You are what you eat, or are you? The challenges of translating high-fat-fed rodents to human obesity and diabetes

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

(2014) Jason Flannick et al.   NATURE GENETICS

Of rodents and men: Species-specific glucose regulation and type 2 diabetes research

(2014) P. Charukeshi Chandrasekera   ALTEX-Alternatives to Animal Experimentation

Modeling dietary patterns to assess sodium recommendations for nutrient adequacy

(2013) Earl S Ford et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The effect of biological age on the metabolic responsiveness of mice fed a high-fat diet

(2013) Laskarina-Maria A Korou et al.   LABORATORY ANIMALS

Fasting of mice: a review

(2013) TL Jensen et al.   LABORATORY ANIMALS

Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats

(2013) Uberdan Guilherme Mendes de Castro et al.   Lipids in Health and Disease

Grape seed proanthocyanidins ameliorate pancreatic beta-cell dysfunction and death in low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats partially by regulating endoplasmic reticulum stress

(2013) Ye Ding et al.   Nutrition & Metabolism

Obesity-Induced Insulin Resistance in Human Skeletal Muscle Is Characterised by Defective Activation of p42/p44 MAP Kinase

(2013) Antonio J. Ruiz-Alcaraz et al.   PLoS One

Long Term Metabolic Syndrome Induced by a High Fat High Fructose Diet Leads to Minimal Renal Injury in C57BL/6 Mice

(2013) Romain Dissard et al.   PLoS One

Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

(2013) Konstantinos K. Tsilidis et al.   PLOS BIOLOGY

The gut microbiota profile is associated with insulin action in humans

(2012) Matteo Serino et al.   ACTA DIABETOLOGICA

Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8

(2012) A. B. Hardy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Epidemiology of general obesity, abdominal obesity and related risk factors in urban adults from 33 communities of northeast china: the CHPSNE study

(2012) Hao Wang et al.   BMC PUBLIC HEALTH

The use of animal models in diabetes research

(2012) Aileen JF King   BRITISH JOURNAL OF PHARMACOLOGY

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

Western-Style Fast Food Intake and Cardiometabolic Risk in an Eastern Country

(2012) Andrew O. Odegaard et al.   CIRCULATION

Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals

(2012) R. Robinson et al.   Disease Models & Mechanisms

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

(2012) Michael Volkmar et al.   EMBO JOURNAL

Early Mitochondrial Adaptations in Skeletal Muscle to Diet-Induced Obesity Are Strain Dependent and Determine Oxidative Stress and Energy Expenditure But Not Insulin Sensitivity

(2012) Sihem Boudina et al.   ENDOCRINOLOGY

Acute effects of different diet compositions on skeletal muscle insulin signalling in obese individuals during caloric restriction

(2012) Cecilia C.L. Wang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Heat or Insulation: Behavioral Titration of Mouse Preference for Warmth or Access to a Nest

(2012) Brianna N. Gaskill et al.   PLoS One

The Physiological Effects of Deleting the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background

(2012) Lynley D. Pound et al.   PLoS One

Effects of Exercise on AMPK Signaling and Downstream Components to PI3K in Rat with Type 2 Diabetes

(2012) Shicheng Cao et al.   PLoS One

Differential Development of Glucose Intolerance and Pancreatic Islet Adaptation in Multiple Diet Induced Obesity Models

(2012) Bilal Omar et al.   Nutrients

Trends in carbohydrate, fat, and protein intakes and association with energy intake in normal-weight, overweight, and obese individuals: 1971–2006

(2011) Gregory L Austin et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Association between dietary patterns and the risk of metabolic syndrome among Lebanese adults

(2011) F. Naja et al.   EUROPEAN JOURNAL OF NUTRITION

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice

(2011) Mikko Hiltunen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pharmacokinetic and Pharmacodynamic Properties of the Glucokinase Activator MK-0941 in Rodent Models of Type 2 Diabetes and Healthy Dogs

(2011) J.-i. Eiki et al.   MOLECULAR PHARMACOLOGY

In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues

(2010) Abdelali Agouni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

(2010) J. E. Ayala et al.   Disease Models & Mechanisms

Spironolactone Improves Glucose and Lipid Metabolism by Ameliorating Hepatic Steatosis and Inflammation and Suppressing Enhanced Gluconeogenesis Induced by High-Fat and High-Fructose Diet

(2010) Tsutomu Wada et al.   ENDOCRINOLOGY

Transgenic expression of cholesterol 7α-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice

(2010) Tiangang Li et al.   HEPATOLOGY

Rodent Models for Metabolic Syndrome Research

(2010) Sunil K. Panchal et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

High-carbohydrate, High-fat Diet–induced Metabolic Syndrome and Cardiovascular Remodeling in Rats

(2010) Sunil K. Panchal et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Nonshivering thermogenesis and its adequate measurement in metabolic studies

(2010) B. Cannon et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Experimental rodent models of type 2 diabetes: A review

(2010) M.S. Islam et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Pharmacological management of appetite expression in obesity

(2010) Jason C. G. Halford et al.   Nature Reviews Endocrinology

"Control" laboratory rodents are metabolically morbid: Why it matters

(2010) B. Martin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

(2010) Emily S. Sena et al.   PLOS BIOLOGY

Deletion of the mouseSlc30a8gene encoding zinc transporter-8 results in impaired insulin secretion

(2009) Lynley D. Pound et al.   BIOCHEMICAL JOURNAL

Why We Should Put Clothes on Mice

(2009) Irfan J. Lodhi et al.   Cell Metabolism

Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes

(2009) H. Hwang et al.   DIABETES

Age-Dependent Decline in  -Cell Proliferation Restricts the Capacity of  -Cell Regeneration in Mice

(2009) S.-I. Tschen et al.   DIABETES

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants

(2009) T. J. Nicolson et al.   DIABETES

The Characterization of High-Fat Diet and Multiple Low-Dose Streptozotocin Induced Type 2 Diabetes Rat Model

(2009) Ming Zhang et al.   Experimental Diabetes Research

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

(2009) K. Lemaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implications of crosstalk between leptin and insulin signaling during the development of diet-induced obesity

(2008) Christopher D. Morrison et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Comparisons of Diets Used in Animal Models of High-Fat Feeding

(2008) Craig H. Warden et al.   Cell Metabolism

Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet-Induced Metabolic Disease

(2008) H. Lan et al.   DIABETES

Assessment of Diet-induced Obese Rats as an Obesity Model by Comparative Functional Genomics

(2008) Shuyu Li et al.   Obesity

Phylometabonomic Patterns of Adaptation to High Fat Diet Feeding in Inbred Mice

(2008) Jane F. Fearnside et al.   PLoS One

Hypothalamic Phosphatidylinositol 3-Kinase Pathway of Leptin Signaling Is Impaired during the Development of Diet-Induced Obesity in FVB/N Mice

(2007) Anantha S. Metlakunta et al.   ENDOCRINOLOGY