Aneuploidy in health, disease, and aging

Tpx2 Controls Spindle Integrity, Genome Stability, and Tumor Development

(2012) C. Aguirre-Portoles et al.   CANCER RESEARCH

Chromosome instability and deregulated proliferation: an unavoidable duo

(2012) Courtney H. Coschi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases

(2012) R M Naylor et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Checkpoint-Independent Stabilization of Kinetochore-Microtubule Attachments by Mad2 in Human Cells

(2012) Lilian Kabeche et al.   CURRENT BIOLOGY

Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres

(2012) Silvia Remeseiro et al.   EMBO JOURNAL

Chromosomal instability and aneuploidy in cancer: from yeast to man

(2012) Sarah J Pfau et al.   EMBO REPORTS

Cancer chromosomal instability: therapeutic and diagnostic challenges

(2012) Nicholas McGranahan et al.   EMBO REPORTS

Chromosome-specific accumulation of aneuploidy in the aging mouse brain

(2012) Francesca Faggioli et al.   HUMAN MOLECULAR GENETICS

Cancer cells preferentially lose small chromosomes

(2012) Pascal H.G. Duijf et al.   INTERNATIONAL JOURNAL OF CANCER

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

(2012) Robin M. Ricke et al.   JOURNAL OF CELL BIOLOGY

USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis

(2012) Ying Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Aneuploidy as a mechanism for stress-induced liver adaptation

(2012) Andrew W. Duncan et al.   JOURNAL OF CLINICAL INVESTIGATION

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

(2012) Darren J. Baker et al.   NATURE CELL BIOLOGY

Human aneuploidy: mechanisms and new insights into an age-old problem

(2012) So I. Nagaoka et al.   NATURE REVIEWS GENETICS

Transcriptional consequences of aneuploidy

(2012) J. M. Sheltzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RB family is required for the self-renewal and survival of human embryonic stem cells

(2012) Jamie F. Conklin et al.   Nature Communications

Tissue-Specific Functional Networks for Prioritizing Phenotype and Disease Genes

(2012) Yuanfang Guan et al.   PLoS Computational Biology

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation

(2012) Tobias Wijshake et al.   PLoS Genetics

Karyotypic Determinants of Chromosome Instability in Aneuploid Budding Yeast

(2012) Jin Zhu et al.   PLoS Genetics

Mad2 Is a Critical Mediator of the Chromosome Instability Observed upon Rb and p53 Pathway Inhibition

(2011) Juan-Manuel Schvartzman et al.   CANCER CELL

Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer

(2011) N. J. Birkbak et al.   CANCER RESEARCH

Chromosomal Instability Confers Intrinsic Multidrug Resistance

(2011) A. J. X. Lee et al.   CANCER RESEARCH

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Chromosome Catastrophes Involve Replication Mechanisms Generating Complex Genomic Rearrangements

(2011) Pengfei Liu et al.   CELL

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

Chromosomal Instability Substantiates Poor Prognosis in Patients with Diffuse Large B-cell Lymphoma

(2011) S. F. Bakhoum et al.   CLINICAL CANCER RESEARCH

Sporadic Aneuploidy in PHA-Stimulated Lymphocytes of Trisomies 21, 18, and 13

(2011) O. Reish et al.   CYTOGENETIC AND GENOME RESEARCH

Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development

(2011) G. Fernandez-Miranda et al.   DEVELOPMENT

Frequent Aneuploidy Among Normal Human Hepatocytes

(2011) Andrew W. Duncan et al.   GASTROENTEROLOGY

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

(2011) Robin M. Ricke et al.   JOURNAL OF CELL BIOLOGY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Stalled Fork Rescue via Dormant Replication Origins in Unchallenged S Phase Promotes Proper Chromosome Segregation and Tumor Suppression

(2011) Tsuyoshi Kawabata et al.   MOLECULAR CELL

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Mutations in CEP57 cause mosaic variegated aneuploidy syndrome

