Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment

A Generally Applicable Translational Strategy Identifies S100A4 as a Candidate Gene in Allergy

(2014) S. Bruhn et al.   Science Translational Medicine

DNA Methylation Changes Separate Allergic Patients from Healthy Controls and May Reflect Altered CD4+ T-Cell Population Structure

(2014) Colm E. Nestor et al.   PLoS Genetics

T-Helper 2 Immunity Is Associated With Reduced Risk of Myocardial Infarction and Stroke

(2013) Daniel Engelbertsen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A guanidine-rich regulatory oligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation

(2012) Xiang Cheng et al.   EMBO Molecular Medicine

BRCA1 gene therapy reduces systemic inflammatory response and multiple organ failure and improves survival in experimental sepsis

(2012) H Teoh et al.   GENE THERAPY

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

Three-dimensional reconstruction of protein networks provides insight into human genetic disease

(2012) Xiujuan Wang et al.   NATURE BIOTECHNOLOGY

Combined Multivariate and Pathway Analyses Show That Allergen-Induced Gene Expression Changes in CD4+ T Cells Are Reversed by Glucocorticoids

(2012) Yelin Zhao et al.   PLoS One

Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms

(2012) Fredrik Barrenäs et al.   GENOME BIOLOGY

Annotating Cancer Variants and Anti-Cancer Therapeutics in Reactome

(2012) Marija Milacic et al.   Cancers

Genomic Differences Distinguish the Myofibroblast Phenotype of Distal Lung Fibroblasts from Airway Fibroblasts

(2011) Xiuxia Zhou et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Principles and Strategies for Developing Network Models in Cancer

(2011) Dana Pe'er et al.   CELL

New IBD genetics: common pathways with other diseases

(2011) C. W. Lees et al.   GUT

Global map of physical interactions among differentially expressed genes in multiple sclerosis relapses and remissions

(2011) Tamir Tuller et al.   HUMAN MOLECULAR GENETICS

Shared genetics in coeliac disease and other immune-mediated diseases

(2011) J. Gutierrez-Achury et al.   JOURNAL OF INTERNAL MEDICINE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Next-generation sequencing to generate interactome datasets

(2011) Haiyuan Yu et al.   NATURE METHODS

DistiLD Database: diseases and traits in linkage disequilibrium blocks

(2011) A. Palleja et al.   NUCLEIC ACIDS RESEARCH

Identification of Novel Biomarkers in Seasonal Allergic Rhinitis by Combining Proteomic, Multivariate and Pathway Analysis

(2011) Hui Wang et al.   PLoS One

Systems medicine and integrated care to combat chronic noncommunicable diseases

(2011) Jean Bousquet et al.   Genome Medicine

Pervasive Sharing of Genetic Effects in Autoimmune Disease

(2011) Chris Cotsapas et al.   PLoS Genetics

A Comprehensive Analysis of Shared Loci between Systemic Lupus Erythematosus (SLE) and Sixteen Autoimmune Diseases Reveals Limited Genetic Overlap

(2011) Paula S. Ramos et al.   PLoS Genetics

A CD8+ T cell transcription signature predicts prognosis in autoimmune disease

(2010) Eoin F McKinney et al.   NATURE MEDICINE

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Genomic patterns of pleiotropy and the evolution of complexity

(2010) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene set enrichment analysis made simple

(2010) Rafael A Irizarry et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Fewer permutations, more accurate P-values

(2009) Theo A. Knijnenburg et al.   BIOINFORMATICS

Heterogeneity and plasticity of T helper cells

(2009) Jinfang Zhu et al.   CELL RESEARCH

Increased IFN-γ activity in seasonal allergic rhinitis is decreased by corticosteroid treatment

(2009) Hui Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natalizumab alters transcriptional expression profiles of blood cell subpopulations of multiple sclerosis patients

(2008) Raija L.P. Lindberg et al.   JOURNAL OF NEUROIMMUNOLOGY