Article
Microbiology
Seoyoung Jeong, Ayeon Kwon, Huijin Jeong, Young-Seo Park
Summary: This study found that the synbiotic combinations of probiotics and prebiotics have higher immunostimulatory activities on macrophages compared to the corresponding probiotic strains and oligosaccharides alone. The synergistic effect of probiotics and the prebiotics in the studied synbiotic preparations is due to the activation of the mitogen-activated protein-kinase-signaling pathway. This suggests the potential use of synbiotic preparations as health supplements.
Article
Multidisciplinary Sciences
Yalda Mahjoory, Reza Mohammadi, Mohammad Amin Hejazi, Yousef Nami
Summary: The potential of two identified probiotic strains, ABRIIFBI-6 and ABRIIFBI-7, to inhibit the growth of aspergilli and reduce aflatoxin availability was investigated. Both strains survived in simulated gastrointestinal conditions and significantly inhibited Aspergillus growth. They also exhibited high auto-aggregation, hydrophobicity, and coaggregation abilities with other bacteria. These findings contribute to the understanding of LAB probiotic potential in dairy products and their use as biocontrol agents against aflatoxin-producing species.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Chul Sang Lee, Mi Hyun Park, Byoung Kook Kim, Sae Hun Kim
Summary: Obesity is a major cause of metabolic diseases, and inhibiting adipogenic differentiation can prevent and suppress obesity. Oral administration of Lactobacillus strains can improve serum lipid profile and normalize gut microbiota, effectively preventing obesity and improving metabolic health.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Food Science & Technology
Marcello Lima Bertuci, Carlos Alberto Alves, Camila Vespucio Bis Souza, Ana Lucia Barretto Penna, Andrea Carla da Silva Barretto
Summary: This study evaluated four potentially probiotic Lacticaseibacillus strains as bio preservatives in fermented meat sausage. Commercial strains exhibited inhibitory effects on tested pathogens and showed better growth on meat additive simulating MRS medium. pH, sodium nitrite, and sodium chloride were limiting factors for the growth of potentially probiotic strains.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Catalina Voaides, Oana Boiu-Sicuia, Florentina Israel-Roming, Medana Zamfir, Silvia Simona Grosu-Tudor, Iulia Roxana Angelescu, Calina Petruta Cornea
Summary: This study characterized several Romanian native lactic acid bacteria strains to select valuable nutritional and probiotic strains for vegetable juice fermentation. HPLC analyses showed high levels of lactic acid in all vegetable juices fermented by LAB.
Article
Agriculture, Dairy & Animal Science
Priscilia Y. Heredia-Castro, Ricardo Reyes-Diaz, Miguel Angel Rendon-Rosales, Lilia M. Beltran-Barrientos, Maria J. Torres-Llanez, Maria C. Estrada-Montoya, Adrian Hernandez-Mendoza, Aaron F. Gonzalez-Cordova, Belinda Vallejo-Cordoba
Summary: This study isolated and characterized bacteriocins produced by two Lactobacillus fermentum strains from artisanal Mexican Cocido cheese. One of the strains exhibited high antimicrobial activity against various indicator microorganisms, suggesting its potential application as a biopreservative in dairy products.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Peijun Tian, Ying Chen, Xin Qian, Renying Zou, Huiyue Zhu, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: The Pediococcus acidilactici strain CCFM6432 has shown psychobiotic potential by improving gut microbial composition, regulating anxiety-like behaviors, and reducing HPA axis hyperactivity. Its key compound for antimicrobial activity was confirmed to be lactic acid, paving the way for potential mental health management during daily life, especially amid the COVID-19 pandemic.
Article
Biotechnology & Applied Microbiology
Jaekoo Lee, Seonyoung Kim, Chang-Ho Kang
Summary: This study screened and identified five strains of immunologically active lactic acid bacteria, including Limosilactobacillus fermentum MG5489, Lactococcus lactis MG5542, Lacticaseibacillus paracasei MG5559, Latilactobacillus sakei MG5468, and Latilactobacillus curvatus MG5609. These strains enhanced immunity by inducing the production of nitric oxide, tumor necrosis factor-alpha, interleukin-6, and interleukin-1 beta in RAW264.7 cells, as well as increasing phagocytic activity and nuclear factor-kappa B activation. Furthermore, the strains exhibited stability and adhesion in the gastrointestinal tract. Overall, these selected strains have the potential to be novel probiotics for enhancing immunity.
