Article
Biochemistry & Molecular Biology
Pedro P. C. de Souza, Petra Henning, Ulf H. Lerner
Summary: Oncostatin M (OSM) is a potent stimulator of osteoclast formation and plays a significant role in bone remodeling by inducing RANKL in osteoblasts. Gene deletion of Osmr in mice leads to decreased osteoclast numbers and increased trabecular bone thickness. OSM can promote osteoblast differentiation and mineralization, but in vivo administration in adult animals does not significantly increase osteoclast formation due to the negative feedback loop through the osteoclastogenesis inhibitor WNT16.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Yifeng Shi, Lin Ye, Shiwei Shen, Tianchen Qian, Youjin Pan, Yuhan Jiang, Jinghao Lin, Chen Liu, Yaosen Wu, Xiangyang Wang, Jiake Xu, Haiming Jin
Summary: The study demonstrated that morin can inhibit osteoclast formation through various pathways and attenuate bone loss induced by ovariectomy. This suggests that morin may be a potential therapeutic agent for postmenopausal osteoporosis treatment.
PHYTOTHERAPY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yin Cheng, Haixia Liu, Jing Li, Yujie Ma, Changheng Song, Yuhan Wang, Pei Li, Yanjing Chen, Zhiguo Zhang
Summary: Monascin was found to inhibit osteoclastogenesis in RANKL-induced RAW264.7 cells by suppressing MAPKs signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Ari Elson, Anuj Anuj, Maayan Barnea-Zohar, Nina Reuven
Summary: Osteoclasts are hematopoietic cells that play a key role in degrading bone by secreting protons and proteases. Insufficient or excessive activity of osteoclasts can lead to changes in bone mass and exacerbate symptoms of diseases. Osteoclasts derive from two embryonic cell lineages and undergo a multi-stage process that involves cell differentiation, fusion, and further maturation. Recent studies also suggest the ability of osteoclasts to undergo fission and recycling.
Article
Genetics & Heredity
Salman M. Toor, Sachin Wani, Omar M. E. Albagha
Summary: Osteoclasts are the only bone resorbing cells and play an important role in skeletal mass and structure. Differentiation of osteoclasts involves a complex regulatory network of genes and LncRNAs, with potential implications for understanding bone-related diseases.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Xuan Liu, Li Diao, Yudie Zhang, Xue Yang, Junnan Zhou, Yuhang Mao, Xiaotian Shi, Fuli Zhao, Mei Liu
Summary: Piperlongumine (PL), a compound from Piper longum fruits, can inhibit osteoclast formation and activation, reduce the expression of osteoclastic marker genes, and suppress NF-kappa B activation. PL can also ameliorate titanium particle-induced bone loss in animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Takahiro Noguchi, Hideki Kitaura, Aseel Marahleh, Afifah Zahra Agista, Yusuke Ohsaki, Hitoshi Shirakawa, Itaru Mizoguchi
Summary: Fermented rice bran (FRB) serves as a supplement with anti-inflammatory properties that can mitigate osteoclastogenesis and bone resorption induced by lipopolysaccharide (LPS) by controlling TNF-a expression in macrophages and directly inhibiting osteoclast formation.
Article
Genetics & Heredity
Xu Cheng, Xiaoting Song, Zhiyan Li, Chiting Yuan, Xinhuan Lei, Mingxuan Feng, Zhenghua Hong, Liwei Zhang, Dun Hong
Summary: Hormonal homeostasis is crucial for bone remodeling. Treating intestinal inflammation can regulate bone resorption in distant bones. Increased intestinal permeability may lead to systemic inflammation and bone loss. LPS could be a key mediator in the gut-bone axis. AOAH participates in bone metabolism mainly through inhibiting osteoclast differentiation.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Endocrinology & Metabolism
Nobuyuki Udagawa, Masanori Koide, Midori Nakamura, Yuko Nakamichi, Teruhito Yamashita, Shunsuke Uehara, Yasuhiro Kobayashi, Yuriko Furuya, Hisataka Yasuda, Chie Fukuda, Eisuke Tsuda
Summary: Osteoclasts and osteoblasts play essential roles in bone remodeling, with the regulation of RANKL and OPG expression being a key mechanism. The balance between these factors is crucial for maintaining bone density and preventing bone loss.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Cell Biology
Ying Peng, Qingzhu Liu, Dong Xu, Ke Li, Hang Li, Ling Qiu, Jianguo Lin
Summary: The study found that IPeDP and IHDP had lower toxicity on BMMs, showed abilities in antiosteoclast formation, antibone absorption, and inducing osteoclast apoptosis. The mechanisms behind these effects may involve interference of small GTPases prenylation and downregulation of JNK and Akt phosphorylation.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Shikha Nayar, Joshua K. Morrison, Mamta Giri, Kyle Gettler, Ling-Shiang Chuang, Laura A. Walker, Huaibin M. Ko, Ephraim Kenigsberg, Subra Kugathasan, Miriam Merad, Jaime Chu, Judy H. Cho
Summary: NOD2 deficiency contributes to fibrosis and stricturing complications in Crohn's disease through dysregulated homeostasis of activated fibroblasts and macrophages, which can be ameliorated by gp130 blockade. Carriers of NOD2 risk alleles exhibit dysregulated homeostasis of activated fibroblasts and macrophages, suggesting a potential role for gp130 blockade in rescuing the activated program caused by NOD2 mutations.
Article
Medicine, Research & Experimental
Biao Wu, Jie Shang, Shiyuan Lin, Ning Jiang, Baizhou Xing, Rong Peng, Xianghe Xu, Huading Lu
Summary: Increased bone resorption caused by excessive osteoclasts is the main cause of osteoporosis. The expression of RILP, a protein, is induced by receptor activator of NF-KB ligand, and its inhibition decreases the number and function of osteoclasts. Inhibition of RILP also reduces preosteoclast migration and bone resorption. The study suggests that RILP plays a crucial role in osteoclast formation and bone resorption, and could be a therapeutic target for bone diseases caused by excessive osteoclasts.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Perry C. Caviness, Dongzheng Gai, Oxana P. Lazarenko, Michael L. Blackburn, Fenghuang Zhan, Jin-Ran Chen
Summary: Osteoclasts derived from hematopoietic stem cells play a crucial role in bone resorption. Identifying new molecules that can epigenetically regulate osteoclastogenesis is essential for the development of novel treatments for bone deterioration disorders like osteoporosis. The protein Ezh2 has been found to be associated with the epigenetic regulation of various cellular processes, but its role in bone cell development is still not fully understood.
Article
Endocrinology & Metabolism
Michael Frech, Gregor Schuster, Fabian T. Andes, Georg Schett, Mario M. Zaiss, Kerstin Sarter
Summary: The study revealed the involvement of the immunomodulatory molecule Btn2a2 in osteoclast differentiation and function, with potential implications in bone homeostasis. Btn2a2 deficiency led to abnormal osteoclast function and numbers, affecting bone architecture.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Fatma Rashed, Shingo Kamijyo, Yuri Shimizu, Yuna Hirohashi, Masud Khan, Yasutaka Sugamori, Ramachandran Murali, Kazuhiro Aoki
Summary: RANKL-binding peptides can stimulate osteoblast differentiation through RANKL-reverse signaling, while OPG cannot achieve the same effect. This may be due to the ability of RANKL-binding peptides to promote the accumulation and membrane clustering of RANKL molecules on the surface of osteoblasts, thus activating osteoblast differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)