Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis

Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint

(2018) Guillaume Combes et al.   CURRENT BIOLOGY

Unique Phylogenetic Distributions of the Ska and Dam1 Complexes Support Functional Analogy and Suggest Multiple Parallel Displacements of Ska by Dam1

(2017) Jolien J. E. van Hooff et al.   Genome Biology and Evolution

Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures

(2017) Yoshitaka Hiruma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Basis of catalytic assembly of the mitotic checkpoint complex

(2017) Alex C. Faesen et al.   NATURE

Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation

(2017) Shawn Yost et al.   NATURE GENETICS

A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling

(2017) Zhejian Ji et al.   eLife

Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing

(2017) Margarida Moura et al.   eLife

Regulation of AURORA B function by mitotic checkpoint protein MAD2

(2016) Jayasha Shandilya et al.   CELL CYCLE

The hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast

(2016) Aldona Ewa Chmielewska et al.   CELL CYCLE

ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores

(2016) Mayumi Isokane et al.   JOURNAL OF CELL BIOLOGY

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

Genome-wide identification of zero nucleotide recursive splicing in Drosophila

(2015) Michael O. Duff et al.   NATURE

The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling

(2015) Pavithra Aravamudhan et al.   NATURE CELL BIOLOGY

Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment

(2015) Zhen Dou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene essentiality and synthetic lethality in haploid human cells

(2015) V. A. Blomen et al.   SCIENCE

Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling

(2015) Y. Hiruma et al.   SCIENCE

Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C

(2015) Z. Ji et al.   SCIENCE

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

Joined at the hip: kinetochores, microtubules, and spindle assembly checkpoint signaling

(2015) Carlos Sacristan et al.   TRENDS IN CELL BIOLOGY

Kinetochore–microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint

(2015) Banafsheh Etemad et al.   Nature Communications

A quantitative description of Ndc80 complex linkage to human kinetochores

(2015) Aussie Suzuki et al.   Nature Communications

Natural Loss of Mps1 Kinase in Nematodes Uncovers a Role for Polo-like Kinase 1 in Spindle Checkpoint Initiation

(2015) Julien Espeut et al.   Cell Reports

Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells

(2015) Conrad von Schubert et al.   Cell Reports

A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

(2015) Katharina Overlack et al.   eLife

Polo-like Kinase 1 Licenses CENP-A Deposition at Centromeres

(2014) Kara L. McKinley et al.   CELL

Nuclear Pores Protect Genome Integrity by Assembling a Premitotic and Mad1-Dependent Anaphase Inhibitor

(2014) Veronica Rodriguez-Bravo et al.   CELL

Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint

(2014) N. London et al.   GENES & DEVELOPMENT

Phosphorylation at Threonine 288 by Cell Cycle Checkpoint Kinase 2 (CHK2) Controls Human Monopolar Spindle 1 (Mps1) Kinetochore Localization

(2014) Chun-Wei Yeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing

(2014) Antonio Espert et al.   JOURNAL OF CELL BIOLOGY

Chk2 prevents mitotic exit when the majority of kinetochores are unattached

(2014) Eleni Petsalaki et al.   JOURNAL OF CELL BIOLOGY

A Bub1–Mad1 interaction targets the Mad1–Mad2 complex to unattached kinetochores to initiate the spindle checkpoint

(2014) Mark W. Moyle et al.   JOURNAL OF CELL BIOLOGY

Accurate phosphoregulation of kinetochore–microtubule affinity requires unconstrained molecular interactions

(2014) Anatoly V. Zaytsev et al.   JOURNAL OF CELL BIOLOGY

Negative feedback at kinetochores underlies a responsive spindle checkpoint signal

(2014) Wilco Nijenhuis et al.   NATURE CELL BIOLOGY

Dynamic Autophosphorylation of Mps1 Kinase Is Required for Faithful Mitotic Progression

