PDCD10 (CCM3) regulates brain endothelial barrier integrity in cerebral cavernous malformation type 3: role of CCM3-ERK1/2-cortactin cross-talk

Highly variable intrafamilial manifestations of a CCM3 mutation ranging from acute childhood cerebral haemorrhage to late-onset meningiomas

(2015) C. Fauth et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

CCM2–CCM3 interaction stabilizes their protein expression and permits endothelial network formation

(2015) Kyle M. Draheim et al.   JOURNAL OF CELL BIOLOGY

Quantitative Analysis of Histological Staining and Fluorescence Using ImageJ

(2014) Ellen C. Jensen   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Cortactin Scaffolds Arp2/3 and WAVE2 at the Epithelial Zonula Adherens

(2014) Siew Ping Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bleeding propensity of cavernous malformations: impact of tight junction alterations on the occurrence of overt hematoma

(2014) Dejan Jakimovski et al.   JOURNAL OF NEUROSURGERY

Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury

(2014) Nikola Sladojevic et al.   NEUROBIOLOGY OF DISEASE

Architecture of tight junctions and principles of molecular composition

(2014) Christina M. Van Itallie et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The role of actin-binding proteins in the control of endothelial barrier integrity

(2014) A. García-Ponce et al.   THROMBOSIS AND HAEMOSTASIS

SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein–protein interactions

(2013) Peter H. Sugden et al.   BIOCHEMICAL JOURNAL

STRIPAK complexes: Structure, biological function, and involvement in human diseases

(2013) Juyeon Hwang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Interaction of p190RhoGAP with C-terminal Domain of p120-catenin Modulates Endothelial Cytoskeleton and Permeability

(2013) Noureddine Zebda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

Dynamic Permeability and Quantitative Susceptibility

(2013) Abdul Ghani Mikati et al.   STROKE

Consecutive Proteolytic Digestion in an Enzyme Reactor Increases Depth of Proteomic and Phosphoproteomic Analysis

(2012) Jacek R. Wiśniewski et al.   ANALYTICAL CHEMISTRY

Ultrastructural analysis of vascular features in cerebral cavernous malformations

(2012) Gamze Tanriover et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

The outlook for adults with epileptic seizure(s) associated with cerebral cavernous malformations or arteriovenous malformations

(2012) Rustam Al-Shahi Salman   EPILEPSIA

Extracellular Signal-regulated Kinase (ERK) Regulates Cortactin Ubiquitination and Degradation in Lung Epithelial Cells

(2012) Jing Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antithrombotic Therapy and Bleeding Risk in a Prospective Cohort Study of Patients With Cerebral Cavernous Malformations

(2012) Hans-Martin Schneble et al.   STROKE

Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility

(2011) Wenqi Wang et al.   BMC CELL BIOLOGY

Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease

(2011) Bilge Yoruk et al.   DEVELOPMENTAL BIOLOGY

Structure-Function Analysis of Core STRIPAK Proteins

(2011) Michelle J. Kean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo

(2011) Michael Schnoor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impairment of Tight Junctions and Glucose Transport in Endothelial Cells of Human Cerebral Cavernous Malformations

(2011) Hannah Schneider et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Editorial

(2011) Issam A. Awad   JOURNAL OF NEUROSURGERY

Loss ofcerebral cavernous malformation 3(Ccm3) in neuroglia leads to CCM and vascular pathology

(2011) Angeliki Louvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zona occludens proteins modulate podosome formation and function

(2010) Joachim Kremerskothen et al.   FASEB JOURNAL

Recent insights into cerebral cavernous malformations: the molecular genetics of CCM

(2010) Florence Riant et al.   FEBS Journal

A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease

(2010) D. A. McDonald et al.   HUMAN MOLECULAR GENETICS

Rho Kinase Inhibition Rescues the Endothelial Cell Cerebral Cavernous Malformation Phenotype

(2010) Asya L. Borikova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCM1 regulates vascular-lumen organization by inducing endothelial polarity

(2010) M. G. Lampugnani et al.   JOURNAL OF CELL SCIENCE

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

(2010) Rebecca A. Stockton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Magnetic Resonance Imaging Evaluation of Cerebral Cavernous Malformations With Susceptibility-Weighted Imaging

(2010) Nicolas Menjot de Champfleur et al.   NEUROSURGERY

The pathogenetic features of cerebral cavernous malformations: a comprehensive review with therapeutic implications

(2010) Khaled M. Krisht et al.   Neurosurgical Focus

Cerebral cavernous malformations as a disease of vascular permeability: from bench to bedside with caution

(2010) Sanjay Yadla et al.   Neurosurgical Focus

Upregulation of transmembrane endothelial junction proteins in human cerebral cavernous malformations

(2010) Jan-Karl Burkhardt et al.   Neurosurgical Focus

Defining the Functional Domain of Programmed Cell Death 10 through Its Interactions with Phosphatidylinositol-3,4,5-Trisphosphate

(2010) Christopher F. Dibble et al.   PLoS One

Cortactin Phosphorylated by ERK1/2 Localizes to Sites of Dynamic Actin Regulation and Is Required for Carcinoma Lamellipodia Persistence

(2010) Laura C. Kelley et al.   PLoS One

Stabilization of VEGFR2 Signaling by Cerebral Cavernous Malformation 3 Is Critical for Vascular Development

(2010) Y. He et al.   Science Signaling

Zonula Occludens-1 and -2 Are Cytosolic Scaffolds That Regulate the Assembly of Cellular Junctions

(2009) Alan S. Fanning et al.   Annals of the New York Academy of Sciences

Caveolae-mediated Internalization of Occludin and Claudin-5 during CCL2-induced Tight Junction Remodeling in Brain Endothelial Cells

(2009) Svetlana M. Stamatovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cortactin: Coordinating adhesion and the actin cytoskeleton at cellular protrusions

(2009) Gang Ren et al.   CELL MOTILITY AND THE CYTOSKELETON

Regulation of Endothelial Junctional Permeability

(2008) Emily Vandenbroucke et al.   Annals of the New York Academy of Sciences

Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier

(2008) Svetlana Stamatovic et al.   Current Neuropharmacology

Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex

(2008) Sonja Stahl et al.   HUMAN MUTATION

ADVANCED MAGNETIC RESONANCE IMAGING OF CEREBRAL CAVERNOUS MALFORMATIONS

(2008) Robert Shenkar et al.   NEUROSURGERY

Structural organization of the tight junctions

(2007) Luca Paris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cerebral cavernous malformations: congruency of histopathological features with the current clinical definition

(2007) J M Frischer et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY