Article
Multidisciplinary Sciences
Patrick Danaher, Youngmi Kim, Brenn Nelson, Maddy Griswold, Zhi Yang, Erin Piazza, Joseph M. Beechem
Summary: The paper introduces SpatialDecon, a method for deconvolution and quantification of cell types in spatial transcriptomics data, demonstrating its application in analyzing immune response heterogeneity in cancer. SpatialDecon incorporates advancements in gene expression deconvolution and provides cell abundance estimates with high spatial resolution.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Hailing Zong, Mark Hazelbaker, Christina Moe, Stephanie C. Ems-McClung, Ke Hu, Claire E. Walczak
Summary: The distribution and regulation of MCAK activity play a crucial role in cell polarity, centrosome positioning, and focal adhesion dynamics during cell migration, contributing to robust directional migration.
MOLECULAR BIOLOGY OF THE CELL
(2021)
Article
Biotechnology & Applied Microbiology
Dylan M. Cable, Evan Murray, Luli S. Zou, Aleksandrina Goeva, Evan Z. Macosko, Fei Chen, Rafael A. Irizarry
Summary: RCTD is a computational method that leverages cell type profiles learned from single-cell RNA-seq to decompose cell type mixtures and correct for differences across sequencing technologies. It successfully detects mixtures, identifies cell types, and reproduces cell type localization patterns in simulated datasets and mouse brain data. By enabling spatial mapping of cell types, RCTD defines the spatial components of cellular identity and uncovers new principles of cellular organization in biological tissues.
NATURE BIOTECHNOLOGY
(2022)
Article
Engineering, Mechanical
Dengji Zhou, Dawen Huang
Summary: This paper establishes a stochastic dynamic model based on the nonlinear characteristics of engine systems, analyzes the influence of uncertainty on thermodynamic and performance parameters, and proposes an optimization method considering stochastic responses. The results show that the robust optimization method significantly reduces uncertainty influence and improves thermodynamics performance.
NONLINEAR DYNAMICS
(2022)
Article
Materials Science, Biomaterials
Wei Zhu, Qi Shan, Jianing Zhao, Guangyao Lv, Zongfeng Hu, Min Liu, Lei Yao, Zhuhong Zhang, Longbing Ling
Summary: A liposomal platform using Pyr-SS-PC lipids was developed for delivering camptothecin with high loading and stability. The π-π stacking of Pyr-SS-PC lipids provides a general gateway for delivering aromatic ring-containing drugs.
BIOMATERIALS SCIENCE
(2023)
Article
Biochemical Research Methods
Yifan Gui, Shuangshuang Xie, Yanan Wang, Ping Wang, Renzhi Yao, Xukai Gao, Yutian Dong, Gaoang Wang, Kuan Yoow Chan
Summary: We developed an application that automatically tracks and assigns mother-daughter relationships of single cells, achieving high fidelity long-term single-cell tracking by integrating cell cycle information and deep learning techniques.
Article
Chemistry, Physical
Xixi Tao, Peng Jiang, Yaojun Dong, Xifeng Yang, Xiaohong Zheng, Yushen Liu
Summary: Our recent work demonstrates that the spin-dependent photogalvanic effect (PGE) is an effective method to induce pure spin current. In this study, we propose a spin optoelectric device using alpha-phase carbon phosphide nanoribbons (alpha-CPNRs) to generate pure spin current through PGE. By designing a centrosymmetric structure, the device can always produce pure spin current without any accompanying charge current, regardless of the polarization type and angle of the photons. Additionally, by applying antiparallel electrical fields, the magnitude of the pure spin current can be significantly increased, and a fully spin-polarized photocurrent can be achieved by applying parallel electrical fields.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Optics
Jia Xu, Greg Gbur, Taco D. Visser
Summary: The study focuses on the transmission behavior of partially polarized, partially coherent beams through non-uniform linear polarizers and polarization elements. The derived expression for transmitted intensity reproduces Malus' law in specific cases, and formulas for the transformation of spatial coherence properties are also obtained.
Review
Biochemical Research Methods
Janet H. Iwasa, Blair Lyons, Graham Johnson
Summary: Spatial simulations are increasingly important in scientific research, particularly in the field of cell biology. To achieve multiscale modeling, simulation technologies need to provide integrated and interoperable methods. Although there are various simulation approaches in this field, they rarely collaborate, requiring a more unified approach in the future.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Mathematics, Interdisciplinary Applications
J. Menezes, R. Barbalho
Summary: This study investigates the importance of weak species in the cyclic spatial game and finds that the spatial organization and positions of weak species in the game order determine the stability of the cyclic game. The results show that the further apart the regions inhabited by different weak species are, the less likely the species will coexist.
CHAOS SOLITONS & FRACTALS
(2023)
Article
Chemistry, Multidisciplinary
Daqin Guan, Kaifeng Zhang, Zhiwei Hu, Xinhao Wu, Jeng-Lung Chen, Chih-Wen Pao, Yanan Guo, Wei Zhou, Zongping Shao
Summary: The 1D face-sharing oxide Ba5Bi0.25Co3.75FeO14-δ has been identified as a highly active and stable candidate for alkaline OER, with its stable face-sharing motifs and superior electron transport ability contributing to impressive performance.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yun Liu, Hui Zhang, Jinrong Zeng, Wenlu Sun, Hao Qian, Fang Fu, Hongcun Bai, Huabin Kong, Hongwei Chen
Summary: In this study, the concept of primary building units (PBUs) is introduced to construct durable and conductive electrode architectures for Si anodes, aiming to achieve high energy and long cycle life.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Yun Liu, Hui Zhang, Jinrong Zeng, Wenlu Sun, Hao Qian, Fang Fu, Hongcun Bai, Huabin Kong, Hongwei Chen
Summary: This paper introduces the concept of primary building units (PBUs) as organizing units to construct durable and conductive electrode architectures for Si anodes, aiming to achieve long cycle life and high energy. The use of PBUs facilitates the coalescence of Si nanoparticles with conductive pathways and prevents nanoparticle aggregation.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Kristopher W. Brannan, Isaac A. Chaim, Ryan J. Marina, Brian A. Yee, Eric R. Kofman, Daniel A. Lorenz, Pratibha Jagannatha, Kevin D. Dong, Assael A. Madrigal, Jason G. Underwood, Gene W. Yeo
Summary: The STAMP technique efficiently detects RBP-RNA interactions and reveals the dynamic regulation of RBPs in single cells. Pairing with long-read sequencing allows for isoform-specific RBP target site identification, while Ribo-STAMP can measure transcriptome-wide ribosome association in cells.
Article
Biophysics
Jiayi Xu, Xiangyu Xu, Xiaojun Li, Shijie He, Dechang Li, Baohua Ji
Summary: This study investigated the cellular behaviors and mechanisms of wound formation in the epithelial layer using experiments and a cell model. The results showed that wound formation occurs at the position of cell division and is influenced by cell polarization and arrangement under tension force. The findings have important implications for tissue engineering and regenerative medicine.
BIOPHYSICAL JOURNAL
(2022)