Article
Fisheries
Emmanuelle Moreau, Lionel Pineau, Florine Bachelet, Antoine Rostang, Kenny Oberle, Segolene Calvez
Summary: This study aimed to develop a method of infectious challenge in large Rainbow trout by immersion, simulating natural infection conditions. The results showed that a 24-hour contact period led to infection in all fish with a mortality rate of 53.25%. The infected fish developed acute infection symptoms and lesions similar to furunculosis, and antibodies against the bacterium were produced 4 weeks after challenging compared to the non-challenged group.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Jin Woo Jun, Jeong Woo Kang, Sib Sankar Giri, Sang Wha Kim, Sang Guen Kim, Jun Kwon, Sung Bin Lee, Won Joon Jung, Young Min Lee, Su Jin Jo, Se Chang Park
Summary: This study investigated the effect of a starch hydrogel-based oral vaccine on rainbow trout's antibody reactivity, immune-related genes expression, and protection against furunculosis infection. The results showed that the vaccine increased the agglutination titers and improved the survival rate of fish. Furthermore, the expression of immune-related genes was altered after vaccination.
Article
Immunology
Jongwon Lim, Suhee Hong
Summary: This study aimed to identify molecular mechanisms affected by a combined vaccine against Aeromonas salmonicida and Vibrio anguillarum. The vaccine upregulated gene expression associated with adaptive immune response markers and triggered differential expression of hundreds of genes on different days. Gene ontology and Kyoto Encyclopedia of Genetic and Genomic analyses identified immune system-related pathways and processes affected by the vaccine. Protein-protein interaction analysis revealed TNF as the central player in immune-related responses at different time points.
Article
Biochemistry & Molecular Biology
Mengqun Liu, Xiaodong Yang, Chu Zeng, Hongkui Zhao, Jifang Li, Zhishuai Hou, Haishen Wen
Summary: Rainbow trout is an important commercial fish, but infectious diseases can cause significant economic losses. Our study reveals the pathophysiological responses of the brain and kidney in rainbow trout infected with furunculosis, including neuroinflammation, neural dysfunction, and immunomodulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Fisheries
Yongji Dang, Yanling Sun, Yangen Zhou, Xianhui Men, Bowen Wang, Bing Li, Yichao Ren
Summary: This study evaluated the effects of probiotics on growth, immune response, and susceptibility to bacterial infection in rainbow trout. The results showed that probiotics promoted weight gain and resistance to bacterial infection in rainbow trout. Different Toll-like receptors were involved in the recognition of beneficial bacteria, and probiotics enhanced the innate immune function of rainbow trout by training immune response pathways.
Article
Fisheries
Baoliang Bi, Yin Yuan, Dan Jia, Wansheng Jiang, Hui Yan, Gailing Yuan, Yu Gao
Summary: In Yunnan Province, China, a group of farmed rainbow trout died from a suspected infection. The pathogens isolated from the infected trout were identified as Acinetobacter johnsonii. The experimentally infected fish showed similar symptoms to naturally infected fish, with vacuolar degeneration observed in the liver and spleen.
AQUACULTURE RESEARCH
(2023)
Article
Fisheries
Rebecca A. Dupre, Ryan Ardoin, Jesse Trushenski, Chris Jackson, Casey Grimm, Brennan Smith
Summary: The present research demonstrates that dietary exposure is an alternative route of geosmin uptake in Rainbow Trout fillets, leading to a significant increase in geosmin concentrations. This finding is important for further investigation of sensory quality and off-flavor mitigation strategies for farm-raised fish.
Article
Immunology
Valerie Cornet, Trinh Dinh Khuyen, Syaghalirwa N. M. Mandiki, Stephane Betoulle, Peter Bossier, Felipe E. Reyes-Lopez, Lluis Tort, Patrick Kestemont
Summary: Beta-glucans, prebiotic and/or food additives used in aquaculture, have varying effects on fish immune response and disease resistance. Gas1 beta-glucan may be more efficient in enhancing immunity and preventing diseases compared to other types already in use.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Felix Docando, Paula Arense, Alba Martin-Martin, Tiehui Wang, Carolina Tafalla, Patricia Diaz-Rosales
Summary: Disease prevention through vaccination is the most appropriate method for pathogen control in aquaculture, but oral vaccines face technical problems in aquatic animals. This study explores different molecules as oral adjuvants and finds that LPS shows strong immunostimulatory potential and could be safely used as a mucosal adjuvant in rainbow trout.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kamil Uney, Duygu Durna Corum, Ertugrul Terzi, Orhan Corum
Summary: This study investigated the pharmacokinetics of carprofen in rainbow trout broodstock via intravenous, intramuscular, and oral routes, showing favorable properties such as good bioavailability and long elimination half-life for the drug when administered via intramuscular and oral routes.
Article
Fisheries
Yelehi Diane Ahongo, Thierry Kerneis, Lionel Goardon, Laurent Labbe, Jerome Bugeon, Pierre-Yves Rescan, Florence Lefevre
Summary: The study examined the changes in technological and organoleptic qualities of female rainbow trout flesh after spawning and found that fillet quality gradually recovered over a period of approximately 24 weeks post-spawning. By around 1400 degree C.days after spawning, the quality parameters of the flesh were mostly restored to pre-spawning levels.
Article
Environmental Sciences
N. Hodkovicova, A. Hollerova, H. Caloudova, J. Blahova, A. Franc, M. Garajova, J. Lenz, F. Tichy, M. Faldyna, P. Kulich, J. Mares, R. Machat, V. Enevova, Z. Svobodova
Summary: The study showed that PE microparticles have toxic effects on rainbow trout, affecting various health indices such as intestinal disintegration, changes in blood indices, and damage to liver and kidney. This findings raise concerns about potential threat to aquatic ecosystems and human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Elham Alsadat Banihashemi, Siyavash Soltanian, Amin Gholamhosseini, Mahdi Banaee
Summary: This study suggests that exposure to MPs and simultaneous challenge with Y. ruckeri could synergistically affect clinical parameters in fish.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Fisheries
Yue Cong Yang, Shan Nan Chen, Zhen Gan, Lin Huang, P. Nie
Summary: The study characterized an IRAK1 orthologue from rainbow trout, showing highly conserved features among different species and suggesting a key role in immune response.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Microbiology
Ana Fernandez-Bravo, Vicente Vega-Sanchez, Alba Perez-Cataluna, Fadua Latif-Eugenin, Roxana Beaz-Hidalgo, Antonio Martinez-Murcia, Edgardo Soriano-Vargas, Omar Alejandro Cabrero-Martinez, Graciela Castro-Escarpulli, Maria Jose Figueras
Summary: This study identified a new strain of Aeromonas lusitana (ESV-351) isolated from a rainbow trout, and compared its phenotypic characteristics, antimicrobial resistance profiles, and virulence genes with the five previously described strains of the species. The genomic analysis revealed a potential capacity for environmental adaptation and suggested a possible virulence role for the citrate synthase gene in A. lusitana (ESV-351).
Article
Immunology
Mikolaj Adamek, Marek Matras, Alexander Rebl, Magdalena Stachnik, Alberto Falco, Julia Bauer, Anne-Carina Miebach, Felix Teitge, Verena Jung-Schroers, Muhammad Abdullah, Torben Krebs, Lars Schroeder, Walter Fuchs, Michal Reichert, Dieter Steinhagen
Summary: Vaccination is the best way to protect fish from viral diseases. Live attenuated virus vaccines have shown to be most effective. This study demonstrates that vaccination with a live attenuated virus can enhance fish immune responses and protect against severe disease caused by a specific pathogen.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Justin T. H. Chan, Safwen Kadri, Bernd Koellner, Alexander Rebl, Tomas Korytar
Summary: The immune system is a complex biological system that has been traditionally studied using conventional methods. The development of single-cell transcriptomics has provided unprecedented opportunities to understand the diversity and interactions of immune cells, particularly in teleost fishes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Mikolaj Adamek, Alexander Rebl, Marek Matras, Christian Lodder, Sahar El Rahman, Magdalena Stachnik, Krzysztof Rakus, Julia Bauer, Alberto Falco, Verena Jung-Schroers, Chutchai Piewbang, Somporn Techangamsuwan, Win Surachetpong, Michal Reichert, Jens Tetens, Dieter Steinhagen
Summary: The emergence of viral diseases in fish, such as tilapia lake virus (TiLV), can cause high mortality and disrupt aquaculture production. A study found that different genetic strains of tilapia have varying levels of resistance to TiLV, with one strain exhibiting a survival rate of nearly 100%. The resistant strain showed lower viral loads and pro-inflammatory responses, suggesting that a stronger antiviral response and reduced pathology contribute to its resistance. These findings suggest the possibility of using TiLV-resistant strains as a cost-effective solution, but integrated measures of biosecurity, diagnostics, and vaccination should still be employed.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Carolin Lisa Michaela Ludwig, Simon Bohleber, Alexander Rebl, Eva Katrin Wirth, Marzia Tindara Venuto, Martina Langhammer, Ulrich Schweizer, Joachim M. Weitzel, Marten Michaelis
Summary: The Dummerstorf high-fertility mouse line FL1, with its doubled offspring per litter, has superior lifetime fecundity compared to the unselected control line. This study aims to characterize FL1 on endocrine and molecular levels and found changes in hormone and transcriptional levels that may be associated with their increased reproductive performance.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2022)
Article
Fisheries
Trine Ytrestoyl, Elise Hjelle, Jelena Kolarevic, Harald Takle, Alexander Rebl, Sergey Afanasyev, Aleksei Krasnov, Per Brunsvik, Bendik Fyhn Terjesen
Summary: The production of Atlantic salmon smolts in recirculation aquaculture systems (RAS) is growing, and the use of continuous light has been shown to have positive effects on growth rate. However, continuous light may reduce feed intake and growth during the initial stage in seawater. Fish exposed to continuous light have a larger size at slaughter compared to those given a winter signal. The best performing group is the control group transferred at 100 g.
