Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency

Does bafilomycin A1block the fusion of autophagosomes with lysosomes?

(2014) Daniel J. Klionsky et al.   Autophagy

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

α-Fucosidase as a novel convenient biomarker for cellular senescence

(2013) Dominic Hildebrand et al.   CELL CYCLE

Chaperone-mediated autophagy degrades mutant p53

(2013) H. Vakifahmetoglu-Norberg et al.   GENES & DEVELOPMENT

Inhibition of lysosomal enzyme activities by proton pump inhibitors

(2013) Wensheng Liu et al.   JOURNAL OF GASTROENTEROLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice

(2013) Darren J. Baker et al.   Cell Reports

C13C4.5/Spinster, an evolutionarily conserved protein that regulates fertility in C. elegans through a lysosome-mediated lipid metabolism process

(2013) Mei Han et al.   Protein & Cell

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling

(2012) Mathew Sajish et al.   Nature Chemical Biology

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Ionizing radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafish

(2012) L Guo et al.   ONCOGENE

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Dissecting the dynamic turnover of GFP-LC3 in the autolysosome

(2011) Hong-Min Ni et al.   Autophagy

Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish

(2011) Koichi Fujisawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Zebrafish as a model to understand autophagy and its role in neurological disease

(2011) Angeleen Fleming et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model

(2011) Eriko Koshimizu et al.   PLoS One

Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation

(2011) Y. Rong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder—murine Pompe disease

(2010) Nina Raben et al.   Autophagy

Analyzing autophagy in zebrafish

(2010) Congcong He et al.   Autophagy

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Selective Yolk Deposition and Mannose Phosphorylation of Lysosomal Glycosidases in Zebrafish

(2010) Xiang Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

Paradoxical suppression of cellular senescence by p53

(2010) Z. N. Demidenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation

(2010) R. Scherz-Shouval et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos

(2009) Congcong He et al.   Autophagy

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

The Guardian Recruits Cops: The p53-p21 Axis Delegates Prosurvival Duties to the Keap1-Nrf2 Stress Pathway

(2009) Michel B. Toledano   MOLECULAR CELL

A Selective Requirement for 53BP1 in the Biological Response to Genomic Instability Induced by Brca1 Deficiency

(2009) Liu Cao et al.   MOLECULAR CELL

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

The regulation of aging: does autophagy underlie longevity?

(2009) Tibor Vellai et al.   TRENDS IN CELL BIOLOGY

Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3

(2008) Samuel Sidi et al.   CELL

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis

(2008) Shintaro Imamura et al.   PLoS One

The Identification of Zebrafish Mutants Showing Alterations in Senescence-Associated Biomarkers

(2008) Shuji Kishi et al.   PLoS Genetics