FERMENTATION-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Pradip Behare, Syed Azmal Ali, Vinay S. N. Mishra, Laura G. Gomez-Mascaraque, Olivia McAuliffe
Summary: In this study, the viability and morphology of different bacterial strains were examined under high fructose concentrations. It was found that fructophilic lactic acid bacteria had reduced viability, while a non-fructophilic strain was significantly affected. Electron microscopy revealed that fructophilic strains remained intact but expanded, while the non-fructophilic strain ruptured and formed cell debris. Genomic analysis showed that fructophilic strains had fewer genes related to fructose metabolism and transport.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Ivana Hyrslova, Antonin Kana, Vera Kantorova, Gabriela Krausova, Iva Mrvikova, Ivo Doskocil
Summary: In this study, the ability of inorganic selenium to accumulate and transform into different selenium species and Se nanoparticles in bacteria from three different genera was evaluated. The cytotoxicity of selenized strains to human adenocarcinoma cells, as well as the effects on antioxidant activity and cell surface hydrophobicity, were determined. The results suggest that these bacterial strains have the potential to be used in selenium-enriched functional foods.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Jun Chen, Huili Pang, Lei Wang, Cunming Ma, Guofang Wu, Yuan Liu, Yifei Guan, Miao Zhang, Guangyong Qin, Zhongfang Tan
Summary: A total of 116 LAB strains were isolated from Bamei pig feces, among which L. plantarum subsp. plantarum QP28-1 was identified as a promising strain for LAB-related food fermentation due to its excellent antimicrobial properties and bacteriocin production capacity. This study provides a comprehensive profile for screening superior functional LAB strains in the food industry.
Article
Biotechnology & Applied Microbiology
Valentina Tolu, Cristina Fraumene, Angela Carboni, Antonio Loddo, Manuela Sanna, Simonetta Fois, Tonina Roggio, Pasquale Catzeddu
Summary: This study investigated the dynamics of microbial ecosystem in three liquid sourdoughs triggered with the same microbial strains under different fermentation conditions and starter inoculation methods. The results showed a high heterogeneity of fungi microbiota and a small number of yeast species in the sourdoughs. Several bacterial species were consistently present in all sourdoughs, while Fructilactobacillus sanfranciscensis became the dominant species at the end of the propagation period.
FERMENTATION-BASEL
(2022)
Article
Food Science & Technology
Caiqing Yao, Jing Li, Jingjing E, Ruixue Wang, Qiaoling Zhang, Junguo Wang
Summary: This study investigated the biofilm production and growth relationship of co-cultured lactic acid bacteria. The results showed that co-cultured lactobacilli strains promoted the growth of Streptococcus thermophilus, and vice versa. However, the formation of biofilm during co-cultivation was not necessarily related to symbiosis among the strains.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Sandra Bolanos-Nunez, Jorge A. Santiago-Urbina, Jean-Pierre Guyot, Gloria Diaz-Ruiz, Carmen Wacher
Summary: This study investigated the microbial ecology of Pozol, a Mexican beverage, and found that interactions between different bacteria in mixed cultures can affect fermentation parameters. Compared to pure cultures, co-fermentation of two strains can increase lactic acid production and growth rate.
Article
Biotechnology & Applied Microbiology
Hongsup Yoon, Yuri Lee, Hye-Ji Kang, Jaehyun Ju, Yosep Ji, Hyunjoon Park, Haryung Park, Heejae Lee, Wilhelm H. Holzapfel
Summary: Supplementation with Lc. rhamnosus BFE5264 and Lp. plantarum NR74 is found to improve diet-induced hypercholesterolemia by suppressing cholesterol absorption in the small intestine and supporting the regulation of cholesterol metabolism in the liver.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Peripheral Vascular Disease
Izabela Kubiszewska, Lidia Gackowska, Lukasz Obrycki, Aldona Wierzbicka, Anna Helmin-Basa, Zbigniew Kulaga, Malgorzta Wiese-Szadkowska, Jacek Michalkiewicz, Mieczyslaw Litwin
Summary: Dendritic cells play a crucial role in T cell alterations in primary hypertension. The study shows that the numbers and maturation markers of DCs in adolescent patients can reflect hypertension-mediated organ damage. Characteristics of DCs in hypertensive patients are associated with organ damage, with reduced tDC and pDC numbers, increased mDC subsets, and other changes.