(2014) Xinghui Wang et al.   PLoS One

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress

(2014) Floris Foijer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modelling chromosome dynamics in mitosis: a historical perspective on models of metaphase and anaphase in eukaryotic cells

(2014) G. Civelekoglu-Scholey et al.   Interface Focus

Phosphorylation of Microtubule-binding Protein Hec1 by Mitotic Kinase Aurora B Specifies Spindle Checkpoint Kinase Mps1 Signaling at the Kinetochore

(2013) Tongge Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B

(2013) Wilco Nijenhuis et al.   JOURNAL OF CELL BIOLOGY

Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation

(2013) Mathijs Vleugel et al.   JOURNAL OF CELL BIOLOGY

Aneuploidy in health, disease, and aging

(2013) Robin M. Ricke et al.   JOURNAL OF CELL BIOLOGY

A minimal number of MELT repeats supports all the functions of KNL1 in chromosome segregation

(2013) Gang Zhang et al.   JOURNAL OF CELL SCIENCE

Universal Quantitative Kinase Assay Based on Diagonal SCX Chromatography and Stable Isotope Dimethyl Labeling Provides High-definition Kinase Consensus Motifs for PKA and Human Mps1

(2013) Marco L. Hennrich et al.   JOURNAL OF PROTEOME RESEARCH

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling

(2013) Ivana Primorac et al.   eLife

The MPS1 Family of Protein Kinases

(2012) Xuedong Liu et al.   Annual Review of Biochemistry

Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint

(2012) Geert J. P. L. Kops et al.   CHROMOSOMA

Kinase Activity of Fission Yeast Mph1 Is Required for Mad2 and Mad3 to Stably Bind the Anaphase Promoting Complex

(2012) Judith Zich et al.   CURRENT BIOLOGY

CDK-Dependent Potentiation of MPS1 Kinase Activity Is Essential to the Mitotic Checkpoint

(2012) Violeta Morin et al.   CURRENT BIOLOGY

Phosphoregulation of Spc105 by Mps1 and PP1 Regulates Bub1 Localization to Kinetochores

(2012) Nitobe London et al.   CURRENT BIOLOGY

The Kinetochore-Bound Ska1 Complex Tracks Depolymerizing Microtubules and Binds to Curved Protofilaments

(2012) Jens C. Schmidt et al.   DEVELOPMENTAL CELL

Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation

(2012) Daisuke Izawa et al.   JOURNAL OF CELL BIOLOGY

Structural analysis reveals features of the spindle checkpoint kinase Bub1–kinetochore subunit Knl1 interaction

(2012) Veronica Krenn et al.   JOURNAL OF CELL BIOLOGY

Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore

(2012) Julien Espeut et al.   JOURNAL OF CELL BIOLOGY

Structure of the mitotic checkpoint complex

(2012) William C. H. Chao et al.   NATURE

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

(2012) Emily A. Foley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multimodal microtubule binding by the Ndc80 kinetochore complex

(2012) Gregory M Alushin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Two LXXLL motifs in the N terminus of Mps1 are required for Mps1 nuclear import during G2/M transition and sustained spindle checkpoint responses

(2011) Xiaojuan Zhang et al.   CELL CYCLE

Mps1 at kinetochores is essential for female mouse meiosis I

(2011) K. Hached et al.   DEVELOPMENT

Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction

(2011) Stefano Santaguida et al.   EMBO JOURNAL

Characterization of Spindle Checkpoint Kinase Mps1 Reveals Domain with Functional and Structural Similarities to Tetratricopeptide Repeat Motifs of Bub1 and BubR1 Checkpoint Kinases

(2011) Semin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner

(2011) Pablo Lara-Gonzalez et al.   JOURNAL OF CELL SCIENCE

Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation

(2011) Maria Maldonado et al.   NATURE CELL BIOLOGY

Quantitative Mass Spectrometry Analysis Reveals Similar Substrate Consensus Motif for Human Mps1 Kinase and Plk1

(2011) Zhen Dou et al.   PLoS One

Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site

(2011) Victor M. Bolanos-Garcia et al.   STRUCTURE

Centriole assembly and the role of Mps1: defensible or dispensable?

