Article
Multidisciplinary Sciences
Cunxian Fan, Xiao Yang, Hui Nie, Shunxin Wang, Liangran Zhang
Summary: This study reveals the transmission of crossover recombination correlation in both human males and females to their offspring, without detectable selection. Additionally, it shows a correlation between chromosome axis length and crossover number, with longer axis pairs having stronger correlation. The findings also suggest that longer chromosome axes are more coordinately regulated and this stronger crossover recombination correlation may contribute to the adaptability of female germlines to changing environments during evolution.
Review
Cell Biology
Wenbin Gai, Zhiqiang Peng, Cui Hua Liu, Lingqiang Zhang, Hong Jiang
Summary: NEDD8 is a key protein involved in the progression of tumors, with its inhibitor MLN4924 showing promise in treating cancer. Inhibiting the neddylation pathway can effectively halt the development of tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Bojun Wang, Tiantian Wang, Huimin Zhu, Rong Yan, Xinru Li, Chengqian Zhang, Wanyu Tao, Xisong Ke, Piliang Hao, Yi Qu
Summary: In this study, it was found that beta-Catenin is not stabilized upon ubiquitylation depletion but is quickly stabilized by neddylation inhibition. The inhibition of neddylation also enhances the interaction between beta-Catenin and TCF4. Beta-TrCP2 is associated with the neddylation and destruction of beta-Catenin.
Article
Oncology
Yelee Kim, Jun Bum Park, Junji Fukuda, Masatoshi Watanabe, Yang-Sook Chun
Summary: The expression status of the p53 gene influences neddylation-mediated cell migration in multiple cancer cell lines via Slug, and neddylation blockade is also affected by the different p53 statuses.
Article
Biochemistry & Molecular Biology
Yang Yue, Takashi Hotta, Takumi Higaki, Kristen J. Verhey, Ryoma Ohi
Summary: Tubulin polymers play a crucial role in cell dynamics and are regulated by post-translational modifications (PTMs) and MAPs. In this study, the activity of VASH1/SVBP in MT detyrosination was found to be greater on GTP-MTs compared to GDP-MTs. Taxol was shown to promote MT detyrosination and CAMSAP2 and CAMSAP3 were identified as MAPs involved in regulating detyrosination in cells.
Article
Cell Biology
Yuli Lin, Yusheng Chen, Wenxue Feng, Rong Hua, Junfeng Zhang, Yanmiao Huo, Hong Jiang, Bo Yin, Xuguang Yang
Summary: The neddylation pathway plays a crucial role in the development of chronic pancreatitis, with dysregulation exacerbating the inflammatory microenvironment and pancreatic fibrosis. Intervention through blocking chemokine CCL5 and macrophages can alleviate fibrosis and inflammation in the pancreas.
CELL DEATH & DISEASE
(2021)
Article
Microbiology
Renata Moreno, Luis Yuste, Fernando Rojo
Summary: This research shows that acetoin is not a preferred carbon source of Pseudomonas putida, and the induction of genes required for its assimilation is down-modulated by different global regulatory systems. The expression of the acetoin degradation genes relies on the RpoN alternative sigma factor and is modulated by the Crc/Hfq, Cyo and PTSNtr regulatory elements.
ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eun-Joo Park, Tae-Houn Kim
Summary: The study reveals that Arabidopsis OSMOTIN 34 acts as a positive regulator in the ABA signaling pathway, with its protein stability controlled by the 26S proteasome. OSM34 plays a crucial role in ABA responses, reducing endogenous ABA response levels, proline levels, and expression of the P5CS1 gene.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Shiho Hashiguchi, Tomoko Tanaka, Ryosuke Mano, Seiji Kondo, Shohta Kodama
Summary: CCN2 promotes lymphangiogenesis by enhancing integrin alpha v beta 5-mediated phosphorylation of ERK, and DUSP6 is a negative regulator of excessive lymphangiogenesis by CCN2.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Lisha Zhou, Luyi Zhang, Siyuan Chen, Dongsheng Sun, Jianhua Qu
Summary: Research has shown that the activation of the neddylation pathway is associated with increased infiltration of Th2 cells in HCC, while there is no significant correlation with Th1 cells. This suggests a potential role of promoting a shift in Th1/Th2 balance towards Th2-dominant immunosuppression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maolin Feng, Yingping Gui, Jinhua An, XinYing Cao, Wuting Lu, Gang Yang, Shaoqing Jian, Baoqing Hu, Chungen Wen
Summary: This study found that the expression of Thioredoxin (Trx) from Cristaria plicata is regulated by the Nrf2/ARE pathway, which plays an important role in inhibiting apoptosis and protecting cells from oxidative stress. The study also discovered that under microcystin stress, Trx mRNA expression was significantly up-regulated in gill and kidney tissues, and knocking down CpNrf2 gene led to a significant down-regulation of Trx expression.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biology
Andres De la Rocha-Munoz, Enrique Nunez, Anjali Amrapali Vishwanath, Sergio Gomez-Lopez, Dhanasak Dhanasobhon, Nelson Rebola, Beatriz Lopez-Corcuera, Jaime De Juan-Sanz, Carmen Aragon
Summary: The Hedgehog pathway was identified as a robust controller of GlyT2 expression and transport activity, affecting presynaptic glycine availability. Modulating the activation state of the Hedgehog pathway can influence the levels of GlyT2 expression and transport capability.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hui Xue, Xingxing Huang, Guofeng Chang, Weihua Ma, J. Joe Hull, Lizhen Chen
Summary: This study investigated the reproductive capacity of Adelphocoris suturalis through RNAi-mediated knockdown, revealing that knockdown of AsIRS1 significantly reduced egg maturation and had effects on lifetime fecundity, egg hatch rate, and other reproductive parameters. These findings suggest that the insulin signaling pathway, particularly IRS1, plays a key role in the reproductive development of A. suturalis.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Microbiology
Chao Yin, Jiaojie Gu, Dan Gu, Zhenyu Wang, Ruoyun Ji, Xinan Jiao, Qiuchun Li
Summary: In this study, a new regulatory factor ItrA was identified to control the expression of ipaJ. Through experiments and analysis, it was demonstrated that IpaJ is an effector of T3SS1 and inhibits the activation of NF-κB pathway and MAPK signaling pathway, thus suppressing the inflammatory response in host cells.
Article
Oncology
Li Tang, Da Wei, Xinyu Xu, Dongping Mo, Daofu Cheng, Feng Yan
Summary: This study demonstrates that CYP1B1-AS1 inhibits protein neddylation to affect breast cancer cell proliferation, providing a new strategy for the treatment of breast cancer by targeting lncRNA-mediated neddylation modification.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Biochemistry & Molecular Biology
Paulina Martinez Palacios, Marie-Pierre Jacquemot, Marion Tapie, Agnes Rousselet, Mamoudou Diop, Carine Remoue, Matthieu Falque, Andrew Lloyd, Eric Jenczewski, Gilles Lassalle, Anne-Marie Chevre, Christine Lelandais, Martin Crespi, Philippe Brabant, Johann Joets, Karine Alix
MOLECULAR BIOLOGY AND EVOLUTION
(2019)
Article
Biochemistry & Molecular Biology