HYPERTENSION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Renata Paprocka, Leszek Pazderski, Liliana Mazur, Malgorzata Wiese-Szadkowska, Jolanta Kutkowska, Michalina Nowak, Anna Helmin-Basa
Summary: This study synthesized new 3,4-dimethyl-1H-pyrrole-2,5-dione derivatives 2a-2f and evaluated their structural and anti-inflammatory properties. The compounds showed significant inhibition of PBMC proliferation, with compound 2a exhibiting the most promising anti-inflammatory activity.
Article
Oncology
Adriana Nowak, Malgorzata Zaklos-Szyda, Justyna Rosicka-Kaczmarek, Ilona Motyl
Summary: Probiotics and their metabolites have inhibitory effects on intestinal cancer cells, which are important for human health. This study identified two strains that can inhibit cancer cell proliferation through oxidative stress induction and programmed cell death.
Article
Biology
Malgorzata Maj, Lukasz Kazmierski, Karolina Balik, Karolina Kowalska, Lidia Gackowska, Anna Bajek, Tomasz Drewa
Summary: Stem cell-based therapies are considered promising for treating bladder cancer. However, the delivery of cells producing paracrine factors may disrupt the microenvironment and potentially reactivate tumors. In this study, we investigated the interaction between adipose-derived stem cells (ASCs) and bladder cancer cells. We found that ASCs increased MCP-1 secretion by bladder cancer cells and altered their morphology. Additionally, soluble factors secreted by bladder cancer cells decreased ASC numbers and affected their behavior. Our results suggest that the interactions between ASCs and bladder cancer cells have a significant impact on the non-muscle-invasive urinary bladder.
Review
Medicine, General & Internal
Natalia Anna Zieleniewska, Malgorzata Kazberuk, Malgorzata Chlabicz, Andrzej Eljaszewicz, Karol Kaminski
Summary: Atherosclerosis is a leading cause of cardiovascular diseases and a major public health challenge. The mechanism of atherosclerosis is not fully understood, but alterations in lipid metabolism and inflammation play important roles. Recent research has shown significant effects of trained immunity on atherosclerotic plaque formation and development. Trained immunity is also a prominent factor in acute and chronic coronary syndrome.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Renata Paprocka, Malgorzata Wiese-Szadkowska, Przemyslaw Kolodziej, Jolanta Kutkowska, Sara Balcerowska, Anna Bogucka-Kocka
Summary: The aim of this research was to synthesize new 1,2,4-triazole derivatives containing propanoic acid moiety and investigate their anti-inflammatory, antibacterial, and anthelmintic activity. The structures of the derivatives were confirmed through various analysis methods. The compounds 3a, 3c, and 3e exhibited the most beneficial anti-inflammatory effects in cell culture experiments.
Article
Multidisciplinary Sciences
Urszula Radzikowska, Andrzej Eljaszewicz, Ge Tan, Nino Stocker, Anja Heider, Patrick Westermann, Silvio Steiner, Anita Dreher, Paulina Wawrzyniak, Beate Ruckert, Juan Rodriguez-Coira, Damir Zhakparov, Mengting Huang, Bogdan Jakiela, Marek Sanak, Marcin Moniuszko, Liam O'Mahony, Marek Jutel, Tatiana Kebadze, J. David Jackson, R. Michael Edwards, Volker Thiel, L. Sebastian Johnston, A. Cezmi Akdis, Milena Sokolowska
Summary: Viral infections and exposure to inhaled allergens, such as rhinovirus and house dust mite, are associated with asthma exacerbations. In this study, the authors found that rhinovirus-induced activation of the RIG-I inflammasome suppresses antiviral immunity, promotes inflammation, and aggravates subsequent infection with SARS-CoV-2, particularly after exposure to house dust mite. Understanding these mechanisms could lead to more effective treatment strategies for asthma and respiratory virus infections.
