A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening
出版年份 2014 全文链接
标题
A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening
作者
关键词
Drug Target, Dasatinib, Panc0813 Cell, Closeness Centrality, Cancer Drug Target
出版物
Genome Medicine
Volume 6, Issue 7, Pages -
出版商
Springer Nature
发表日期
2014-07-29
DOI
10.1186/s13073-014-0057-7
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mutational landscape and significance across 12 major cancer types
- (2013) Cyriac Kandoth et al. NATURE
- Emerging landscape of oncogenic signatures across human cancers
- (2013) Giovanni Ciriello et al. NATURE GENETICS
- Aiding and abetting cancer: mRNA export and the nuclear pore
- (2013) Biljana Culjkovic-Kraljacic et al. TRENDS IN CELL BIOLOGY
- CancerDR: Cancer Drug Resistance Database
- (2013) Rahul Kumar et al. Scientific Reports
- A randomised phase II trial of the Polo-like kinase inhibitor BI 2536 in chemo-naïve patients with unresectable exocrine adenocarcinoma of the pancreas – a study within the Central European Society Anticancer Drug Research (CESAR) collaborative network
- (2012) K Mross et al. BRITISH JOURNAL OF CANCER
- A Landscape of Driver Mutations in Melanoma
- (2012) Eran Hodis et al. CELL
- Molecular Pathways: Dysregulated Glutamatergic Signaling Pathways in Cancer
- (2012) T. D. Prickett et al. CLINICAL CANCER RESEARCH
- Machine Learning Techniques and Drug Design
- (2012) J.C. Gertrudes et al. CURRENT MEDICINAL CHEMISTRY
- Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy
- (2012) Cristina E Tognon et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- Semaphorin 3A lytic hybrid peptide binding to neuropilin-1 as a novel anti-cancer agent in pancreatic cancer
- (2011) Hanae Ueyama et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Correlation of Somatic Mutation and Expression Identifies Genes Important in Human Glioblastoma Progression and Survival
- (2011) D. L. Masica et al. CANCER RESEARCH
- Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency
- (2011) L. Wang et al. GENOME RESEARCH
- Unknown
- (2011) Michalis Karamouzis et al. MOLECULAR MEDICINE
- Targeting ATR and Chk1 kinases for cancer treatment: A new model for new (and old) drugs
- (2011) Luis I. Toledo et al. Molecular Oncology
- Predicting selective drug targets in cancer through metabolic networks
- (2011) O. Folger et al. Molecular Systems Biology
- Beyond natural antibodies: the power of in vitro display technologies
- (2011) Andrew R M Bradbury et al. NATURE BIOTECHNOLOGY
- Trends in the exploitation of novel drug targets
- (2011) Mathias Rask-Andersen et al. NATURE REVIEWS DRUG DISCOVERY
- Gene3D: a domain-based resource for comparative genomics, functional annotation and protein network analysis
- (2011) J. Lees et al. NUCLEIC ACIDS RESEARCH
- STITCH 3: zooming in on protein-chemical interactions
- (2011) M. Kuhn et al. NUCLEIC ACIDS RESEARCH
- SMART 7: recent updates to the protein domain annotation resource
- (2011) I. Letunic et al. NUCLEIC ACIDS RESEARCH
- ChEMBL: a large-scale bioactivity database for drug discovery
- (2011) A. Gaulton et al. NUCLEIC ACIDS RESEARCH
- The Pfam protein families database
- (2011) M. Punta et al. NUCLEIC ACIDS RESEARCH
- A New Methodology to Associate SNPs with Human Diseases According to Their Pathway Related Context
- (2011) Burcu Bakir-Gungor et al. PLoS One
- Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
- (2011) Richard Marcotte et al. Cancer Discovery
- UniProt Knowledgebase: a hub of integrated protein data
- (2011) M. Magrane et al. Database-The Journal of Biological Databases and Curation
- Prediction of Drug Combinations by Integrating Molecular and Pharmacological Data
- (2011) Xing-Ming Zhao et al. PLoS Computational Biology
- Identifying essential genes in bacterial metabolic networks with machine learning methods
- (2010) Kitiporn Plaimas et al. BMC Systems Biology
- Integrative Genomic Profiling of Human Prostate Cancer
- (2010) Barry S. Taylor et al. CANCER CELL
- Dasatinib Inhibits the Development of Metastases in a Mouse Model of Pancreatic Ductal Adenocarcinoma
- (2010) Jennifer P. Morton et al. GASTROENTEROLOGY
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs
- (2010) C. Knox et al. NUCLEIC ACIDS RESEARCH
- COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
- (2010) S. A. Forbes et al. NUCLEIC ACIDS RESEARCH
- WD40 proteins propel cellular networks
- (2010) Christian U. Stirnimann et al. TRENDS IN BIOCHEMICAL SCIENCES
- Combining tissue transcriptomics and urine metabolomics for breast cancer biomarker identification
- (2009) Hojung Nam et al. BIOINFORMATICS
- Peptide Inhibitors Targeting Protein Kinases
- (2009) Hagit Eldar-Finkelman et al. CURRENT PHARMACEUTICAL DESIGN
- Targeting cancer with phosphodiesterase inhibitors
- (2009) Rajkumar Savai et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Cancer genome sequencing: a review
- (2009) E. R. Mardis et al. HUMAN MOLECULAR GENETICS
- Identification of a novel antitumor peptide based on the screening of an Ala-library derived from the LALF32â51 region
- (2009) Maribel G. Vallespi et al. JOURNAL OF PEPTIDE SCIENCE
- The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model
- (2009) E. C. VanderPorten et al. MOLECULAR CANCER THERAPEUTICS
- Tissue specificity and the human protein interaction network
- (2009) Alice Bossi et al. Molecular Systems Biology
- Predicting new molecular targets for known drugs
- (2009) Michael J. Keiser et al. NATURE
- PepX: a structural database of non-redundant protein–peptide complexes
- (2009) Peter Vanhee et al. NUCLEIC ACIDS RESEARCH
- The role of COX-2 in intestinal inflammation and colorectal cancer
- (2009) D Wang et al. ONCOGENE
- Human Disease-Drug Network Based on Genomic Expression Profiles
- (2009) Guanghui Hu et al. PLoS One
- SVMs Modeling for Highly Imbalanced Classification
- (2008) Yuchun Tang et al. IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART B-CYBERNETICS
- An integrated approach to inferring gene-disease associations in humans
- (2008) Predrag Radivojac et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
- (2008) S. Jones et al. SCIENCE
- Drug Target Identification Using Side-Effect Similarity
- (2008) M. Campillos et al. SCIENCE
- Targeting FLT3 for the Treatment of Leukemia
- (2008) Donald Small SEMINARS IN HEMATOLOGY
- Effects of α-adrenoreceptor antagonists on apoptosis and proliferation of pancreatic cancer cells in vitro
- (2008) Su-Gang Shen et al. WORLD JOURNAL OF GASTROENTEROLOGY
- PTTG: an important target gene for ovarian cancer therapy
- (2008) Siva Panguluri et al. Journal of Ovarian Research
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