Article
Cell Biology
Amir Tirosh, Gurol Tuncman, Ediz S. Calay, Moran Rathaus, Idit Ron, Amit Tirosh, Abdullah Yalcin, Yankun G. Lee, Rinat Livne, Sophie Ron, Neri Minsky, Ana Paula Arruda, Gokhan S. Hotamisligil
Summary: ERS in obesity leads to increased Cx43-mediated intercellular propagation, exacerbating hepatic steatosis and impairing whole-body glucose metabolism.
Article
Parasitology
Laura Lafon-Hughes, Silvia H. Fernandez Villamil, Salome C. Vilchez Larrea
Summary: The study found that TNKS inhibitors can reduce T. cruzi infection and interfere with parasite-host cell signaling. Infection by T. cruzi induces nuclear translocation of beta-catenin and upregulation of TNF-alpha expression, which can be blocked by TNKSi. Further research is needed to monitor additional signals in this model and in vivo.
Article
Biology
Edem Fiatsonu, Aniruddha Deka, Martial L. Ndeffo-Mbah
Summary: Chagas disease, transmitted by triatomines, can cause severe cardiac issues and mortality in mammals. This study assessed the impact of insecticide treatment on dogs in reducing the transmission of Trypanosoma cruzi. The results show that dog treatment can significantly reduce the incidence of T. cruzi infections in humans, but it may increase infections in dogs. A holistic approach targeting different hosts is necessary for Chagas elimination.
Article
Cell Biology
Chang Gon Kim, June-Young Koh, Su-Jin Shin, Ji-Hee Shin, Moonki Hong, Hyun Cheol Chung, Sun Young Rha, Hyo Song Kim, Choong-Kun Lee, Ji Hyun Lee, Yejeong Han, Hyoyong Kim, Xiumei Che, Un-Jung Yun, Hyunki Kim, Jee Hung Kim, Seo Young Lee, Su Kyoung Park, Sejung Park, Hyunwook Kim, Jin Young Ahn, Hei-Cheul Jeung, Jeong Seok Lee, Young-Do Nam, Minkyu Jung
Summary: Evidence suggests that prior antibiotic (pATB) administration may have a negative impact on the outcomes of PD-1 inhibitors in advanced gastric cancer (AGC) patients. pATB use is consistently associated with poorer progression-free survival (PFS) and overall survival (OS) in AGC patients treated with PD-1 inhibitors. pATB use is also linked to reduced gut microbiome diversity, decreased levels of beneficial bacteria Lactobacillus gasseri, and disproportionate enrichment of circulating exhaustive CD8+ T cells, all of which contribute to worse outcomes.
CELL REPORTS MEDICINE
(2023)
Article
Infectious Diseases
Tayany de D. Barros-Goncalves, Andrea F. Saavedra, Luzinei da Silva-Couto, Raquel P. Ribeiro-Romao, Milla Bezerra-Paiva, Adriano Gomes-Silva, Vinicius F. Carvalho, Alda Maria Da-Cruz, Eduardo F. Pinto
Summary: Leishmania (Leishmania) infantum infection in hamsters is associated with elevated levels of cortisol, which is linked to hematological, biochemical, and immunological parameters related to the severity of visceral leishmaniasis.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Parasitology
Karolina Ribeiro Goncalves, Ana Lia Mazzeti, Alvaro Fernando da Silva Nascimento, Jessica Mara Castro-Lacerda, Nivia Carolina Nogueira-Paiva, Fernando Augusto Siqueira Mathias, Alexandre Barbosa Reis, Sergio Caldas, Maria Terezinha Bahia
Summary: This study compares the effects of different infection routes via oral and blood infection of Trypanosoma cruzi on mice infection outcomes. Oral infection leads to a wide distribution of the parasite, while blood infection results in higher levels of parasitemia. Oral infection is associated with muscle tissue in the gastrointestinal tract, while blood infection leads to higher inflammation levels.
Article
Parasitology
Maria F. Pacini, Camila Bulfoni Balbi, Brenda Dinatale, Florencia B. Gonzalez, Estefania Prochetto, Maria A. De Hernandez, Pamela Cribb, Cecilia Farre, Martin Espariz, Victor S. Blancato, Christian Magni, Ivan Marcipar, Ana R. Perez
Summary: A nasal vaccine based on a Trans-sialidase (TS) fragment plus the mucosal STING agonist c-di-AMP can stimulate the expression of cytokines in the nasopharyngeal-associated lymphoid tissue (NALT) and induce both mucosal and systemic immune responses to protect against Chagas disease.
Article
Medicine, General & Internal
Eda Agascioglu, Ridvan Colak, Mehmet Can Atayik, Ahmet Cevik Tufan, Ufuk Cakatay
Summary: There is no significant effect of hypoxic/normoxic exercise and hypoxia on the redox homeostasis of the brain, but individuals exposed to long-term hypoxia and engaging in normoxic exercise may mitigate the damage caused by hypoxia to the brain.
PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Maria Talita Pacheco de Oliveira, Diego de Sa Coutinho, Silvia Staniscuaski Guterres, Adriana Raffin Pohlmann, Patricia Machado Rodrigues e Silva, Marco Aurelio Martins, Andressa Bernardi
Summary: The study demonstrated that nanoencapsulated resveratrol can increase its bioavailability, enhancing therapeutic effects in an LPS-induced lung injury model by improving antioxidant and anti-inflammatory effects, reducing pulmonary inflammation, and improving lung function.
Article
Immunology
Daniella Bianchi Reis Insuela, Maximiliano Ruben Ferrero, Cassiano Felippe Goncalves-de-Albuquerque, Amanda da Silva Chaves, Adriano Yagho Oliveira da Silva, Hugo Caire Castro-Faria-Neto, Rafael Loureiro Simoes, Thereza Christina Barja-Fidalgo, Patricia Machado Rodrigues e Silva, Marco Aurelio Martins, Adriana Ribeiro Silva, Vinicius Frias Carvalho
Summary: The study suggests that glucagon may reduce neutrophil migration and increase susceptibility to sepsis in diabetic mice. Inhibiting the glucagon receptor can restore neutrophil migration and improve survival rate in diabetic mice after CLP procedure. This finding contributes to a better understanding of sepsis susceptibility in diabetics and may lead to the development of new therapeutic strategies for diabetic septic patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Nathalia Santos Magalhaes, Wilson Savino, Patricia Machado Rodrigues Silva, Marco Aurelio Martins, Vinicius Frias Carvalho
Summary: Elderly, diabetic, and hypertensive individuals with COVID-19 are more likely to experience poor outcomes due to dysbiosis in the gut microbiota, leading to an increased inflammatory environment and weakened intestinal barrier, possibly contributing to a cytokine storm. Exploring the correlation between gut dysbiosis and disease severity may aid in the development of new therapeutic strategies.
FRONTIERS IN MEDICINE
(2021)
Article
Chemistry, Medicinal
Maximiliano Ruben Ferrero, Cristiana Couto Garcia, Marcella Dutra de Almeida, Jullian Torres Braz da Silva, Daniella Bianchi Reis Insuela, Tatiana Paula Teixeira Ferreira, Diego de Sa Coutinho, Carolina Trindade de Azevedo, Patricia Machado Rodrigues e Silva, Marco Aurelio Martins
Summary: The study found that in cigarette smoke-exposed mice, H1N1 infection exacerbated airway obstruction, neutrophil infiltration, and reduced survival rate. However, the CCR5 antagonist Maraviroc significantly attenuated these inflammatory responses, suggesting it could be an effective therapy for controlling acute exacerbations of respiratory diseases such as COPD.
Article
Multidisciplinary Sciences
Harshi Weerakoon, John J. Miles, Ailin Lepletier, Michelle M. Hill
Summary: Regulatory T cells (Tregs) are crucial for maintaining immune tolerance and homeostasis. A comprehensive proteomic dataset of Tregs from healthy individuals has been generated, which identifies specific biological processes and pathways associated with Tregs. This dataset provides valuable insights into Treg immunophysiology and may lead to the discovery of novel therapeutics for Treg regulation.
Review
Immunology
Poliana Guiomar De Almeida Brasiel, Fernanda Verdini Guimaraes, Patricia Machado Rodrigues Silva, Dumith Chequer Bou-Habib, Vinicius de Frias Carvalho
Summary: This systematic review assessed the clinical efficacy of flavonoid supplements on allergic diseases. The review suggests that flavonoids may provide a viable strategy for mitigating allergic symptoms.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Cell Biology
Tatiana Paula Teixeira Ferreira, Fernanda Verdini Guimaraes, Yago Amigo Pinho Jannini Sa, Natalia Barreto da Silva Ribeiro, Ana Carolina Santos de Arantes, Vinicius de Frias Carvalho, Lirlandia Pires Sousa, Mauro Perretti, Marco Aurelio Martins, Patricia Machado Rodrigues Silva
Summary: The study found that the peptide Ac2-26 and its derivative AnxA1 regulate the inflammatory response in allergic asthma triggered by house dust mite extract. The peptide Ac2-26 decreased eosinophil infiltration, fibrosis, and mucus exacerbation caused by the allergen challenge and also inhibited airway hyperreactivity and mediator production. These findings suggest that Ac2-26 or similar compounds could be potential therapeutic candidates for allergic asthma treatment.
Article
Biochemistry & Molecular Biology
Magda F. Serra, Amanda C. Cotias, Andreza S. Pimentel, Ana Carolina S. de Arantes, Ana Lucia A. Pires, Manuella Lanzetti, Jandir M. Hickmann, Emiliano Barreto, Vinicius F. Carvalho, Patricia M. R. E. Silva, Renato S. B. Cordeiro, Marco Aurelio Martins
Summary: This study found that nebulized gold nanoparticles (AuNPs) can improve steroid-insensitive asthma by preserving HDAC2 and NRF2 levels, reducing oxidative stress and inflammation.
