A Computational Model of Liver Iron Metabolism

Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice

(2013) Chia-Yu Wang et al.   HEPATOLOGY

A community-driven global reconstruction of human metabolism

(2013) Ines Thiele et al.   NATURE BIOTECHNOLOGY

Condor-COPASI: high-throughput computing for biochemical networks

(2012) Edward Kent et al.   BMC Systems Biology

The core control system of intracellular iron homeostasis: A mathematical model

(2012) J. Chifman et al.   JOURNAL OF THEORETICAL BIOLOGY

PaxDb, a Database of Protein Abundance Averages Across All Three Domains of Life

(2012) M. Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Rethinking Iron Regulation and Assessment in Iron Deficiency, Anemia of Chronic Disease, and Obesity: Introducing Hepcidin

(2012) Lisa Tussing-Humphreys et al.   Journal of the Academy of Nutrition and Dietetics

Integrating Cellular Metabolism into a Multiscale Whole-Body Model

(2012) Markus Krauss et al.   PLoS Computational Biology

A Boolean probabilistic model of metabolic adaptation to oxygen in relation to iron homeostasis and oxidative stress

(2011) Fiona Achcar et al.   BMC Systems Biology

Mathematical modeling of the dynamic storage of iron in ferritin

(2010) J Cristian Salgado et al.   BMC Systems Biology

Reduction of Serum Hepcidin by Hemodialysis in Pediatric and Adult Patients

(2010) J. Zaritsky et al.   Clinical Journal of the American Society of Nephrology

A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis

(2010) D. Girelli et al.   HAEMATOLOGICA

Iron uptake from plasma transferrin by a transferrin receptor 2 mutant mouse model of haemochromatosis

(2010) Anita C.G. Chua et al.   JOURNAL OF HEPATOLOGY

HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology

(2010) Christoph Gille et al.   Molecular Systems Biology

Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus

(2010) Wei Bao et al.   PLoS One

Covering a Broad Dynamic Range: Information Processing at the Erythropoietin Receptor

(2010) V. Becker et al.   SCIENCE

Serum heme oxygenase-1 levels are increased in Parkinson’s disease but not in Alzheimer’s disease

(2009) I. Mateo et al.   ACTA NEUROLOGICA SCANDINAVICA

Stoichiometries of transferrin receptors 1 and 2 in human liver

(2009) Maja Chloupková et al.   BLOOD CELLS MOLECULES AND DISEASES

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

(2009) Douglas B Kell   BMC Medical Genomics

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

(2009) Junwei Gao et al.   Cell Metabolism

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload

(2009) Daniel F. Wallace et al.   HEPATOLOGY

The Unique Kinetics of Iron Release from Transferrin: The Role of Receptor, Lobe–Lobe Interactions, and Salt at Endosomal pH

(2009) Shaina L. Byrne et al.   JOURNAL OF MOLECULAR BIOLOGY

A general map of iron metabolism and tissue-specific subnetworks

(2009) Valerie Hower et al.   Molecular BioSystems

The Systems Biology Graphical Notation

(2009) Nicolas Le Novère et al.   NATURE BIOTECHNOLOGY

Serum hepcidin levels are innately low inHFE-related haemochromatosis but differ between C282Y-homozygotes with elevated and normal ferritin levels

(2008) Boukje A. C. van Dijk et al.   BRITISH JOURNAL OF HAEMATOLOGY

The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome

(2008) Kristopher E. Van Zandt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A new strategy for assessing sensitivities in biochemical models

(2008) S. Sahle et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Advances in Quantitative Hepcidin Measurements by Time-of-Flight Mass Spectrometry

(2008) Dorine W. Swinkels et al.   PLoS One