Hepatitis B Virus Polymerase Blocks Pattern Recognition Receptor Signaling via Interaction with DDX3: Implications for Immune Evasion

Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKK  and DDX3

(2010) S. Yu et al.   JOURNAL OF GENERAL VIROLOGY

Early kinetics of innate and adaptive immune responses during hepatitis B virus infection

(2009) P Fisicaro et al.   GUT

Control of hepatitis B virus replication by innate response of HepaRG cells

(2009) Julie Lucifora et al.   HEPATOLOGY

Stimulation of hepatitis B virus genome replication by HBx is linked to both nuclear and cytoplasmic HBx expression

(2009) M.-Y. Cha et al.   JOURNAL OF GENERAL VIROLOGY

DDX3 DEAD-Box RNA Helicase Inhibits Hepatitis B Virus Reverse Transcription by Incorporation into Nucleocapsids

(2009) H. Wang et al.   JOURNAL OF VIROLOGY

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response

(2008) Didier Soulat et al.   EMBO JOURNAL

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation

(2008) Martina Schröder et al.   EMBO JOURNAL

Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells

(2008) Jun Wu et al.   HEPATOLOGY

Differential recognition of double-stranded RNA by RIG-I–like receptors in antiviral immunity: Figure 1.

(2008) Takeshi Saito et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of the innate immune signalling pathways in hepatocyte cell lines

(2008) S. Preiss et al.   JOURNAL OF VIRAL HEPATITIS

Activation of Pattern Recognition Receptor-Mediated Innate Immunity Inhibits the Replication of Hepatitis B Virus in Human Hepatocyte-Derived Cells

(2008) H. Guo et al.   JOURNAL OF VIROLOGY

Oncogenic role of DDX3 in breast cancer biogenesis

(2008) M Botlagunta et al.   ONCOGENE

Hepatitis B viruses: Reverse transcription a different way

(2008) Michael Nassal   VIRUS RESEARCH

Hepatitis B virus polymerase suppresses translation of pregenomic RNA via a mechanism involving its interaction with 5′ stem–loop structure

(2007) Dong-Kyun Ryu et al.   VIROLOGY