期刊
JOURNAL OF BIOLOGICAL ENGINEERING
卷 9, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13036-015-0011-2
关键词
Cell-cell communication; Synthetic biology; Cellular consortia; Synthetic circuit engineering; Signal molecule pathways
资金
- Research Training Group Nano- and Biotechnologies for the Packaging of Electronic Systems (German Research Foundation) [DFG 1401/2]
- German Research Foundation
- Open Access Publication Funds of the TU Dresden
Cell-cell communication is a widespread phenomenon in nature, ranging from bacterial quorum sensing and fungal pheromone communication to cellular crosstalk in multicellular eukaryotes. These communication modes offer the possibility to control the behavior of an entire community by modifying the performance of individual cells in specific ways. Synthetic biology, i.e., the implementation of artificial functions within biological systems, is a promising approach towards the engineering of sophisticated, autonomous devices based on specifically functionalized cells. With the growing complexity of the functions performed by such systems, both the risk of circuit crosstalk and the metabolic burden resulting from the expression of numerous foreign genes are increasing. Therefore, systems based on a single type of cells are no longer feasible. Synthetic biology approaches with multiple subpopulations of specifically functionalized cells, wired by artificial cell-cell communication systems, provide an attractive and powerful alternative. Here we review recent applications of synthetic cell-cell communication systems with a specific focus on recent advances with fungal hosts.
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