EpCAM ectodomain EpEX is a ligand of EGFR that counteracts EGF-mediated epithelial-mesenchymal transition through modulation of phospho-ERK1/2 in head and neck cancers
出版年份 2018 全文链接
标题
EpCAM ectodomain EpEX is a ligand of EGFR that counteracts EGF-mediated epithelial-mesenchymal transition through modulation of phospho-ERK1/2 in head and neck cancers
作者
关键词
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出版物
PLOS BIOLOGY
Volume 16, Issue 9, Pages e2006624
出版商
Public Library of Science (PLoS)
发表日期
2018-09-28
DOI
10.1371/journal.pbio.2006624
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Extracellular domain of EpCAM enhances tumor progression through EGFR signaling in colon cancer cells
- (2018) Kang-Hao Liang et al. CANCER LETTERS
- Epithelial cell adhesion molecule overexpression regulates epithelial-mesenchymal transition, stemness and metastasis of nasopharyngeal carcinoma cells via the PTEN/AKT/mTOR pathway
- (2018) Meng-He Wang et al. Cell Death & Disease
- Spatiotemporal patterning of EpCAM is important for murine embryonic endo- and mesodermal differentiation
- (2018) Sannia Sarrach et al. Scientific Reports
- Epithelial cell adhesion molecule fragments and signaling in primary human liver cells
- (2017) Jörg C. Gerlach et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Upholding a role for EMT in breast cancer metastasis
- (2017) Xin Ye et al. NATURE
- Upholding a role for EMT in pancreatic cancer metastasis
- (2017) Nicole M. Aiello et al. NATURE
- EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α
- (2017) I.-I. Kuan et al. Scientific Reports
- EpCAM-Regulated Transcription Exerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to-Mesenchymal Transition
- (2016) Ya-Ting Hsu et al. CANCER RESEARCH
- Involvement of c-Fos in the Promotion of Cancer Stem-like Cell Properties in Head and Neck Squamous Cell Carcinoma
- (2016) Naoshad Muhammad et al. CLINICAL CANCER RESEARCH
- Predominant expression of truncated EpCAM is associated with a more aggressive phenotype and predicts poor overall survival in colorectal cancer
- (2016) Andreas Seeber et al. INTERNATIONAL JOURNAL OF CANCER
- Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S): a multicentre cohort study
- (2016) Brian O'Sullivan et al. LANCET ONCOLOGY
- The ERK–ZEB1 pathway mediates epithelial–mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids
- (2016) L-Y Chiu et al. ONCOGENE
- Prognostic and predictive value of EGFR in head and neck squamous cell carcinoma
- (2016) Paolo Bossi et al. Oncotarget
- EGFR Signal-Network Reconstruction Demonstrates Metabolic Crosstalk in EMT
- (2016) Kumari Sonal Choudhary et al. PLoS Computational Biology
- Phenotypic Plasticity Determines Cancer Stem Cell Therapeutic Resistance in Oral Squamous Cell Carcinoma
- (2016) Adrian Biddle et al. EBioMedicine
- Soluble EpCAM levels in ascites correlate with positive cytology and neutralize catumaxomab activity in vitro
- (2015) Andreas Seeber et al. BMC CANCER
- MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma
- (2015) S. Mohan et al. CLINICAL CANCER RESEARCH
- MEK Inhibitor PD-0325901 Overcomes Resistance to CK2 Inhibitor CX-4945 and Exhibits Anti-Tumor Activity in Head and Neck Cancer
- (2015) Yansong Bian et al. International Journal of Biological Sciences
- Cleavage and Cell Adhesion Properties of Human Epithelial Cell Adhesion Molecule (HEPCAM)
- (2015) Thanos Tsaktanis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Current Treatment Options for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
- (2015) Assuntina G. Sacco et al. JOURNAL OF CLINICAL ONCOLOGY
- MCRIP1, an ERK Substrate, Mediates ERK-Induced Gene Silencing during Epithelial-Mesenchymal Transition by Regulating the Co-Repressor CtBP
- (2015) Kenji Ichikawa et al. MOLECULAR CELL
- HPV-Positive Oropharyngeal Carcinoma
- (2015) Marilene B. Wang et al. OTOLARYNGOLOGY-HEAD AND NECK SURGERY
- Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression
- (2015) Xin Ye et al. TRENDS IN CELL BIOLOGY
- Detection of soluble EpCAM (sEpCAM) in malignant ascites predicts poor overall survival in patients treated with catumaxomab
- (2015) Andreas Seeber et al. Oncotarget
- Intra-tumor Genetic Heterogeneity and Mortality in Head and Neck Cancer: Analysis of Data from The Cancer Genome Atlas
- (2015) Edmund A. Mroz et al. PLOS MEDICINE
- EpCAM is overexpressed in local and metastatic prostate cancer, suppressed by chemotherapy and modulated by MET-associated miRNA-200c/205
- (2014) P Massoner et al. BRITISH JOURNAL OF CANCER
- Endothelial Cell-Secreted EGF Induces Epithelial to Mesenchymal Transition and Endows Head and Neck Cancer Cells with Stem-like Phenotype
- (2014) Z. Zhang et al. CANCER RESEARCH
- Dynamic EpCAM expression on circulating and disseminating tumor cells: causes and consequences
- (2014) Olivier Gires et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients
- (2014) T. Z. Tan et al. EMBO Molecular Medicine
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
- (2014) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by AP1-Dependent EpCAM Expression in MCF-7 Cells
- (2014) Jiujiao Gao et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis
- (2014) Jeffrey N Savas et al. Nature Protocols
- Molecular mechanisms of epithelial–mesenchymal transition
- (2014) Samy Lamouille et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma: Results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)
- (2014) Fabian Lohaus et al. RADIOTHERAPY AND ONCOLOGY
- Crystal structure and its bearing towards an understanding of key biological functions of EpCAM
- (2014) Miha Pavšič et al. Nature Communications
- EpCAM proteolysis: new fragments with distinct functions?
