Article
Microbiology
He Zhang, Wenjie Ma, Zhi Sun, Changkang Zhu, Gebremeskel Mamu Werid, Yassein M. Ibrahim, Wenli Zhang, Yu Pan, Dongfang Shi, Hongyan Chen, Yue Wang
Summary: The study suggests that specific members of gut microbiota, such as Lactobacillus, may play a role in regulating the immune response following immunization in pigs. After vaccination, the richness and diversity of gut microbial community in the high and low groups were similar, with a decrease in diversity over time. The findings indicate that gut microbial composition may impact the immune response after vaccination.
VETERINARY MICROBIOLOGY
(2021)
Review
Microbiology
Hui Han, Bao Yi, Ruqing Zhong, Mengyu Wang, Shunfen Zhang, Jie Ma, Yulong Yin, Jie Yin, Liang Chen, Hongfu Zhang
Summary: Feelings of hunger and satiety play crucial roles in maintaining life; gut microbiota have been implicated in appetite control, potentially affecting host metabolic health and leading to various metabolic disorders.
Article
Nutrition & Dietetics
Zhengjun Xie, Meng Li, Mengqi Qian, Zhiren Yang, Xinyan Han
Summary: This study aims to explore the effects of co-cultures from Lactobacillus acidophilus and Bacillus subtilis on the intestinal mucosal barrier. The results showed that FAM supplementation can increase body weight, reduce diarrhea incidence, alleviate mucosal damage, and increase the levels of tight junction proteins, serum diamine oxidase, and antimicrobial peptides. In addition, FAM supplementation also affects the composition of gut microbiota, increases the levels of beneficial bacteria and short-chain fatty acids, and enhances immune cell and SIgA production. FAM has great potential in promoting gut health.
Article
Food Science & Technology
Fangfang Min, Jielun Hu, Tao Huang, Yousheng Huang, Shaoping Nie, Tao Xiong, Mingyong Xie
Summary: L. casei NCU011054 was found to improve intestinal immune dysfunction and modulate Th1/Th2 balance via the TLRs/NF-kappa B pathway in cyclophosphamide-induced immunosuppressed mice. It increased the levels of mucin and tight junction proteins, upregulated TLRs/NF-kappa B pathway and two transcription factors, and enhanced CD4+T cell numbers. It also increased Th1- and Th2-related cytokines and remodeled gut microbiota and gut metabolites.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gengan Du, Qi Guo, Xiaohai Yan, Hong Chen, Yahong Yuan, Tianli Yue
Summary: Tibetan kefir (TK) protects the liver from ochratoxin A (OTA) induced injury by improving intestinal barriers, modulating gut microbiota and metabolites, and reducing inflammation and oxidative stress.
Article
Food Science & Technology
Xiaolan Chen, Bingyan Cai, Jing Wang, Zhicun Sheng, Haifeng Yang, Dada Wang, Jiahao Chen, Qingqing Ning
Summary: Mulberry leaf polysaccharide (MLP) can restore immune function and alleviate inflammatory response by impacting the distribution and characteristics of the gut microbiota, as well as protecting the liver from oxidative damage.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Nutrition & Dietetics
Marta Calatayud, Rosa Aragao Boerner, Jonas Ghyselinck, Lynn Verstrepen, Jelle De Medts, Pieter Van den Abbeele, Claire L. Boulange, Sarah Priour, Massimo Marzorati, Sami Damak
Summary: This research investigated the effects of water kefir on gut microbiota, epithelial barrier function, and immunomodulation using in vitro tools. Water kefir increased beneficial short-chain fatty acid production and improved gut microbiota composition, showing potential health benefits for humans.
Article
Immunology
Malin Holm Meyer-Myklestad, Asle Wilhelm Medhus, Kristina Berg Lorvik, Ingebjorg Seljeflot, Simen Hyll Hansen, Kristian Holm, Birgitte Stiksrud, Marius Troseid, Johannes Roksund Hov, Dag Kvale, Anne Margarita Dyrhol-Riise, Martin Kummen, Dag Henrik Reikvam
Summary: Restricted to the colon, enterocyte damage and mucosal immune dysfunction play a role for insufficient immune reconstitution in HIV infection independent of the gut microbiota.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Sang-Kap Han, Yeon-Jeong Shin, Dong-Yeon Lee, Kyung Min Kim, Seo-Jin Yang, Du Seong Kim, Ji-Whi Choi, Seunghun Lee, Dong-Hyun Kim
Summary: Oral administration of HDB1258 can enhance immune response by increasing NK cell cytotoxicity and macrophage phagocytosis in healthy mice, while suppressing systemic inflammation in mice with LPS-induced inflammation by modulating gut microbiota and IL-10 to TNF-alpha expression ratio in immune cells.
