Article
Medicine, Research & Experimental
Sailaja Battula, Gregory Papastoitsis, Howard L. Kaufman, K. Dane Wittrup, Michael M. Schmidt
Summary: IL-12 is a potent cytokine that can promote anticancer immunity, but its clinical development has been limited by toxicity. The use of ANK-101, an engineered IL-12 variant, can enhance the efficacy and safety of IL-12 in tumor treatment. This study demonstrates the importance of ANK-101 in future clinical development.
Article
Microbiology
Stella G. G. Hoft, Keith D. D. Kauffman, Shunsuke Sakai, Cecilia S. Lindestam S. Arlehamn, Alessandro Sette, Daniel F. F. Hoft, Richard Herbert, Daniel L. L. Barber
Summary: Alternative delivery routes of BCG vaccine for tuberculosis, such as intradermal injection, may provide better protection. In this study, rhesus macaques were used to compare the airway immune response induced by intradermal versus intragastric delivery of BCG. The results showed that intragastric delivery induced lower T cell response in the airways, possibly due to the imprinting of gut-homing receptors on T cells.
Article
Behavioral Sciences
Jared A. Rowland, Jennifer R. Stapleton-Kotloski, Greg E. Alberto, April T. Davenport, Phillip M. Epperly, Dwayne W. Godwin, James B. Daunais
Summary: The study found that alcohol consumption alters functional brain networks, shifting hubs and Rich Club membership away from previous regions in a non-systematic manner. Analysis of naive brain network characteristics before alcohol exposure can predict future drinking behaviors.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Immunology
Sriram Yandrapally, Anushka Agarwal, Archismita Chatterjee, Satarupa Sarkar, Krishnaveni Mohareer, Sharmistha Banerjee
Summary: This study found that the Mtb-secreted transcription factor EspR can directly regulate the expression of host cytokine genes, thereby increasing the survival of mycobacteria and the propagation of HIV. EspR activates the expression of IL-4, inducing a specific immune microenvironment and shifting macrophage polarization to an M2 state, which inhibits the clearance of intracellular mycobacteria and promotes the propagation of HIV.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Peng Xiong, Tonglin Liu, Hao Huang, Yi Yuan, Wendi Zhang, Lina Fu, Yu Chen
Summary: IL-27 overexpression inhibits Th9 differentiation and regulates the imbalance of Th1/Th2, thereby alleviating inflammatory response in allergic asthma. The findings suggest that IL-27 overexpression may be a potential strategy for clinical treatment of allergic asthma.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Virology
Santhi Devasundaram, Margherita Rosati, Antonio Valentin, Svenja Weiss, Vincenza Itri, Hung V. Trinh, Jenifer Bear, Bhabadeb Chowdhury, Celia C. LaBranche, David Montefiori, Guido Ferrari, Mangala Rao, Xiang-Peng Kong, Susan Zolla-Pazner, George N. Pavlakis, Barbara K. Felber
Summary: Priming with DNA expressing the trimeric V1V2 scaffold alters the hierarchy of humoral immune responses to V2 region epitopes, providing a method for more efficient induction and maintenance of V2-specific Env Abs associated with reduced risk of HIV infection. This work demonstrates that focusing immune responses on the V1V2 region through DNA priming vaccination induces improved recognition of epitopes important for protective immunity, particularly V2-specific humoral immune responses inversely correlating with HIV risk of infection in the RV144 trial.
JOURNAL OF VIROLOGY
(2021)
Article
Neurosciences
Reesha R. Patel, Florence P. Varodayan, Melissa A. Herman, Vanessa Jimenez, Rebecca Agnore, Lina Gao, Michal Bajo, Verginia C. Cuzon Carlson, Nicole A. Walter, Suzanne S. Fei, Kathleen A. Grant, Marisa Roberto
Summary: This study investigated the neuroadaptations in the central amygdala (CeA) following chronic alcohol use and repeated abstinence in male macaques, suggesting a conserved mechanism that may underlie excessive alcohol consumption. The researchers found that while interleukin-1 beta (IL-1 beta) had different effects on CeA GABA release in controls and abstinent drinkers, corticotropin releasing factor (CRF) signaling had similar effects in both groups. These findings indicate both conserved and divergent actions of chronic alcohol on neuroimmune and stress signaling in CeA GABA transmission across rodents and macaques.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Immunology
Kacy S. Yount, Jesse M. Hall, Kyle Caution, Mohamed M. Shamseldin, Myra Guo, Keirsten Marion, Audra R. Fullen, Yimin Huang, Jennifer A. Maynard, Sally A. Quataert, Rajendar Deora, Purnima Dubey
Summary: The resurgence of pertussis caused by Bordetella pertussis calls for new vaccines and vaccination strategies. In this study, the addition of the Th1/17 polarizing adjuvant BcfA to the alum-adjuvanted acellular pertussis vaccine (aPV) was found to reduce nasal colonization. The prime-pull immunization strategy with systemic priming and mucosal booster further enhanced this effect.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Juan Manuel Leyva-Castillo, Mrinmoy Das, Emilie Artru, Juhan Yoon, Claire Galand, Raif S. Geha
Summary: The study found that IL-13 released by cutaneous MCs in response to mechanical skin injury inhibits the T(H)1 cell response to cutaneous antigen exposure in AD.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Yuxuan Li, Yang Jie, Xiaofei Wang, Jing Lu
Summary: The study found that serum IL-35 levels were associated with obesity in patients with rheumatoid arthritis (RA). Overweight patients with RA had significantly lower IL-35 levels compared to lean patients and showed characteristic immunological features of Th1/Th2/Th17-related cytokines.
