Versatility or Promiscuity: The Estrogen Receptors, Control of Ligand Selectivity and an Update on Subtype Selective Ligands

The Relationship between Umbilical Cord Estrogens and Perinatal Characteristics

(2014) M. Hickey et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Aliphatic Substitution of o-Carboranyl Phenols Enhances Estrogen Receptor Beta Selectivity

(2014) Kiminori Ohta et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Steroid signaling: Ligand-binding promiscuity, molecular symmetry, and the need for gating

(2014) Richard Lathe et al.   STEROIDS

Design, synthesis, and biological evaluation of cyclopropyl analogues of stilbene with raloxifene side chain as subtype-selective ligands for estrogen receptor

(2013) Hye Lim Yeo et al.   ARCHIVES OF PHARMACAL RESEARCH

Enhanced estrogen receptor beta (ERβ) selectivity of fluorinated carborane-containing ER modulators

(2013) Kiminori Ohta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design of a Highly Selective and Potent Class of Non-planar Estrogen Receptor β Agonists

(2013) Henrik Sundén et al.   ChemMedChem

State of the Science of Endocrine Disruptors

(2013) Linda S. Birnbaum   ENVIRONMENTAL HEALTH PERSPECTIVES

Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens

(2013) Yan Jiang et al.   FASEB JOURNAL

Proline Primed Helix Length as a Modulator of the Nuclear Receptor–Coactivator Interaction

(2013) Sascha Fuchs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α

(2013) Sathish Srinivasan et al.   Nature Chemical Biology

EADB: An Estrogenic Activity Database for Assessing Potential Endocrine Activity

(2013) Jie Shen et al.   TOXICOLOGICAL SCIENCES

Towards β-selectivity in functional estrogen receptor antagonists

(2012) Jose Juan Rodríguez et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors

(2012) J. Osz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes

(2012) V. Delfosse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-function relationship of estrogen receptors in cardiovascular pathophysiological models

(2012) Jean-François Arnal et al.   THROMBOSIS RESEARCH

Hydrophobic Interactions Improve Selectivity to ERα for Benzothiophene SERMs

(2012) Michael J. Chalmers et al.   ACS Medicinal Chemistry Letters

Sulfonamides as selective oestrogen receptor β agonists

(2011) Lee R. Roberts et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An ADIOL-ERβ-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated Inflammation

(2011) Kaoru Saijo et al.   CELL

Structure of Estradiol Metal Chelate and Estrogen Receptor Complex: The Basis for Designing a New Class of Selective Estrogen Receptor Modulators

(2011) Min-Jun Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Evaluation of Fragment-Like Estrogen Receptor Tetrahydroisoquinoline Ligands from a Scaffold-Detection Approach

(2011) Sabine Möcklinghoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Endocrine disrupting chemicals and disease susceptibility

(2011) Thaddeus T. Schug et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Design and Structure of Stapled Peptides Binding to Estrogen Receptors

(2011) Chris Phillips et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

27-Hydroxycholesterol: the first identified endogenous SERM

(2011) Michihisa Umetani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The EDKB: an established knowledge base for endocrine disrupting chemicals

(2010) Don Ding et al.   BMC BIOINFORMATICS

Cancer risk in DES daughters

(2010) Janneke Verloop et al.   CANCER CAUSES & CONTROL

Synthesis and Crystal Structure of a Phosphorylated Estrogen Receptor Ligand Binding Domain

(2010) Sabine Möcklinghoff  et al.   CHEMBIOCHEM

Coupling of receptor conformation and ligand orientation determine graded activity

(2010) John B Bruning et al.   Nature Chemical Biology

Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement

(2009) Evanthia Diamanti-Kandarakis et al.   ENDOCRINE REVIEWS

Discovery of estrogen receptor modulators: a review of virtual screening and SAR efforts

(2009) Xue Xu et al.   Expert Opinion on Drug Discovery

Estrogen receptor β ligands: Recent advances and biomedical applications

(2009) Filippo Minutolo et al.   MEDICINAL RESEARCH REVIEWS

Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands

(2008) Jing Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An amphioxus orthologue of the estrogen receptor that does not bind estradiol: Insights into estrogen receptor evolution

(2008) Mathilde Paris et al.   BMC EVOLUTIONARY BIOLOGY

Selective Estrogen Receptor Modulator Medicinal Chemistry At Merck. A Review

(2008) T. Blizzard   CURRENT TOPICS IN MEDICINAL CHEMISTRY

NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

(2008) Kendall W Nettles et al.   Nature Chemical Biology

Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method

(2008) S. Y. Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

27-Hydroxycholesterol Is an Endogenous Selective Estrogen Receptor Modulator

(2007) Carolyn D. DuSell et al.   MOLECULAR ENDOCRINOLOGY

Molecular characterization of a B-ring unsaturated estrogen: Implications for conjugated equine estrogen components of Premarin

(2007) Robert W. Hsieh et al.   STEROIDS