Article
Cell Biology
Alexandra Linke, Hakan Cicek, Anne Mueller, Catherine Meyer-Schwesinger, Simon Melderis, Thorsten Wiech, Claudia Wegscheid, Julius Ridder, Oliver M. Steinmetz, Linda Diehl, Gisa Tiegs, Katrin Neumann
Summary: This study found that proximal tubular epithelial cells (PTECs) have the capacity for antigen cross-presentation, which can modulate the immune response in immune-mediated glomerular diseases, such as lupus nephritis.
Article
Virology
Leon C. W. Lin, Sarah N. Croft, Nathan P. Croft, Yik Chun Wong, Stewart A. Smith, Swee-Seong Tang, Anthony W. Purcell, David C. Tscharke
Summary: The study investigated the CD8(+) T cell priming pathways for Vaccinia virus (VACV) by engineering the virus to express inhibitors of antigen presentation. While the inhibitors had diverse impacts on CD8(+) T cell responses, unexpectedly, the direct priming of CD8(+) T cells by poxviruses was robust enough to withstand potent viral inhibitors of antigen presentation. This demonstrates the flexibility and robustness of immune processes in activating immune responses required to fight infection.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Nicholas J. Shields, Estelle M. Peyroux, Katrin Campbell, Sunali Mehta, Adele G. Woolley, Claudio Counoupas, Silke Neumann, Sarah L. Young
Summary: Proteases released from dying cells can degrade antigens and generate proteolytic intermediates that enhance immune cell responses.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Martina Damo, D. Scott Wilson, Elyse A. Watkins, Jeffrey A. Hubbell
Summary: Hepatocytes play a crucial role in inducing immunologic tolerance in the liver through cross-presentation of extracellular antigens. This study demonstrates that hepatocytes are capable of efficiently inducing cross-tolerance of specific T cells, providing evidence for their potential as valuable candidates for targeted tolerogenic treatments in vivo.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Rui Dai, Xiaopei Huang, Yiping Yang
Summary: This study demonstrates the critical role of gamma delta T cells in promoting the CD8(+) T cell response to VV infection. Gamma delta T cells are able to present viral antigens and activate CD8(+) T cells, with MyD88 signaling playing a key role in this process. Understanding the regulation of adaptive T cell response by gamma delta T cells may provide insight for the development of more effective vaccine strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jennifer Currenti, Becker M. P. Law, Kai Qin, Mina John, Mark A. Pilkinton, Anju Bansal, Shay Leary, Ramesh Ram, Abha Chopra, Rama Gangula, Ling Yue, Christian Warren, Louise Barnett, Eric Alves, Wyatt J. McDonnell, Anuradha Sooda, Sonya L. Heath, Simon Mallal, Paul Goepfert, Spyros A. Kalams, Silvana Gaudieri
Summary: Loss of T cell immunogenicity due to mutations in virally encoded epitopes is a well-described adaptation strategy to limit host anti-viral immunity. Another adaptation strategy, involving the selection of mutations within epitopes that retain immune recognition despite immune pressure, is less understood. This strategy may modulate the transcriptome of CD8(+) T cells and potentially select for less effective T cell clones over time.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Lizhong Ding, Lu Sun, Melissa T. Bu, Yanjun Zhang, Lauren N. Scott, Robert M. Prins, Maureen A. Su, Melissa G. Lechner, Willy Hugo
Summary: Tumors of melanoma patients who respond to ICI or MAPKi therapies show increased T cell infiltration and IFNγ pathway activation. However, the rate of durable tumor control is higher with ICI therapy, indicating the presence of additional mechanisms beneficial for anti-tumor immunity in ICI responders.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eunjung Cho, Seongeun Han, Hyeon Seok Eom, Sang-Jin Lee, Chungyong Han, Rohit Singh, Seon-Hee Kim, Bo-Mi Park, Byoung-Gie Kim, Young H. Kim, Byoung S. Kwon, Ki Taek Nam, Beom K. Choi
Summary: The interaction between regulatory T (Treg) cells and self-reactive T cells is crucial for maintaining immune tolerance. This study reveals that self-antigens can activate CD8(+) T cells and induce delayed proliferation of Treg cells. The P53 signaling pathway plays a critical role in this process. Understanding the mechanisms of Treg cell stimulation and its implications in autoimmune diseases and cancer immunotherapy is important.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Hoyoung Lee, Min Kyung Jung, Ji Yun Noh, Su-Hyung Park, Yeonseok Chung, Sang-Jun Ha, Eui-Cheol Shin
Summary: The first conference on 'Infection and Immunity' focused on the biology of CD8+ T cells in the context of viral disease and cancer.
