Article
Oncology
Snehanshu Chowdhury, Anwesha Kar, Debaleena Bhowmik, Anupam Gautam, Debashree Basak, Ishita Sarkar, Puspendu Ghosh, Deborpita Sarkar, Alvina Deka, Paramita Chakraborty, Asima Mukhopadhyay, Shikhar Mehrotra, Soumen Basak, Sandip Paul, Shilpak Chatterjee
Summary: IL-12 stimulation increases intracellular acetyl CoA levels in CD8(+) T cells, allowing them to maintain effector function in nutrient-deprived tumor microenvironments. Inhibition of ATP-citrate lyase, an enzyme involved in the glucose-citrate-acetyl CoA pathway, impairs IFN gamma production and viability of CD8(+) T cells in nutrient-restricted conditions. CD8(+) T cells cultured in high pyruvate-containing media acquire metabolic features of IL-12-stimulated CD8(+) T cells and display improved antitumor potential.
Article
Neurosciences
Tugberk Kaya, Nicola Mattugini, Lu Liu, Hao Ji, Ludovico Cantuti-Castelvetri, Jianping Wu, Martina Schifferer, Janos Groh, Rudolf Martini, Simon Besson-Girard, Seiji Kaji, Arthur Liesz, Ozgun Gokce, Mikael Simons
Summary: This study identified age-related alterations of oligodendrocyte cell state in aging murine white matter and found interferon (IFN)-responsive oligodendrocytes in proximity to CD8(+) T cells. Functional lymphocytes were shown to influence the number of IFN-responsive oligodendrocytes, with T-cell checkpoint inhibition exacerbating the aging response.
NATURE NEUROSCIENCE
(2022)
Article
Immunology
Caylin G. Winchell, Sarah K. Nyquist, Michael C. Chao, Pauline Maiello, Amy J. Myers, Forrest Hopkins, Michael Chase, Hannah P. Gideon, Kush V. Patel, Joshua D. Bromley, Andrew W. Simonson, Roisin Floyd-O'Sullivan, Marc Wadsworth, Jacob M. Rosenberg, Rockib Uddin, Travis Hughes, Ryan J. Kelly, Josephine Griffo, Jaime Tomko, Edwin Klein, Bonnie Berger, Charles A. Scanga, Joshua Mattila, Sarah M. Fortune, Alex K. Shalek, Philana Ling Lin, JoAnne L. Flynn
Summary: The functional role of CD8(+) lymphocytes in tuberculosis is not well understood. Depleting innate and/or adaptive CD8(+) lymphocytes in macaques revealed that the loss of all CD8 alpha+ cells significantly impaired early control of Mycobacterium tuberculosis (Mtb) infection, leading to increased granulomas, lung inflammation, and bacterial burden. Depletion of all CD8(+) lymphocytes allowed increased establishment of Mtb in the lungs and dissemination within lungs and lymph nodes, while depletion of only adaptive CD8(+) T cells worsened bacterial control in lymph nodes. The study highlights the essential role of CD8(+) lymphocytes in early protection against Mtb and suggests polyfunctional cytotoxic responses as a potential vaccine target.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Cell Biology
Ahto Salumets, Liina Tserel, Anna P. Rumm, Lehte Turk, Kulli Kingo, Kai Saks, Astrid Oras, Raivo Uibo, Riin Tamm, Hedi Peterson, Kai Kisand, Part Peterson
Summary: Age-related changes in T-cell populations play an important role in immunosenescence. CD8(+) TEMRA cells and their subsets have characteristics of cellular senescence and increase in older individuals and age-related chronic inflammatory diseases. CD8(+) TEMRA proportions correlate with cytomegalovirus (CMV) antibody levels but not with chronological age. TRANCE/RANKL levels are associated with differentiated T-cell populations, including CD8(+) TEMRA and its CD28(-) subsets. Deep-amplicon bisulfite sequencing can be used to predict CD8(+) TEMRA cell proportions as a biomarker of immunosenescence.