Article
Virology
Siva Thirugnanam, Edith M. Walker, Faith Schiro, Pyone P. Aye, Jay Rappaport, Namita Rout
Summary: Previous studies have shown that the loss of CD161-expressing CD4(+) Th17 cells is associated with the progression of chronic HIV infection. These cells are significantly reduced in the peripheral blood and gut mucosa of HIV-infected individuals, leading to inflammation and disruption of the gut barrier. However, the impact of HIV infection on CD161-expressing CD8(+) T cells is still unclear.
Article
Behavioral Sciences
Chris Gunter, R. Alan Harris, Zsofia Kovacs-Balint, Muthuswamy Raveendran, Vasiliki Michopoulos, Jocelyne Bachevalier, Jessica Raper, Mar M. Sanchez, Jeffrey Rogers
Summary: Rhesus macaques have been valuable animal models for studying neurobiology and developmental psychology. This study reveals the significant heritability of social behavior in juvenile macaques and provides evidence for genetic associations with autism spectrum disorders.
Article
Endocrinology & Metabolism
Lijie Li, Zhouzhou Liao, Mingzhu Ye, Jianfa Jiang
Summary: The study demonstrated that rhIL-37 protects against endometriosis by increasing the ratio of Th1/Th2 cells, inducing DCs maturation, and inhibiting IL-4 expression in DCs. Additionally, rhIL-37 promotes DCs maturation by inhibiting STAT3 phosphorylation. These findings suggest a potential novel approach for the treatment of endometriosis.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Dermatology
Davide Neri, Melanie Carevic-Neri, Juergen Brueck, Julia Holstein, Iris Schaefer, Farzan Solimani, Rupert Handgretinger, Dominik Hartl, Kamran Ghoreschi
Summary: This study identified an expanded population of PMN-MDSCs in pemphigus patients, with the ability to suppress T-cell proliferation and increased expression of characteristic effector molecules. The frequency of MDSCs was also found to correlate with an increased Th2/Th1 cell ratio in pemphigus patients.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Wei Liu, Meng Li, Xinzhong Zhang, Zengtong Zhou, Zhengyu Shen, Xuemin Shen
Summary: This study aimed to investigate the genetic associations between SNPs in 6 cytokines (IFN-g, IL-18, TGFb1, IL-13, IL-2, IL-4) and OLP susceptibility. A significant association was found between IFN-g (874A/T) and IL-18 (137G/C) polymorphisms with OLP. A marginally significant association was found between TGFb1 (509C/T) polymorphism and OLP. However, no significant associations were found for IL-1b (3954C/T), IL-2 (330T/G), IL-4 (590C/T), and IL-18 (607C/A) polymorphisms with OLP.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Jewell N. Walters, Bernadette Ferraro, Elizabeth K. Duperret, Kimberly A. Kraynyak, Jaemi Chu, Ashley Saint-Fleur, Jian Yan, Hy Levitsky, Amir S. Khan, Niranjan Y. Sardesai, David B. Weiner
Article
Immunology
Trevor R. F. Smith, Katherine Schultheis, Matthew P. Morrow, Kimberly A. Kraynyak, Jay R. McCoy, Kevin C. Yim, Karuppiah Muthumani, Laurent Humeau, David B. Weiner, Niranjan Y. Sardesai, Kate E. Broderick
Article
Multidisciplinary Sciences
Ami Patel, Antonio DiGiandomenico, Ashley E. Keller, Trevor R. F. Smith, Daniel H. Park, Stephanie Ramos, Katherine Schultheis, Sarah T. C. Elliott, Janess Mendoza, Kate E. Broderick, Megan C. Wise, Jian Yan, Jingjing Jiang, Seleeke Flingai, Amir S. Khan, Kar Muthumani, Laurent Humeau, Lily I. Cheng, Leslie Wachter-Rosati, C. Kendall Stover, Niranjan Y. Sardesai, David B. Weiner
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Bryan D. Griffin, Kar Muthumani, Bryce M. Warner, Anna Majer, Mable Hagan, Jonathan Audet, Derek R. Stein, Charlene Ranadheera, Trina Racine, Marc-Antoine De la Vega, Jocelyne Piret, Stephanie Kucas, Kaylie N. Tran, Kathy L. Frost, Christine De Graff, Geoff Soule, Leanne Scharikow, Jennifer Scott, Gordon McTavish, Valerie Smid, Young K. Park, Joel N. Maslow, Niranjan Y. Sardesai, J. Joseph Kim, Xiao-jian Yao, Alexander Bello, Robbin Lindsay, Guy Boivin, Stephanie A. Booth, Darwyn Kobasa, Carissa Embury-Hyatt, David Safronetz, David B. Weiner, Gary P. Kobinger