Article
Immunology
Hoyoung Lee, Min Kyung Jung, Ji Yun Noh, Su-Hyung Park, Yeonseok Chung, Sang-Jun Ha, Eui-Cheol Shin
Summary: The first conference on 'Infection and Immunity' focused on the biology of CD8+ T cells in the context of viral disease and cancer.
Article
Oncology
Monika Semmrich, Jean-Baptiste Marchand, Laetitia Fend, Matilda Rehn, Christelle Remy, Petra Holmkvist, Nathalie Silvestre, Carolin Svensson, Patricia Kleinpeter, Jules Deforges, Fred Junghus, Kirstie L. Cleary, Mimoza Boden, Linda Martensson, Johann Foloppe, Ingrid Teige, Eric Quemeneur, Bjorn Frendeus
Summary: This study demonstrates a highly effective and safe strategy to target CTLA-4 using a vectorized alpha CTLA-4 with strong Treg-depleting and checkpoint-blocking properties. This approach shows promising results in enhancing anti-tumor immunity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Valentina Tedeschi, Giorgia Paldino, Josephine Alba, Emanuele Molteni, Fabiana Paladini, Rossana Scrivo, Mattia Congia, Alberto Cauli, Rosalba Caccavale, Marino Paroli, Manuela Di Franco, Loretta Tuosto, Rosa Sorrentino, Marco D'Abramo, Maria Teresa Fiorillo
Summary: The HLA-B*27 family of alleles is strongly associated with ankylosing spondylitis (AS), but some non-associated HLA-B*27 variants have been found. The quantity of presented epitopes, rather than the quality, may explain the difference. The ERAP1/2 haplotype and the B*27:05 allele play crucial roles in shaping the CD8+ T cell response to viral and self-B*27 peptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Haochen Yao, Na Shen, Guofeng Ji, Juanjuan Huang, Jiali Sun, Guoqing Wang, Zhaohui Tang, Xuesi Chen
Summary: The study demonstrates the strong antitumor immune response of cisplatin-based nanoparticles in a tumor-bearing mouse model. The sustained retention of nanoparticles leads to persistent tumor MHC-I overexpression, promoting the formation of pMHC-I and enhancing the interaction with T cell receptors. Additionally, the nanoparticles upregulate OX40 on intratumoral CD8+ T cells and synergize with an agonistic OX40 antibody to suppress tumor growth by 89.2%.
Review
Immunology
Jarrod York, Kavitha Gowrishankar, Kenneth Micklethwaite, Sarah Palmer, Anthony L. Cunningham, Najla Nasr
Summary: Despite the effectiveness of ART in reducing morbidity and mortality associated with HIV infection, the latent HIV reservoir remains a major barrier to immune clearance and HIV cure. CAR T cell therapies, involving genetically engineered T cells, offer promising potential in targeting HIV-infected cells and have shown efficacy, safety, and long-term persistence in peripheral blood.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Huafeng Zhang, Jincheng Liu, Zhuoshun Yang, Liping Zeng, Keke Wei, Liyan Zhu, Liang Tang, Dianheng Wang, Yabo Zhou, Jiadi Lv, Nannan Zhou, Ke Tang, Jingwei Ma, Bo Huang
Summary: Glycolysis plays a crucial role in the recall response of CD8(+) memory T cells. This study reveals that intracellular glycogen serves as the major carbon source for the early recall response, and TCR signaling regulates this process through the phosphorylation of PYGB. This discovery highlights the specific dependence of memory T cell activation on glycogen and its potential therapeutic implications.