Article
Multidisciplinary Sciences
Louise Malle, Roosheel S. Patel, Marta Martin-Fernandez, O'Jay Stewart, Quentin Philippot, Sofija Buta, Ashley Richardson, Vanessa Barcessat, Justin Taft, Paul Bastard, Julie Samuels, Clotilde Mircher, Anne-Sophie Rebillat, Louise Maillebouis, Marie Vilaire-Meunier, Kevin Tuballes, Brad R. Rosenberg, Rebecca Trachtman, Jean-Laurent Casanova, Luigi D. Notarangelo, Sacha Gnjatic, Douglas Bush, Dusan Bogunovic
Summary: Individuals with Down's syndrome (DS) exhibit multiple impairments such as cardiac, neurocognitive, and growth issues. They are also prone to severe infections and autoimmune disorders. This study reveals an autoimmune-prone state in DS characterized by persistent elevation of cytokines, chronic activation of CD4 T cells, and ongoing B cell activation. Furthermore, auto-antibodies targeting various organs and systems were detected in DS individuals' plasma, suggesting a breach in immune tolerance.
Article
Cell Biology
A. Helena Jonsson, Fan Zhang, Garrett Dunlap, Emma Gomez-Rivas, Gerald F. M. Watts, Heather J. Faust, Karishma Vijay Rupani, Joseph R. Mears, Nida Meednu, Runci Wang, Gregory Keras, Jonathan S. Coblyn, Elena M. Massarotti, Derrick J. Todd, Jennifer H. Anolik, Andrew McDavid, Kevin Wei, Deepak A. Rao, Soumya Raychaudhuri, Michael B. Brenner
Summary: CD8 T cells play a significant role in the pathogenesis of rheumatoid arthritis by producing pro-inflammatory cytokines. These CD8 T cells are abundant in synovial tissue and belong to an effector population characterized by high expression of granzyme K and low expression of granzyme B and perforin. They are clonally expanded in synovial tissues and maintain their characteristics in blood, suggesting their enrichment in tissues. They also exist in other tissues and diseases, indicating their role as tissue-associated T cells.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Esmee K. van der Ploeg, Lisette Krabbendam, Heleen Vroman, Menno van Nimwegen, Marjolein J. W. de Bruijn, Geertje M. de Boer, Ingrid M. Bergen, Mirjam Kool, Gerdien A. Tramper-Standers, Gert-Jan Braunstahl, Danny Huylebroeck, Rudi W. Hendriks, Ralph Stadhouders
Summary: CD8+ cytotoxic T cells can also produce type-2 cytokines in severe asthma patients, and their abundance is associated with increased disease burden, higher exacerbation rates, and steroid insensitivity. The type-2 skewing of lung Tc cells in asthma is controlled by conventional type-1 dendritic cells and IFN gamma. Interleukin-33 (IL-33) critically promotes type-2 cytokine production by lung Tc cells in experimental allergic airway inflammation.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Yi Cai, Yejun Wang, Chenyan Shi, Youchao Dai, Fuxiang Li, Yuzhong Xu, Peize Zhang, Fanhui Kong, Guofang Deng, Zhihua Wen, Qi Zhou, Boxi Chris Kang, Amit Singhal, Qianting Yang, Carl G. Feng, Xinchun Chen
Summary: The study reveals the landscape of local T cell immunity in tuberculosis and provides insights into the involvement of specific T cell populations in the pathogenesis of tuberculous pleural effusion (TPE). The findings suggest a link between clonal expansion of Granzyme K-expressing CD8 T cells and TPE.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Zeyu Wang, Ziyu Dai, Hao Zhang, Xisong Liang, Xun Zhang, Zhipeng Wen, Peng Luo, Jian Zhang, Zaoqu Liu, Mingyu Zhang, Quan Cheng
Summary: In this study, lactate was found to contribute to the immune suppressive microenvironment in glioblastoma through RNA sequencing and machine learning algorithms. High levels of lactate can affect the migration and infiltration of CD8 T cells in glioblastoma.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Heleen H. Van Acker, Shixin Ma, Tommaso Scolaro, Susan M. Kaech, Massimiliano Mazzone
Summary: In the tumor microenvironment, CD8+ T cells face competition for metabolic resources from cancer cells, leading to impaired epigenetic mechanisms and functional limitations. This study discusses the impact of glucose/amino acid deficiency and elevated ROS levels in the TME on DNA methylation and histone modifications in CD8+ T cells, as well as the translational potential of epigenetic interventions to enhance current immunotherapeutic strategies.