Article
Immunology
Maria Botia-Sanchez, Georgina Galicia, Lorena Albaladejo-Marico, Daniel Toro-Dominguez, Maria Morell, Raquel Marcos-Fernandez, Abelardo Margolles, Marta E. Alarcon-Riquelme
Summary: Systemic lupus erythematosus is an autoimmune disease that can cause intestinal inflammation, leading to changes in the intestinal barrier and gut microbiota composition, which can in turn affect the interaction between the host immune system and gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Kun-Ho Seo, Hyeon Gyu Lee, Ju Young Eor, Hye Jin Jeon, Wallace Yokoyama, Hyunsook Kim
Summary: The combination of postbiotic lactic bacteria cellular components and prebiotic wine grape seed flour can help improve gut microbiota imbalance and obesity caused by a high-fat diet. This combination has a significant impact on the composition of gut bacteria and adipocyte gene expression, which is beneficial for preventing obesity and obesity-related diseases.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Food Science & Technology
Weizhe Chen, Jie Wang, Liyu Du, Junjie Chen, Qikai Zheng, Pan Li, Bing Du, Xiang Fang, Zhenlin Liao
Summary: Kefir, a fermented food with probiotics, can regulate intestinal microbiota balance and enhance immune response to shape mucosal immunity. Its metabolites and microbial antigens can shape the mucosal immunity and regulate antibody levels to maintain intestinal homeostasis, affecting the occurrence of intestinal inflammation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Nutrition & Dietetics
Karolina Kazmierczak-Siedlecka, Giandomenico Roviello, Martina Catalano, Karol Polom
Summary: The critical roles of commensal microbes in cancer progression have been revealed, with probiotics supplementation showing potential in improving treatment efficacy, especially in gastrointestinal cancers. These bacteria exert immunomodulatory effects locally and systemically, potentially affecting immunotherapy effectiveness. More data is needed to confirm the speculation that probiotics might enhance the efficiency of immunotherapy based on PD-1/PD-L1 and CTLA-4.
Article
Biotechnology & Applied Microbiology
Mariana de Fatima Albuquerque Pereira, Larissa Gabriela Morais de Avila, Gabriela de Cassia Avila Alpino, Bruna Cristina dos Santos Cruz, Lucas Filipe Almeida, Jordana Macedo Simoes, Andressa Ladeira Bernardes, Iasmim Xisto Campos, Andrea de Oliveira Barros Ribon, Tiago Antonio de Oliveira Mendes, Maria do Carmo Gouveia Peluzio
Summary: This study analyzed the microbial community profile of milk kefir and its effects on metabolism, oxidative stress, and the microbiota-gut-brain axis in a mouse model. The results showed that kefir improved gut microbiota, increased production of short-chain fatty acids, and positively influenced brain health. Therefore, kefir has potential benefits for maintaining gut and brain health.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Yan-Xia Wei, Kui-Yang Zheng, Yu-Gang Wang
Summary: Understanding the interactions between gut microbiota and the host is crucial for treating metabolic diseases. Intestinal mucosal barrier dysfunction plays a key role in metabolic disorders, and research in this area can lead to improved therapeutic strategies.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Chemistry, Physical
Patricia A. Bolla, Agustina Sanz, Sofia Huggias, Jose F. Ruggera, Maria A. Serradell, Mnica L. Casella
MOLECULAR CATALYSIS
(2020)
Article
Immunology
Mariano Malamud, Paula Carasi, Matias H. Assandri, Teresa Freire, Bernd Lepenies, Maria de los Angeles Serradell
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Sofia Huggias, Patricia A. Bolla, Maria A. Serradell, Monica Casella, Pablo J. Peruzzo
Article
Biochemistry & Molecular Biology
Mariano Malamud, Gustavo J. Cavallero, Adriana C. Casabuono, Bernd Lepenies, Maria de los Angeles Serradell, Alicia S. Couto
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Chemistry, Applied
Sofia Huggias, Patricia A. Bolla, Julio C. Azcarate, Maria A. Serradell, Monica L. Casella, Pablo J. Peruzzo
Summary: This study synthesized platinum and silver nanoparticles dispersed on a support, demonstrating excellent catalytic activity, especially in the reduction of p-nitrophenol, with high conversion rates and recyclability. These bionanocatalysts show potential as emerging alternatives in the field of heterogeneous catalysts based on supported noble metal nanoparticles.