Article
Endocrinology & Metabolism
Amanda da Silva Chaves, Nathalia Santos Magalhaes, Daniella Bianchi Reis Insuela, Patricia Machado Rodrigues E Silva, Marco Aurelio Martins, Vinicius Frias Carvalho
Summary: This study investigates the role of the renin-angiotensin system (RAS) in the overproduction of corticosterone in diabetic mice. The results suggest that inhibition of angiotensin synthesis and AT(1) receptor activity can reduce corticosterone levels in diabetic mice. Furthermore, the protective effect of Olmesartan on corticosterone overproduction in diabetic mice depends on both AT(1) receptor blockade and AT(2) receptor activation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Simone Reynolds, Rukshan Ahamed Mohamed Rafeek, Adam Hamlin, Ailin Lepletier, Manisha Pandey, Natkunam Ketheesan, Michael F. Good
Summary: We developed a candidate vaccine containing two synthetic peptides derived from Streptococcus pyogenes proteins to protect against multiple strains of infections. In a rat autoimmune valvulitis model, we found that the vaccine candidate antigens did not induce autoimmune complications and inflammatory pathology. The study provides preclinical evidence of the safety and suitability of the vaccine candidates for human clinical trials.
Article
Biochemistry & Molecular Biology
Rodrigo A. S. Peres, Rodrigo P. Silva-Aguiar, Douglas E. Teixeira, Diogo B. Peruchetti, Sarah A. S. Alves, Anna Beatriz C. Leal, Guilherme F. Castro, Natalia B. S. Ribeiro, Fernanda Guimaraes, Ana Acacia S. Pinheiro, Patricia M. R. e Silva, Marco A. Martins, Celso Caruso-Neves
Summary: Subclinical acute kidney injury (subAKI) refers to tubule-interstitial injury without significant changes in glomerular function. It is associated with the pathogenesis and progression of acute and chronic kidney diseases, and current therapeutic options are limited. The use of gold nanoparticles (AuNPs) has shown promising benefits in different disease models, but their effects on subAKI remain unknown.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2023)
Article
Multidisciplinary Sciences
Victoria Ozberk, Mehfuz Zaman, Ailin Lepletier, Sharareh Eskandari, Jacqualine Kaden, Jamie-Lee Mills, Ainslie Calcutt, Jessica Dooley, Yongbao Huo, Emma L. Langshaw, Glen C. Ulett, Michael R. Batzloff, Michael F. Good, Manisha Pandey
Summary: This study demonstrates the utility of a mucosal vaccine platform to induce long-lived humoral and cellular immunity against a highly virulent pathogen using liposomes incorporating Streptococcus pyogenes peptide antigen, diphtheria toxoid, and the immunostimulatory glycolipid 3D(6-acyl) PHAD, administered intranasally.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Applied
Bianca Costa, Luana Barbosa Correa, Patricia MachadoRodrigues E. Silva, Yago Amigo Pinho Jannini de Sa, Fernanda Verdini Guimaraes, Luciana Magalhaes Rebelo Alencar, Rafael Loureiro Simoes, Edward Helal-Neto, Eduardo Ricci-Junior, Maria das Gracas Muller de Oliveira Henriques, Elaine Cruz Rosas, Ralph Santos-Oliveira
Summary: Inflammation is a disruption of homeostasis caused by various factors. Developing new products that can effectively treat and image inflammation has become a global issue. This study evaluated the potential of Fucoidan as a therapeutic and imaging agent. The results showed that Fucoidan has anti-inflammatory effects, especially in the lung model. Furthermore, radiolabeled Fucoidan demonstrated high bioaccumulation at inflammation sites, suggesting its potential as an imaging agent.
FOOD HYDROCOLLOIDS FOR HEALTH
(2022)
Article
Immunology
Manisha Pandey, Victoria Ozberk, Sharareh Eskandari, Ahmed O. Shalash, Michael A. Joyce, Holly A. Saffran, Christopher J. Day, Ailin Lepletier, Belinda L. Spillings, Jamie-Lee Mills, Ainslie Calcutt, Fan Fan, James T. Williams, Danielle Stanisic, Laetitia Hattingh, John Gerrard, Mariusz Skwarczynski, Johnson Mak, Michael P. Jennings, Istvan Toth, D. Lorne Tyrrell, Michael F. Good
Summary: Identified minimal epitopes on the RBD can induce antibody responses that block the interaction of the RBD and ACE2, reducing the risk of inducing immunopathology. The study found that epitope-specific antibodies can synergistically block RBD-ACE2 interaction, highlighting their potential importance in vaccine development.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Immunology
Harshi Weerakoon, Jasmin Straube, Katie Lineburg, Leanne Cooper, Steven Lane, Corey Smith, Saleh Alabbas, Jakob Begun, John J. Miles, Michelle M. Hill, Ailin Lepletier
Summary: The study investigates the importance of CD49f expression on Treg cells in physiological immunity and pathological autoimmunity through functional and genomic analysis of Treg cells from UC patients and healthy controls. CD49f negative Treg display enhanced suppressive capacity, while CD49f high Treg exhibit a pro-inflammatory phenotype and accumulate in the blood of UC patients. Dysregulation of CD49f Treg subsets in patients with UC is associated with disease activity.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)