TRENDS IN IMMUNOLOGY
(2021)
Article
Immunology
Chen Yao, Guohua Lou, Hong-Wei Sun, Ziang Zhu, Yi Sun, Zeyu Chen, Daniel Chauss, E. Ashley Moseman, Jun Cheng, Marc A. D'Antonio, Wangke Shi, Junwei Shi, Kohei Kometani, Tomohiro Kurosaki, E. John Wherry, Behdad Afzali, Luca Gattinoni, Yuwen Zhu, Dorian B. McGavern, John J. O'Shea, Pamela L. Schwartzberg, Tuoqi Wu
Summary: The study shows that the transcriptional repressor BACH2 is crucial early after chronic viral infection in influencing CD8(+) T cells, enforcing a stem-like fate and suppressing the formation of exhausted cells.
Article
Multidisciplinary Sciences
Aenne Harberts, Constantin Schmidt, Joanna Schmid, Daniel Reimers, Friedrich Koch-Nolte, Hans-Willi Mittruecker, Friederike Raczkowski
Summary: IRF4 is essential for the activation and reactivation of CD8(+) memory T cells, but does not affect their overall survival. However, the formation and maintenance of CD8(+) tissue-resident memory T cells appears to depend on IRF4.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
David R. Collins, Jonathan M. Urbach, Zachary J. Racenet, Umar Arshad, Karen A. Power, Ruchi M. Newman, Geetha H. Mylvaganam, Ngoc L. Ly, Xiaodong Lian, Anna Rull, Yelizaveta Rassadkina, Adrienne G. Yanez, Michael J. Peluso, Steven G. Deeks, Francesc Vidal, Mathias Lichterfeld, Xu G. Yu, Gaurav D. Gaiha, Todd M. Allen, Bruce D. Walker
Summary: Selective functional impairment of HIV-specific CD8(+) T cells may be prognostic of aborted HIV control.
Article
Immunology
Hsiao-Wei Tsao, James Kaminski, Makoto Kurachi, R. Anthony Barnitz, Michael A. DiIorio, Martin W. LaFleur, Wataru Ise, Tomohiro Kurosaki, E. John Wherry, W. Nicholas Haining, Nir Yosef
Summary: This study investigated the role of the basic leucine zipper ATF-like transcription factor Batf in the response of naive CD8(+) T cells to their cognate antigen. It was found that Batf cooperates with transcription factors such as Irf4, Runx3, and T-bet, to regulate the accessibility, interactions, and expression of key regulatory regions, with implications for T cell function.
SCIENCE IMMUNOLOGY
(2022)
Article
Cell Biology
Paolo Strati, Xubin Li, Qing Deng, Mario L. Marques-Piubelli, Jared Henderson, Grace Watson, Laurel Deaton, Taylor Cain, Haopeng Yang, Vida Ravanmehr, Luis E. Fayad, Swaminathan P. Iyer, Loretta J. Nastoupil, Frederick B. Hagemeister, Edwin R. Parra, Neeraj Saini, Koichi Takahashi, Nathan H. Fowler, Jason R. Westin, Raphael E. Steiner, Ranjit Nair, Christopher R. Flowers, Linghua Wang, Sairah Ahmed, Gheath Al-Atrash, Francisco Vega, Sattva S. Neelapu, Michael R. Green
Summary: Autologous anti-CD19 CAR T therapy shows high effectiveness in rrLBCL, but its toxicities result in delayed recovery. The pathophysiology of prolonged cytopenia after CAR T infusion is poorly understood. Single-cell RNA sequencing reveals that clonally expanded CX3CR1(hi) cytotoxic T cells with high IFN-g and cytokine signaling are associated with prolonged cytopenia, suggesting a potential mechanism-based approach for its treatment.
