn Pinyakorn, Bonnie M. Slike, Diane L. Bolton, Shelly J. Krebs, Leigh Anne Eller, Chayada Sajjaweerawan, Amelie Pagliuzza, Nicolas Chomont, Rungsun Rerknimitr, Nitiya Chomchey, Nittaya Phanuphak, Mark S. de Souza, Nelson L. Michael, Merlin L. Robb, Jintanat Ananworanich, Johan K. Sandberg, Michael A. Eller, Alexandra Schuetz
Summary: This study found that iNKT cells are early targets for HIV-1 infection, leading to their rapid depletion during AHI. The cells in blood had elevated expression of cell death-associated transcripts during untreated AHI, and they showed diminished responsiveness to stimulation early in chronic infection. Moreover, HIV-1 DNA and viral RNA were detected in iNKT cells, suggesting active infection of these cells in vivo.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
SeungHye Han, Minho Lee, Youngjin Shin, Regina Giovanni, Ram P. Chakrabarty, Mariana M. Herrerias, Laura A. Dada, Annette S. Flozak, Paul A. Reyfman, Basil Khuder, Colleen R. Reczek, Lin Gao, Jose Lopez-Barneo, Cara J. Gottardi, G. R. Scott Budinger, Navdeep S. Chandel
Summary: Alveolar epithelial type 1 (AT1) cells are necessary for gas exchange, while alveolar epithelial type 2 (AT2) cells play a role in lung development and repair. In this study, deleting a specific subunit of the mitochondrial electron transport chain complex I in lung epithelial cells led to abnormal alveolar development and death. Restoring NAD(+) regeneration was able to correct the developmental defects and prevent lethality. These findings highlight the importance of mitochondrial complex I-dependent NAD(+) regeneration in directing cell fate during lung development.
Article
Dentistry, Oral Surgery & Medicine
Y. Liu, T. Xu, W. Jiang, Y. Ma, Q. Zhang, N. Chen, M. Chu, F. Chen
Summary: Inflammatory bowel disease (IBD) is a common immune-related gastrointestinal disease with extraintestinal manifestations, and periodontitis is one of them. This study used single-cell RNA sequencing to analyze the cellular heterogeneity in periodontal tissues. The results revealed the complex cellular landscape of immune cells in the oral mucosa, highlighting the role of certain immune cell subpopulations in exacerbating inflammation. These findings provide new insights for controlling and preventing IBD exacerbations.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Materials Science, Biomaterials
Samuel S. Hinman, Angelo Massaro, Yuli Wang, Christopher E. Sims, Raehyun Kim, Nancy L. Allbritton
Summary: This study describes a method to create an in vitro model of human colon physiology with a collagen hydrogel scaffold, allowing co-culture of primary gastrointestinal epithelium and immune cells. The model demonstrates that it possesses a functional primary colonic epithelial layer with a recruitable immune cell compartment in response to pro-inflammatory cues.
Article
Immunology
Yanan Li, Liwei Sun, Ying Zhang
Summary: The epithelial barrier composed of nasal epithelial cells plays a crucial role in protecting the host immune system from harmful stimuli in allergic rhinitis (AR). However, the mechanism leading to abnormal changes in nasal epithelial cells in response to allergens remains unknown. Understanding the regulatory mechanism and signal pathway of programmed cell death in epithelial cells is important for clarifying the pathogenesis of AR and developing treatment strategies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hector F. Pelaez-Prestel, Jose L. Sanchez-Trincado, Esther M. Lafuente, Pedro A. Reche
Summary: The oral mucosa is a highly active site of immune activity where various immune cells play a crucial role in defending against pathogens. It is exposed to a variety of antigens from food and commensal bacteria that need to be tolerated, with mechanisms involving dendritic cells, regulatory T cells, and epithelial cells contributing to this tolerance. These tolerogenic mechanisms in the oral mucosa are intricately intertwined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Felipe Castro-Martinez, Maria Del Rocio Encarnacion-Garcia, Aurora Candelario-Martinez, Oscar Medina-Contreras, Genaro Patino-Lopez, Michael Schnoor, Porfirio Nava
Summary: The impairment of epithelial barrier and micro-erosions are associated with the development of pathologies such as inflammatory bowel diseases. The use of a 10 kDa fluorescent dye can help visualize high permeability regions in the colonic mucosa, providing an important tool for studying intestinal epithelial barrier function.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Gastroenterology & Hepatology
Lena Bohaumilitzky, Klaus Kluck, Robert Hueneburg, Richard Gallon, Jacob Nattermann, Martina Kirchner, Glen Kristiansen, Oliver Hommerding, Pauline L. Pfuderer, Lelia Wagner, Fabian Echterdiek, Svenja Koesegi, Nico Mueller, Konstantin Fischer, Nina Nelius, Ben Hartog, Gillian Borthwick, Elena Busch, Georg Martin Haag, Hendrik Blaeker, Gabriela Moeslein, Magnus von Knebel Doeberitz, Toni T. Seppala, Maarit Ahtiainen, Jukka-Pekka Mecklin, D. Timothy Bishop, John Burn, Albrecht Stenzinger, Jan Budczies, Matthias Kloor, Aysel Ahadova
Summary: The immune infiltrate in tumor-distant normal colorectal mucosa from individuals with Lynch syndrome (LS) was assessed. It was found that LS carriers show elevated mucosal T-cell infiltration even in the absence of cancer, and this immune profile may impact tumor risk in LS carriers.