NATURE COMMUNICATIONS
(2023)
Correction
Multidisciplinary Sciences
Urszula Radzikowska, Andrzej Eljaszewicz, Ge Tan, Nino Stocker, Anja Heider, Patrick Westermann, Silvio Steiner, Anita Dreher, Paulina Wawrzyniak, Beate Ruckert, Juan Rodriguez-Coira, Damir Zhakparov, Mengting Huang, Bogdan Jakiela, Marek Sanak, Marcin Moniuszko, Liam O'Mahony, Marek Jutel, Tatiana Kebadze, David J. Jackson, Michael R. Edwards, Volker Thiel, Sebastian L. Johnston, Cezmi A. Akdis, Milena Sokolowska
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Pawel Dubiela, Paulina Szymanska-Rozek, Andrzej Eljaszewicz, Patryk Lipinski, Piotr Hasinski, Dorota Giersz, Alicja Walewska, Marlena Tynecka, Marcin Moniuszko, Anna Tylki-Szymanska
Summary: Gaucher disease, caused by GBA1 gene variants, is characterized by hepatosplenomegaly, hematological abnormalities, and bone disease. GBA1 variants are also important risk factors for Parkinson's disease. A study investigated biomarkers for Gaucher disease and Parkinson's disease in patients receiving enzyme replacement therapy (ERT). The results showed elevated levels of alpha-synuclein mRNA in GD3 patients and L444P carriers, while GD1 patients, GBA1 carriers with unknown variants, and healthy controls had low levels of alpha-synuclein mRNA. The level of alpha-synuclein mRNA did not correlate with age in GD patients treated with ERT, except for L444P carriers.
Article
Biochemistry & Molecular Biology
Anna Helmin-Basa, Izabela Kubiszewska, Malgorzata Wiese-Szadkowska, Edyta Strzyzewska, Aleksandra Skalska-Bugala, Sara Balcerowska, Marta Rasmus, Daria Balcerczyk, Marta Pokrywczynska, Jacek Michalkiewicz, Aneta Krogulska, Adam Glowczewski, Anna Szaflarska-Poplawska
Summary: H. pylori gastritis is associated with upregulation of MMPs in the gastric mucosa. MMP-9 is overexpressed in cases where H. pylori eradication is unsuccessful. MMPs play an important role in stomach remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Cwiklinska-Jurkowska, Malgorzata Wiese-Szadkowska, Sabina Janciauskiene, Renata Paprocka
Summary: Cisplatin, a widely used anticancer drug, shows unexpected diversity in cytotoxicity values in different tumor cell lines. After reviewing data from 2018 to 2022, we found large differences between studies using the same cell line, indicating experimental heterogeneity as the main cause. The available data is therefore diverse and not suitable as a reference, and researchers are advised to conduct preliminary testing before experiments.
Review
Cell Biology
Alicja Walewska, Adrian Janucik, Marlena Tynecka, Marcin Moniuszko, Andrzej Eljaszewicz
Summary: Mesenchymal stem cells (MSC) are versatile stem cells with the ability to differentiate into multiple cell types and modulate immune responses. Epigenetic modifications play a critical role in controlling MSC differentiation.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Lukasz Bolkun, Marlena Tynecka, Alicja Walewska, Malgorzata Bernatowicz, Jaroslaw Piszcz, Edyta Cichocka, Tomasz Wandtke, Magdalena Czemerska, Agnieszka Wierzbowska, Marcin Moniuszko, Kamil Grubczak, Andrzej Eljaszewicz
Summary: Despite promising results in clinical trials, the use of immune checkpoint inhibitors (ICI) in acute myeloid leukaemia (AML) is limited. This study analysed the expression patterns of selected checkpoint proteins in AML patients and found that the expression of certain proteins was associated with the response to therapy and overall survival. Further validation through multicentre studies is needed.
Article
Multidisciplinary Sciences
Anna Helmin-Basa, Lidia Gackowska, Sara Balcerowska, Marcelina Ornawka, Natalia Naruszewicz
Summary: Innate immune cells play an important role in tumor surveillance and clearance, and harnessing their function has proven to be an effective therapy for cancer treatment. Various immunotherapeutic strategies, including pharmacological agents, vaccines, cell transfer, and oncolytic virus-based therapy, are being investigated for anti-tumor activity. This review focuses on the preclinical and clinical applications of NK cell, macrophage, and DC immunotherapy in cancer treatment.
PHYSICAL SCIENCES REVIEWS
(2022)