CELL REPORTS MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Deborah Delbue, Bruna S. Mendonca, Marcela C. Robaina, Lauana G. T. Lemos, Pedro Lucena, Joao P. B. Viola, Lidia M. Magalhaes, Susanne Crocamo, Caio A. B. Oliveira, Felipe R. Teixeira, Raquel C. Maia, Gabriela Nestal de Moraes
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2020)
Article
Cell Biology
Patricia S. de Araujo-Souza, Steffi C. H. Hanschke, Ana Flavia F. R. Nardy, Cristiane Secca, Barbara Oliveira-Vieira, Karina L. Silva, Sheila C. Soares-Lima, Joao P. B. Viola
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Andreia C. de Melo, Luiz C. S. Thuler, Jesse L. da Silva, Lucas Z. de Albuquerque, Ana C. Pecego, Luciana de O. R. Rodrigues, Magda S. da Conceicao, Marianne M. Garrido, Gelcio L. Quintella Mendes, Ana Cristina P. Mendes Pereira, Marcelo A. Soares, Joao P. B. Viola
Article
Pathology
Adhemar Longatto-Filho, Jose Humberto Fregnani, Allini Mafra da Costa, Patricia Savio de Araujo-Souza, Cristovam Scapulatempo-Neto, Suellen Herbster, Enrique Boccardo, Lara Termini
Summary: The study found that PI3/Elafin expression is consistently downregulated in CC samples, with protein expression at the cell membrane being more frequent and gradually lost during CC progression. Advanced stages of CC are often associated with a more intense PI3/Elafin reaction in the nuclei and cytoplasm.
Article
Oncology
Saloe Bispo, Ticiana D. J. Farias, Patricia Savio de Araujo-Souza, Ricardo Cintra, Hellen Geremias dos Santos, Natasha Andressa Nogueira Jorge, Mauro Antonio Alves Castro, Gabriel Wajnberg, Nicole de Miranda Scherer, Maria Luiza Nogueira Dias Genta, Jesus Paula Carvalho, Luisa Lina Villa, Laura Sichero, Fabio Passetti
Summary: SCC and ADC are the most common histological types of cervical cancer, with ADC showing a worse prognosis. Molecular characterization revealed unique pathways for each histological type, such as epithelial maintenance in SCC and the MODY pathway in ADC. This study identified potential transcription factor networks associated with these pathways, which could be explored for more efficient diagnostic tools.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ana Carolina Rodrigues, Douglas Adamoski, Gustavo Genelhould, Felipe Zhen, Guilherme Eiji Yamaguto, Patricia Savio Araujo-Souza, Meri Bordignon Nogueira, Sonia Mara Raboni, Ana Claudia Bonatto, Daniela Fiori Gradia, Jaqueline Carvalho de Oliveira
Summary: This study investigated the expression of lncRNAs in saliva and nasopharyngeal samples of COVID-19 patients for the first time, finding higher expression of NEAT1 and MALAT1 in positive samples, providing new insights into the initial response to infection and infectivity.
MOLECULAR ORAL MICROBIOLOGY
(2021)
Article
Cell Biology
Leticia Boslooper Goncalves, Patricia Pinho de Franca, Natalia Angelica Petry, Marina Barbara de Souza Xavier, Newton Sergio de Carvalho, Maria da Graca Bicalho, Angelica Beate Winter Boldt, Patricia Savio de Araujo-Souza
Summary: This study found that HLA-DRB1*13:01 is associated with protection against CIN II/III, while HLA-C*03:04 may increase susceptibility. By examining the association between HLA and amino acid residues with cervical cancer, a better understanding of genetic risk and immune response to CC development can be achieved.
Editorial Material
Cell Biology
Jessica Tavares, Natalia A. Petry, Jose Samuel da Silva, Maria da Graca Bicalho, Patricia Savio de Araujo-Souza
Summary: This study identified 12 novel HLA class I and II alleles in Brazilian bone marrow donors.
Article
Cell Biology
Esdras Matheus Gomes da Silva, Leticia Graziela Costa Santos, Flavia Santiago de Oliveira, Flavia Cristina de Paula Freitas, Vinicius da Silva Coutinho Parreira, Hellen Geremias dos Santos, Raphael Tavares, Paulo Costa Carvalho, Ana Gisele da Costa Neves-Ferreira, Andrea Siqueira Haibara, Patricia Savio de Araujo-Souza, Adriana Abalen Martins Dias, Fabio Passetti
Summary: Using a proteogenomics strategy, this study identified orthologous AS proteoforms between humans and mice. Identical proteotypic peptides of six orthologous AS proteoforms were found in both species and validated at the transcript level. Additionally, higher abundances of certain proteoforms were detected in an AD mouse model, suggesting a potential role in amyloid-like aggregate formation. This study provides valuable insights for future neurodegenerative disease research using mouse models.