Chao Yang, Kostika Sofroni, Erik Wijnker, Yuki Hamamural, Lena Carstens, Hirofumi Harashima, Sara Christina Stolze, Daniel Vezon, Liudmila Chelysheva, Zsuzsanna Orban-Nemeth, Gaetan Pochon, Hirofumi Nakagami, Peter Schloegelhofer, Mathilde Grelon, Arp Schnittger
Article
Genetics & Heredity
Kamel Jebreen, Marianyela Petrizzelli, Olivier C. Martin
FRONTIERS IN GENETICS
(2019)
Article
Plant Sciences
Pasquale Termolino, Matthieu Falque, Riccardo Aiese Cigliano, Gaetana Cremona, Rosa Paparo, Antoine Ederveen, Olivier C. Martin, Federica M. Consiglio, Clara Conicella
Article
Genetics & Heredity
Elise Tourrette, Rex Bernardo, Matthieu Falque, Olivier C. Martin
G3-GENES GENOMES GENETICS
(2019)
Article
Genetics & Heredity
Matthieu Falque, Kamel Jebreen, Etienne Paux, Carsten Knaak, Sofiane Mezmouk, Olivier C. Martin
Article
Genetics & Heredity
Margaux-Alison Fustier, Natalia E. Martinez-Ainsworth, Jonas A. Aguirre-Liguori, Anthony Venon, Helene Corti, Agnes Rousselet, Fabrice Dumas, Hannes Dittberner, Maria G. Camarena, Daniel Grimanelli, Otso Ovaskainen, Matthieu Falque, Laurence Moreau, Juliette de Meaux, Salvador Montes-Hernandez, Luis E. Eguiarte, Yves Vigouroux, Domenica Manicacci, Maud Tenaillon
Article
Multidisciplinary Sciences
E. Carrillo-Perdomo, A. Vidal, J. Kreplak, H. Duborjal, M. Leveugle, J. Duarte, C. Desmetz, C. Deulvot, B. Raffiot, P. Marget, N. Tayeh, J. P. Pichon, M. Falque, O. C. Martin, J. Burstin, G. Aubert
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Bipin K. Pandey, Guoqiang Huang, Rahul Bhosale, Sjon Hartman, Craig J. Sturrock, Lottie Jose, Olivier C. Martin, Michal Karady, Laurentius A. C. J. Voesenek, Karin Ljung, Jonathan P. Lynch, Kathleen M. Brown, William R. Whalley, Sacha J. Mooney, Dabing Zhang, Malcolm J. Bennett
Summary: Soil compaction hinders root growth by reducing gas diffusion and causing accumulation of ethylene in root tissues, triggering hormone responses that restrict growth. Ethylene acts as an early warning signal for roots to avoid compacted soils, which is relevant for breeding crops resilient to soil compaction.
Article
Multidisciplinary Sciences
Laia Capilla-Perez, Stephanie Durand, Aurelie Hurel, Qichao Lian, Aurelie Chambon, Christelle Taochy, Victor Solier, Mathilde Grelon, Raphael Mercier
Summary: The spatial organization of transverse filaments is essential for CO formation during meiosis, with the absence of ZYP1 leading to an unexpected increase in CO formation. The tripartite synaptonemal complex plays a key role in regulating the number and distribution of COs, affecting CO interference and heterochiasmy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Antoine Nicolas, Aude Maugarny-Cales, Bernard Adroher, Liudmila Chelysheva, Yu Li, Jasmine Burguet, Anne-Maarit Bagman, Margot E. Smit, Siobhan M. Brady, Yunhai Li, Patrick Laufs
Summary: Stem cells play crucial roles in animal and plant biology. Two transcription factors are discovered to repress the expression of CUC gene, thus ensuring proper meristem establishment and de novo stem cell niche formation in Arabidopsis thaliana.
Article
Biochemical Research Methods
Adrien Vidal, Franck Gauthier, Willy Rodrigez, Nadege Guiglielmoni, Damien Leroux, Nicolas Chevrolier, Sylvain Jasson, Elise Tourrette, Olivier C. Martin, Matthieu Falque
Summary: In this study, a fully automatic linkage mapping software called SeSAM was developed to construct high-robustness framework maps and high-density total maps. It can be used with a wide range of biparental mapping populations and offers various functions and analysis tools.
BMC BIOINFORMATICS
(2022)
Article
Agriculture, Dairy & Animal Science
Elise Tourrette, Matthieu Falque, Olivier C. Martin
Summary: This paper evaluates the impact of increased recombination on the efficiency of introgression programs in Brassicaceae through simulations. The results show that increasing the recombination rate can significantly decrease linkage drag and improve the return to the recurrent parent in regions lacking crossovers, but may be detrimental in regions already rich in crossovers. These simulations help understand the benefits of increased recombination rate and identify the best methods for different situations.
GENETICS SELECTION EVOLUTION
(2021)