Article
Oncology
Ling Zhang, John S. Davies, Carylinda Serna, Zhiya Yu, Nicholas P. Restifo, Steven A. Rosenberg, Richard A. Morgan, Christian S. Hinrichs
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Biochemistry & Molecular Biology
Eva Perez-Guijarro, Howard H. Yang, Romina E. Araya, Rajaa El Meskini, Helen T. Michael, Suman Kumar Vodnala, Kerrie L. Marie, Cari Smith, Sung Chin, Khiem C. Lam, Andres Thorkelsson, Anthony J. Iacovelli, Alan Kulaga, Anyen Fon, Aleksandra M. Michalowski, Willy Hugo, Roger S. Lo, Nicholas P. Restifo, Shyam K. Sharan, Terry Van Dyke, Romina S. Goldszmid, Zoe Weaver Ohler, Maxwell P. Lee, Chi-Ping Day, Glenn Merlino
Article
Multidisciplinary Sciences
Christopher Dextras, Myagmarjav Dashnyam, Lesley A. Mathews Griner, Janani Sundaresan, Bryan Chim, Zhiya Yu, Suman Vodnala, Chyi-Chia Richard Lee, Xin Hu, Noel Southall, Juan J. Marugan, Ajit Jadhav, Nicholas P. Restifo, Nicolas Acquavella, Marc Ferrer, Anju Singh
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Devikala Gurusamy, Amanda N. Henning, Tori N. Yamamoto, Zhiya Yu, Nikolaos Zacharakis, Krishna, Rigel J. Kishton, Suman K. Vodnala, Arash Eidizadeh, Li Jia, Christine M. Kariya, Mary A. Black, Robert Eil, Douglas C. Palmer, Jenny H. Pan, Madhusudhanan Sukumar, Shashank J. Patel, Nicholas P. Restifo
Article
Immunology
Devin Dersh, James D. Phelan, Megan E. Gumina, Boya Wang, Jesse H. Arbuckle, Jaroslav Holly, Rigel J. Kishton, Tovah E. Markowitz, Mina O. Seedhom, Nathan Fridlyand, George W. Wright, Da Wei Huang, Michele Ceribelli, Craig J. Thomas, Justin B. Lack, Nicholas P. Restifo, Thomas M. Kristie, Louis M. Staudt, Jonathan W. Yewdell
Summary: Genome-wide screening in diffuse large B cell lymphomas identified genes that modulate MHC-I cell surface expression in multiple pathways. These genes represent potential targets for manipulating MHC-I immunosurveillance in cancers and other diseases. Pharmacological inhibition of negative regulators of antigen presentation enhanced MHC-I presentation in DLBCL.