NATURE COMMUNICATIONS
(2017)
Article
Biotechnology & Applied Microbiology
Kathleen A. Cashman, Eric R. Wilkinson, Carl I. Shaia, Paul R. Facemire, Todd M. Bell, Jeremy J. Bearss, Joshua D. Shamblin, Suzanne E. Wollen, Kate E. Broderick, Niranjan Y. Sardesai, Connie S. Schmaljohn
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2017)
Article
Biotechnology & Applied Microbiology
Xintao Hu, Antonio Valentin, Margherita Rosati, Siriphan Manocheewa, Candido Alicea, Bhabadeb Chowdhury, Jenifer Bear, Kate E. Broderick, Niranjan Y. Sardesai, Sylvie Le Gall, James I. Mullins, George N. Pavlakis, Barbara K. Felber
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2017)
Article
Immunology
Sarah T. C. Elliott, Nicole L. Kallewaard, Ebony Benjamin, Leslie Wachter-Rosati, Josephine M. McAuliffe, Ami Patel, Trevor R. F. Smith, Katherine Schultheis, Daniel H. Park, Seleeke Flingai, Megan C. Wise, Janess Mendoza, Stephanie Ramos, Kate E. Broderick, Jian Yan, Laurent M. Humeau, Niranjan Y. Sardesai, Kar Muthumani, Qing Zhu, David B. Weiner
Article
Biotechnology & Applied Microbiology
Xintao Hu, Antonio Valentin, Yanhui Cai, Frances Dayton, Margherita Rosati, Eric G. Ramirez-Salazar, Viraj Kulkarni, Kate E. Broderick, Niranjan Y. Sardesai, Linda S. Wyatt, Patricia L. Earl, Bernard Moss, James I. Mullins, George N. Pavlakis, Barbara K. Felber
HUMAN GENE THERAPY
(2018)
Article
Virology
Shakti Singh, Eric G. Ramirez-Salazar, Rami Doueiri, Antonio Valentin, Margherita Rosati, Xintao Hu, Brandon F. Keele, Xiaoying Shen, Georgia D. Tomaras, Guido Ferrari, Celia LaBranche, David C. Montefiori, Jishnu Das, Galit Alter, Hung Trinh, Christopher Hamlin, Mangala Rao, Frances Dayton, Jenifer Bear, Bhabadeb Chowdhury, Candido Alicea, Jeffrey D. Lifson, Kate E. Broderick, Niranjan Y. Sardesai, Sandra J. Sivananthan, Christopher B. Fox, Steven G. Reed, David J. Venzon, Vanessa M. Hirsch, George N. Pavlakis, Barbara K. Felber
JOURNAL OF VIROLOGY
(2018)
Article
Immunology
Jian Yan, Matthew P. Morrow, Jaemi S. Chu, Trina Racine, Charles C. Reed, Amir S. Khan, Kate E. Broderick, J. Joseph Kim, Gary P. Kobinger, Niranjan Y. Sardesai, David B. Weiner
Article
Biotechnology & Applied Microbiology
Xintao Hu, Zhongyan Lu, Antonio Valentin, Margherita Rosati, Kate E. Broderick, Niranjan Y. Sardesai, Preston A. Marx, James I. Mullins, George N. Pavlakis, Barbara K. Felber
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2018)
Article
Oncology
Elizabeth K. Duperret, Alfredo Perales-Puchalt, Regina Stoltz, G. H. Hiranjith, Nitin Mandloi, James Barlow, Amitabha Chaudhuri, Niranjan Y. Sardesai, David B. Weiner
CANCER IMMUNOLOGY RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Worawat Songjang, Chatchai Nensat, Nitirut Nernpermpisooth, Porrnthanate Seenak, Panyupa Pankhong, Noppadon Jumroon, Sarawut Kumphune, Arunya Jiraviriyakul
Summary: Damage-associated molecular patterns (DAMPs) are the molecular signature of immunogenic cell death (ICD). The expression of drug-induced DAMPs and their role in tumor progression are crucial for evaluating the efficacy of chemotherapy treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Matthew P. Morrow, Kimberly A. Kraynyak, Albert J. Sylvester, Michael Dallas, Dawson Knoblock, Jean D. Boyer, Jian Yan, Russell Vang, Amir S. Khan, Laurent Humeau, Niranjan Y. Sardesai, J. Joseph Kim, Stanley Plotkin, David B. Weiner, Cornelia L. Trimble, Mark L. Bagarazzi
CLINICAL CANCER RESEARCH
(2018)
Article
Oncology
Kar Muthumani, Liron Marnin, Sagar B. Kudchodkar, Alfredo Perales-Puchalt, Hyeree Choi, Sangya Agarwal, Veronica L. Scott, Emma L. Reuschel, Faraz I. Zaidi, Elizabeth K. Duperret, Megan C. Wise, Kimberly A. Kraynyak, Kenneth. E. Ugen, Niranjan Y. Sardesai, J. Joseph Kim, David B. Weiner
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2017)