Review
Engineering, Chemical
Fernanda Costa Brandao Berti, Sara Cristina Lobo-Alves, Camila de Freitas Oliveira-Tore, Amanda Salviano-Silva, Karen Brajao de Oliveira, Patricia Savio de Araujo-Souza, Jong Kook Park, Gabriel Adelman Cipolla, Danielle Malheiros
Summary: MicroRNAs regulate gene expression by binding to target mRNAs, while interacting in competitive ceRNA networks. Long noncoding RNAs play essential roles in cervical cancer, impacting cell processes by modulating miRNA sponging. This dynamic molecular interaction affects cell growth, proliferation, apoptosis, and adhesion in CC.
Article
Biochemistry & Molecular Biology
Fernanda Costa Brandao Berti, Carolina Mathias, Leandro Encarnacao Garcia, Daniela Fiori Gradia, Patricia Savio de Araujo-Souza, Gabriel Adelman Cipolla, Jaqueline Carvalho de Oliveira, Danielle Malheiros
Summary: Research suggests that XIST plays a crucial role in HPV-mediated cervical cancer, potentially implicating different molecular signatures between HPV16 and HPV18-associated tumors. XIST regulates cellular functions by co-expressing with multiple lncRNA-mRNA pairs and sharing miRNAs, impacting biological effects.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Environmental Sciences
Isisdoris Rodrigues de Souza, Patricia Savio de Araujo-Souza, Daniela Morais Leme
Summary: The skin can be affected by exposure to chemicals, leading to immune-mediated dermal disorders. The differences in individual susceptibility to chemical-induced skin immune reactions are associated with genetic variations. Understanding the genetic variants that influence skin immunotoxicity can help reduce uncertainties in estimating chemical hazards and risks to human health in the future.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2022)
Article
Infectious Diseases
Gustavo Genelhoud, Douglas Adamoski, Regiane Nogueira Spalanzani, Lucas Bochnia-Bueno, Jaqueline Carvalho de Oliveira, Daniela Fiori Gradia, Ana Claudia Bonatto, Roseli Wassem, Sonia Mara Raboni, Meri Bordignon Nogueira, Patricia Savio de Araujo-Souza
Summary: The study compared the efficiency of nasopharyngeal swabs with saliva and gargle samples in detecting SARS-CoV-2, and found that saliva performed similarly to nasopharyngeal samples as a reliable source of viral RNA.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2022)
Article
Virology
Valeria Bumiller-Bini Hoch, Ana Flavia Kohler, Danillo G. Augusto, Sara Cristina Lobo-Alves, Danielle Malheiros, Gabriel Adelman Cipolla, Angelica Beate Winter Boldt, Karin Braun-Prado, Michael Wittig, Andre Franke, Claudia Pfohler, Margitta Worm, Nina van Beek, Matthias Goebeler, Miklos Sardy, Saleh Ibrahim, Hauke Busch, Enno Schmidt, Jennifer Elisabeth Hundt, Patricia Savio de Araujo-Souza, Maria Luiza Petzl-Erler
Summary: This study identified 12 variants within 11 genes associated with differential susceptibility to endemic pemphigus foliaceus (EPF), highlighting the potential impact on viral control mechanisms. Additionally, increased levels of CCL5, P4HB, and APOBEC3G mRNA in CD4+ T lymphocytes of EPF patients support the viral trigger hypothesis.
Article
Infectious Diseases
Patricia Savio de Araujo-Souza, Mariam El-Zein, Aline do N. Bolpetti, Paulo Cesar Maciag, Tatiana Rabachini, Eduardo L. Franco, Luisa L. Villa
Summary: A study in Brazilian women found that human leukocyte antigen polymorphisms may influence the natural history of human papillomavirus infections, suggesting that genetic factors play a role in the risk of cervical neoplasia.
SEXUALLY TRANSMITTED DISEASES
(2023)