Article
Immunology
Nuo Xu, Douglas C. Palmer, Alexander C. Robeson, Peishun Shou, Hemamalini Bommiasamy, Sonia J. Laurie, Caryn Willis, Gianpietro Dotti, Benjamin G. Vincent, Nicholas P. Restifo, Jonathan S. Serody
Summary: The study demonstrates that enhancing CAR T cell therapy targeting solid tumors with STING agonists, specifically DMXAA, can greatly improve tumor control by promoting CAR T cell trafficking and persistence in the tumor microenvironment. The single-cell RNA sequencing results show that DMXAA generates a chemokine milieu that facilitates CART cell recruitment and modulates the immunosuppressive TME.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Cell & Tissue Engineering
Selami Demirci, Juan J. Haro-Mora, Alexis Leonard, Claire Drysdale, Daniela Malide, Keyvan Keyvanfar, Khaled Essawi, Raul Vizcardo, Naritaka Tamaoki, Nicholas P. Restifo, John F. Tisdale, Naoya Uchida
STEM CELL RESEARCH & THERAPY
(2020)
Correction
Biochemistry & Molecular Biology
Eva Perez-Guijarro, Howard H. Yang, Romina E. Araya, Rajaa El Meskini, Helen T. Michael, Suman Kumar Vodnala, Kerrie L. Marie, Cari Smith, Sung Chin, Khiem C. Lam, Andres Thorkelsson, Anthony J. Iacovelli, Alan Kulaga, Anyen Fon, Aleksandra M. Michalowski, Willy Hugo, Roger S. Lo, Nicholas P. Restifo, Shyam K. Sharan, Terry Van Dyke, Romina S. Goldszmid, Zoe Weaver Ohler, Maxwell P. Lee, Chi-Ping Day, Glenn Merlino
Article
Cell & Tissue Engineering
Keli L. Hippen, Scott N. Furlan, Rahul Roychoudhuri, Ena Wang, Yigang Zhang, Mark J. Osborn, Sarah C. Merkel, Sophia Hani, Margaret L. MacMillan, Frank Cichocki, Jeffrey S. Miller, John E. Wagner, Nicholas P. Restifo, Leslie S. Kean, Bruce R. Blazar
Summary: Human tTregs expanded through repetitive restimulation maintain their Treg gene expression pattern without developing the exhaustion signature of effector T cells. This method of expansion produces Tregs with stable FoxP3 expression and enhanced suppressor function, supporting the possibility of off-the-shelf Treg therapeutics.
Article
Multidisciplinary Sciences
Fei Mo, Zhiya Yu, Peng Li, Jangsuk Oh, Rosanne Spolski, Liang Zhao, Caleb R. Glassman, Tori N. Yamamoto, Yun Chen, Filip M. Golebiowski, Dalton Hermans, Sonia Majri-Morrison, Lora K. Picton, Wei Liao, Min Ren, Xiaoxuan Zhuang, Suman Mitra, Jian-Xin Lin, Luca Gattinoni, Jonathan D. Powell, Nicholas P. Restifo, K. Christopher Garcia, Warren J. Leonard
Summary: Adoptive transfer of antigen-specific T cells is a significant advancement in cancer immunotherapy, and maintaining a stem-cell-like state before transfer is beneficial for therapeutic efficacy.
Review
Immunology
Rigel J. Kishton, Suman K. Vodnala, Raul Vizcardo, Nicholas P. Restifo
Summary: The administration of T cells as cellular therapy has shown clinical benefit in cancer patients. However, these therapies are not curative for most patients, especially those with solid tumors. Recent research has focused on understanding key factors that regulate the efficacy of T cell therapy and developing strategies to improve clinical outcomes in solid tumors.
CURRENT OPINION IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu Zhang, Vu Trang, Douglas C. Palmer, Rigel J. Kishton, Lanqi Gong, Jiao Huang, Thanh Nguyen, Zuojia Chen, Cari Smith, Ferenc Livak, Rohit Paul, Chi-Ping Day, Chuan Wu, Glenn Merlino, Kenneth Aldape, Xin-yuan Guan, Peng Jiang
Summary: This study developed a computational model Tres utilizing single-cell transcriptomic data to identify resilient T cell signatures to tumor-derived immunosuppressive signals, predicting clinical responses to immunotherapy and identifying potential therapeutic targets.
Article
Immunology
Scott W. W. McPherson, Neal D. D. Heuss, Md. Abedin, Heidi Roehrich, Mark J. J. Pierson, Dale S. S. Gregerson
Summary: This study reveals a unique aspect of retinal autoimmunity by analyzing the origin of antigen presenting cells associated with autoimmune uveoretinitis.
JOURNAL OF NEUROINFLAMMATION
(2022)
Editorial Material
Biochemistry & Molecular Biology
Rigel J. Kishton, Rachel C. Lynn, Nicholas P. Restifo