(2011) Katie Snape et al.   NATURE GENETICS

Single-Cell Analysis of Ploidy and Centrosomes Underscores the Peculiarity of Normal Hepatocytes

(2011) Francesca Faggioli et al.   PLoS One

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Aneuploidy Drives Genomic Instability in Yeast

(2011) J. M. Sheltzer et al.   SCIENCE

Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer

(2011) D. A. Solomon et al.   SCIENCE

pRB, a tumor suppressor with a stabilizing presence

(2011) Amity L. Manning et al.   TRENDS IN CELL BIOLOGY

The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components

(2011) Peter C. Stirling et al.   PLoS Genetics

Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy

(2011) Michal Ozery-Flato et al.   GENOME BIOLOGY

High chromosomal instability in brain metastases of colorectal carcinoma

(2010) Angelika Gutenberg et al.   CANCER GENETICS AND CYTOGENETICS

Molecular Causes for BUBR1 Dysfunction in the Human Cancer Predisposition Syndrome Mosaic Variegated Aneuploidy

(2010) Saskia J.E. Suijkerbuijk et al.   CANCER RESEARCH

Chromosome missegregation causes colon cancer byAPCloss of heterozygosity

(2010) Darren J. Baker et al.   CELL CYCLE

Meiotic Chromosome Segregation in Triploid Strains of Saccharomyces cerevisiae

(2010) J. S. Charles et al.   GENETICS

Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

(2010) Janine H. van Ree et al.   JOURNAL OF CELL BIOLOGY

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division

(2010) L. H.-C. Wang et al.   JOURNAL OF CELL SCIENCE

The ploidy conveyor of mature hepatocytes as a source of genetic variation

(2010) Andrew W. Duncan et al.   NATURE

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

Rad21-Cohesin Haploinsufficiency Impedes DNA Repair and Enhances Gastrointestinal Radiosensitivity in Mice

(2010) Huiling Xu et al.   PLoS One

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle

(2010) A. A. Guerrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

(2010) M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Incremental Genetic Perturbations to MCM2-7 Expression and Subcellular Distribution Reveal Exquisite Sensitivity of Mice to DNA Replication Stress

(2010) Chen-Hua Chuang et al.   PLoS Genetics

Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity

(2009) Darren J. Baker et al.   CANCER CELL

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

(2009) Ji Luo et al.   CELL

Unattached Kinetochores Catalyze Production of an Anaphase Inhibitor that Requires a Mad2 Template to Prime Cdc20 for BubR1 Binding

(2009) Anita Kulukian et al.   DEVELOPMENTAL CELL

Loss of spindle assembly checkpoint–mediated inhibition of Cdc20 promotes tumorigenesis in mice

(2009) Min Li et al.   JOURNAL OF CELL BIOLOGY

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

Mechanisms of change in gene copy number

(2009) P. J. Hastings et al.   NATURE REVIEWS GENETICS

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

(2009) William T. Silkworth et al.   PLoS One

Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice

(2009) S. Leland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ploidy Reductions in Murine Fusion-Derived Hepatocytes

(2009) Andrew W. Duncan et al.   PLoS Genetics

Clinical and genetic heterogeneity in patients with mosaic variegated aneuploidy: Delineation of clinical subtypes

(2008) Herbert García‐Castillo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Impaired Bub1 Function In vivo Compromises Tension-Dependent Checkpoint Function Leading to Aneuploidy and Tumorigenesis

(2008) M. Schliekelman et al.   CANCER RESEARCH

Control of chromosome stability by the β-TrCP–REST–Mad2 axis

(2008) Daniele Guardavaccaro et al.   NATURE

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

(2008) Darren J. Baker et al.   NATURE CELL BIOLOGY

Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo

(2008) E. Diaz-Rodriguez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE

Whole chromosome instability and cancer: a complex relationship

(2008) Robin M. Ricke et al.   TRENDS IN GENETICS