- (2013) Ulrike Schnell et al. BIOSCIENCE REPORTS
- High intratumor genetic heterogeneity is related to worse outcome in patients with head and neck squamous cell carcinoma
- (2013) Edmund A. Mroz et al. CANCER
- Loss of membranous expression of the intracellular domain of EpCAM is a frequent event and predicts poor survival in patients with pancreatic cancer
- (2013) Dominic Fong et al. HISTOPATHOLOGY
- The epigenetics of epithelial-mesenchymal plasticity in cancer
- (2013) Wai Leong Tam et al. NATURE MEDICINE
- Context-dependent adaption of EpCAM expression in early systemic esophageal cancer
- (2013) C Driemel et al. ONCOGENE
- Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition
- (2012) Tobias M Gorges et al. BMC CANCER
- Epithelial-to-mesenchymal transition and cancer stem(-like) cells in head and neck squamous cell carcinoma
- (2012) Chao Chen et al. CANCER LETTERS
- Epidermal Growth Factor Receptor Protein Detection in Head and Neck Cancer Patients: A Many-Faceted Picture
- (2012) Juliette Thariat et al. CLINICAL CANCER RESEARCH
- Current Treatment Options for Metastatic Head and Neck Cancer
- (2012) Katharine A. R. Price et al. CURRENT TREATMENT OPTIONS IN ONCOLOGY
- Epithelial Cell Adhesion Molecule Regulates Tumor Initiation and Tumorigenesis via Activating Reprogramming Factors and Epithelial-Mesenchymal Transition Gene Expression in Colon Cancer
- (2012) Cheng-Wei Lin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- EpCAM regulates cell cycle progression via control of cyclin D1 expression
- (2012) A Chaves-Pérez et al. ONCOGENE
- Cancer Stem Cells in Squamous Cell Carcinoma Switch between Two Distinct Phenotypes That Are Preferentially Migratory or Proliferative
- (2011) A. Biddle et al. CANCER RESEARCH
- Concentrations of EpCAM ectodomain as found in sera of cancer patients do not significantly impact redirected lysis and T-cell activation by EpCAM/CD3-bispecific BiTE antibody MT110
- (2011) Silke Petsch et al. mAbs
- Evidence for Epithelial-Mesenchymal Transition in Cancer Stem Cells of Head and Neck Squamous Cell Carcinoma
- (2011) Chao Chen et al. PLoS One
- The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
- (2011) N. Stransky et al. SCIENCE
- Mesenchymal Transition and Dissemination of Cancer Cells Is Driven by Myeloid-Derived Suppressor Cells Infiltrating the Primary Tumor
- (2011) Benjamin Toh et al. PLOS BIOLOGY
- p16 expression in oropharyngeal cancer: its impact on staging and prognosis compared with the conventional clinical staging parameters
- (2010) C. A. Fischer et al. ANNALS OF ONCOLOGY
- The prognostic significance of p16 overexpression in oropharyngeal squamous cell carcinoma: implications for treatment strategies and future clinical studies
- (2010) J. A. Langendijk et al. ANNALS OF ONCOLOGY
- Epithelial Cell Adhesion Molecule Regulation Is Associated with the Maintenance of the Undifferentiated Phenotype of Human Embryonic Stem Cells
- (2010) Tung-Ying Lu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ERK2 but Not ERK1 Induces Epithelial-to-Mesenchymal Transformation via DEF Motif-Dependent Signaling Events
- (2010) Sejeong Shin et al. MOLECULAR CELL
- TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma
- (2010) M E Kupferman et al. ONCOGENE
- Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells
- (2010) Y Gan et al. ONCOGENE
- Initial activation of EpCAM cleavage viacell-to-cell contact
- (2009) Sabine Denzel et al. BMC CANCER
- Extracellular Signal-Regulated Kinase Signaling Pathway Regulates Breast Cancer Cell Migration by Maintaining slug Expression
- (2009) H. Chen et al. CANCER RESEARCH
- Mechanisms of resistance to EGFR inhibitors in head and neck cancer
- (2009) Jonathan B. Cooper et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- Nuclear signalling by tumour-associated antigen EpCAM
- (2009) Dorothea Maetzel et al. NATURE CELL BIOLOGY
- The Epithelial Cell Adhesion Molecule EpCAM Is Required for Epithelial Morphogenesis and Integrity during Zebrafish Epiboly and Skin Development
- (2009) Krasimir Slanchev et al. PLoS Genetics
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
- (2008) Jing Yang et al. DEVELOPMENTAL CELL
- EGFR Antagonists in Cancer Treatment
- (2008) Fortunato Ciardiello et al. NEW ENGLAND JOURNAL OF MEDICINE
- CD44s and CD44v6 Expression in Head and Neck Epithelia
- (2008) Brigitte Mack et al. PLoS One
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