Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKK  and DDX3

The Liver as a Lymphoid Organ

(2009) Ian Nicholas Crispe   Annual Review of Immunology

Human DEAD-box protein 3 has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation

(2009) Martina Schröder   BIOCHEMICAL PHARMACOLOGY

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

Control of hepatitis B virus replication by innate response of HepaRG cells

(2009) Julie Lucifora et al.   HEPATOLOGY

DDX3 DEAD-Box RNA Helicase Inhibits Hepatitis B Virus Reverse Transcription by Incorporation into Nucleocapsids

(2009) H. Wang et al.   JOURNAL OF VIROLOGY

Hepatitis B virus infection

(2009) Yun-Fan Liaw et al.   LANCET

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response

(2008) Didier Soulat et al.   EMBO JOURNAL

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation

(2008) Martina Schröder et al.   EMBO JOURNAL

Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells

(2008) Jun Wu et al.   HEPATOLOGY

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

Poxvirus K7 Protein Adopts a Bcl-2 Fold: Biochemical Mapping of Its Interactions with Human DEAD Box RNA Helicase DDX3

(2008) Arnout P. Kalverda et al.   JOURNAL OF MOLECULAR BIOLOGY

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE