Recent progress in adjuvant discovery for peptide-based subunit vaccines

A Simple Mycobacterial Monomycolated Glycerol Lipid Has Potent Immunostimulatory Activity

(2014) C. S. Andersen et al.   JOURNAL OF IMMUNOLOGY

Self-Adjuvanting Polymer–Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer

(2013) Tzu-Yu Liu et al.   BIOMACROMOLECULES

Chitin, Chitosan, and Glycated Chitosan Regulate Immune Responses: The Novel Adjuvants for Cancer Vaccine

(2013) Xiaosong Li et al.   Clinical & Developmental Immunology

Vaccination induced antibodies to recombinant avian influenza A virus M2 protein or synthetic M2e peptide do not bind to the M2 protein on the virus or virus infected cells

(2013) Willem J C Swinkels et al.   Virology Journal

M-Protein-derived Conformational Peptide Epitope Vaccine Candidate against Group A Streptococcus

(2013) Mariusz Skwarczynski et al.   Current Drug Delivery

Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope

(2012) Jai S. Rudra et al.   BIOMATERIALS

Advances in Peptide-based Human Papillomavirus Therapeutic Vaccines

(2012) Tzu-Yu Liu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Development and evaluation of AS03, an Adjuvant System containing α-tocopherol and squalene in an oil-in-water emulsion

(2012) Nathalie Garçon et al.   Expert Review of Vaccines

PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses

(2012) Wenxue Ma et al.   International Journal of Nanomedicine

“Monovalent” ligands that trigger TLR-4 and TCR are not necessarily truly monovalent

(2012) Alexander B. Sigalov   MOLECULAR IMMUNOLOGY

Liposome-based delivery system for vaccine candidates: constructing an effective formulation

(2012) Ashwini Kumar Giddam et al.   Nanomedicine

Immunological Evaluation of Lipopeptide Group A Streptococcus (GAS) Vaccine: Structure-Activity Relationship

(2012) Mehfuz Zaman et al.   PLoS One

Peptide-Based Subunit Vaccine against Hookworm Infection

(2012) Mariusz Skwarczynski et al.   PLoS One

The mechanism of action of MF59 – An innately attractive adjuvant formulation

(2012) D.T. O’Hagan et al.   VACCINE

Peptide-Based Subunit Nanovaccines

(2012) Mariusz Skwarczynski et al.   Current Drug Delivery

Antitumor activity of liposomal ErbB2/HER2 epitope peptide-based vaccine constructs incorporating TLR agonists and mannose receptor targeting

(2011) Jean-Sébastien Thomann et al.   BIOMATERIALS

Current status of multiple antigen-presenting peptide vaccine systems: Application of organic and inorganic nanoparticles

(2011) Yoshio Fujita et al.   Chemistry Central Journal

CpG DNA as a vaccine adjuvant

(2011) Christian Bode et al.   Expert Review of Vaccines

ISCOMATRIX Adjuvant Combines Immune Activation with Antigen Delivery to Dendritic Cells In Vivo Leading to Effective Cross-Priming of CD8+ T Cells

(2011) P. Duewell et al.   JOURNAL OF IMMUNOLOGY

DNA released from dying host cells mediates aluminum adjuvant activity

(2011) Thomas Marichal et al.   NATURE MEDICINE

Polyacrylate Dendrimer Nanoparticles: A Self-Adjuvanting Vaccine Delivery System

(2010) Mariusz Skwarczynski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Generation of a tumor vaccine candidate based on conjugation of a MUC1 peptide to polyionic papillomavirus virus-like particles

(2010) Sharmila Pejawar-Gaddy et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Evaluation of a new oil adjuvant for use in peptide-based cancer vaccination

(2010) Kanako Iseki et al.   CANCER SCIENCE

Comparison of the adjuvanticity of two different delivery systems on the induction of humoral and cellular responses to synthetic peptides

(2010) Elena Mata et al.   DRUG DELIVERY

Advances in the design and delivery of peptide subunit vaccines with a focus on Toll-like receptor agonists

(2010) Matthew Black et al.   Expert Review of Vaccines

Self-adjuvanting polyacrylic nanoparticulate delivery system for group A streptococcus (GAS) vaccine

(2010) Mehfuz Zaman et al.   Nanomedicine-Nanotechnology Biology and Medicine

Immunization with Cocktail of HIV-Derived Peptides in Montanide ISA-51 Is Immunogenic, but Causes Sterile Abscesses and Unacceptable Reactogenicity

(2010) Barney S. Graham et al.   PLoS One

Structure–activity relationship of lipopeptide Group A streptococcus (GAS) vaccine candidates on toll-like receptor 2

(2010) Mehfuz Zaman et al.   VACCINE

Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists

(2009) Jörg Vollmer et al.   ADVANCED DRUG DELIVERY REVIEWS

Lipid Core Peptide System for Gene, Drug, and Vaccine Delivery

(2009) Wei Zhong et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Co-assembling peptides as defined matrices for endothelial cells

(2009) Jangwook P. Jung et al.   BIOMATERIALS

Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy

(2009) Joseph R. Podojil et al.   IMMUNOLOGICAL REVIEWS

T-helper 1 and T-helper 2 adjuvants induce distinct differences in the magnitude, quality and kinetics of the early inflammatory response at the site of injection

(2009) Karen Smith Korsholm et al.   IMMUNOLOGY

A Nonadjuvanted Polypeptide Nanoparticle Vaccine Confers Long-Lasting Protection against Rodent Malaria

(2009) S. A. Kaba et al.   JOURNAL OF IMMUNOLOGY

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A self-assembling peptide acting as an immune adjuvant

(2009) J. S. Rudra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liposome fusogenicity and entrapment efficiency of antigen determine the Th1/Th2 bias of antigen-specific immune response

(2009) Marija Brgles et al.   VACCINE

Lipid vesicle size of an oral influenza vaccine delivery vehicle influences the Th1/Th2 bias in the immune response and protection against infection

(2009) Jamie F.S. Mann et al.   VACCINE

Novel immunoadjuvants based on cationic lipid: Preparation, characterization and activity in vivo

(2009) Nilton Lincopan et al.   VACCINE

Synthetic peptides coupled to the surface of liposomes effectively induce SARS coronavirus-specific cytotoxic T lymphocytes and viral clearance in HLA-A*0201 transgenic mice

(2009) Satoshi Ohno et al.   VACCINE

A universal epitope-based influenza vaccine and its efficacy against H5N1

(2009) Y. Adar et al.   VACCINE

Immunogenicity and safety in adults of one dose of influenza A H1N1v 2009 vaccine formulated with and without AS03A-adjuvant: Preliminary report of an observer-blind, randomised trial

(2009) François Roman et al.   VACCINE

Two novel HLA-A*0201 T-cell epitopes in avian H5N1 viral nucleoprotein induced specific immune responses in HHD mice

(2009) Ying-Kit Cheung et al.   VETERINARY RESEARCH

The potential of mannosylated chitosan microspheres to target macrophage mannose receptors in an adjuvant-delivery system for intranasal immunization

(2008) Hu-Lin Jiang et al.   BIOMATERIALS

Self-Adjuvanting Lipopeptide Vaccines

(2008) Peter Moyle et al.   CURRENT MEDICINAL CHEMISTRY

DiC14-amidine cationic liposomes stimulate myeloid dendritic cells through Toll-like receptor 4

(2008) Tetsuya Tanaka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity

(2008) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Vitamin E ingestion improves several immune functions in elderly men and women

(2008) Monica De la Fuente et al.   FREE RADICAL RESEARCH

Chitosan formulations improve the immunogenicity of a GnRH-I peptide-based vaccine

(2008) Leonardo Sáenz et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

(2008) Mirjam Kool et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Modulation of adaptive immunity by different adjuvant–antigen combinations in mice lacking Nod2

(2008) Lilian O. Moreira et al.   VACCINE

A self-adjuvanting lipopeptide-based vaccine candidate for the treatment of hepatitis C virus infection

(2008) Brendon Y. Chua et al.   VACCINE

Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice

(2008) Andreas Wack et al.   VACCINE