Article
Biochemistry & Molecular Biology
Martin Kim, Sonja Reidenbach, Tanja Schlechter, Ann Christin Rothmann, Rainer Will, Ilse Hofmann
Summary: PKP1 is an important component of cell-cell adhesion and involved in the post-transcriptional regulation of gene expression. Downregulation of PKP1 in prostate cancer is associated with increased recruitment of immune cells, establishment of a tumor-specific environment, and accelerated tumor progression and metastasis.
Article
Multidisciplinary Sciences
Jing Zhou, Xingli Zhang, Jiajia Hu, Rihao Qu, Zhibin Yu, Hao Xu, Huifang Chen, Lichong Yan, Chenbo Ding, Qiang Zou, Youqiong Ye, Zhengting Wang, Richard A. Flavell, Hua-Bing Li
Summary: The m(6)A eraser ALKBH5 plays a crucial role in controlling the pathogenicity of CD4(+) T cells during autoimmunity, as its deficiency results in weakened immune responses and reduced recruitment of neutrophils into the central nervous system.
Article
Multidisciplinary Sciences
Se Eun Ha, Byungchang Jin, Brian G. Jorgensen, Hannah Zogg, Lai Wei, Rajan Singh, Chanjae Park, Masaaki Kurahashi, Sei Kim, Gain Baek, Sandra M. Poudrier, Moon Young Lee, Kenton M. Sanders, Seungil Ro
Summary: Researchers isolated MuPαC cells from colonic mucosal tissue, obtained their transcriptome data, identified selectively expressed markers and enriched genetic signatures, and added the data to an online resource for comprehensive reference of genetic transcripts of MuPαC and related cells in the mouse colon and jejunum.
Article
Pathology
Justin Cruz, Michael A. Irvine, Vishal Avinashi, Edmond S. Chan, Bruce A. Vallance, Lianne Soller, Jonathan W. Bush
Summary: The study aimed to validate and apply the EoEHSS for predicting symptoms and endoscopy response in eosinophilic esophagitis (EoE). The results showed that almost all EoEHSS variables were significantly associated with active EoE and high PEC, with basal zone hyperplasia, eosinophil abscesses, and surface epithelial alteration being the most predictive features for identifying active EoE.
FETAL AND PEDIATRIC PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kazuyoshi Funato, Motoyuki Otsuka, Kazuma Sekiba, Yu Miyakawa, Takahiro Seimiya, Chikako Shibata, Takahiro Kishikawa, Mitsuhiro Fujishiro
Summary: DNA repair processes are potential therapeutic targets for cancer treatment. This study reveals that HBV-associated HCC with a deficiency in the Smc5/6 complex is more susceptible to PARP inhibitors due to impaired homologous recombination. The findings suggest a potential treatment strategy for HBV-related HCC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Williams Turpin, Mei Dong, Gila Sasson, Juan Antonio Raygoza Garay, Osvaldo Espin-Garcia, Sun-Ho Lee, Anna Neustaeter, Michelle Smith, Haim Leibovitzh, David S. Guttman, Ashleigh Goethel, Anne M. Griffiths, Hien Q. Huynh, Levinus A. Dieleman, Remo Panaccione, A. Hillary Steinhart, Mark S. Silverberg, Guy Aumais, Kevan Jacobson, David Mack, Sanjay K. Murthy, John K. Marshall, Charles N. Bernstein, Maria T. Abreu, Paul Moayyedi, Andrew D. Paterson, Wei Xu, Kenneth Croitoru
Summary: Mediterranean-like dietary patterns are associated with specific gut microbial compositions and lower levels of intestinal inflammation.
