Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy

Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC).

(2017) J. Jassem et al.   JOURNAL OF CLINICAL ONCOLOGY

Investigation of the insulin-like growth factor-1 signaling pathway in localized Ewing sarcoma

(2011) Scott C. Borinstein et al.   CANCER

ATP-Competitive Inhibitors of mTOR: An Update

(2011) S. Schenone et al.   CURRENT MEDICINAL CHEMISTRY

Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer

(2011) Elizabeth Buck et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Targeting the insulin-like growth factor signaling pathway: figitumumab and other novel anticancer strategies

(2011) Timothy A Yap et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Targeting neurotrophin-3 and its dependence receptor tyrosine kinase receptor C: a new antitumoral strategy

(2011) Servane Tauszig-Delamasure et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Novel molecular therapies in hepatocellular carcinoma

(2011) Sandrine Faivre et al.   LIVER INTERNATIONAL

Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFR / 

(2011) A. Bielen et al.   MOLECULAR CANCER THERAPEUTICS

Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells

(2010) Mahvash Zakikhani et al.   BREAST CANCER RESEARCH AND TREATMENT

Expression of IGF1R in normal breast tissue and subsequent risk of breast cancer

(2010) Rulla M. Tamimi et al.   BREAST CANCER RESEARCH AND TREATMENT

Synthetic Lethality Screens Reveal RPS6 and MST1R as Modifiers of Insulin-like Growth Factor-1 Receptor Inhibitor Activity in Childhood Sarcomas

(2010) J. C. Potratz et al.   CANCER RESEARCH

ETV6-NTRK3-Mediated Breast Epithelial Cell Transformation Is Blocked by Targeting the IGF1R Signaling Pathway

(2010) C. E. Tognon et al.   CANCER RESEARCH

A Phase I Study of Weekly R1507, A Human Monoclonal Antibody Insulin-like Growth Factor-I Receptor Antagonist, in Patients with Advanced Solid Tumors

(2010) R. Kurzrock et al.   CLINICAL CANCER RESEARCH

Targeting the Insulin-like Growth Factor Receptor-1R Pathway for Cancer Therapy

(2010) J. Zha et al.   CLINICAL CANCER RESEARCH

Figitumumab (CP-751,871) for cancer therapy

(2010) Antonio Gualberto   EXPERT OPINION ON BIOLOGICAL THERAPY

Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4

(2010) Qingqiu Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Is Beautiful: Insulin-Like Growth Factors and Their Role in Growth, Development, and Cancer

(2010) Robert G. Maki   JOURNAL OF CLINICAL ONCOLOGY

Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not

(2010) Vassiliki Nikoletopoulou et al.   NATURE

Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy

(2010) D. B. Ulanet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Kinase-Independent Role for Unoccupied Insulin and IGF-1 Receptors in the Control of Apoptosis

(2010) J. Boucher et al.   Science Signaling

Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma

(2009) Paul Haluska et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Expression and function of the insulin receptor substrate proteins in cancer

(2009) Katerina Mardilovich et al.   Cell Communication and Signaling

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor

(2009) Mark J Mulvihill et al.   Future Medicinal Chemistry

Phase I, Pharmacokinetic, and Pharmacodynamic Study of AMG 479, a Fully Human Monoclonal Antibody to Insulin-Like Growth Factor Receptor 1

(2009) Anthony W. Tolcher et al.   JOURNAL OF CLINICAL ONCOLOGY

IGF-1R targeted treatment of sarcoma

(2009) Jeffrey A Toretsky et al.   LANCET ONCOLOGY

Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study

(2009) David Olmos et al.   LANCET ONCOLOGY

Insulin receptor substrate 1 modulates the transcriptional activity and the stability of androgen receptor in breast cancer cells

(2008) Marilena Lanzino et al.   BREAST CANCER RESEARCH AND TREATMENT

Addiction to Elevated Insulin-like Growth Factor I Receptor and Initial Modulation of the AKT Pathway Define the Responsiveness of Rhabdomyosarcoma to the Targeting Antibody

(2008) L. Cao et al.   CANCER RESEARCH

Co-Targeting Insulin-Like Growth Factor I Receptor and HER2: Dramatic Effects of HER2 Inhibitors on Nonoverexpressing Breast Cancer

(2008) A. K. Chakraborty et al.   CANCER RESEARCH

A Pivotal Role for Heat Shock Protein 90 in Ewing Sarcoma Resistance to Anti-Insulin-like Growth Factor 1 Receptor Treatment: In vitro and In vivo Study

(2008) A. S. Martins et al.   CANCER RESEARCH

Molecularly targeted therapy for hepatocellular carcinoma

(2008) Shinji Tanaka et al.   CANCER SCIENCE

The insulin receptor substrate-1: A biomarker for cancer?

(2008) Renato Baserga   EXPERIMENTAL CELL RESEARCH

Emerging drugs for adrenocortical carcinoma

(2008) Alfredo Berruti et al.   EXPERT OPINION ON EMERGING DRUGS

Cross-Talk Between the ErbB/HER Family and the Type I Insulin-Like Growth Factor Receptor Signaling Pathway in Breast Cancer

(2008) Quanri Jin et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

IGF-1 Receptor Inhibitors in Clinical Trials—Early Lessons

(2008) S. John Weroha et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Crosstalk Between IGF1R and Estrogen Receptor Signaling in Breast Cancer

(2008) Dedra H. Fagan et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924

(2008) P. Haluska et al.   MOLECULAR CANCER THERAPEUTICS

IGF1 Is a Common Target Gene of Ewing's Sarcoma Fusion Proteins in Mesenchymal Progenitor Cells

(2008) Luisa Cironi et al.   PLoS One

The role of insulin receptor substrate-1 in transformation by v-src

(2007) Hongzhi Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program

(2007) Peter J. Houghton et al.   PEDIATRIC BLOOD & CANCER