Article
Chemistry, Multidisciplinary
Patricia A. Bolla, Sofia Huggias, Maria A. Serradell, Jose F. Ruggera, Monica L. Casella
Article
Food Science & Technology
Maria Lucila Estilarte, E. Elizabeth Tymczyszyn, Maria de los Angeles Serradell, Paula Carasi
Summary: The study demonstrated that lactulose is the best protectant agent for preserving E. durans strains by freeze-drying, which showed resistance to high temperatures and could act as a biopreservative in food production. Additionally, E. durans strains showed potential inhibitory effects on pathogens, suggesting their suitability for developing dried symbiotic products.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Maria Dolores Pendon, Jose V. Madeira, David E. Romanin, Martin Rumbo, Andreas K. Gombert, Graciela L. Garrote
Summary: The study demonstrates that K. marxianus CIDCA 9121 efficiently ferments lactose in whey permeate to ethanol, while the remaining yeast biomass has probiotic properties, enabling an integrated process for obtaining whey protein, fuel ethanol, and probiotics from cheese whey.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Renata Curciarello, Karina E. Canziani, Ileana Salto, Emanuel Barbiera Romero, Andres Rocca, Ivan Doldan, Emmanuel Peton, Santiago Brayer, Alicia M. Sambuelli, Silvina Goncalves, Pablo Tirado, Gustavo J. Correa, Martin Yantorno, Laura Garbi, Guillermo H. Docena, Maria de los Angeles Serradell, Cecilia I. Muglia
Summary: This study found that Lactobacillus kefiri has immunomodulatory effects on intestinal T cells from patients with IBD, reducing inflammation and increasing the frequency of regulatory T cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Developmental Biology
Maria Silvia Ventimiglia, Natalin Jimena Valeff, Marlon Pozo Alban, Juan Manuel Paturlanne, Lorena Juriol, Florencia Quadrana, Martina Cecotti, Mariano Malamud, Marcos Javier Dibo, Maria de Los Angeles Serradell, Federico Jensen
Summary: The study evaluated the preventive effect of probiotic Lactobacillus kefiri on preterm birth in mice, showing a significant reduction in LPS-induced preterm birth and stillbirth rates, as well as improvements in postnatal development. This protective effect was associated with reduced inflammation-induced damage, decreased leucocyte infiltration, and modulation of vaginal microbiota diversity.
Review
Microbiology
P. Carasi, M. Malamud, M. A. Serradell
Summary: L. kefiri is a main lactic acid bacteria species from kefir and other fermented foods, with potential probiotic properties and health benefits. Many strains lack transmissible antibiotic resistance genes, tolerate harsh gastrointestinal conditions, exhibit antimicrobial activity, immunomodulatory effects, and beneficial metabolic effects.
CURRENT MICROBIOLOGY
(2022)
Article
Critical Care Medicine
Leandro Emmanuel Vecchio Dezillio, David Emmanuel Romanin, Ivana Mariel Ivanoff Marinoff, Julieta Vernengo, Juan Cruz Abate Zarate, Mariana Alejandra Machuca, Gabriel Eduardo Gondolesi, Natalia Raquel Lausada, Pablo Luis Stringa, Martin Rumbo
Summary: This study compared the effects of NE and DA on intestinal graft quality in a rat brain-dead donation model. The results favor the use of DA to manage hemodynamic instability associated with brain death, as it may contribute to improving the quality of the intestinal graft.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Veterinary Sciences
Juan Cruz Abate, Natalia Lausada, Leandro Vecchio Dezillio, Jeremias Moreira, Ivana Ivanoff Marinoff, Maria Malena Ferreyra Compagnucci, Ane Miren Andres Moreno, Carlota Largo, Martin Rumbo, Francisco Hernandez Oliveros, David Romanin, Pablo Stringa
Summary: In order to reduce and refine the use of animals in disease research, we have developed and applied a new surgical technique in the field of intestinal research. This technique has successfully reduced the number of animals used and improved the overall success and clinical recovery rate of the surgical procedures.
LABORATORY ANIMALS
(2023)
Article
Microbiology
Matias H. Assandri, Mariano Malamud, Fernando M. Trejo, Maria de los A. Serradell
Summary: In bacteria, surface compounds interact with host cells through pattern recognition receptors, triggering cellular responses and immunomodulation. The S-layer is a macromolecular structure formed by (glyco)-protein subunits on the surface of bacteria and archaea. S-layer proteins (SLPs) play a crucial role in the interaction between bacterial cells and the immune system. The presence of S-layer can differ between pathogenic and non-pathogenic bacteria, with potential implications for virulence and therapeutic targeting. Understanding the role of SLPs in the interaction between host immune cells and bacteria is important for studying commensal microbiota and probiotics.
CURRENT RESEARCH IN MICROBIAL SCIENCES
(2023)