(2011) Amanda N Pike et al.   Cell Division

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis

(2011) Adrian T. Saurin et al.   Nature Communications

Relocation of the Chromosomal Passenger Complex Prevents Mitotic Checkpoint Engagement at Anaphase

(2010) María Dolores Vázquez-Novelle et al.   CURRENT BIOLOGY

Degradation of the Human Mitotic Checkpoint Kinase Mps1 Is Cell Cycle-regulated by APC-cCdc20and APC-cCdh1Ubiquitin Ligases

(2010) Yongping Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the Molecular Basis of BubR1 Kinetochore Interactions and APC/C-CDC20 Inhibition

(2010) Sheena D'Arcy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling

(2010) John Maciejowski et al.   JOURNAL OF CELL BIOLOGY

Release of Mps1 from kinetochores is crucial for timely anaphase onset

(2010) Nannette Jelluma et al.   JOURNAL OF CELL BIOLOGY

Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase

(2010) Dan Liu et al.   JOURNAL OF CELL BIOLOGY

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

(2010) Laura Hewitt et al.   JOURNAL OF CELL BIOLOGY

N-terminal regions of Mps1 kinase determine functional bifurcation

(2010) Yasuhiro Araki et al.   JOURNAL OF CELL BIOLOGY

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

(2010) Julie P.I. Welburn et al.   MOLECULAR CELL

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

(2010) Beate Neumann et al.   NATURE

The CHK2–BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells

(2010) Ailine Stolz et al.   NATURE CELL BIOLOGY

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

(2010) Nicholas Kwiatkowski et al.   Nature Chemical Biology

Chemical Genetic Inhibition of Mps1 in Stable Human Cell Lines Reveals Novel Aspects of Mps1 Function in Mitosis

(2010) Tale Sliedrecht et al.   PLoS One

The Human Kinetochore Ska1 Complex Facilitates Microtubule Depolymerization-Coupled Motility

(2009) Julie P.I. Welburn et al.   DEVELOPMENTAL CELL

Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling

(2009) Stefan Kemmler et al.   EMBO JOURNAL

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin

(2009) S. A. Kawashima et al.   SCIENCE

The Crystal Structure of the N-Terminal Region of BUB1 Provides Insight into the Mechanism of BUB1 Recruitment to Kinetochores

(2009) Victor M. Bolanos-Garcia et al.   STRUCTURE

Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment

(2008) Nannette Jelluma et al.   CELL

Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint

(2008) S. H. Lee et al.   GENES & DEVELOPMENT

Aneuploidy: Cells Losing Their Balance

(2008) Eduardo M. Torres et al.   GENETICS

Structural and mechanistic insights into Mps1 kinase activation

(2008) Wei Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Characterization of the Tetratricopeptide-Containing Domain of BUB1, BUBR1, and PP5 Proves That Domain Amphiphilicity over Amino Acid Sequence Specificity Governs Protein Adsorption and Interfacial Activity

(2008) Sylvie Beaufils et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Regulation of Kinetochore Recruitment of Two Essential Mitotic Spindle Checkpoint Proteins by Mps1 Phosphorylation

(2008) Quanbin Xu et al.   MOLECULAR BIOLOGY OF THE CELL

Kinase-Selective Enrichment Enables Quantitative Phosphoproteomics of the Kinome across the Cell Cycle

(2008) Henrik Daub et al.   MOLECULAR CELL

TTK/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress

(2008) K Nihira et al.   ONCOGENE

Chromosomal Instability by Inefficient Mps1 Auto-Activation Due to a Weakened Mitotic Checkpoint and Lagging Chromosomes

(2008) Nannette Jelluma et al.   PLoS One