Article
Immunology
Carlene L. Zindl, Steven J. Witte, Vincent A. Laufer, Min Gao, Zongliang Yue, Karen M. Janowski, Baiyi Cai, Blake F. Frey, Daniel J. Silberger, Stacey N. Harbour, Jeffrey R. Singer, Henrietta Turner, Frances E. Lund, Bruce A. Vallance, Alexander F. Rosenberg, Trenton R. Schoeb, Jake Y. Chen, Robin D. Hatton, Casey T. Weaver
Summary: IL-22 produced by ILCs and T cells plays different roles in immune defense against Citrobacter rodentium infection. ILC-derived IL-22 temporarily restrains bacterial growth, while T cell-derived IL-22 protects the intestinal crypts by inducing a host-protective transcriptomic program.
Article
Biochemistry & Molecular Biology
Hiroaki Kanzaki, Tetsuhiro Chiba, Tatsuya Kaneko, Junjie Ao, Motoyasu Kan, Ryosuke Muroyama, Shingo Nakamoto, Tatsuo Kanda, Hitoshi Maruyama, Jun Kato, Yoh Zen, Ai Kotani, Kazuma Sekiba, Motoyuki Otsuka, Masayuki Ohtsuka, Naoya Kato
Summary: ELAVL1 protein is not only involved in the replication of hepatitis B virus, but also has an impact on the cell growth of hepatocellular carcinoma, making it a potential therapeutic target for HBV-related HCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Amanda S. Nitschke, Jalisa L. Karim, Bruce A. Vallance, Celeste Bickford, Angie Ip, Nancy Lanphear, Bruce Lanphear, Whitney Weikum, Tim F. Oberlander, Gillian E. Hanley
Summary: Research findings suggest that the use of antibiotics during labor and delivery is not associated with an increased risk of autism spectrum disorder in offspring. This indicates that concerns about autism should not influence the decision to administer antibiotics during labor and delivery.
Article
Gastroenterology & Hepatology
Torsten P. M. Scheithauer, Hilde Herrema, Hongbing Yu, Guido J. Bakker, Maaike Winkelmeijer, Galina Soukhatcheva, Derek Dai, Caixia Ma, Stefan R. Havik, Manon Balvers, Mark Davids, Abraham S. Meijnikman, Omrum Aydin, Bert-Jan H. Van den Born, Marc G. Besselink, Olivier R. Busch, Maurits de Brauw, Arnold van de Laar, Clara Belzer, Martin Stahl, Willem M. de Vos, Bruce A. Vallance, Max Nieuwdorp, C. Bruce Verchere, Daniel H. van Raalte
Summary: This study found that flagellin, which is more abundant in the gut of individuals with T2D, induces an inflammatory response in pancreatic islets and leads to beta-cell dysfunction, suggesting it as a potential therapeutic target for T2D.