JOURNAL OF THE WORLD AQUACULTURE SOCIETY
(2023)
Article
Genetics & Heredity
Hege Lund, Anne Bakke, Preben Boysen, Sergey Afanasyev, Alexander Rebl, Farah Manji, Gordon Ritchie, Aleksei Krasnov
Summary: The assessment of immune competence in farmed Atlantic salmon during smoltification and early sea life is crucial. Recent tools were used to analyze gene expression, antibody levels, and IgM transcripts in salmon from different farming systems. The study found differences in immune gene expression and antibody levels between the two cohorts, suggesting a more agitated immune system in RAS-raised salmon initially, but leveling off over time.
Article
Reproductive Biology
Carolin Lisa Michaela Ludwig, Simon Bohleber, Rebecca Lapp, Alexander Rebl, Eva Katrin Wirth, Martina Langhammer, Ulrich Schweizer, Joachim M. M. Weitzel, Marten Michaelis
Summary: The development and maturation of ovarian follicles is a complex and highly regulated process, which is essential for successful ovulation. The FL1 mouse model, a unique selection experiment for increased female reproductive performance, provides insights into the regulation of folliculogenesis.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Environmental Sciences
Marc-Christopher Hildebrand, Alexander Rebl, Julien Alban Nguinkal, Harry Wilhelm Palm, Bjoern Bassmann
Summary: Fingerlings and juveniles of African catfish were reared under experimental conditions and exposed to different concentrations of Fe-DTPA. Various factors such as growth, behavior, immune response, histopathological changes, and genetic biomarkers were evaluated. The results indicate that Fe-DTPA supplementation at the tested concentrations is relatively harmless for the health and welfare of African catfish.
Article
Biochemistry & Molecular Biology
Doret R. van Muilekom, Bertrand Collet, Henrike Rebl, Kristina Zlatina, Fabio Sarais, Tom Goldammer, Alexander Rebl
Summary: NF-kappa B signaling is controlled by the family of 'inhibitors of NF-kappa B' (I kappa B). Rainbow trout genome contains multiple gene copies coding for different I kappa B proteins, except for two types. The expression levels of these genes vary, suggesting their involvement in immune-regulatory processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Justin T. H. Chan, Amparo Picard-Sanchez, Jovana Majstorovic, Alexander Rebl, Dirk Koczan, Filip Dycka, Astrid S. Holzer, Tomas Korytar
Summary: The presence of pathogen antibodies on red blood cells of infected rainbow trout indicates that red blood cells play a larger role in host immunity than previously appreciated.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Volker Roettgen, Lisa-Maria Tuemmler, Dirk Koczan, Alexander Rebl, Bjoern Kuhla, Jens Vanselow, Anja Baufeld
Summary: This study analyzed the effects of milk replacer feeding on the number and gene expression characteristics of granulosa cells in cattle. The results showed that the number of granulosa cells in puberty was not affected by the number of follicles in the group fed less milk replacer, while in the group fed more milk replacer, the number of granulosa cells increased with the number of follicles. The gene expression analysis revealed that feeding different milk replacers can affect immune response pathways.
Article
Fisheries
Bjoern Bassmann, Lisa Hahn, Alexander Rebl, Lisa Carolina Wenzel, Marc-Christopher Hildebrand, Marieke Verleih, Harry Wilhelm Palm
Summary: This study investigated the effects of different stocking densities (semi-intensive, intensive, and super-intensive) on the growth and welfare of African catfish. The results showed that the semi-intensively stocked fish had the highest weight, while the super-intensively stocked fish had the lowest weight. The management of stocking densities should be carefully considered to avoid external stressors.
Article
Fisheries
Tatyana Gebauer, Radek Gebauer, Petr Cisar, Jan Cerny, Deepali Rahi Roy, Mahyar Zare, Marieke Verleih, Vlastimil Stejskal, Alexander Rebl
Summary: The sensitivity to stress and its impact on immunity are related to a fish's personality. This study found clear differences between shy and bold individuals in a European perch population, based on cognitive tests. Shy individuals exhibited frozen activity and lower explorative behavior, as well as higher cortisol levels. Gene expression analysis showed modest differences between stimulated bold and shy perch, indicating a link between fish personality and immune-defense strategy. This research has implications for future selective breeding programs.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Meeting Abstract
Fisheries
Doret Van Muilekom, Bertrand Collet, Henrike Rebl, Kristina Zlatina, Fabio Sarais, Tom Goldammer, Alexander Rebl
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)