Article
Oncology
Chikako Shibata, Motoyuki Otsuka, Takahiro Seimiya, Takahiro Kishikawa, Kazunaga Ishigaki, Mitsuhiro Fujishiro
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Kevin Tsai, Caixia Ma, Xiao Han, Joannie Allaire, Genelle R. Lunken, Shauna M. Crowley, Hongbing Yu, Kevan Jacobson, Lijun Xia, John J. Priatel, Bruce A. Vallance
Summary: This article introduces a flow cytometry-based method of measuring intestinal permeability. By detecting orally gavaged ovalbumin (OVA) leaking from the gut and using minute blood samples collected from the tail vein, it allows for repeated testing of the same animal at multiple time points to measure intestinal permeability. The OVA assay shows high sensitivity and effectiveness compared to current methods.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenjie Shi, Kaixin Peng, Hongbing Yu, Zi Wang, Shuhong Xia, Siqi Xiao, Dean Tian, Bruce A. Vallance, Qin Yu
Summary: Inflammatory bowel disease (IBD) is an immune-mediated disease. Autotaxin (ATX) is associated with increased inflammatory molecules, however, its effect on IBD is not well understood. This study aimed to explore the possible mechanisms of ATX affecting autophagy leading to the disruption of intestinal epithelial barrier, thereby exacerbating colitis. The results showed that ATX can inhibit autophagy through the mTOR pathway, resulting in exaggerated damage to the intestinal epithelial barrier during colitis. These findings suggest that ATX may be a key pro-colitic factor, and represent a potential therapeutic target for treating IBD in the future.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Gastroenterology & Hepatology
Alexandra E. Livanos, Alexandra Dunn, Jeremy Fischer, Ryan C. Ungaro, Williams Turpin, Sun -Ho Lee, Shumin Rui, Diane Marie Del Valle, Julia J. Jougon, Gustavo Martinez-Delgado, Mark S. Riddle, Joseph A. Murray, Renee M. Laird, Joana Torres, Manasi Agrawal, Jared S. Magee, Thierry Dervieux, Sacha Gnjatic, Dean Sheppard, Bruce E. Sands, Chad K. Poster, Kenneth Croitoru, Francesca Petralia, Jean-Frederic Colombel, Saurabh Mehandru
Summary: This study found that anti-integrin avfi6 autoantibodies are present in patients with ulcerative colitis (UC) and are associated with disease development and outcomes before diagnosis. These findings suggest that anti-avfi6 antibodies may be a useful biomarker for prediction and prognosis of UC.
Letter
Gastroenterology & Hepatology
Genelle Rose Healey, Liam Golding, Alana Schick, Abdelilah Majdoubi, Pascal M. Lavoie, Bruce Andrew Vallance
Article
Gastroenterology & Hepatology
Juan Antonio Raygoza Garay, Williams Turpin, Sun-Ho Lee, Michelle I. Smith, Ashleigh Goethel, Anne M. Griffiths, Paul Moayyedi, Osvaldo Espin-Garcia, Maria Abreu, Guy L. Aumais, Charles N. Bernstein, Irit A. Biron, Maria Cino, Colette Deslandres, Iris Dotan, Wael El-Matary, Brian Feagan, David S. Guttman, Hien Huynh, Levinus A. Dieleman, Jeffrey S. Hyams, Kevan Jacobson, David Mack, John K. Marshall, Anthony Otley, Remo Panaccione, Mark Ropeleski, Mark S. Silverberg, A. Hillary Steinhart, Dan Turner, Baruch Yerushalmi, Andrew D. Paterson, Kenneth Croitoru, W. Xu
Summary: This study is the first to demonstrate that gut microbiome composition is associated with the future onset of Crohn's disease (CD), suggesting that gut microbiome is a contributor in the pathogenesis of CD.
Article
Multidisciplinary Sciences
Qiaochu Liang, Caixia Ma, Shauna M. Crowley, Joannie M. Allaire, Xiao Han, Raymond W. W. Chong, Nicolle H. Packer, Hong Bing Yu, Bruce A. Vallance
Summary: Enteric bacterial pathogens, such as Citrobacter rodentium, are able to adapt to the host's intestinal environment through metabolizing sialic acid derived from mucins and utilizing it as a carbon source for growth. The bacteria also sense and display chemotactic activity toward sialic acid. Sialic acid induces the secretion of autotransporter proteins, Pic and EspC, which enhance the bacteria's ability to degrade intestinal mucus and adhere to epithelial cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Hyunjin Jeong, Eun-Hye Hong, Jae-Hee Ahn, Jaewon Cho, Jae-Hyeon Jeong, Chae-Won Kim, Byung-Il Yoon, Ja Hyun Koo, Yun-Yong Park, Yoon Mee Yang, Takao Iwawaki, Bruce A. Vallance, Sun-Young Chang, Hyun-Jeong Ko
Summary: A study on inflammatory bowel disease reveals that an enzyme can protect intestinal goblet cells from cell death during gut inflammation. Modifying the molecular mechanisms of this enzyme could potentially prevent and treat inflammatory bowel disease.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)